EuRBPDB

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  • Description
  • RBDs
  • RBPome
  • PRI
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Phenotypes
  • GWAS
  • PPI
  • Paralogs
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000129351 (Gene tree)
Gene ID
3609
Gene Symbol
ILF3
Alias
NF90|MPHOSPH4|MPP4|NFAR-1|NFAR110|NFAR-2|TCP110|NF110|DRBP76|NFAR90|NF110b|NF90a|NF90c|NF90ctv|MPP4110
Full Name
interleukin enhancer binding factor 3
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
38,159 bases
Position
chr19:10,654,261-10,692,419
Accession
6038
RBP type
canonical RBP
Summary
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Dec 2014]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000250241DZFPF07528.143e-10811
ENSP00000465515DZFPF07528.143.1e-10811
ENSP00000384660DZFPF07528.143.1e-10811
ENSP00000465219DZFPF07528.143.1e-10811
ENSP00000404121DZFPF07528.145.3e-10811
ENSP00000468181DZFPF07528.145.3e-10811
ENSP00000468156DZFPF07528.145.3e-10811
ENSP00000465654DZFPF07528.143.3e-6311
ENSP00000468134DZFPF07528.148.8e-1711
ENSP00000464974DZFPF07528.145.3e-0611
ENSP00000250241dsrmPF00035.264.7e-2512
ENSP00000250241dsrmPF00035.264.7e-2522
ENSP00000465515dsrmPF00035.264.8e-2512
ENSP00000465515dsrmPF00035.264.8e-2522
ENSP00000465219dsrmPF00035.264.9e-2512
ENSP00000465219dsrmPF00035.264.9e-2522
ENSP00000384660dsrmPF00035.265e-2512
ENSP00000384660dsrmPF00035.265e-2522
ENSP00000468156dsrmPF00035.266.7e-2512
ENSP00000468156dsrmPF00035.266.7e-2522
ENSP00000404121dsrmPF00035.266.7e-2512
ENSP00000404121dsrmPF00035.266.7e-2522
ENSP00000468181dsrmPF00035.266.7e-2512
ENSP00000468181dsrmPF00035.266.7e-2522
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNANascentRICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
27453046Comprehensive Identification of RNA-Binding Domains in Human CellsRIC & Hela2016 Aug 18Castello ADOI: 10.1016/j.molcel.2016.06.029
30352994Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome captureRIC & Jurkat2018 Oct 23Perez-Perri JIDOI:10.1038/s41467-018-06557-8
Protein-RNA interaction(RNA-Binding Site)
Click here to download all RNA binding sites
Click here to download all RNA binding sites

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
22833610NF45 dimerizes with NF90, Zfr and SPNR via a conserved domain that has a nucleotidyltransferase fold.Nucleic Acids Res2012 OctWolkowicz UMdoi: 10.1093/nar/gks696
10337617Cloning and characterization of the mouse interleukin enhancer binding factor 3 (Ilf3) homolog in a screen for RNA binding proteins.Mamm Genome1999 MayBuaas FW-
11777942Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.J Cell Biol2002 Jan 7Brownawell AM-
17913627Analysis of RNA:protein interactions in vivo: identification of RNA-binding partners of nuclear factor 90.Methods Enzymol2007Parrott AM-
29545014Identification and analysis of host proteins that interact with the 3'-untranslated region of tick-borne encephalitis virus genomic RNA.Virus Res2018 Apr 2Muto Mdoi: 10.1016/j.virusres.2018.03.006
29590119NF90/ILF3 is a transcription factor that promotes proliferation over differentiation by hierarchical regulation in K562 erythroleukemia cells.PLoS One2018 Mar 28Wu THdoi: 10.1371/journal.pone.0193126
23976881The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA.PLoS Biol2013Yao Pdoi: 10.1371/journal.pbio.1001635
26795062Coordinated Action of Two Double-Stranded RNA Binding Motifs and an RGG Motif Enables Nuclear Factor 90 To Flexibly Target Different RNA Substrates.Biochemistry2016 Feb 16Schmidt Tdoi: 10.1021/acs.biochem.5b01072
28117799Visualization of Protein-protein Interaction in Nuclear and Cytoplasmic Fractions by Co-immunoprecipitation and In Situ Proximity Ligation Assay.J Vis Exp2017 Jan 16Zhu Xdoi: 10.3791/55218.
30796096Oncogenic splicing factor SRSF3 regulates ILF3 alternative splicing to promote cancer cell proliferation and transformation.RNA2019 MayJia Rdoi: 10.1261/rna.068619.118
9671709Activities of adenovirus virus-associated RNAs: purification and characterization of RNA binding proteins.Proc Natl Acad Sci U S A1998 Jul 21Liao HJ-
12946349Selective regulation of gene expression by nuclear factor 110, a member of the NF90 family of double-stranded RNA-binding proteins.J Mol Biol2003 Sep 5Reichman TW-
21386893NF90 binds the dengue virus RNA 3' terminus and is a positive regulator of dengue virus replication.PLoS One2011 Feb 28Gomila RCdoi: 10.1371/journal.pone.0016687.
14570900Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3.J Biol Chem2004 Jan 9Gwizdek C-
30383449RNA stability protein ILF3 mediates cytokine-induced angiogenesis.FASEB J2019 MarVrakas CNdoi: 10.1096/fj.201801315R
30895953[RNA Enhancement by lncRNA Promotes Translation Through Recruitment of ILF3 and EIF4A1 to the Target Mammalian mRNAs].Mol Biol (Mosk)2019 Jan-FebJin SHdoi: 10.1134/S002689841901004X.
20112001Characterization of proteins associating with 5' terminus of PGHS-1 mRNA.Cell Mol Biol Lett2010 JunBunimov Ndoi: 10.2478/s11658-010-0005-5
18490444MKP-1 mRNA stabilization and translational control by RNA-binding proteins HuR and NF90.Mol Cell Biol2008 JulKuwano Ydoi: 10.1128/MCB.00165-08
17855395Novel rapidly evolving hominid RNAs bind nuclear factor 90 and display tissue-restricted distribution.Nucleic Acids Res2007Parrott AM-
21763496HIV-1 replication and latency are regulated by translational control of cyclin T1.J Mol Biol2011 Jul 29Hoque Mdoi: 10.1016/j.jmb.2011.03.060.
21401756Phosphorylation at serine 482 affects stability of NF90 and its functional role in mitosis.Cell Prolif2011 AprSmith NLdoi: 10.1111/j.1365-2184.2011.00742.x.
26240280The NF45/NF90 Heterodimer Contributes to the Biogenesis of 60S Ribosomal Subunits and Influences Nucleolar Morphology.Mol Cell Biol2015 OctWandrey Fdoi: 10.1128/MCB.00306-15
11438540Nuclear factor 90 is a substrate and regulator of the eukaryotic initiation factor 2 kinase double-stranded RNA-activated protein kinase.J Biol Chem2001 Aug 31Parker LM-
18927617Hepatic transcriptome analysis of hepatitis C virus infection in chimpanzees defines unique gene expression patterns associated with viral clearance.PLoS One2008Nanda Sdoi: 10.1371/journal.pone.0003442
18039850Double-stranded RNA-binding protein regulates vascular endothelial growth factor mRNA stability, translation, and breast cancer angiogenesis.Mol Cell Biol2008 JanVumbaca F-
17890166The nuclear PP1 interacting protein ZAP3 (ZAP) is a putative nucleoside kinase that complexes with SAM68, CIA, NF110/45, and HNRNP-G.Biochim Biophys Acta2007 OctUlke-Lemee A-
22639388ILF-3 is a regulator of the neural plate border marker Zic1 in chick embryos.Dev Dyn2012 AugFishwick KJdoi: 10.1002/dvdy.23809
21624892EBP1 and DRBP76/NF90 binding proteins are included in the major histocompatibility complex class II RNA operon.Nucleic Acids Res2011 Sep 1Corso Cdoi: 10.1093/nar/gkr278
29040738NF90-NF45 is a selective RNA chaperone that rearranges viral and cellular riboswitches: biochemical analysis of a virus host factor activity.Nucleic Acids Res2017 Dec 1Schmidt Tdoi: 10.1093/nar/gkx931.
30060955A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA, miR-7.Biochem Biophys Res Commun2018 Sep 10Higuchi Tdoi: 10.1016/j.bbrc.2018.07.119
10400669DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR.J Biol Chem1999 Jul 16Patel RC-
16537583Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76.J Virol2006 AprMerrill MK-
12702813RNA binding and intramolecular interactions modulate the regulation of gene expression by nuclear factor 110.RNA2003 MayReichman TW-
12504009Nuclear export of NF90 is required for interleukin-2 mRNA stabilization.Mol Cell2002 DecShim J-
11739746The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.Mol Cell Biol2002 JanReichman TW-
16396631Identification of Ebp1 as a component of cytoplasmic bcl-2 mRNP (messenger ribonucleoprotein particle) complexes.Biochem J2006 May 15Bose SK-
11167023Alternative splicing in the human interleukin enhancer binding factor 3 (ILF3) gene.Gene2000 Dec 31Duchange N-
10931159Widespread susceptibility among inbred mouse strains to the induction of lupus autoantibodies by pristane.Clin Exp Immunol2000 AugSatoh M-
10607473Molecular cloning and characterization of a translational inhibitory protein that binds to coding sequences of human acid beta-glucosidase and other mRNAs.Mol Genet Metab1999 DecXu YH-
15934098Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus.Arthritis Rheum2005 JunGraham KL-
15811368RNA binding and phosphorylation determine the intracellular distribution of nuclear factors 90 and 110.J Mol Biol2005 Apr 29Parrott AM-
15746098NF90 regulates cell cycle exit and terminal myogenic differentiation by direct binding to the 3'-untranslated region of MyoD and p21WAF1/CIP1 mRNAs.J Biol Chem2005 May 13Shi L-
15694175Translation modulation of acid beta-glucosidase in HepG2 cells: participation of the PKC pathway.Mol Genet Metab2005 MarXu YH-
16809299The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site.J Virol2006 JulMerrill MK-
15254228Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5.Mol Cell Biol2004 AugChen T-
23117626NF90 coordinately represses the senescence-associated secretory phenotype.Aging (Albany NY)2012 OctTominaga-Yamanaka K-
19850717NF90 selectively represses the translation of target mRNAs bearing an AU-rich signature motif.Nucleic Acids Res2010 JanKuwano Ydoi: 10.1093/nar/gkp861
19494010Nuclear factor 90 negatively regulates influenza virus replication by interacting with viral nucleoprotein.J Virol2009 AugWang Pdoi: 10.1128/JVI.00735-09
18458058Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control.Mol Cell Biol2008 JulGuan Ddoi: 10.1128/MCB.00120-08
17565659Modulation of RANTES expression by HCV core protein in liver derived cell lines.BMC Gastroenterol2007 Jun 12Ruggieri A-
23321469Proteomic analysis of interleukin enhancer binding factor 3 (Ilf3) and nuclear factor 90 (NF90) interactome.Biochimie2013 JunChaumet Adoi: 10.1016/j.biochi.2013.01.004
21969602The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.Mol Cell Biol2011 DecShamanna RAdoi: 10.1128/MCB.05849-11
21987769DRBP76 associates with Ebola virus VP35 and suppresses viral polymerase function.J Infect Dis2011 NovShabman RSdoi: 10.1093/infdis/jir343.
21811582L-Ilf3 and L-NF90 traffic to the nucleolus granular component: alternatively-spliced exon 3 encodes a nucleolar localization motif.PLoS One2011Viranaicken Wdoi: 10.1371/journal.pone.0022296
24719423hnRNP L and NF90 interact with hepatitis C virus 5'-terminal untranslated RNA and promote efficient replication.J Virol2014 JulLi Ydoi: 10.1128/JVI.00225-14
26289635Nanog RNA-binding proteins YBX1 and ILF3 affect pluripotency of embryonic stem cells.Cell Biol Int2016 AugGuo Cdoi: 10.1002/cbin.10539
24623135NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells.J Immunol2014 Apr 15Wen Xdoi: 10.4049/jimmunol.1302813
28062840The properties of the RNA-binding protein NF90 are considerably modulated by complex formation with NF45.Biochem J2017 Jan 15Schmidt Tdoi: 10.1042/BCJ20160790
26891316NF45 and NF90 Bind HIV-1 RNA and Modulate HIV Gene Expression.Viruses2016 Feb 16Li Ydoi: 10.3390/v8020047.
26491010Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation.J Biol Chem2015 Dec 11Wu CLdoi: 10.1074/jbc.M115.661785
26381409The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.J Biol Chem2015 Oct 30Nakadai Tdoi: 10.1074/jbc.M115.688317
28625552Coordinated circRNA Biogenesis and Function with NF90/NF110 in Viral Infection.Mol Cell2017 Jul 20Li Xdoi: 10.1016/j.molcel.2017.05.023
29449553Nuclear factor 90 promotes angiogenesis by regulating HIF-1α/VEGF-A expression through the PI3K/Akt signaling pathway in human cervical cancer.Cell Death Dis2018 Feb 15Zhang Wdoi: 10.1038/s41419-018-0334-2.
30272251Cooperative translational control of polymorphic BAFF by NF90 and miR-15a.Nucleic Acids Res2018 Dec 14Idda MLdoi: 10.1093/nar/gky866.
30784348NF90 regulation of immune factor expression in response to malaria antigens.Cell Cycle2019 Mar - AprIdda MLdoi: 10.1080/15384101.2019.1580496
24965446Host factors that interact with the pestivirus N-terminal protease, Npro, are components of the ribonucleoprotein complex.J Virol2014 SepJefferson Mdoi: 10.1128/JVI.00984-14
22504300Synthetic oligonucleotides recruit ILF2/3 to RNA transcripts to modulate splicing.Nat Chem Biol2012 Apr 15Rigo Fdoi: 10.1038/nchembio.939.
24920670RNA granule assembly and disassembly modulated by nuclear factor associated with double-stranded RNA 2 and nuclear factor 45.J Biol Chem2014 Jul 25Shiina N-
26579211RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships.Epigenetics Chromatin2015 Nov 16Nadel Jdoi: 10.1186/s13072-015-0040-6
10320367Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR.Biochemistry1999 May 11Langland JO-
25447144NF90 isoforms, a new family of cellular proteins involved in viral replication?Biochimie2015 JanPatino Cdoi: 10.1016/j.biochi.2014.10.022
25399696Regulation of cell cycle of hepatocellular carcinoma by NF90 through modulation of cyclin E1 mRNA stability.Oncogene2015 Aug 20Jiang Wdoi: 10.1038/onc.2014.373
26647875The mechanism of adenosine-mediated activation of lncRNA MEG3 and its antitumor effects in human hepatoma cells.Int J Oncol2016 JanLiu LXdoi: 10.3892/ijo.2015.3248
28558830LincIN, a novel NF90-binding long non-coding RNA, is overexpressed in advanced breast tumors and involved in metastasis.Breast Cancer Res2017 May 30Jiang Zdoi: 10.1186/s13058-017-0853-2.
31144362LncRNA MEG3 contributes to adenosine-induced cytotoxicity in hepatoma HepG2 cells by downregulated ILF3 and autophagy inhibition via regulation PI3K-AKT-mTOR and beclin-1 signaling pathway.J Cell Biochem2019 May 29Pu Zdoi: 10.1002/jcb.29123
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000587840ILF3-207655-ENSP0000046770455 (aa)-K7EQ75
ENST00000589416ILF3-214773-ENSP00000465831158 (aa)-K7EKY0
ENST00000587941ILF3-209533-ENSP00000464974122 (aa)-K7EJ09
ENST00000591649ILF3-2212579--- (aa)--
ENST00000585835ILF3-204849-ENSP00000467950180 (aa)-K7EQR9
ENST00000589283ILF3-213599-ENSP0000046639699 (aa)-K7EM82
ENST00000587505ILF3-206791-ENSP0000046699179 (aa)-K7ENK6
ENST00000250241ILF3-2013035-ENSP00000250241690 (aa)-Q12906
ENST00000589998ILF3-2172622XM_024451490ENSP00000465219702 (aa)XP_024307258Q12906
ENST00000407004ILF3-2023671-ENSP00000384660706 (aa)-Q12906
ENST00000586544ILF3-2053859--- (aa)--
ENST00000589485ILF3-215620-ENSP0000046737273 (aa)-K7EPG3
ENST00000589600ILF3-216839-ENSP00000468134161 (aa)-K7ER69
ENST00000589173ILF3-212570--- (aa)--
ENST00000589052ILF3-211637-ENSP0000046809279 (aa)-K7ENK6
ENST00000592763ILF3-2223866-ENSP00000465515698 (aa)-Q12906
ENST00000449870ILF3-2036119XM_006722742ENSP00000404121898 (aa)XP_006722805Q12906
ENST00000588657ILF3-2102697-ENSP00000468181898 (aa)-Q12906
ENST00000587928ILF3-2084230--- (aa)--
ENST00000593061ILF3-223475-ENSP00000466724113 (aa)-K7EMZ8
ENST00000590869ILF3-220531-ENSP00000466235116 (aa)-K7ELV3
ENST00000590261ILF3-2193219-ENSP00000468156894 (aa)-Q12906
ENST00000593199ILF3-224413-ENSP0000046832377 (aa)-K7ERM6
ENST00000590009ILF3-218953-ENSP00000465654254 (aa)-K7EKJ9
Gene Model
Click here to download ENSG00000129351's gene model file
Phenotypes
ensgIDTraitpValuePubmed ID
ENSG00000129351Body Height2E-1625429064
ENSG00000129351Body Height8E-1125282103
ENSG00000129351Triglycerides7E-623251661
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000129351rs25695071910688228GObesity-related traits23251661[NR] mg/dL increase0.02EFO_0004530
ENSG00000129351rs22293831910683954?Stroke29531354EFO_0000712
ENSG00000129351rs22293831910683954?Ischemic stroke29531354HP_0002140
ENSG00000129351rs72500711910655143THeight25429064[0.03-0.054] unit decrease0.042EFO_0004339
ENSG00000129351rs81023801910690509AHeight25282103[0.014-0.026] unit decrease0.02EFO_0004339
ENSG00000129351rs1476221131910661265TRheumatoid arthritis30423114[0.26-0.51] unit decrease0.38854EFO_0000685
ENSG00000129351rs22293831910683954?Ischemic stroke29531354HP_0002140
ENSG00000129351rs22293831910683954?Stroke29531354EFO_0000712
ENSG00000129351rs81023801910690509?Hair color30595370EFO_0007822
ENSG00000129351rs1476221131910661265?Systemic lupus erythematosus28714469[1.19-1.56]1.369863EFO_0002690
ENSG00000129351rs72482051910659629TChronotype306968231.0270597EFO_0008328
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129351's network

* RBP PPI network refers to all genes directly bind to RBP
Paralogs
Ensembl IDGene SymbolCoverageIdentiy ParalogGene SymbolCoverageIdentiy
ENSG00000129351ILF39754.839ENSG00000056097ZFR8549.123
ENSG00000129351ILF36433.333ENSG00000143621ILF26130.544
ENSG00000129351ILF310063.529ENSG00000165209STRBP8861.412
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000129351ILF39975.889ENSAPOG00000011438ilf3b9272.742Acanthochromis_polyacanthus
ENSG00000129351ILF39997.974ENSAMEG00000011152ILF39997.553Ailuropoda_melanoleuca
ENSG00000129351ILF39974.704ENSACIG00000020521ilf3b9171.584Amphilophus_citrinellus
ENSG00000129351ILF39976.285ENSAOCG00000000579ilf3b7272.170Amphiprion_ocellaris
ENSG00000129351ILF39976.285ENSAPEG00000017659ilf3b7472.170Amphiprion_percula
ENSG00000129351ILF39269.277ENSATEG00000012690ilf3b8769.742Anabas_testudineus
ENSG00000129351ILF39975.889ENSATEG00000012555ilf3b9970.141Anabas_testudineus
ENSG00000129351ILF310085.490ENSACAG00000015632ILF310081.989Anolis_carolinensis
ENSG00000129351ILF310099.150ENSANAG00000026889ILF310099.150Aotus_nancymaae
ENSG00000129351ILF39973.913ENSACLG00000001608ilf3b9968.961Astatotilapia_calliptera
ENSG00000129351ILF39977.075ENSAMXG00000020710ilf3b9968.776Astyanax_mexicanus
ENSG00000129351ILF310097.151ENSBTAG00000040076ILF310097.151Bos_taurus
ENSG00000129351ILF3100100.000ENSCJAG00000006374ILF310099.575Callithrix_jacchus
ENSG00000129351ILF310097.826ENSCAFG00000017691ILF310097.656Canis_familiaris
ENSG00000129351ILF310098.300ENSCAFG00020024492ILF310098.300Canis_lupus_dingo
ENSG00000129351ILF310096.667ENSCHIG00000024731ILF310096.667Capra_hircus
ENSG00000129351ILF310098.159ENSTSYG00000000317ILF310098.159Carlito_syrichta
ENSG00000129351ILF310098.433ENSCAPG00000009767ILF310098.433Cavia_aperea
ENSG00000129351ILF310098.425ENSCPOG00000013726ILF310096.760Cavia_porcellus
ENSG00000129351ILF3100100.000ENSCCAG00000019834ILF310099.292Cebus_capucinus
ENSG00000129351ILF3100100.000ENSCATG00000023258ILF310099.858Cercocebus_atys
ENSG00000129351ILF310098.718ENSCLAG00000011537ILF310098.718Chinchilla_lanigera
ENSG00000129351ILF3100100.000ENSCSAG00000006983ILF310099.858Chlorocebus_sabaeus
ENSG00000129351ILF310095.902ENSCHOG00000002009ILF37994.737Choloepus_hoffmanni
ENSG00000129351ILF310086.220ENSCPBG00000010274ILF310083.223Chrysemys_picta_bellii
ENSG00000129351ILF3100100.000ENSCANG00000014037ILF310099.858Colobus_angolensis_palliatus
ENSG00000129351ILF310095.733ENSCGRG00001021577Ilf310095.733Cricetulus_griseus_chok1gshd
ENSG00000129351ILF310095.669ENSCGRG00000005960Ilf39895.726Cricetulus_griseus_crigri
ENSG00000129351ILF39970.866ENSCSEG00000016231ilf3b7369.692Cynoglossus_semilaevis
ENSG00000129351ILF310073.622ENSCVAG00000007840ilf3b9968.118Cyprinodon_variegatus
ENSG00000129351ILF39975.781ENSDARG00000105177ilf3b10075.124Danio_rerio
ENSG00000129351ILF310096.670ENSDNOG00000002518ILF310096.670Dasypus_novemcinctus
ENSG00000129351ILF310096.457ENSDORG00000015231Ilf310096.011Dipodomys_ordii
ENSG00000129351ILF37994.633ENSETEG00000015741ILF310094.068Echinops_telfairi
ENSG00000129351ILF39997.093ENSEASG00005008476ILF310096.497Equus_asinus_asinus
ENSG00000129351ILF310096.957ENSECAG00000017640ILF310096.425Equus_caballus
ENSG00000129351ILF39975.686ENSELUG00000000372ilf3b9969.553Esox_lucius
ENSG00000129351ILF310097.875ENSFCAG00000004887ILF310097.875Felis_catus
ENSG00000129351ILF310082.422ENSFALG00000013695ILF36686.640Ficedula_albicollis
ENSG00000129351ILF310097.578ENSFDAG00000012706ILF310097.578Fukomys_damarensis
ENSG00000129351ILF39973.913ENSFHEG00000009438ilf3b9968.073Fundulus_heteroclitus
ENSG00000129351ILF39971.542ENSGMOG00000018300ilf3b10076.304Gadus_morhua
ENSG00000129351ILF39988.745ENSGALG00000030351ILF38688.789Gallus_gallus
ENSG00000129351ILF39972.727ENSGAFG00000014161ilf3b7372.757Gambusia_affinis
ENSG00000129351ILF39972.332ENSGACG00000006270ilf3b10076.907Gasterosteus_aculeatus
ENSG00000129351ILF310088.842ENSGAGG00000001571ILF310090.678Gopherus_agassizii
ENSG00000129351ILF3100100.000ENSGGOG00000004144ILF310099.858Gorilla_gorilla
ENSG00000129351ILF39973.913ENSHBUG00000019941ilf3b9968.961Haplochromis_burtoni
ENSG00000129351ILF310098.031ENSHGLG00000019494-10097.578Heterocephalus_glaber_female
ENSG00000129351ILF39981.761ENSHGLG00000017093-9872.714Heterocephalus_glaber_female
ENSG00000129351ILF39990.625ENSHGLG00000015334-9777.135Heterocephalus_glaber_female
ENSG00000129351ILF310093.789ENSHGLG00000018011-9984.473Heterocephalus_glaber_female
ENSG00000129351ILF39990.873ENSHGLG00100003442-8983.093Heterocephalus_glaber_male
ENSG00000129351ILF39889.873ENSHGLG00100011979-9877.175Heterocephalus_glaber_male
ENSG00000129351ILF39990.625ENSHGLG00100007409-9775.543Heterocephalus_glaber_male
ENSG00000129351ILF310091.803ENSHGLG00100016819-9692.806Heterocephalus_glaber_male
ENSG00000129351ILF310098.031ENSHGLG00100007068-10097.436Heterocephalus_glaber_male
ENSG00000129351ILF39972.332ENSHCOG00000019528ilf3b7369.122Hippocampus_comes
ENSG00000129351ILF39976.471ENSIPUG00000007610ilf37473.053Ictalurus_punctatus
ENSG00000129351ILF310097.863ENSSTOG00000007786ILF310097.863Ictidomys_tridecemlineatus
ENSG00000129351ILF39691.279ENSJJAG00000020378-9172.892Jaculus_jaculus
ENSG00000129351ILF310096.457ENSJJAG00000013051-10095.726Jaculus_jaculus
ENSG00000129351ILF39976.285ENSKMAG00000010770ilf3b9968.443Kryptolebias_marmoratus
ENSG00000129351ILF36164.501ENSLBEG00000002708-6162.093Labrus_bergylta
ENSG00000129351ILF39974.308ENSLBEG00000023354ilf3b9968.707Labrus_bergylta
ENSG00000129351ILF310077.907ENSLACG00000003810ILF310068.606Latimeria_chalumnae
ENSG00000129351ILF39384.431ENSLOCG00000008430ilf3b9961.448Lepisosteus_oculatus
ENSG00000129351ILF39997.110ENSLAFG00000021667ILF39996.997Loxodonta_africana
ENSG00000129351ILF3100100.000ENSMFAG00000039557ILF310099.858Macaca_fascicularis
ENSG00000129351ILF3100100.000ENSMMUG00000014673ILF310099.858Macaca_mulatta
ENSG00000129351ILF3100100.000ENSMNEG00000042707ILF310099.858Macaca_nemestrina
ENSG00000129351ILF39997.324ENSMLEG00000042847ILF39997.324Mandrillus_leucophaeus
ENSG00000129351ILF39975.099ENSMAMG00000010601ilf3b9969.231Mastacembelus_armatus
ENSG00000129351ILF39973.913ENSMZEG00005002368ilf3b9968.961Maylandia_zebra
ENSG00000129351ILF310095.276ENSMAUG00000020405Ilf310093.638Mesocricetus_auratus
ENSG00000129351ILF310098.148ENSMICG00000009694ILF310098.148Microcebus_murinus
ENSG00000129351ILF310094.488ENSMOCG00000018740Ilf310095.021Microtus_ochrogaster
ENSG00000129351ILF39974.308ENSMMOG00000006290ilf3b9168.125Mola_mola
ENSG00000129351ILF39991.304ENSMODG00000005911ILF39992.580Monodelphis_domestica
ENSG00000129351ILF39973.913ENSMALG00000002228ilf3b9969.577Monopterus_albus
ENSG00000129351ILF310095.669MGP_CAROLIEiJ_G0031871Ilf310095.448Mus_caroli
ENSG00000129351ILF310095.669ENSMUSG00000032178Ilf310095.448Mus_musculus
ENSG00000129351ILF310095.669MGP_PahariEiJ_G0014737Ilf310095.590Mus_pahari
ENSG00000129351ILF310095.669MGP_SPRETEiJ_G0032995Ilf310095.590Mus_spretus
ENSG00000129351ILF310098.031ENSMPUG00000006205ILF310097.210Mustela_putorius_furo
ENSG00000129351ILF39996.471ENSMLUG00000008365ILF39995.424Myotis_lucifugus
ENSG00000129351ILF39383.234ENSNGAG00000015146-9779.077Nannospalax_galili
ENSG00000129351ILF310095.584ENSNGAG00000009786-10095.584Nannospalax_galili
ENSG00000129351ILF35590.909ENSNBRG00000010095ilf3b9156.927Neolamprologus_brichardi
ENSG00000129351ILF310068.852ENSNBRG00000010130-7065.789Neolamprologus_brichardi
ENSG00000129351ILF310099.180ENSNLEG00000012290ILF39997.216Nomascus_leucogenys
ENSG00000129351ILF37092.500ENSMEUG00000012684ILF38289.817Notamacropus_eugenii
ENSG00000129351ILF39994.477ENSOPRG00000014990ILF310092.402Ochotona_princeps
ENSG00000129351ILF310097.244ENSODEG00000015951ILF310089.338Octodon_degus
ENSG00000129351ILF39973.913ENSONIG00000008081ilf3b9969.846Oreochromis_niloticus
ENSG00000129351ILF39997.250ENSOCUG00000013990ILF39996.440Oryctolagus_cuniculus
ENSG00000129351ILF310076.230ENSORLG00000016379ilf3b9968.406Oryzias_latipes
ENSG00000129351ILF310076.230ENSORLG00020022000ilf3b7173.899Oryzias_latipes_hni
ENSG00000129351ILF310076.230ENSORLG00015015108ilf3b9968.829Oryzias_latipes_hsok
ENSG00000129351ILF310076.230ENSOMEG00000017273ilf3b9968.768Oryzias_melastigma
ENSG00000129351ILF39979.094ENSOGAG00000030527-9977.438Otolemur_garnettii
ENSG00000129351ILF310097.270ENSOGAG00000015244-10097.111Otolemur_garnettii
ENSG00000129351ILF310095.657ENSOARG00000016982ILF310095.657Ovis_aries
ENSG00000129351ILF3100100.000ENSPPAG00000040547ILF310099.717Pan_paniscus
ENSG00000129351ILF310098.017ENSPPRG00000021486ILF310098.017Panthera_pardus
ENSG00000129351ILF310098.017ENSPTIG00000021627ILF310098.017Panthera_tigris_altaica
ENSG00000129351ILF3100100.000ENSPTRG00000010480ILF310099.717Pan_troglodytes
ENSG00000129351ILF3100100.000ENSPANG00000014995ILF310099.858Papio_anubis
ENSG00000129351ILF310075.000ENSPKIG00000007019ilf3b9968.303Paramormyrops_kingsleyae
ENSG00000129351ILF310074.590ENSPKIG00000008409-9669.189Paramormyrops_kingsleyae
ENSG00000129351ILF310083.607ENSPSIG00000008298ILF310083.624Pelodiscus_sinensis
ENSG00000129351ILF39973.913ENSPMGG00000001413ilf3b7270.579Periophthalmus_magnuspinnatus
ENSG00000129351ILF310094.488ENSPEMG00000000465-10095.448Peromyscus_maniculatus_bairdii
ENSG00000129351ILF310091.102ENSPCIG00000015447ILF310093.079Phascolarctos_cinereus
ENSG00000129351ILF39973.123ENSPFOG00000001014ilf3b9967.797Poecilia_formosa
ENSG00000129351ILF39973.307ENSPLAG00000018261ilf3b9967.797Poecilia_latipinna
ENSG00000129351ILF39973.123ENSPMEG00000013635ilf3b9967.938Poecilia_mexicana
ENSG00000129351ILF39973.123ENSPREG00000013654ilf3b9967.938Poecilia_reticulata
ENSG00000129351ILF39699.768ENSPPYG00000029648ILF310099.768Pongo_abelii
ENSG00000129351ILF310097.638ENSPCAG00000003315ILF310092.402Procavia_capensis
ENSG00000129351ILF310099.150ENSPCOG00000019611ILF310099.150Propithecus_coquereli
ENSG00000129351ILF310096.850ENSPVAG00000012152ILF39394.931Pteropus_vampyrus
ENSG00000129351ILF39974.308ENSPNYG00000002063ilf3b9969.101Pundamilia_nyererei
ENSG00000129351ILF39977.559ENSPNAG00000008276ilf3b9969.522Pygocentrus_nattereri
ENSG00000129351ILF310095.669ENSRNOG00000022741Ilf310093.200Rattus_norvegicus
ENSG00000129351ILF310099.606ENSRBIG00000038846ILF310099.555Rhinopithecus_bieti
ENSG00000129351ILF310099.717ENSRROG00000031702ILF310099.717Rhinopithecus_roxellana
ENSG00000129351ILF3100100.000ENSSBOG00000027756ILF310099.433Saimiri_boliviensis_boliviensis
ENSG00000129351ILF310090.945ENSSHAG00000001712ILF39692.455Sarcophilus_harrisii
ENSG00000129351ILF39972.727ENSSFOG00015008720-9068.265Scleropages_formosus
ENSG00000129351ILF39973.745ENSSFOG00015014881ilf3b9969.220Scleropages_formosus
ENSG00000129351ILF39972.727ENSSMAG00000002392ilf3b9969.101Scophthalmus_maximus
ENSG00000129351ILF39973.913ENSSDUG00000008684ilf3b9969.437Seriola_dumerili
ENSG00000129351ILF39973.913ENSSLDG00000017171ilf3b9969.437Seriola_lalandi_dorsalis
ENSG00000129351ILF310093.168ENSSARG00000007303ILF38594.378Sorex_araneus
ENSG00000129351ILF36871.250ENSSPUG00000009023-8577.941Sphenodon_punctatus
ENSG00000129351ILF39975.889ENSSPAG00000018249ilf3b7272.327Stegastes_partitus
ENSG00000129351ILF310095.669ENSSSCG00000013638ILF310093.626Sus_scrofa
ENSG00000129351ILF39986.272ENSTGUG00000013676ILF310084.585Taeniopygia_guttata
ENSG00000129351ILF39972.332ENSTRUG00000010961ilf3b8970.000Takifugu_rubripes
ENSG00000129351ILF39276.647ENSTNIG00000008329ilf3b5276.823Tetraodon_nigroviridis
ENSG00000129351ILF310089.610ENSTTRG00000016632ILF310084.263Tursiops_truncatus
ENSG00000129351ILF39997.678ENSUAMG00000017664ILF39997.542Ursus_americanus
ENSG00000129351ILF310098.148ENSUMAG00000025049ILF310098.148Ursus_maritimus
ENSG00000129351ILF310095.082ENSVPAG00000009089ILF393100.000Vicugna_pacos
ENSG00000129351ILF310098.291ENSVVUG00000017504ILF310097.656Vulpes_vulpes
ENSG00000129351ILF39976.680ENSXETG00000011651ilf310068.436Xenopus_tropicalis
ENSG00000129351ILF39974.104ENSXMAG00000008854ilf3b7772.995Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0003677DNA binding7519613.10574923.IDAFunction
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0003723RNA binding10400669.NASFunction
GO:0003725double-stranded RNA binding21873635.IBAFunction
GO:0003725double-stranded RNA binding10574923.11777942.IDAFunction
GO:0003727single-stranded RNA binding21873635.IBAFunction
GO:0005515protein binding9442054.10574923.10749851.11739746.11777942.14731398.17932509.18337511.21987769.22810585.23853584.23976881.24965446.IPIFunction
GO:0005576extracellular region27068509.HDAComponent
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus8885239.10749851.11739746.21123651.IDAComponent
GO:0005634nucleus10400669.NASComponent
GO:0005654nucleoplasm-IDAComponent
GO:0005730nucleolus-IDAComponent
GO:0005737cytoplasm21123651.IDAComponent
GO:0005739mitochondrion-IDAComponent
GO:0006468protein phosphorylation21123651.IDAProcess
GO:0016020membrane19946888.HDAComponent
GO:0017091AU-rich element binding14731398.IDAFunction
GO:0017148negative regulation of translation-ISSProcess
GO:0045071negative regulation of viral genome replication-ISSProcess
GO:0045892negative regulation of transcription, DNA-templated11739746.IDAProcess
GO:0045893positive regulation of transcription, DNA-templated11739746.IDAProcess
GO:0051607defense response to virus-IEAProcess
GO:1990904ribonucleoprotein complex17289661.IDAComponent

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
30060955A negative feedback loop between nuclear factor 90 (NF90) and an anti-oncogenic microRNA, miR-7.Biochem Biophys Res Commun2018 Sep 10Higuchi Tdoi: 10.1016/j.bbrc.2018.07.119
21971700Correlations among ERCC1, XPB, UBE2I, EGF, TAL2 and ILF3 revealed by gene signatures of histological subtypes of patients with epithelial ovarian cancer.Oncol Rep2012 JanGuo Ydoi: 10.3892/or.2011.1483
27735951MiR-590-5p inhibits colorectal cancer angiogenesis and metastasis by regulating nuclear factor 90/vascular endothelial growth factor A axis.Cell Death Dis2016 Oct 13Zhou Qdoi: 10.1038/cddis.2016.306.

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
ACCchr1910687497Silentrs778107003H737H0.6
BLCAchr1910679185Missense_Mutationrs750756508R247Q0.17
BLCAchr1910687376Missense_MutationnovelG697A0.33
BLCAchr1910682606Missense_MutationNAE484K0.22
BLCAchr1910684148Intronnovel0.4
BLCAchr1910689264Silentrs766248749G879G0.16
BLCAchr1910683932Missense_MutationnovelS674N0.23
BLCAchr1910684061Intronnovel0.41
BLCAchr1910679813Splice_Regionnovel0.51
BLCAchr1910684570Intronnovel0.39
BLCAchr1910682099SilentnovelA429A0.74
BLCAchr1910687646Missense_Mutationrs773828957S787L0.57
BRCAchr1910684951Intronnovel0.18
BRCAchr1910689253Missense_MutationnovelS876P0.26
BRCAchr1910687517Missense_MutationNAS744C0.41
BRCAchr1910684057Intronnovel0.1
BRCAchr1910684162Intronnovel0.43
BRCAchr1910684568Intronnovel0.17
BRCAchr1910681313Missense_MutationNAK388N0.53
BRCAchr1910682620Silentrs755769030A488A0.35
BRCAchr1910671079Missense_MutationNAH37D0.19
BRCAchr1910671158Missense_MutationNAD63G0.24
BRCAchr1910671108Silentrs143578737S46S0.12
BRCAchr1910684465IntronNA0.3
CESCchr1910684937Intronnovel0.24
CESCchr1910683443SilentnovelA584A0.31
CESCchr1910682007Frame_Shift_DelnovelQ401Rfs*30.14
CESCchr1910679827SilentnovelL253L0.25
CESCchr19106896463'UTRnovel0.17
CESCchr1910684858Intronnovel0.11
CESCchr1910684962Intronnovel0.59
CESCchr1910678687Missense_MutationnovelH212N0.21
CESCchr1910684073Intronnovel0.14
CHOLchr1910684946Intronnovel0.2
COADchr1910688653SilentNAG842G0.49
COADchr1910681065Missense_MutationNAG335D0.5
COADchr1910671120SilentnovelD50D0.15
COADchr1910684827Intronrs3756937380.13
COADchr1910671026Missense_MutationNAS19Y0.44
COADchr1910679161Missense_MutationnovelR239H0.07
COADchr1910681297Missense_MutationNAP383L0.19
COADchr1910684591Intronnovel0.19
COADchr1910687412Missense_MutationnovelG709D0.29
COADchr19106706055'Flanknovel0.29
COADchr1910684965Intronnovel0.37
COADchr1910678629SilentNAN192N0.26
COADchr1910681252Missense_MutationNAT368M0.44
COADchr1910687297Intronnovel0.32
COADchr1910683513Missense_Mutationrs575931762V608I0.13
COADchr1910682637Missense_Mutationrs780654204A494V0.43
COADchr1910689279SilentNAN884N0.26
COADchr1910682167Missense_Mutationrs370373655T452M0.32
COADchr1910684473Intronnovel0.11
COADchr1910671093Silentrs764217068A41A0.42
COADchr1910684850Intronnovel0.43
COADchr1910684728Intronnovel0.17
COADchr1910677237Silentrs756744264E162E0.15
COADchr1910683939SilentnovelG676G0.33
COADchr1910679163Missense_Mutationrs200955896V240M0.34
COADchr1910684563Intronnovel0.13
COADchr1910680436Missense_MutationNAS317N0.18
ESCAchr1910683964Missense_MutationnovelG685R0.13
ESCAchr1910678616Missense_MutationnovelT188M0.42
ESCAchr1910679171SilentnovelT242T0.14
GBMchr1910677189Missense_MutationnovelI146M0.1
GBMchr1910671068Missense_MutationnovelN33T0.49
GBMchr1910679886Missense_MutationnovelR273Q0.51
GBMchr19106896643'UTRnovel0.23
GBMchr1910684352Intronnovel0.33
GBMchr1910683139Missense_MutationnovelQ517H0.16
GBMchr1910678629SilentNAN192N0.39
GBMchr1910687684Missense_Mutationrs755277787D800N0.19
GBMchr1910683392SilentNAQ567Q0.38
GBMchr1910688639Missense_Mutationrs371015547G838R0.03
HNSCchr1910678641Silentrs751279668D196D0.29
HNSCchr1910682620Silentrs755769030A488A0.09
HNSCchr1910682558Missense_Mutationrs779369130P468A0.07
HNSCchr1910679913In_Frame_InsnovelG282_I283insH0.08
HNSCchr1910687616Missense_MutationnovelY777C0.35
HNSCchr1910684061Intronnovel0.12
HNSCchr1910680440Silentrs150021624A318A0.1
HNSCchr1910683533SilentnovelF614F0.41
KICHchr1910683942SilentNAY677Y0.4
KIRCchr1910677176Missense_MutationNAD142G0.04
KIRCchr1910688593SilentNAG822G0.18
KIRCchr19106893133'UTRnovel0.3
KIRCchr19106705455'Flankrs5551106170.27
LAMLchr1910682575SilentnovelG473G0.4
LGGchr1910671021Missense_MutationnovelK17N0.27
LGGchr1910671424Missense_MutationnovelK100N0.08
LGGchr1910682034Missense_Mutationrs777089402R408W0.13
LGGchr1910683474Missense_MutationnovelA595T0.39
LGGchr1910683750Nonsense_MutationnovelG656*0.32
LGGchr1910684418IntronNA0.36
LIHCchr1910684359Intronnovel0.28
LIHCchr19106893703'UTRnovel0.11
LIHCchr1910681066SilentNAG335G0.34
LUADchr1910683541Missense_MutationNAK617M0.79
LUADchr1910684353Intronnovel0.18
LUADchr1910679849Missense_MutationNAT261A0.4
LUADchr1910683233Missense_MutationnovelG549R0.22DZF
LUADchr1910678639Missense_MutationnovelD196Y0.23
LUADchr1910684342Intronnovel0.27
LUADchr1910688564Nonsense_MutationnovelG813*0.16
LUADchr1910677263In_Frame_InsnovelL171_T172insFLQQ0.08
LUADchr19106895763'UTRrs3736565240.31
LUADchr1910679927Missense_MutationnovelD287Y0.22
LUADchr1910684023Intronrs7759284470.31
LUSCchr1910682028Silentrs141175607L406L0.29
LUSCchr1910683471Missense_MutationnovelL594F0.07
LUSCchr1910687455SilentnovelN723N0.61
LUSCchr1910679192Frame_Shift_InsnovelC255Lfs*350.07
LUSCchr1910687708Frame_Shift_InsnovelN819Lfs*40.29
LUSCchr1910688591Missense_Mutationrs137952515G822S0.26
LUSCchr1910680427Missense_Mutationrs780504546I314T0.23
LUSCchr1910671370Silentrs769019863T82T0.3
LUSCchr1910687569Missense_MutationNAQ761H0.07
LUSCchr1910683957Silentrs745697673A682A0.21
LUSCchr1910681021Splice_RegionNAH320H0.21
OVchr1910684751Intronnovel0.08
OVchr1910682038Nonsense_MutationnovelL409*0.25
OVchr1910682081Silentrs35968299Q423Q0.16
OVchr1910687686Missense_MutationNAD800E0.33
OVchr1910679158Missense_MutationNAT238S0.64
OVchr1910689246SilentnovelS873S0.06
OVchr1910684386Intronnovel0.19
OVchr1910682665SilentNAS503S0.32
OVchr1910683728SilentnovelI648I0.08
PAADchr1910671004Missense_MutationnovelR12C0.19
PAADchr1910677285Missense_MutationnovelE178D0.19
PAADchr1910683468Missense_MutationnovelP593S0.08
PCPGchr1910689194Missense_Mutationrs767690509S856L0.07
PRADchr19106893203'UTRrs3715027990.14
PRADchr1910670609Splice_SitenovelX1_splice0.14
PRADchr1910679184Nonsense_MutationnovelR247*0.46
PRADchr1910680391Missense_MutationnovelA302V0.23
READchr1910677213Silentrs142885843A154A0.32
READchr1910684118Intronnovel0.67
READchr1910684963Intronnovel0.34
READchr1910683789Missense_MutationNAG669S0.32
READchr1910683690Frame_Shift_DelNAN638Tfs*290.36
READchr1910684698Intronnovel0.27
READchr1910688656SilentNAG843G0.31
SARCchr1910683136Splice_SitenovelX517_splice0.12
SARCchr1910687366Missense_MutationnovelG694R0.31
SARCchr1910687367Missense_MutationnovelG694E0.31
SKCMchr1910684087Intronnovel0.36
SKCMchr1910682624Missense_MutationnovelP490S0.3
SKCMchr1910683736Missense_Mutationrs201318830R651Q0.43
SKCMchr1910679861Missense_MutationNAP265S0.3
SKCMchr1910682137Missense_MutationNAS442L0.1
SKCMchr1910687664Missense_MutationNAP793L0.24
SKCMchr1910687337Intronnovel0.5
SKCMchr1910689215Missense_MutationNAS863F0.39
SKCMchr1910688620Silentrs202066185G831G0.7
SKCMchr1910679923Splice_SitenovelX286_splice0.36
SKCMchr1910684368Intronnovel0.41
SKCMchr19106894613'UTRnovel0.35
SKCMchr1910683688Missense_Mutationrs765854694P635L0.4
SKCMchr1910683504Missense_MutationnovelP605S0.16
SKCMchr1910684516Intronnovel0.45
SKCMchr1910683458Silentrs565885328F589F0.56
SKCMchr1910679907Missense_MutationNAA280V0.36
SKCMchr1910683459Missense_MutationnovelP590S0.36DZF
SKCMchr1910687438Missense_MutationnovelQ718K0.27
SKCMchr1910681247SilentNAA366A0.16
SKCMchr1910689206Missense_MutationnovelS860F0.34
SKCMchr1910689207SilentnovelS860S0.33
SKCMchr1910684802Intronnovel0.4
SKCMchr1910679904Missense_MutationNAL279Q0.18
SKCMchr19106895543'UTRnovel0.34
SKCMchr19106894063'UTRnovel0.43
SKCMchr1910682052Missense_MutationnovelP414S0.31
SKCMchr1910682053Missense_MutationnovelP414L0.32
SKCMchr1910682684Missense_MutationnovelP510S0.53
SKCMchr1910682595Missense_MutationNAE480G0.13
SKCMchr19106895333'UTRnovel0.25
STADchr1910677264SilentnovelL171L0.22
STADchr1910680439Missense_MutationnovelA318V0.2
STADchr1910681044Missense_MutationNAG328D0.3
STADchr1910683926Missense_MutationNAY672C0.29
STADchr1910671035Missense_MutationNAY22C0.56
STADchr19106895703'UTRnovel0.3
STADchr1910684018Intronnovel0.34
STADchr1910682551Missense_MutationnovelM465I0.13
STADchr19106896513'UTRnovel0.57
STADchr1910677239Missense_MutationNAP163H0.18
STADchr1910683141Missense_MutationNAG518V0.5
STADchr1910687478Missense_MutationNAA731D0.47
STADchr1910671367SilentNAK81K0.13
STADchr1910682007Frame_Shift_DelnovelQ401Rfs*30.26
STADchr1910681021Splice_RegionNAH320H0.22
STADchr1910683518Frame_Shift_InsnovelP612Tfs*60.23
STADchr1910684020Intronnovel0.18
STADchr1910684772Intronnovel0.54
STADchr1910682007Frame_Shift_DelnovelQ401Rfs*30.17
STADchr1910683197Missense_MutationNAR537C0.14DZF
TGCTchr1910687461SilentnovelP725P0.14
UCECchr1910684034Intronnovel0.28
UCECchr1910682093SilentNAV427V0.14
UCECchr1910684814Intronnovel0.26
UCECchr19106705405'Flanknovel0.36
UCECchr1910683941Missense_MutationnovelY677C0.12
UCECchr1910677190Missense_MutationnovelL147M0.16
UCECchr1910689203Missense_MutationnovelN859S0.12
UCECchr1910677204Silentrs774704338D151D0.08
UCECchr1910683210Missense_MutationNAY541C0.41DZF
UCECchr1910683678Missense_MutationNAE632K0.07
UCECchr19106893193'UTRrs7699241820.38
UCECchr19106897333'UTRnovel0.1
UCECchr1910680403Missense_MutationnovelL306P0.33
UCECchr1910670984Missense_MutationnovelR5Q0.06
UCECchr1910687418Missense_MutationnovelS711C0.04
UCECchr1910671200Missense_Mutationrs540302759A77V0.24
UCECchr1910687647SilentNAS787S0.32
UCECchr1910684712Intronnovel0.47
UCECchr1910687698SilentnovelE804E0.4
UCECchr1910687647SilentNAS787S0.2
UCECchr1910682034Missense_Mutationrs777089402R408W0.31
UCECchr1910683368Splice_RegionNAV559V0.24
UCECchr1910683413SilentnovelK574K0.35
UCECchr1910677183SilentnovelY144Y0.15
UCECchr1910684233Intronnovel0.32
UCECchr1910685081Intronnovel0.38
UCECchr1910677189Missense_MutationnovelI146M0.48
UCECchr1910671193Missense_MutationnovelE75K0.11
UCECchr1910679884SilentnovelL272L0.41
UCECchr1910683399Missense_MutationNAG570S0.38DZF
UCECchr1910684477Intronnovel0.22
UCECchr1910681129Splice_RegionnovelT356T0.29
UCECchr1910684232Intronnovel0.75
UCECchr1910683161Missense_Mutationrs745657850G525S0.44
UCECchr1910682007Frame_Shift_DelnovelQ401Rfs*30.38
UCECchr1910678642Missense_MutationnovelV197I0.55
UCECchr1910677213Silentrs142885843A154A0.38
UCECchr1910684795Intronnovel0.33
UCECchr1910682007Frame_Shift_DelnovelQ401Rfs*30.44
UCECchr1910683942SilentNAY677Y0.13
UCECchr1910684756Intronnovel0.32
UCECchr1910684352Intronnovel0.41
UCECchr1910671379Missense_MutationnovelM85I0.35
UCECchr1910683369Missense_MutationnovelE560K0.07DZF
UCECchr1910687671Silentrs758956770G795G0.32
UCECchr1910683418Missense_MutationNAA576V0.54DZF
UCECchr1910682131Missense_MutationnovelG440D0.11
UCECchr19106897333'UTRnovel0.22
UCECchr1910677213Silentrs142885843A154A0.28
UCECchr1910681313Missense_MutationnovelK388N0.38
UCECchr1910682580Missense_MutationnovelD475G0.43
UCECchr1910684362Intronnovel0.31
UCECchr1910688570Nonsense_MutationnovelR815*0.23
UCECchr1910677183SilentnovelY144Y0.71
UCECchr1910683702Nonsense_MutationnovelR640*0.44
UCECchr19106893203'UTRrs3715027990.4
UCECchr1910683145Silentrs563695791P519P0.4
UCECchr1910683678Missense_MutationNAE632K0.42
UCECchr1910677265Missense_MutationnovelT172S0.41
UCECchr1910682184Missense_MutationnovelA458T0.25
UCECchr1910683368Splice_RegionNAV559V0.52
UCECchr1910683953Missense_Mutationrs778052848S681L0.43
UCECchr1910679911Silentrs778503927S281S0.32
UCECchr1910680417Missense_MutationnovelR311W0.26
UCECchr1910682705Splice_SitenovelX516_splice0.29
UCECchr1910684373Intronnovel0.46
UCECchr1910684706Intronnovel0.16
UCECchr1910684317Intronnovel0.34
UCECchr19106705735'Flanknovel0.32
UCECchr1910681022Missense_MutationNAA321T0.25
UCECchr1910681316Missense_MutationnovelK389N0.11
UCECchr1910682603Missense_MutationnovelA483T0.19
UCECchr1910683160Silentrs757462288H524H0.41
UCECchr1910688636Missense_MutationnovelG837S0.47
UCECchr1910689195Silentrs371219362S856S0.41
UCECchr19106893663'UTRrs5581484920.44
UCECchr1910684620Intronnovel0.36
UCECchr1910682007Frame_Shift_DelnovelQ401Rfs*30.31
UCECchr1910684754Intronnovel0.26
UCECchr1910681021Splice_RegionNAH320H0.22
UCECchr1910682142Missense_Mutationrs577832581E444K0.38
UCECchr1910683702Nonsense_MutationnovelR640*0.12
UCECchr1910671021Missense_MutationnovelK17N0.33
UCECchr1910683254Missense_MutationNAV556I0.3DZF
UCECchr1910689280Missense_Mutationrs755616743A885T0.34
UCSchr19106896203'UTRnovel0.31
UCSchr19106705705'Flankrs7521608190.32
UCSchr1910671511Frame_Shift_InsnovelD130Cfs*1300.15
UCSchr1910671513Frame_Shift_InsnovelD130Efs*120.14
UCSchr1910683133Splice_Regionnovel0.37
UCSchr1910683678Missense_MutationNAE632K0.38
UCSchr1910671047Missense_MutationnovelE26V0.23

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
PAADAMP0.0380.1091
PAADDEL0.09780.2014
READDEL0.07880.23023
THCADEL0.0140.10598
UCSAMP0.32140.00085866

Survival Analysis
CancerP-value Q-value
THYM0.0012

Kaplan-Meier Survival Analysis

KIRC0.046

Kaplan-Meier Survival Analysis

STAD0.017

Kaplan-Meier Survival Analysis

SARC0.0023

Kaplan-Meier Survival Analysis

MESO0.0011

Kaplan-Meier Survival Analysis

ACC0.00016

Kaplan-Meier Survival Analysis

HNSC0.012

Kaplan-Meier Survival Analysis

SKCM0.0035

Kaplan-Meier Survival Analysis

KIRP0.0042

Kaplan-Meier Survival Analysis

READ0.026

Kaplan-Meier Survival Analysis

LIHC0.0012

Kaplan-Meier Survival Analysis

Drugs

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Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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