EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000129460 (Gene tree)
Gene ID: 25983
Gene Symbol: NGDN
Alias: DKFZP564O092|LCP5|lpd-2|NGD|CANu1|C14orf120
Full Name: neuroguidin
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 40,235 bases
Position: chr14:23,469,628-23,509,862
Accession: 20271
RBP type: canonical RBP
Summary: Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]).[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000380340	Sas10_Utp3	PF04000.15	1.3e-13	1	1
ENSP00000386134	Sas10_Utp3	PF04000.15	1.4e-13	1	1
ENSP00000450659	Sas10_Utp3	PF04000.15	4.8e-12	1	1
ENSP00000451779	Sas10_Utp3	PF04000.15	5.2e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
18631138	Translational control in early development: CPEB, P-bodies and germinal granules.	Biochem Soc Trans	2008 Aug	Standart N	doi: 10.1042/BST0360671.
17942399	CPEB interacts with an ovary-specific eIF4E and 4E-T in early Xenopus oocytes.	J Biol Chem	2007 Dec 28	Minshall N	-
15550246	Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation.	Cell	2004 Nov 24	Barnard DC	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000553336	NGDN-203	712	-	-	- (aa)	-	-
ENST00000556699	NGDN-211	725	-	ENSP00000451942	74 (aa)	-	H0YJQ1
ENST00000553439	NGDN-204	2763	-	-	- (aa)	-	-
ENST00000408901	NGDN-202	1143	-	ENSP00000386134	315 (aa)	-	Q8NEJ9
ENST00000556483	NGDN-209	838	-	ENSP00000450659	263 (aa)	-	H0YJ17
ENST00000556953	NGDN-212	614	-	-	- (aa)	-	-
ENST00000557097	NGDN-213	270	-	-	- (aa)	-	-
ENST00000556580	NGDN-210	629	-	-	- (aa)	-	-
ENST00000556103	NGDN-207	454	-	-	- (aa)	-	-
ENST00000556378	NGDN-208	803	-	-	- (aa)	-	-
ENST00000397154	NGDN-201	2204	-	ENSP00000380340	311 (aa)	-	Q8NEJ9
ENST00000555128	NGDN-205	786	-	ENSP00000451779	141 (aa)	-	G3V4G1
ENST00000556022	NGDN-206	999	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000129460's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000129460	Cardiovascular Physiological Phenomena	1.4940000E-005	-
ENSG00000129460	Heart Rate	3E-8	20639392

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000129460	rs223116	14	23507801	A	Resting heart rate	20639392	[4.85-9.95] ms decrease	7.4	EFO_0004351

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129460's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000129460	NGDN	97	55.944	ENSAPOG00000016411	ngdn	98	55.052	Acanthochromis_polyacanthus
ENSG00000129460	NGDN	100	90.071	ENSAMEG00000016660	NGDN	98	91.693	Ailuropoda_melanoleuca
ENSG00000129460	NGDN	98	53.147	ENSACIG00000021676	ngdn	96	54.516	Amphilophus_citrinellus
ENSG00000129460	NGDN	98	56.250	ENSAOCG00000015818	ngdn	96	56.026	Amphiprion_ocellaris
ENSG00000129460	NGDN	98	55.556	ENSAPEG00000009589	ngdn	98	55.137	Amphiprion_percula
ENSG00000129460	NGDN	98	52.083	ENSATEG00000020513	ngdn	96	53.896	Anabas_testudineus
ENSG00000129460	NGDN	94	69.178	ENSACAG00000007340	NGDN	93	68.525	Anolis_carolinensis
ENSG00000129460	NGDN	95	95.918	ENSANAG00000037066	NGDN	98	94.839	Aotus_nancymaae
ENSG00000129460	NGDN	93	56.507	ENSACLG00000016289	ngdn	96	56.169	Astatotilapia_calliptera
ENSG00000129460	NGDN	99	54.730	ENSAMXG00000000514	ngdn	98	53.795	Astyanax_mexicanus
ENSG00000129460	NGDN	100	91.489	ENSBTAG00000009595	NGDN	98	94.035	Bos_taurus
ENSG00000129460	NGDN	74	36.957	WBGene00003059	lpd-2	69	36.681	Caenorhabditis_elegans
ENSG00000129460	NGDN	100	94.286	ENSCJAG00000007530	NGDN	98	94.194	Callithrix_jacchus
ENSG00000129460	NGDN	100	90.071	ENSCAFG00000011631	NGDN	96	93.115	Canis_familiaris
ENSG00000129460	NGDN	100	90.071	ENSCAFG00020004943	NGDN	96	93.115	Canis_lupus_dingo
ENSG00000129460	NGDN	100	91.489	ENSCHIG00000015780	NGDN	98	92.903	Capra_hircus
ENSG00000129460	NGDN	100	93.333	ENSTSYG00000009606	NGDN	98	93.226	Carlito_syrichta
ENSG00000129460	NGDN	89	80.159	ENSCAPG00000014742	NGDN	100	81.919	Cavia_aperea
ENSG00000129460	NGDN	100	88.652	ENSCPOG00000008240	NGDN	98	85.484	Cavia_porcellus
ENSG00000129460	NGDN	99	95.498	ENSCCAG00000023047	NGDN	99	95.498	Cebus_capucinus
ENSG00000129460	NGDN	100	96.825	ENSCATG00000042790	NGDN	100	96.825	Cercocebus_atys
ENSG00000129460	NGDN	100	88.652	ENSCLAG00000012885	NGDN	98	88.710	Chinchilla_lanigera
ENSG00000129460	NGDN	100	96.508	ENSCSAG00000015952	NGDN	100	96.508	Chlorocebus_sabaeus
ENSG00000129460	NGDN	100	92.908	ENSCHOG00000009857	NGDN	100	92.605	Choloepus_hoffmanni
ENSG00000129460	NGDN	97	63.279	ENSCPBG00000025903	NGDN	74	62.500	Chrysemys_picta_bellii
ENSG00000129460	NGDN	100	96.508	ENSCANG00000031356	NGDN	100	96.508	Colobus_angolensis_palliatus
ENSG00000129460	NGDN	100	90.071	ENSCGRG00001024371	Ngdn	98	90.000	Cricetulus_griseus_chok1gshd
ENSG00000129460	NGDN	100	90.071	ENSCGRG00000018219	Ngdn	98	90.000	Cricetulus_griseus_crigri
ENSG00000129460	NGDN	98	50.694	ENSCSEG00000008801	ngdn	96	54.545	Cynoglossus_semilaevis
ENSG00000129460	NGDN	97	58.865	ENSDARG00000045372	ngdn	97	54.662	Danio_rerio
ENSG00000129460	NGDN	100	90.071	ENSDNOG00000005395	NGDN	98	91.290	Dasypus_novemcinctus
ENSG00000129460	NGDN	100	89.362	ENSDORG00000010731	Ngdn	98	92.157	Dipodomys_ordii
ENSG00000129460	NGDN	79	55.357	FBgn0031736	CG11030	93	41.433	Drosophila_melanogaster
ENSG00000129460	NGDN	95	83.729	ENSETEG00000007531	NGDN	100	83.601	Echinops_telfairi
ENSG00000129460	NGDN	95	55.147	ENSEBUG00000000664	ngdn	94	45.161	Eptatretus_burgeri
ENSG00000129460	NGDN	99	90.000	ENSEASG00005011793	NGDN	100	92.759	Equus_asinus_asinus
ENSG00000129460	NGDN	100	92.381	ENSECAG00000006081	NGDN	98	92.258	Equus_caballus
ENSG00000129460	NGDN	100	87.234	ENSEEUG00000011829	NGDN	100	87.764	Erinaceus_europaeus
ENSG00000129460	NGDN	90	56.738	ENSELUG00000022676	ngdn	90	53.922	Esox_lucius
ENSG00000129460	NGDN	100	92.698	ENSFCAG00000009093	NGDN	98	91.613	Felis_catus
ENSG00000129460	NGDN	100	90.780	ENSFDAG00000011611	NGDN	98	91.613	Fukomys_damarensis
ENSG00000129460	NGDN	98	56.643	ENSFHEG00000007207	ngdn	96	56.026	Fundulus_heteroclitus
ENSG00000129460	NGDN	94	54.545	ENSGMOG00000003876	ngdn	99	53.381	Gadus_morhua
ENSG00000129460	NGDN	98	56.250	ENSGAFG00000017102	ngdn	96	54.545	Gambusia_affinis
ENSG00000129460	NGDN	99	55.245	ENSGACG00000002164	ngdn	95	56.631	Gasterosteus_aculeatus
ENSG00000129460	NGDN	97	61.889	ENSGAGG00000016471	NGDN	98	60.596	Gopherus_agassizii
ENSG00000129460	NGDN	100	99.365	ENSGGOG00000005000	NGDN	100	99.365	Gorilla_gorilla
ENSG00000129460	NGDN	93	56.164	ENSHBUG00000019489	ngdn	96	55.844	Haplochromis_burtoni
ENSG00000129460	NGDN	100	90.780	ENSHGLG00000008896	NGDN	98	91.613	Heterocephalus_glaber_female
ENSG00000129460	NGDN	100	90.780	ENSHGLG00100014352	NGDN	98	91.613	Heterocephalus_glaber_male
ENSG00000129460	NGDN	96	55.882	ENSHCOG00000019913	ngdn	96	52.751	Hippocampus_comes
ENSG00000129460	NGDN	95	58.955	ENSIPUG00000008128	ngdn	98	53.822	Ictalurus_punctatus
ENSG00000129460	NGDN	100	91.489	ENSSTOG00000002637	NGDN	98	93.871	Ictidomys_tridecemlineatus
ENSG00000129460	NGDN	100	85.816	ENSJJAG00000010601	-	98	84.194	Jaculus_jaculus
ENSG00000129460	NGDN	98	53.846	ENSKMAG00000018719	ngdn	94	55.519	Kryptolebias_marmoratus
ENSG00000129460	NGDN	98	54.167	ENSLBEG00000027237	ngdn	98	54.723	Labrus_bergylta
ENSG00000129460	NGDN	82	63.793	ENSLACG00000005765	NGDN	97	57.732	Latimeria_chalumnae
ENSG00000129460	NGDN	100	92.199	ENSLAFG00000013953	NGDN	98	93.226	Loxodonta_africana
ENSG00000129460	NGDN	100	96.508	ENSMFAG00000033387	NGDN	100	96.508	Macaca_fascicularis
ENSG00000129460	NGDN	100	96.508	ENSMMUG00000014766	NGDN	100	96.508	Macaca_mulatta
ENSG00000129460	NGDN	100	96.190	ENSMNEG00000038334	NGDN	100	96.190	Macaca_nemestrina
ENSG00000129460	NGDN	100	96.825	ENSMLEG00000037525	NGDN	100	96.825	Mandrillus_leucophaeus
ENSG00000129460	NGDN	98	53.623	ENSMAMG00000007995	ngdn	88	51.987	Mastacembelus_armatus
ENSG00000129460	NGDN	93	56.507	ENSMZEG00005011874	ngdn	96	56.169	Maylandia_zebra
ENSG00000129460	NGDN	84	91.525	ENSMAUG00000011909	Ngdn	98	93.130	Mesocricetus_auratus
ENSG00000129460	NGDN	100	93.333	ENSMICG00000010111	NGDN	98	93.226	Microcebus_murinus
ENSG00000129460	NGDN	95	89.116	ENSMOCG00000021605	Ngdn	98	88.710	Microtus_ochrogaster
ENSG00000129460	NGDN	98	54.930	ENSMMOG00000005420	ngdn	92	52.174	Mola_mola
ENSG00000129460	NGDN	100	82.270	ENSMODG00000004257	NGDN	96	85.161	Monodelphis_domestica
ENSG00000129460	NGDN	98	52.716	ENSMALG00000019654	ngdn	95	52.273	Monopterus_albus
ENSG00000129460	NGDN	95	88.475	MGP_CAROLIEiJ_G0019285	Ngdn	98	88.387	Mus_caroli
ENSG00000129460	NGDN	95	88.814	ENSMUSG00000022204	Ngdn	98	88.710	Mus_musculus
ENSG00000129460	NGDN	100	90.071	MGP_PahariEiJ_G0030302	Ngdn	98	88.710	Mus_pahari
ENSG00000129460	NGDN	95	89.153	MGP_SPRETEiJ_G0020174	Ngdn	98	89.032	Mus_spretus
ENSG00000129460	NGDN	100	90.780	ENSMPUG00000006439	NGDN	98	92.982	Mustela_putorius_furo
ENSG00000129460	NGDN	100	86.525	ENSMLUG00000017232	NGDN	95	88.852	Myotis_lucifugus
ENSG00000129460	NGDN	94	91.468	ENSNGAG00000003165	Ngdn	98	91.613	Nannospalax_galili
ENSG00000129460	NGDN	98	57.343	ENSNBRG00000023962	ngdn	94	50.489	Neolamprologus_brichardi
ENSG00000129460	NGDN	100	97.778	ENSNLEG00000027739	NGDN	100	97.778	Nomascus_leucogenys
ENSG00000129460	NGDN	100	80.851	ENSMEUG00000010596	NGDN	99	84.566	Notamacropus_eugenii
ENSG00000129460	NGDN	100	87.234	ENSOPRG00000016594	NGDN	98	89.032	Ochotona_princeps
ENSG00000129460	NGDN	100	89.362	ENSODEG00000002730	NGDN	98	92.642	Octodon_degus
ENSG00000129460	NGDN	98	53.846	ENSONIG00000008106	ngdn	96	55.844	Oreochromis_niloticus
ENSG00000129460	NGDN	99	79.286	ENSOANG00000013060	NGDN	98	81.350	Ornithorhynchus_anatinus
ENSG00000129460	NGDN	96	89.262	ENSOCUG00000013973	NGDN	98	88.065	Oryctolagus_cuniculus
ENSG00000129460	NGDN	91	54.035	ENSORLG00000006124	ngdn	91	53.035	Oryzias_latipes
ENSG00000129460	NGDN	94	57.576	ENSORLG00020004656	ngdn	96	53.896	Oryzias_latipes_hni
ENSG00000129460	NGDN	89	56.071	ENSORLG00015001467	ngdn	96	54.545	Oryzias_latipes_hsok
ENSG00000129460	NGDN	98	54.167	ENSOMEG00000016586	ngdn	96	54.545	Oryzias_melastigma
ENSG00000129460	NGDN	100	92.908	ENSOGAG00000008735	NGDN	98	92.581	Otolemur_garnettii
ENSG00000129460	NGDN	100	89.362	ENSOARG00000019301	NGDN	98	91.935	Ovis_aries
ENSG00000129460	NGDN	100	99.365	ENSPPAG00000039327	NGDN	100	99.365	Pan_paniscus
ENSG00000129460	NGDN	100	89.362	ENSPPRG00000020120	NGDN	98	91.935	Panthera_pardus
ENSG00000129460	NGDN	100	92.908	ENSPTIG00000012462	NGDN	98	91.935	Panthera_tigris_altaica
ENSG00000129460	NGDN	100	99.048	ENSPTRG00000006177	NGDN	100	99.048	Pan_troglodytes
ENSG00000129460	NGDN	100	96.508	ENSPANG00000026138	NGDN	100	96.508	Papio_anubis
ENSG00000129460	NGDN	92	56.849	ENSPKIG00000008183	ngdn	89	55.844	Paramormyrops_kingsleyae
ENSG00000129460	NGDN	94	51.701	ENSPMGG00000022036	ngdn	99	50.000	Periophthalmus_magnuspinnatus
ENSG00000129460	NGDN	100	89.362	ENSPEMG00000010734	Ngdn	98	89.355	Peromyscus_maniculatus_bairdii
ENSG00000129460	NGDN	97	54.487	ENSPMAG00000004469	ngdn	96	53.922	Petromyzon_marinus
ENSG00000129460	NGDN	100	80.851	ENSPCIG00000012961	NGDN	98	83.819	Phascolarctos_cinereus
ENSG00000129460	NGDN	99	55.862	ENSPFOG00000010423	ngdn	98	54.890	Poecilia_formosa
ENSG00000129460	NGDN	99	56.552	ENSPLAG00000022684	ngdn	96	55.195	Poecilia_latipinna
ENSG00000129460	NGDN	99	56.552	ENSPMEG00000020850	ngdn	96	55.519	Poecilia_mexicana
ENSG00000129460	NGDN	98	56.944	ENSPREG00000011208	ngdn	96	54.870	Poecilia_reticulata
ENSG00000129460	NGDN	100	98.730	ENSPPYG00000005670	NGDN	100	98.730	Pongo_abelii
ENSG00000129460	NGDN	72	90.566	ENSPCAG00000007252	-	68	86.301	Procavia_capensis
ENSG00000129460	NGDN	95	93.898	ENSPCOG00000027627	NGDN	98	93.548	Propithecus_coquereli
ENSG00000129460	NGDN	100	88.652	ENSPVAG00000005178	NGDN	100	90.997	Pteropus_vampyrus
ENSG00000129460	NGDN	93	55.822	ENSPNYG00000013193	ngdn	94	55.987	Pundamilia_nyererei
ENSG00000129460	NGDN	91	56.164	ENSPNAG00000005995	ngdn	98	54.259	Pygocentrus_nattereri
ENSG00000129460	NGDN	100	92.199	ENSRNOG00000018069	Ngdn	98	90.000	Rattus_norvegicus
ENSG00000129460	NGDN	100	96.508	ENSRBIG00000035850	NGDN	100	96.508	Rhinopithecus_bieti
ENSG00000129460	NGDN	100	96.508	ENSRROG00000031932	NGDN	100	96.552	Rhinopithecus_roxellana
ENSG00000129460	NGDN	95	95.918	ENSSBOG00000029466	NGDN	99	95.862	Saimiri_boliviensis_boliviensis
ENSG00000129460	NGDN	100	79.433	ENSSHAG00000015351	NGDN	98	84.194	Sarcophilus_harrisii
ENSG00000129460	NGDN	90	59.011	ENSSFOG00015012601	ngdn	96	55.806	Scleropages_formosus
ENSG00000129460	NGDN	99	54.777	ENSSMAG00000020166	ngdn	96	54.693	Scophthalmus_maximus
ENSG00000129460	NGDN	90	57.447	ENSSDUG00000020600	ngdn	96	54.221	Seriola_dumerili
ENSG00000129460	NGDN	90	57.447	ENSSLDG00000007140	ngdn	96	54.221	Seriola_lalandi_dorsalis
ENSG00000129460	NGDN	95	83.333	ENSSARG00000000643	NGDN	100	83.601	Sorex_araneus
ENSG00000129460	NGDN	92	53.979	ENSSPAG00000021672	ngdn	95	52.104	Stegastes_partitus
ENSG00000129460	NGDN	100	87.943	ENSSSCG00000002020	-	98	90.323	Sus_scrofa
ENSG00000129460	NGDN	90	52.482	ENSTRUG00000006677	ngdn	96	50.325	Takifugu_rubripes
ENSG00000129460	NGDN	94	54.362	ENSTNIG00000018972	ngdn	98	52.848	Tetraodon_nigroviridis
ENSG00000129460	NGDN	100	92.063	ENSTTRG00000010655	NGDN	100	91.935	Tursiops_truncatus
ENSG00000129460	NGDN	100	90.071	ENSUAMG00000007475	NGDN	98	92.982	Ursus_americanus
ENSG00000129460	NGDN	100	90.071	ENSUMAG00000014789	NGDN	85	92.013	Ursus_maritimus
ENSG00000129460	NGDN	100	88.652	ENSVPAG00000010012	NGDN	100	91.640	Vicugna_pacos
ENSG00000129460	NGDN	100	89.362	ENSVVUG00000025104	NGDN	97	92.484	Vulpes_vulpes
ENSG00000129460	NGDN	96	64.444	ENSXETG00000014562	ngdn	98	61.415	Xenopus_tropicalis
ENSG00000129460	NGDN	94	53.237	ENSXCOG00000005102	ngdn	95	51.911	Xiphophorus_couchianus
ENSG00000129460	NGDN	98	56.250	ENSXMAG00000006206	ngdn	96	56.026	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	21873635.	IBA	Process
GO:0000775	chromosome, centromeric region	-	IEA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	25416956.30021884.30177828.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0006417	regulation of translation	-	IEA	Process
GO:0030175	filopodium	-	IEA	Component
GO:0030424	axon	-	IEA	Component
GO:0030425	dendrite	-	IEA	Component
GO:0032040	small-subunit processome	21873635.	IBA	Component