EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000129484 (Gene tree)
Gene ID: 10038
Gene Symbol: PARP2
Alias: ADPRTL2
Full Name: poly(ADP-ribose) polymerase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 14,329 bases
Position: chr14:20,343,582-20,357,910
Accession: 272
RBP type: canonical RBP
Summary: This gene encodes poly(ADP-ribosyl)transferase-like 2 protein, which contains a catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000250416	PARP	PF00644.20	7.5e-70	1	1
ENSP00000392972	PARP	PF00644.20	9.2e-70	1	1
ENSP00000432283	PARP	PF00644.20	1.5e-55	1	1
ENSP00000445524	PARP	PF00644.20	9e-45	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
24510188	ARTD2 activity is stimulated by RNA.	Nucleic Acids Res	2014 Apr	Leger K	doi: 10.1093/nar/gku131

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000539930	PARP2-210	635	-	ENSP00000445524	177 (aa)	-	H0YH02
ENST00000528465	PARP2-205	551	-	-	- (aa)	-	-
ENST00000529465	PARP2-206	717	-	ENSP00000431867	110 (aa)	-	E9PJ27
ENST00000429687	PARP2-202	1881	XM_017020912	ENSP00000392972	570 (aa)	XP_016876401	Q9UGN5
ENST00000530598	PARP2-207	842	-	-	- (aa)	-	-
ENST00000555140	PARP2-211	530	-	-	- (aa)	-	-
ENST00000527915	PARP2-204	1980	-	ENSP00000432283	531 (aa)	-	G3V167
ENST00000534664	PARP2-209	566	-	-	- (aa)	-	-
ENST00000527384	PARP2-203	429	-	-	- (aa)	-	-
ENST00000532299	PARP2-208	876	-	-	- (aa)	-	-
ENST00000250416	PARP2-201	1886	XM_005267247	ENSP00000250416	583 (aa)	XP_005267304	Q9UGN5

Gene Model

Click here to download ENSG00000129484's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03410	Base excision repair	KEGG
hsa04210	Apoptosis	KEGG
hsa04217	Necroptosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000129484	Alcohol Drinking	1.38358566389269E-11	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129484's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000129484	PARP2	93	69.512	ENSAPOG00000007639	parp2	82	61.781	Acanthochromis_polyacanthus
ENSG00000129484	PARP2	100	90.526	ENSAMEG00000005544	PARP2	98	91.171	Ailuropoda_melanoleuca
ENSG00000129484	PARP2	93	68.485	ENSACIG00000012715	parp2	84	65.469	Amphilophus_citrinellus
ENSG00000129484	PARP2	93	70.122	ENSAOCG00000007473	parp2	82	61.781	Amphiprion_ocellaris
ENSG00000129484	PARP2	93	70.122	ENSAPEG00000020186	parp2	82	61.967	Amphiprion_percula
ENSG00000129484	PARP2	94	63.822	ENSATEG00000017409	parp2	82	63.031	Anabas_testudineus
ENSG00000129484	PARP2	96	67.336	ENSACAG00000008301	PARP2	95	67.336	Anolis_carolinensis
ENSG00000129484	PARP2	93	97.576	ENSANAG00000021389	PARP2	99	87.842	Aotus_nancymaae
ENSG00000129484	PARP2	93	68.293	ENSACLG00000005390	parp2	98	62.197	Astatotilapia_calliptera
ENSG00000129484	PARP2	93	68.293	ENSAMXG00000004311	parp2	83	62.936	Astyanax_mexicanus
ENSG00000129484	PARP2	99	90.141	ENSBTAG00000009374	PARP2	98	90.926	Bos_taurus
ENSG00000129484	PARP2	90	31.522	WBGene00004050	parp-2	87	30.083	Caenorhabditis_elegans
ENSG00000129484	PARP2	99	96.837	ENSCJAG00000009885	PARP2	99	96.837	Callithrix_jacchus
ENSG00000129484	PARP2	100	87.895	ENSCAFG00000005389	PARP2	97	88.649	Canis_familiaris
ENSG00000129484	PARP2	97	88.448	ENSCAFG00020014348	PARP2	97	88.468	Canis_lupus_dingo
ENSG00000129484	PARP2	93	93.333	ENSCHIG00000024572	PARP2	97	82.759	Capra_hircus
ENSG00000129484	PARP2	100	91.930	ENSTSYG00000003944	-	98	92.613	Carlito_syrichta
ENSG00000129484	PARP2	100	80.070	ENSTSYG00000027897	-	98	80.180	Carlito_syrichta
ENSG00000129484	PARP2	93	95.758	ENSCPOG00000022667	PARP2	100	87.796	Cavia_porcellus
ENSG00000129484	PARP2	99	97.364	ENSCCAG00000038084	PARP2	99	97.364	Cebus_capucinus
ENSG00000129484	PARP2	97	95.246	ENSCATG00000006864	PARP2	97	95.246	Cercocebus_atys
ENSG00000129484	PARP2	93	93.939	ENSCLAG00000000756	PARP2	100	88.342	Chinchilla_lanigera
ENSG00000129484	PARP2	100	97.368	ENSCSAG00000016798	PARP2	100	97.368	Chlorocebus_sabaeus
ENSG00000129484	PARP2	93	94.545	ENSCHOG00000007172	PARP2	98	74.081	Choloepus_hoffmanni
ENSG00000129484	PARP2	93	51.515	ENSCING00000005644	-	95	47.308	Ciona_intestinalis
ENSG00000129484	PARP2	93	59.036	ENSCSAVG00000000862	-	99	51.456	Ciona_savignyi
ENSG00000129484	PARP2	93	54.217	ENSCSAVG00000004832	-	99	46.545	Ciona_savignyi
ENSG00000129484	PARP2	93	98.788	ENSCANG00000003195	PARP2	97	98.337	Colobus_angolensis_palliatus
ENSG00000129484	PARP2	97	83.423	ENSCGRG00001013817	Parp2	98	83.423	Cricetulus_griseus_chok1gshd
ENSG00000129484	PARP2	97	83.784	ENSCGRG00000007431	-	98	83.784	Cricetulus_griseus_crigri
ENSG00000129484	PARP2	100	66.102	ENSCGRG00000007794	-	97	66.126	Cricetulus_griseus_crigri
ENSG00000129484	PARP2	93	68.902	ENSCSEG00000021341	parp2	99	62.427	Cynoglossus_semilaevis
ENSG00000129484	PARP2	93	69.091	ENSCVAG00000000616	parp2	87	55.401	Cyprinodon_variegatus
ENSG00000129484	PARP2	93	70.303	ENSDARG00000079202	parp2	82	63.031	Danio_rerio
ENSG00000129484	PARP2	100	86.934	ENSDNOG00000017471	PARP2	97	88.288	Dasypus_novemcinctus
ENSG00000129484	PARP2	93	94.545	ENSDORG00000002521	Parp2	99	88.582	Dipodomys_ordii
ENSG00000129484	PARP2	93	90.909	ENSETEG00000016727	PARP2	100	89.144	Echinops_telfairi
ENSG00000129484	PARP2	88	64.331	ENSEBUG00000012647	PARP2	91	58.893	Eptatretus_burgeri
ENSG00000129484	PARP2	100	87.631	ENSEASG00005017456	PARP2	97	89.189	Equus_asinus_asinus
ENSG00000129484	PARP2	100	89.199	ENSECAG00000005548	PARP2	99	91.992	Equus_caballus
ENSG00000129484	PARP2	93	92.727	ENSEEUG00000012056	PARP2	98	87.809	Erinaceus_europaeus
ENSG00000129484	PARP2	93	69.512	ENSELUG00000004067	parp2	92	62.222	Esox_lucius
ENSG00000129484	PARP2	99	89.317	ENSFCAG00000006925	PARP2	97	90.270	Felis_catus
ENSG00000129484	PARP2	93	92.727	ENSFDAG00000018296	PARP2	97	87.748	Fukomys_damarensis
ENSG00000129484	PARP2	93	64.634	ENSFHEG00000023027	parp2	82	60.074	Fundulus_heteroclitus
ENSG00000129484	PARP2	89	63.924	ENSGMOG00000010852	parp2	89	62.675	Gadus_morhua
ENSG00000129484	PARP2	89	68.153	ENSGAFG00000020999	parp2	84	50.960	Gambusia_affinis
ENSG00000129484	PARP2	93	67.683	ENSGACG00000017794	parp2	96	60.813	Gasterosteus_aculeatus
ENSG00000129484	PARP2	93	67.273	ENSGAGG00000002180	PARP2	99	66.085	Gopherus_agassizii
ENSG00000129484	PARP2	100	99.474	ENSGGOG00000022241	PARP2	100	99.474	Gorilla_gorilla
ENSG00000129484	PARP2	93	68.293	ENSHBUG00000007397	parp2	87	62.796	Haplochromis_burtoni
ENSG00000129484	PARP2	87	90.909	ENSHGLG00000002524	PARP2	97	88.222	Heterocephalus_glaber_female
ENSG00000129484	PARP2	98	88.750	ENSHGLG00100001415	PARP2	98	89.189	Heterocephalus_glaber_male
ENSG00000129484	PARP2	93	67.273	ENSHCOG00000012275	parp2	92	64.047	Hippocampus_comes
ENSG00000129484	PARP2	93	69.512	ENSIPUG00000015405	parp2	84	62.593	Ictalurus_punctatus
ENSG00000129484	PARP2	93	95.152	ENSSTOG00000028763	PARP2	98	88.649	Ictidomys_tridecemlineatus
ENSG00000129484	PARP2	93	92.727	ENSJJAG00000006912	Parp2	98	85.481	Jaculus_jaculus
ENSG00000129484	PARP2	93	68.293	ENSKMAG00000017955	parp2	95	63.944	Kryptolebias_marmoratus
ENSG00000129484	PARP2	93	62.805	ENSLBEG00000004930	parp2	96	59.598	Labrus_bergylta
ENSG00000129484	PARP2	93	74.556	ENSLACG00000004086	PARP2	100	72.112	Latimeria_chalumnae
ENSG00000129484	PARP2	93	67.273	ENSLOCG00000000267	parp2	100	52.713	Lepisosteus_oculatus
ENSG00000129484	PARP2	99	91.213	ENSLAFG00000027659	PARP2	98	91.727	Loxodonta_africana
ENSG00000129484	PARP2	100	97.544	ENSMFAG00000013069	PARP2	100	97.544	Macaca_fascicularis
ENSG00000129484	PARP2	100	97.544	ENSMMUG00000016253	PARP2	100	97.544	Macaca_mulatta
ENSG00000129484	PARP2	100	97.193	ENSMNEG00000036792	PARP2	100	97.193	Macaca_nemestrina
ENSG00000129484	PARP2	100	97.193	ENSMLEG00000033209	PARP2	100	97.193	Mandrillus_leucophaeus
ENSG00000129484	PARP2	93	70.122	ENSMAMG00000008233	parp2	96	60.670	Mastacembelus_armatus
ENSG00000129484	PARP2	93	68.293	ENSMZEG00005024239	parp2	98	62.197	Maylandia_zebra
ENSG00000129484	PARP2	93	89.091	ENSMAUG00000016215	Parp2	98	83.423	Mesocricetus_auratus
ENSG00000129484	PARP2	100	92.321	ENSMICG00000001491	PARP2	97	93.153	Microcebus_murinus
ENSG00000129484	PARP2	97	87.027	ENSMOCG00000006895	Parp2	98	87.027	Microtus_ochrogaster
ENSG00000129484	PARP2	93	68.902	ENSMMOG00000019548	parp2	86	59.503	Mola_mola
ENSG00000129484	PARP2	93	87.879	ENSMODG00000007171	PARP2	72	78.598	Monodelphis_domestica
ENSG00000129484	PARP2	93	69.512	ENSMALG00000014182	parp2	93	61.553	Monopterus_albus
ENSG00000129484	PARP2	93	90.909	ENSMUSG00000036023	Parp2	98	86.331	Mus_musculus
ENSG00000129484	PARP2	97	86.306	MGP_PahariEiJ_G0030227	Parp2	98	86.306	Mus_pahari
ENSG00000129484	PARP2	97	86.511	MGP_SPRETEiJ_G0020096	Parp2	98	86.511	Mus_spretus
ENSG00000129484	PARP2	100	89.860	ENSMPUG00000018126	PARP2	98	90.811	Mustela_putorius_furo
ENSG00000129484	PARP2	75	91.667	ENSMLUG00000015313	PARP2	96	79.318	Myotis_lucifugus
ENSG00000129484	PARP2	93	92.727	ENSNGAG00000022005	Parp2	96	85.714	Nannospalax_galili
ENSG00000129484	PARP2	93	68.293	ENSNBRG00000015824	parp2	84	63.025	Neolamprologus_brichardi
ENSG00000129484	PARP2	100	99.314	ENSNLEG00000010714	PARP2	100	99.314	Nomascus_leucogenys
ENSG00000129484	PARP2	93	87.879	ENSMEUG00000010763	PARP2	100	71.912	Notamacropus_eugenii
ENSG00000129484	PARP2	98	67.826	ENSOPRG00000013873	PARP2	73	88.976	Ochotona_princeps
ENSG00000129484	PARP2	99	86.420	ENSODEG00000002170	PARP2	97	87.748	Octodon_degus
ENSG00000129484	PARP2	93	67.683	ENSONIG00000015194	parp2	82	60.146	Oreochromis_niloticus
ENSG00000129484	PARP2	99	87.346	ENSOCUG00000002303	PARP2	96	89.111	Oryctolagus_cuniculus
ENSG00000129484	PARP2	93	71.951	ENSORLG00000003023	parp2	93	63.872	Oryzias_latipes
ENSG00000129484	PARP2	93	71.951	ENSORLG00015009807	parp2	94	63.273	Oryzias_latipes_hsok
ENSG00000129484	PARP2	93	70.732	ENSOMEG00000022765	parp2	90	60.823	Oryzias_melastigma
ENSG00000129484	PARP2	97	92.626	ENSOGAG00000013297	PARP2	97	92.626	Otolemur_garnettii
ENSG00000129484	PARP2	97	90.975	ENSOARG00000019777	PARP2	99	90.975	Ovis_aries
ENSG00000129484	PARP2	100	97.719	ENSPPAG00000035197	PARP2	100	97.719	Pan_paniscus
ENSG00000129484	PARP2	99	88.468	ENSPPRG00000013205	PARP2	98	88.908	Panthera_pardus
ENSG00000129484	PARP2	99	88.967	ENSPTIG00000004560	PARP2	97	89.910	Panthera_tigris_altaica
ENSG00000129484	PARP2	100	100.000	ENSPTRG00000006089	PARP2	100	100.000	Pan_troglodytes
ENSG00000129484	PARP2	95	97.459	ENSPANG00000018567	PARP2	96	97.459	Papio_anubis
ENSG00000129484	PARP2	93	71.951	ENSPKIG00000007938	parp2	95	61.552	Paramormyrops_kingsleyae
ENSG00000129484	PARP2	93	68.485	ENSPMGG00000002431	parp2	83	58.716	Periophthalmus_magnuspinnatus
ENSG00000129484	PARP2	93	91.515	ENSPEMG00000000490	Parp2	100	86.101	Peromyscus_maniculatus_bairdii
ENSG00000129484	PARP2	93	87.879	ENSPCIG00000023266	PARP2	70	81.594	Phascolarctos_cinereus
ENSG00000129484	PARP2	93	70.122	ENSPFOG00000003524	parp2	81	62.709	Poecilia_formosa
ENSG00000129484	PARP2	93	69.697	ENSPLAG00000018418	parp2	93	64.525	Poecilia_latipinna
ENSG00000129484	PARP2	93	70.122	ENSPMEG00000023255	parp2	87	62.709	Poecilia_mexicana
ENSG00000129484	PARP2	93	69.512	ENSPREG00000001464	parp2	85	60.215	Poecilia_reticulata
ENSG00000129484	PARP2	100	98.772	ENSPPYG00000005562	PARP2	100	98.772	Pongo_abelii
ENSG00000129484	PARP2	93	94.545	ENSPCAG00000009733	PARP2	98	82.777	Procavia_capensis
ENSG00000129484	PARP2	100	91.938	ENSPCOG00000024502	PARP2	98	92.254	Propithecus_coquereli
ENSG00000129484	PARP2	100	89.365	ENSPVAG00000010730	PARP2	98	90.317	Pteropus_vampyrus
ENSG00000129484	PARP2	93	66.463	ENSPNYG00000003361	parp2	98	61.639	Pundamilia_nyererei
ENSG00000129484	PARP2	93	70.732	ENSPNAG00000011697	parp2	86	61.210	Pygocentrus_nattereri
ENSG00000129484	PARP2	97	85.405	ENSRNOG00000008892	Parp2	98	85.405	Rattus_norvegicus
ENSG00000129484	PARP2	100	97.193	ENSRBIG00000043424	PARP2	100	97.193	Rhinopithecus_bieti
ENSG00000129484	PARP2	100	96.842	ENSRROG00000036678	PARP2	100	96.842	Rhinopithecus_roxellana
ENSG00000129484	PARP2	93	86.441	ENSSBOG00000012234	PARP2	83	91.781	Saimiri_boliviensis_boliviensis
ENSG00000129484	PARP2	93	86.061	ENSSHAG00000013256	PARP2	100	84.047	Sarcophilus_harrisii
ENSG00000129484	PARP2	93	72.727	ENSSFOG00015012443	parp2	99	63.489	Scleropages_formosus
ENSG00000129484	PARP2	93	68.293	ENSSMAG00000010446	parp2	80	62.454	Scophthalmus_maximus
ENSG00000129484	PARP2	93	67.073	ENSSDUG00000006387	parp2	80	61.754	Seriola_dumerili
ENSG00000129484	PARP2	93	67.073	ENSSLDG00000007736	parp2	85	58.275	Seriola_lalandi_dorsalis
ENSG00000129484	PARP2	93	93.333	ENSSARG00000014464	PARP2	98	87.148	Sorex_araneus
ENSG00000129484	PARP2	93	66.467	ENSSPUG00000001145	PARP2	72	70.356	Sphenodon_punctatus
ENSG00000129484	PARP2	93	68.293	ENSSPAG00000012344	parp2	85	60.000	Stegastes_partitus
ENSG00000129484	PARP2	99	89.437	ENSSSCG00000002143	PARP2	98	90.450	Sus_scrofa
ENSG00000129484	PARP2	93	67.273	ENSTRUG00000010876	parp2	69	63.438	Takifugu_rubripes
ENSG00000129484	PARP2	93	66.667	ENSTNIG00000004223	parp2	96	60.329	Tetraodon_nigroviridis
ENSG00000129484	PARP2	93	92.727	ENSTBEG00000001332	PARP2	98	80.721	Tupaia_belangeri
ENSG00000129484	PARP2	93	93.939	ENSTTRG00000012376	PARP2	97	89.354	Tursiops_truncatus
ENSG00000129484	PARP2	100	90.351	ENSUAMG00000011044	PARP2	96	93.254	Ursus_americanus
ENSG00000129484	PARP2	100	90.351	ENSUMAG00000008125	PARP2	98	90.991	Ursus_maritimus
ENSG00000129484	PARP2	98	69.421	ENSVPAG00000005917	-	70	82.609	Vicugna_pacos
ENSG00000129484	PARP2	99	86.949	ENSVVUG00000008887	PARP2	100	88.665	Vulpes_vulpes
ENSG00000129484	PARP2	93	68.485	ENSXETG00000001748	parp2	94	65.804	Xenopus_tropicalis
ENSG00000129484	PARP2	93	69.697	ENSXMAG00000005402	parp2	98	64.811	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003677	DNA binding	-	IEA	Function
GO:0003950	NAD+ ADP-ribosyltransferase activity	21873635.	IBA	Function
GO:0005515	protein binding	21812934.27067600.28190768.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	15615785.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	15615785.	IDA	Component
GO:0006281	DNA repair	7260241.	TAS	Process
GO:0006284	base-excision repair	-	IEA	Process
GO:0006302	double-strand break repair	21873635.	IBA	Process
GO:0006471	protein ADP-ribosylation	7260241.	TAS	Process
GO:0018312	peptidyl-serine ADP-ribosylation	28190768.	IDA	Process
GO:0030592	DNA ADP-ribosylation	27471034.	IDA	Process
GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development	-	IEA	Process
GO:0070212	protein poly-ADP-ribosylation	21873635.	IBA	Process
GO:0070212	protein poly-ADP-ribosylation	25043379.	IDA	Process
GO:0097191	extrinsic apoptotic signaling pathway	-	IEA	Process
GO:1901215	negative regulation of neuron death	-	IEA	Process
GO:1990404	protein ADP-ribosylase activity	21873635.	IBA	Function
GO:1990404	protein ADP-ribosylase activity	25043379.28190768.	IDA	Function