EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000129566 (Gene tree)
Gene ID: 7011
Gene Symbol: TEP1
Alias: TP1|TLP1|VAULT2|p240|TROVE1
Full Name: telomerase associated protein 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 48,979 bases
Position: chr14:20,365,667-20,414,645
Accession: 11726
RBP type: canonical RBP
Summary: This gene product is a component of the ribonucleoprotein complex responsible for telomerase activity which catalyzes the addition of new telomeres on the chromosome ends. The telomerase-associated proteins are conserved from ciliates to humans. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000262715	TROVE	PF05731.11	1.3e-204	1	1
ENSP00000452574	TROVE	PF05731.11	6.1e-137	1	2
ENSP00000452574	TROVE	PF05731.11	6.1e-137	2	2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
15701761	The p80 homology region of TEP1 is sufficient for its association with the telomerase and vault RNAs, and the vault particle.	Nucleic Acids Res	2005 Feb 8	Poderycki MJ	-
9443919	Reconstitution of human telomerase activity in vitro.	Curr Biol	1998 Jan 29	Beattie TL	-
11027287	Telomerase-associated protein TEP1 is not essential for telomerase activity or telomere length maintenance in vivo.	Mol Cell Biol	2000 Nov	Liu Y	-
11029039	Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding.	Mol Biol Cell	2000 Oct	Beattie TL	-
12007281	Expression of MRE11 complex (MRE11, RAD50, NBS1) and hRap1 and its relation with telomere regulation, telomerase activity in human gastric carcinomas.	Pathobiology	2001	Matsutani N	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000557627	TEP1-211	1081	-	-	- (aa)	-	-
ENST00000557314	TEP1-210	2698	-	ENSP00000450830	70 (aa)	-	H0YJ53
ENST00000553984	TEP1-204	602	-	ENSP00000450508	201 (aa)	-	H0YIZ2
ENST00000556935	TEP1-209	7643	XM_011537110	ENSP00000452574	2519 (aa)	XP_011535412	G3V5X7
ENST00000262715	TEP1-201	10695	XM_005268027	ENSP00000262715	2627 (aa)	XP_005268084	Q99973
ENST00000471684	TEP1-202	732	-	ENSP00000451919	78 (aa)	-	H0YJP8
ENST00000555727	TEP1-206	7832	-	ENSP00000451634	1481 (aa)	-	G3V470
ENST00000556488	TEP1-207	1055	-	ENSP00000451409	102 (aa)	-	H0YJF6
ENST00000553365	TEP1-203	2967	-	ENSP00000450475	250 (aa)	-	H0YIY9
ENST00000555008	TEP1-205	6697	-	ENSP00000450541	1904 (aa)	-	G3V2A4
ENST00000556549	TEP1-208	581	-	ENSP00000452240	166 (aa)	-	G3V591

Gene Model

Click here to download ENSG00000129566's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000129566	Cholesterol, HDL	6.52425684686264E-5	17903299
ENSG00000129566	Platelet Function Tests	2.6838500E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000129566	rs8009925	14	20403486	?	White matter microstructure in first episode schizophrenia (left anterior cingulate cortex)	28924203	unit increase	0.04	EFO_0000692\|EFO_0005674\|EFO_0007738

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000129566's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000129566	TEP1	99	80.272	ENSAMEG00000005467	TEP1	100	78.504	Ailuropoda_melanoleuca
ENSG00000129566	TEP1	97	41.715	ENSACAG00000008296	TEP1	95	41.825	Anolis_carolinensis
ENSG00000129566	TEP1	100	93.761	ENSANAG00000029318	TEP1	99	93.761	Aotus_nancymaae
ENSG00000129566	TEP1	99	82.282	ENSBTAG00000001179	TEP1	99	79.696	Bos_taurus
ENSG00000129566	TEP1	100	93.761	ENSCJAG00000009781	TEP1	99	93.761	Callithrix_jacchus
ENSG00000129566	TEP1	99	74.104	ENSCAFG00000005404	TEP1	100	72.431	Canis_familiaris
ENSG00000129566	TEP1	98	74.329	ENSCAFG00020014352	TEP1	96	73.673	Canis_lupus_dingo
ENSG00000129566	TEP1	100	81.666	ENSCHIG00000026555	TEP1	100	81.666	Capra_hircus
ENSG00000129566	TEP1	99	85.436	ENSTSYG00000003977	TEP1	99	85.240	Carlito_syrichta
ENSG00000129566	TEP1	90	84.127	ENSCAPG00000017353	TEP1	100	70.477	Cavia_aperea
ENSG00000129566	TEP1	90	84.127	ENSCPOG00000001064	TEP1	100	71.021	Cavia_porcellus
ENSG00000129566	TEP1	100	93.178	ENSCCAG00000035524	TEP1	99	93.178	Cebus_capucinus
ENSG00000129566	TEP1	100	94.939	ENSCATG00000039214	TEP1	100	95.015	Cercocebus_atys
ENSG00000129566	TEP1	99	72.862	ENSCLAG00000002055	TEP1	100	72.500	Chinchilla_lanigera
ENSG00000129566	TEP1	100	94.753	ENSCSAG00000016766	TEP1	100	94.829	Chlorocebus_sabaeus
ENSG00000129566	TEP1	99	95.321	ENSCANG00000031878	TEP1	100	93.849	Colobus_angolensis_palliatus
ENSG00000129566	TEP1	99	76.131	ENSCGRG00001014974	Tep1	100	74.592	Cricetulus_griseus_chok1gshd
ENSG00000129566	TEP1	99	76.131	ENSCGRG00000006704	Tep1	100	74.592	Cricetulus_griseus_crigri
ENSG00000129566	TEP1	99	80.214	ENSDNOG00000019848	TEP1	79	78.781	Dasypus_novemcinctus
ENSG00000129566	TEP1	100	79.309	ENSDORG00000002528	Tep1	100	79.309	Dipodomys_ordii
ENSG00000129566	TEP1	90	80.939	ENSETEG00000016732	TEP1	92	80.939	Echinops_telfairi
ENSG00000129566	TEP1	99	84.498	ENSEASG00005017468	TEP1	99	85.053	Equus_asinus_asinus
ENSG00000129566	TEP1	99	84.708	ENSECAG00000010629	TEP1	99	82.830	Equus_caballus
ENSG00000129566	TEP1	90	80.864	ENSEEUG00000012112	TEP1	83	80.864	Erinaceus_europaeus
ENSG00000129566	TEP1	99	82.239	ENSFCAG00000006927	TEP1	99	81.211	Felis_catus
ENSG00000129566	TEP1	99	77.639	ENSFDAG00000020795	TEP1	100	75.019	Fukomys_damarensis
ENSG00000129566	TEP1	100	99.057	ENSGGOG00000000206	TEP1	100	98.972	Gorilla_gorilla
ENSG00000129566	TEP1	98	75.120	ENSHGLG00000004168	TEP1	100	70.113	Heterocephalus_glaber_female
ENSG00000129566	TEP1	98	75.120	ENSHGLG00100013013	TEP1	100	69.808	Heterocephalus_glaber_male
ENSG00000129566	TEP1	99	82.458	ENSSTOG00000010031	TEP1	100	80.272	Ictidomys_tridecemlineatus
ENSG00000129566	TEP1	100	78.325	ENSJJAG00000000067	Tep1	100	76.847	Jaculus_jaculus
ENSG00000129566	TEP1	99	80.293	ENSLAFG00000002487	TEP1	100	78.823	Loxodonta_africana
ENSG00000129566	TEP1	100	95.396	ENSMFAG00000001130	TEP1	100	95.472	Macaca_fascicularis
ENSG00000129566	TEP1	100	95.871	ENSMMUG00000016255	TEP1	100	95.510	Macaca_mulatta
ENSG00000129566	TEP1	100	95.282	ENSMNEG00000032040	TEP1	100	95.358	Macaca_nemestrina
ENSG00000129566	TEP1	100	92.771	ENSMLEG00000035455	TEP1	98	94.017	Mandrillus_leucophaeus
ENSG00000129566	TEP1	99	74.027	ENSMAUG00000013833	Tep1	99	72.965	Mesocricetus_auratus
ENSG00000129566	TEP1	99	86.653	ENSMICG00000001497	TEP1	99	86.086	Microcebus_murinus
ENSG00000129566	TEP1	100	75.313	ENSMOCG00000015190	Tep1	99	73.588	Microtus_ochrogaster
ENSG00000129566	TEP1	99	63.874	ENSMODG00000007200	TEP1	99	60.317	Monodelphis_domestica
ENSG00000129566	TEP1	99	76.847	MGP_CAROLIEiJ_G0019205	Tep1	100	75.228	Mus_caroli
ENSG00000129566	TEP1	99	76.892	ENSMUSG00000006281	Tep1	100	75.246	Mus_musculus
ENSG00000129566	TEP1	99	77.392	MGP_PahariEiJ_G0030228	Tep1	99	74.255	Mus_pahari
ENSG00000129566	TEP1	99	76.489	MGP_SPRETEiJ_G0020097	Tep1	100	74.905	Mus_spretus
ENSG00000129566	TEP1	99	79.937	ENSMPUG00000018125	TEP1	100	78.144	Mustela_putorius_furo
ENSG00000129566	TEP1	99	82.757	ENSMLUG00000015336	TEP1	100	81.095	Myotis_lucifugus
ENSG00000129566	TEP1	99	78.863	ENSNGAG00000024249	Tep1	99	77.879	Nannospalax_galili
ENSG00000129566	TEP1	99	92.880	ENSNLEG00000010800	TEP1	100	92.325	Nomascus_leucogenys
ENSG00000129566	TEP1	94	63.531	ENSMEUG00000010782	TEP1	99	63.556	Notamacropus_eugenii
ENSG00000129566	TEP1	89	88.710	ENSOPRG00000013897	TEP1	90	80.000	Ochotona_princeps
ENSG00000129566	TEP1	90	83.165	ENSODEG00000001777	TEP1	99	72.295	Octodon_degus
ENSG00000129566	TEP1	90	66.667	ENSOANG00000012576	-	100	52.888	Ornithorhynchus_anatinus
ENSG00000129566	TEP1	99	82.081	ENSOCUG00000002312	TEP1	100	80.550	Oryctolagus_cuniculus
ENSG00000129566	TEP1	99	84.268	ENSOGAG00000013302	TEP1	99	80.938	Otolemur_garnettii
ENSG00000129566	TEP1	99	81.303	ENSOARG00000019765	TEP1	100	78.666	Ovis_aries
ENSG00000129566	TEP1	100	98.474	ENSPPAG00000032973	TEP1	100	98.372	Pan_paniscus
ENSG00000129566	TEP1	99	80.800	ENSPPRG00000012870	TEP1	99	80.681	Panthera_pardus
ENSG00000129566	TEP1	99	80.557	ENSPTIG00000017993	TEP1	99	80.628	Panthera_tigris_altaica
ENSG00000129566	TEP1	100	98.743	ENSPTRG00000006090	TEP1	100	98.650	Pan_troglodytes
ENSG00000129566	TEP1	100	95.053	ENSPANG00000024122	TEP1	100	95.129	Papio_anubis
ENSG00000129566	TEP1	64	56.429	ENSPKIG00000008322	-	65	56.429	Paramormyrops_kingsleyae
ENSG00000129566	TEP1	99	75.694	ENSPEMG00000012018	Tep1	100	74.707	Peromyscus_maniculatus_bairdii
ENSG00000129566	TEP1	99	63.854	ENSPCIG00000023260	TEP1	99	60.098	Phascolarctos_cinereus
ENSG00000129566	TEP1	100	96.634	ENSPPYG00000005563	TEP1	100	96.498	Pongo_abelii
ENSG00000129566	TEP1	87	82.982	ENSPCAG00000009855	TEP1	74	88.636	Procavia_capensis
ENSG00000129566	TEP1	99	87.651	ENSPCOG00000025352	TEP1	99	87.163	Propithecus_coquereli
ENSG00000129566	TEP1	91	89.401	ENSPVAG00000010731	TEP1	90	89.401	Pteropus_vampyrus
ENSG00000129566	TEP1	99	75.962	ENSRNOG00000051706	Tep1	100	74.603	Rattus_norvegicus
ENSG00000129566	TEP1	99	94.452	ENSRBIG00000031160	TEP1	99	94.462	Rhinopithecus_bieti
ENSG00000129566	TEP1	100	95.205	ENSRROG00000037023	TEP1	100	95.282	Rhinopithecus_roxellana
ENSG00000129566	TEP1	98	90.069	ENSSBOG00000019509	TEP1	99	91.697	Saimiri_boliviensis_boliviensis
ENSG00000129566	TEP1	99	64.108	ENSSHAG00000013013	TEP1	100	62.594	Sarcophilus_harrisii
ENSG00000129566	TEP1	87	77.242	ENSSARG00000014469	TEP1	89	70.396	Sorex_araneus
ENSG00000129566	TEP1	99	82.133	ENSSSCG00000002142	TEP1	100	80.250	Sus_scrofa
ENSG00000129566	TEP1	99	81.135	ENSTTRG00000012415	TEP1	98	80.557	Tursiops_truncatus
ENSG00000129566	TEP1	99	84.058	ENSUAMG00000011292	TEP1	100	78.915	Ursus_americanus
ENSG00000129566	TEP1	99	82.609	ENSUMAG00000008304	TEP1	99	80.502	Ursus_maritimus
ENSG00000129566	TEP1	99	71.002	ENSVVUG00000008975	TEP1	99	71.002	Vulpes_vulpes
ENSG00000129566	TEP1	89	38.098	ENSXETG00000001751	tep1	100	39.728	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000722	telomere maintenance via recombination	10810353.	IDA	Process
GO:0000781	chromosome, telomeric region	-	IEA	Component
GO:0002039	p53 binding	10597287.	IPI	Function
GO:0003720	telomerase activity	12135483.	IDA	Function
GO:0003723	RNA binding	-	ISS	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005697	telomerase holoenzyme complex	12135483.	IDA	Component
GO:0005737	cytoplasm	7876352.	IDA	Component
GO:0006278	RNA-dependent DNA biosynthetic process	-	IEA	Process
GO:0016363	nuclear matrix	7876352.	IDA	Component
GO:0019899	enzyme binding	15169895.	IPI	Function
GO:0070034	telomerase RNA binding	-	ISS	Function
GO:1990904	ribonucleoprotein complex	15701761.	TAS	Component