EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130038 (Gene tree)
Gene ID: 84766
Gene Symbol: CRACR2A
Alias: MGC4266|EFCAB4B
Full Name: calcium release activated channel regulator 2A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 158,187 bases
Position: chr12:3,606,633-3,764,819
Accession: 28657
RBP type: canonical RBP
Summary: CRACR2A (Calcium Release Activated Channel Regulator 2A) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is CRACR2B.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000409382	MMR_HSR1	PF01926.23	1.8e-06	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000535507	CRACR2A-206	2511	-	-	- (aa)	-	-
ENST00000333750	CRACR2A-202	3207	-	ENSP00000331047	198 (aa)	-	H7BXT2
ENST00000440314	CRACR2A-203	2697	XM_006719021	ENSP00000409382	731 (aa)	XP_006719084	Q9BSW2
ENST00000514026	CRACR2A-204	7554	-	-	- (aa)	-	-
ENST00000535292	CRACR2A-205	630	-	ENSP00000438777	118 (aa)	-	H0YFI5
ENST00000252322	CRACR2A-201	2186	-	ENSP00000252322	395 (aa)	-	Q9BSW2

Gene Model

Click here to download ENSG00000130038's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130038	Parkinson Disease	3.734896E-5	17052657
ENSG00000130038	Myocardial Infarction	6.1480995E-004	-
ENSG00000130038	Body Height	4.813e-006	18193045
ENSG00000130038	Body Height	3.239e-006	18193045
ENSG00000130038	Altruism	5.468e-005	-
ENSG00000130038	Ankle Brachial Index	9.9556637E-005	-
ENSG00000130038	Platelet Function Tests	9.8800000E-006	-
ENSG00000130038	Platelet Function Tests	4.5700000E-006	-
ENSG00000130038	Parathyroid Hormone	6.4860000E-005	-
ENSG00000130038	Breast Neoplasms	5.5100000E-006	-
ENSG00000130038	Breast Neoplasms	2.1990000E-005	-
ENSG00000130038	Breast Neoplasms	5.1320000E-005	-
ENSG00000130038	Neuropsychological Tests	8E-6	20125193
ENSG00000130038	Insulin Resistance	9E-6	24204828
ENSG00000130038	Insulin	8E-6	24204828
ENSG00000130038	Liver Cirrhosis	8E-7	20708005
ENSG00000130038	Non-alcoholic Fatty Liver Disease	8E-7	20708005
ENSG00000130038	Infertility, Male	4E-6	19478329
ENSG00000130038	Viruses	5E-6	21993531

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130038	rs10848918	12	3744163	?	Velopharyngeal dysfunction	29855589	[NR] unit decrease	0.11454327	EFO_0009336
ENSG00000130038	rs10744625	12	3759002	C	Homeostasis model assessment of insulin resistance (dietary factor interaction)	24204828			EFO_0008111\|EFO_0004501
ENSG00000130038	rs10744625	12	3759002	C	Fasting insulin (dietary factor interaction)	24204828			EFO_0008111\|EFO_0004466
ENSG00000130038	rs10848911	12	3705072	?	Male infertility	19478329			EFO_0004248
ENSG00000130038	rs10744620	12	3629928	C	Monocyte chemoattractant protein-1 levels	27989323	[0.047-0.11] SD units decrease	0.0788	EFO_0004749
ENSG00000130038	rs4766152	12	3640962	G	Cytomegalovirus antibody response	21993531	[0.13-0.32] unit decrease	0.223	GO_0009615
ENSG00000130038	rs887304	12	3648382	A	Non-alcoholic fatty liver disease histology (lobular)	20708005	[NR] unit increase	0.36	EFO_0003095\|EFO_0001422
ENSG00000130038	rs242016	12	3679094	A	Chronic periodontitis (localised)	30284742	[2.32-6.29]	3.7	EFO_0000649

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130038's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130038	CRACR2A	83	46.939	ENSAPOG00000009642	cracr2b	93	45.238	Acanthochromis_polyacanthus
ENSG00000130038	CRACR2A	91	61.667	ENSAPOG00000013779	cracr2ab	83	57.778	Acanthochromis_polyacanthus
ENSG00000130038	CRACR2A	78	88.312	ENSAMEG00000005041	-	97	86.747	Ailuropoda_melanoleuca
ENSG00000130038	CRACR2A	91	61.667	ENSACIG00000010099	CRACR2A	94	54.131	Amphilophus_citrinellus
ENSG00000130038	CRACR2A	88	62.857	ENSACIG00000004009	cracr2ab	97	50.771	Amphilophus_citrinellus
ENSG00000130038	CRACR2A	91	61.667	ENSAOCG00000023189	cracr2ab	81	58.601	Amphiprion_ocellaris
ENSG00000130038	CRACR2A	91	62.778	ENSAOCG00000008147	-	94	55.274	Amphiprion_ocellaris
ENSG00000130038	CRACR2A	84	47.619	ENSAOCG00000019493	cracr2b	92	47.619	Amphiprion_ocellaris
ENSG00000130038	CRACR2A	85	46.701	ENSAPEG00000021843	cracr2b	94	46.701	Amphiprion_percula
ENSG00000130038	CRACR2A	91	62.778	ENSAPEG00000002244	CRACR2A	94	54.965	Amphiprion_percula
ENSG00000130038	CRACR2A	88	62.857	ENSAPEG00000006383	cracr2ab	99	48.753	Amphiprion_percula
ENSG00000130038	CRACR2A	86	45.495	ENSATEG00000010344	cracr2b	96	45.495	Anabas_testudineus
ENSG00000130038	CRACR2A	91	61.111	ENSATEG00000018003	cracr2ab	81	57.602	Anabas_testudineus
ENSG00000130038	CRACR2A	91	62.222	ENSATEG00000017411	CRACR2A	98	53.444	Anabas_testudineus
ENSG00000130038	CRACR2A	93	41.126	ENSACAG00000015413	CRACR2B	94	40.693	Anolis_carolinensis
ENSG00000130038	CRACR2A	100	93.570	ENSANAG00000036979	CRACR2A	100	93.570	Aotus_nancymaae
ENSG00000130038	CRACR2A	91	61.111	ENSACLG00000023670	cracr2ab	81	57.895	Astatotilapia_calliptera
ENSG00000130038	CRACR2A	91	63.889	ENSACLG00000007547	CRACR2A	94	54.986	Astatotilapia_calliptera
ENSG00000130038	CRACR2A	91	34.574	ENSACLG00000013916	cracr2b	89	43.939	Astatotilapia_calliptera
ENSG00000130038	CRACR2A	58	46.137	ENSAMXG00000010368	cracr2ab	99	46.358	Astyanax_mexicanus
ENSG00000130038	CRACR2A	100	82.787	ENSBTAG00000018940	CRACR2A	100	82.650	Bos_taurus
ENSG00000130038	CRACR2A	100	92.202	ENSCJAG00000018917	CRACR2A	100	92.202	Callithrix_jacchus
ENSG00000130038	CRACR2A	100	82.377	ENSCAFG00000015404	CRACR2A	100	82.104	Canis_familiaris
ENSG00000130038	CRACR2A	100	82.377	ENSCAFG00020014835	CRACR2A	100	82.104	Canis_lupus_dingo
ENSG00000130038	CRACR2A	100	82.377	ENSCHIG00000018141	CRACR2A	100	82.377	Capra_hircus
ENSG00000130038	CRACR2A	100	86.749	ENSTSYG00000014194	CRACR2A	100	86.749	Carlito_syrichta
ENSG00000130038	CRACR2A	86	77.229	ENSCAPG00000006188	CRACR2A	100	77.229	Cavia_aperea
ENSG00000130038	CRACR2A	99	81.669	ENSCPOG00000020119	CRACR2A	99	81.669	Cavia_porcellus
ENSG00000130038	CRACR2A	100	92.066	ENSCCAG00000019735	CRACR2A	100	92.066	Cebus_capucinus
ENSG00000130038	CRACR2A	100	96.990	ENSCATG00000040964	CRACR2A	100	96.990	Cercocebus_atys
ENSG00000130038	CRACR2A	100	80.628	ENSCLAG00000013246	CRACR2A	100	80.628	Chinchilla_lanigera
ENSG00000130038	CRACR2A	100	96.322	ENSCSAG00000011199	CRACR2A	100	96.322	Chlorocebus_sabaeus
ENSG00000130038	CRACR2A	88	82.184	ENSCPBG00000009731	CRACR2A	99	64.218	Chrysemys_picta_bellii
ENSG00000130038	CRACR2A	93	42.877	ENSCPBG00000007146	CRACR2B	73	56.019	Chrysemys_picta_bellii
ENSG00000130038	CRACR2A	100	96.717	ENSCANG00000032776	CRACR2A	100	96.717	Colobus_angolensis_palliatus
ENSG00000130038	CRACR2A	100	80.191	ENSCGRG00001008752	-	100	80.191	Cricetulus_griseus_chok1gshd
ENSG00000130038	CRACR2A	100	79.508	ENSCGRG00000015501	-	100	79.508	Cricetulus_griseus_crigri
ENSG00000130038	CRACR2A	91	55.000	ENSCSEG00000003612	CRACR2A	93	50.575	Cynoglossus_semilaevis
ENSG00000130038	CRACR2A	96	56.701	ENSCSEG00000008307	cracr2ab	80	55.263	Cynoglossus_semilaevis
ENSG00000130038	CRACR2A	78	45.745	ENSCSEG00000007618	cracr2b	94	45.128	Cynoglossus_semilaevis
ENSG00000130038	CRACR2A	91	57.778	ENSCVAG00000009954	cracr2ab	97	51.893	Cyprinodon_variegatus
ENSG00000130038	CRACR2A	90	59.218	ENSCVAG00000013782	CRACR2A	97	52.849	Cyprinodon_variegatus
ENSG00000130038	CRACR2A	90	59.218	ENSDARG00000068231	CRACR2A	96	54.232	Danio_rerio
ENSG00000130038	CRACR2A	90	56.983	ENSDARG00000045758	cracr2ab	99	46.737	Danio_rerio
ENSG00000130038	CRACR2A	100	77.973	ENSDNOG00000043722	CRACR2A	99	77.973	Dasypus_novemcinctus
ENSG00000130038	CRACR2A	100	83.060	ENSEASG00005017095	CRACR2A	100	83.060	Equus_asinus_asinus
ENSG00000130038	CRACR2A	100	84.563	ENSECAG00000034127	CRACR2A	100	84.563	Equus_caballus
ENSG00000130038	CRACR2A	90	59.218	ENSELUG00000018918	CRACR2A	94	53.249	Esox_lucius
ENSG00000130038	CRACR2A	90	58.101	ENSELUG00000001781	cracr2ab	73	56.176	Esox_lucius
ENSG00000130038	CRACR2A	100	81.967	ENSFCAG00000015741	CRACR2A	100	81.967	Felis_catus
ENSG00000130038	CRACR2A	88	81.609	ENSFALG00000004782	CRACR2A	99	63.534	Ficedula_albicollis
ENSG00000130038	CRACR2A	100	77.467	ENSFDAG00000013877	CRACR2A	100	77.467	Fukomys_damarensis
ENSG00000130038	CRACR2A	91	59.444	ENSGAFG00000008771	cracr2ab	97	47.125	Gambusia_affinis
ENSG00000130038	CRACR2A	89	35.977	ENSGAFG00000020778	cracr2b	81	46.842	Gambusia_affinis
ENSG00000130038	CRACR2A	88	60.345	ENSGAFG00000014607	CRACR2A	94	52.496	Gambusia_affinis
ENSG00000130038	CRACR2A	88	81.609	ENSGAGG00000002264	CRACR2A	99	64.315	Gopherus_agassizii
ENSG00000130038	CRACR2A	100	99.590	ENSGGOG00000010289	CRACR2A	100	99.590	Gorilla_gorilla
ENSG00000130038	CRACR2A	91	61.111	ENSHBUG00000018719	cracr2ab	81	57.895	Haplochromis_burtoni
ENSG00000130038	CRACR2A	91	63.333	ENSHBUG00000017137	CRACR2A	94	54.843	Haplochromis_burtoni
ENSG00000130038	CRACR2A	100	79.673	ENSHGLG00000003776	CRACR2A	100	79.673	Heterocephalus_glaber_female
ENSG00000130038	CRACR2A	100	79.564	ENSHGLG00100005482	CRACR2A	100	79.564	Heterocephalus_glaber_male
ENSG00000130038	CRACR2A	94	56.061	ENSHCOG00000004942	cracr2ab	97	50.644	Hippocampus_comes
ENSG00000130038	CRACR2A	91	58.889	ENSHCOG00000006842	CRACR2A	99	51.626	Hippocampus_comes
ENSG00000130038	CRACR2A	91	56.111	ENSIPUG00000017914	cracr2ab	94	48.237	Ictalurus_punctatus
ENSG00000130038	CRACR2A	99	53.042	ENSIPUG00000015191	CRACR2A	100	52.722	Ictalurus_punctatus
ENSG00000130038	CRACR2A	81	46.429	ENSIPUG00000013598	cracr2b	90	46.429	Ictalurus_punctatus
ENSG00000130038	CRACR2A	100	85.130	ENSSTOG00000021197	CRACR2A	99	85.130	Ictidomys_tridecemlineatus
ENSG00000130038	CRACR2A	97	74.022	ENSJJAG00000014186	-	98	74.022	Jaculus_jaculus
ENSG00000130038	CRACR2A	90	60.894	ENSKMAG00000021906	CRACR2A	96	51.136	Kryptolebias_marmoratus
ENSG00000130038	CRACR2A	91	58.889	ENSKMAG00000016358	cracr2ab	82	56.357	Kryptolebias_marmoratus
ENSG00000130038	CRACR2A	99	32.527	ENSLBEG00000014261	cracr2b	99	40.562	Labrus_bergylta
ENSG00000130038	CRACR2A	88	60.920	ENSLBEG00000018669	cracr2ab	97	50.431	Labrus_bergylta
ENSG00000130038	CRACR2A	91	61.111	ENSLBEG00000010713	CRACR2A	96	54.126	Labrus_bergylta
ENSG00000130038	CRACR2A	93	41.270	ENSLACG00000007778	-	100	39.633	Latimeria_chalumnae
ENSG00000130038	CRACR2A	93	39.744	ENSLACG00000009026	-	100	39.745	Latimeria_chalumnae
ENSG00000130038	CRACR2A	91	62.222	ENSLOCG00000016848	cracr2ab	96	56.838	Lepisosteus_oculatus
ENSG00000130038	CRACR2A	100	96.443	ENSMFAG00000036067	CRACR2A	100	96.443	Macaca_fascicularis
ENSG00000130038	CRACR2A	100	96.306	ENSMMUG00000023583	CRACR2A	100	96.306	Macaca_mulatta
ENSG00000130038	CRACR2A	100	96.443	ENSMNEG00000031773	CRACR2A	100	96.443	Macaca_nemestrina
ENSG00000130038	CRACR2A	100	96.854	ENSMLEG00000044159	CRACR2A	99	96.854	Mandrillus_leucophaeus
ENSG00000130038	CRACR2A	91	59.444	ENSMAMG00000011388	cracr2ab	82	56.598	Mastacembelus_armatus
ENSG00000130038	CRACR2A	88	35.429	ENSMAMG00000005360	cracr2b	88	43.694	Mastacembelus_armatus
ENSG00000130038	CRACR2A	91	61.667	ENSMAMG00000001270	CRACR2A	95	55.274	Mastacembelus_armatus
ENSG00000130038	CRACR2A	88	62.286	ENSMZEG00005005975	cracr2ab	96	50.509	Maylandia_zebra
ENSG00000130038	CRACR2A	91	63.333	ENSMZEG00005016858	CRACR2A	94	54.843	Maylandia_zebra
ENSG00000130038	CRACR2A	100	79.945	ENSMAUG00000010171	-	100	79.945	Mesocricetus_auratus
ENSG00000130038	CRACR2A	100	86.066	ENSMICG00000012907	CRACR2A	100	86.066	Microcebus_murinus
ENSG00000130038	CRACR2A	99	80.301	ENSMOCG00000016052	-	99	80.301	Microtus_ochrogaster
ENSG00000130038	CRACR2A	91	60.000	ENSMMOG00000019358	CRACR2A	94	52.045	Mola_mola
ENSG00000130038	CRACR2A	91	60.556	ENSMMOG00000001929	cracr2ab	97	50.491	Mola_mola
ENSG00000130038	CRACR2A	91	59.444	ENSMALG00000021818	CRACR2A	95	54.178	Monopterus_albus
ENSG00000130038	CRACR2A	91	59.444	ENSMALG00000012964	cracr2ab	78	55.556	Monopterus_albus
ENSG00000130038	CRACR2A	93	35.584	ENSMALG00000006310	cracr2b	99	42.623	Monopterus_albus
ENSG00000130038	CRACR2A	100	80.328	ENSMUSG00000061414	Cracr2a	100	80.328	Mus_musculus
ENSG00000130038	CRACR2A	100	81.037	ENSMPUG00000009336	CRACR2A	100	80.764	Mustela_putorius_furo
ENSG00000130038	CRACR2A	100	81.855	ENSNGAG00000014625	-	100	81.855	Nannospalax_galili
ENSG00000130038	CRACR2A	88	62.286	ENSNBRG00000005924	cracr2ab	96	50.796	Neolamprologus_brichardi
ENSG00000130038	CRACR2A	91	62.222	ENSNBRG00000015888	CRACR2A	91	59.327	Neolamprologus_brichardi
ENSG00000130038	CRACR2A	100	95.622	ENSNLEG00000003001	CRACR2A	99	95.622	Nomascus_leucogenys
ENSG00000130038	CRACR2A	100	81.421	ENSODEG00000002836	CRACR2A	100	81.421	Octodon_degus
ENSG00000130038	CRACR2A	100	83.607	ENSOCUG00000005317	CRACR2A	100	82.650	Oryctolagus_cuniculus
ENSG00000130038	CRACR2A	91	58.889	ENSORLG00000014854	cracr2ab	83	54.839	Oryzias_latipes
ENSG00000130038	CRACR2A	91	59.444	ENSORLG00000025905	CRACR2A	94	54.155	Oryzias_latipes
ENSG00000130038	CRACR2A	91	60.000	ENSORLG00020010617	CRACR2A	94	54.077	Oryzias_latipes_hni
ENSG00000130038	CRACR2A	90	58.659	ENSORLG00015013042	cracr2ab	83	54.545	Oryzias_latipes_hsok
ENSG00000130038	CRACR2A	91	58.889	ENSORLG00015001413	CRACR2A	98	50.860	Oryzias_latipes_hsok
ENSG00000130038	CRACR2A	92	57.513	ENSOMEG00000007213	cracr2ab	97	50.363	Oryzias_melastigma
ENSG00000130038	CRACR2A	96	88.462	ENSOGAG00000001502	CRACR2A	100	87.607	Otolemur_garnettii
ENSG00000130038	CRACR2A	92	35.673	ENSOARG00000013673	-	96	35.912	Ovis_aries
ENSG00000130038	CRACR2A	100	81.992	ENSOARG00000010465	CRACR2A	100	81.992	Ovis_aries
ENSG00000130038	CRACR2A	100	99.180	ENSPPAG00000026014	CRACR2A	100	99.180	Pan_paniscus
ENSG00000130038	CRACR2A	100	81.557	ENSPPRG00000006970	CRACR2A	100	81.557	Panthera_pardus
ENSG00000130038	CRACR2A	100	99.180	ENSPTRG00000004545	CRACR2A	100	99.180	Pan_troglodytes
ENSG00000130038	CRACR2A	99	96.810	ENSPANG00000025412	CRACR2A	98	96.810	Papio_anubis
ENSG00000130038	CRACR2A	90	59.218	ENSPKIG00000019679	-	95	51.748	Paramormyrops_kingsleyae
ENSG00000130038	CRACR2A	98	50.344	ENSPKIG00000001449	-	99	50.137	Paramormyrops_kingsleyae
ENSG00000130038	CRACR2A	88	61.714	ENSPMGG00000005501	-	90	52.496	Periophthalmus_magnuspinnatus
ENSG00000130038	CRACR2A	91	60.556	ENSPMGG00000009818	cracr2ab	97	52.540	Periophthalmus_magnuspinnatus
ENSG00000130038	CRACR2A	66	76.923	ENSPCIG00000001087	-	99	71.429	Phascolarctos_cinereus
ENSG00000130038	CRACR2A	100	34.127	ENSPFOG00000010947	cracr2b	90	45.789	Poecilia_formosa
ENSG00000130038	CRACR2A	91	60.556	ENSPFOG00000005266	cracr2ab	99	52.533	Poecilia_formosa
ENSG00000130038	CRACR2A	94	35.233	ENSPLAG00000003773	cracr2b	90	45.789	Poecilia_latipinna
ENSG00000130038	CRACR2A	90	59.777	ENSPLAG00000001077	-	94	54.196	Poecilia_latipinna
ENSG00000130038	CRACR2A	91	60.000	ENSPLAG00000003905	cracr2ab	97	51.778	Poecilia_latipinna
ENSG00000130038	CRACR2A	83	46.316	ENSPMEG00000020754	cracr2b	90	46.316	Poecilia_mexicana
ENSG00000130038	CRACR2A	91	60.556	ENSPMEG00000007308	cracr2ab	97	51.804	Poecilia_mexicana
ENSG00000130038	CRACR2A	90	59.777	ENSPMEG00000005485	-	94	54.054	Poecilia_mexicana
ENSG00000130038	CRACR2A	90	59.218	ENSPREG00000021082	CRACR2A	96	52.528	Poecilia_reticulata
ENSG00000130038	CRACR2A	91	60.556	ENSPREG00000002593	cracr2ab	97	52.542	Poecilia_reticulata
ENSG00000130038	CRACR2A	100	87.158	ENSPCOG00000020329	CRACR2A	100	87.158	Propithecus_coquereli
ENSG00000130038	CRACR2A	91	63.333	ENSPNYG00000020714	CRACR2A	92	57.851	Pundamilia_nyererei
ENSG00000130038	CRACR2A	88	61.714	ENSPNYG00000000606	cracr2ab	97	50.211	Pundamilia_nyererei
ENSG00000130038	CRACR2A	90	60.894	ENSPNAG00000020348	CRACR2A	94	55.651	Pygocentrus_nattereri
ENSG00000130038	CRACR2A	91	57.778	ENSPNAG00000029103	cracr2ab	96	49.591	Pygocentrus_nattereri
ENSG00000130038	CRACR2A	100	96.990	ENSRBIG00000044914	CRACR2A	100	96.990	Rhinopithecus_bieti
ENSG00000130038	CRACR2A	88	98.857	ENSRROG00000028125	CRACR2A	99	91.447	Rhinopithecus_roxellana
ENSG00000130038	CRACR2A	100	92.760	ENSSBOG00000024718	CRACR2A	100	92.760	Saimiri_boliviensis_boliviensis
ENSG00000130038	CRACR2A	91	60.556	ENSSFOG00015008628	-	98	53.024	Scleropages_formosus
ENSG00000130038	CRACR2A	91	57.778	ENSSFOG00015004037	cracr2ab	97	53.890	Scleropages_formosus
ENSG00000130038	CRACR2A	93	35.580	ENSSMAG00000013579	cracr2b	91	47.475	Scophthalmus_maximus
ENSG00000130038	CRACR2A	91	58.889	ENSSMAG00000001304	cracr2ab	81	55.942	Scophthalmus_maximus
ENSG00000130038	CRACR2A	91	62.222	ENSSMAG00000011200	CRACR2A	95	54.930	Scophthalmus_maximus
ENSG00000130038	CRACR2A	91	62.222	ENSSDUG00000000911	CRACR2A	95	53.547	Seriola_dumerili
ENSG00000130038	CRACR2A	93	35.967	ENSSDUG00000013283	cracr2b	93	43.243	Seriola_dumerili
ENSG00000130038	CRACR2A	91	62.222	ENSSLDG00000010742	CRACR2A	95	53.547	Seriola_lalandi_dorsalis
ENSG00000130038	CRACR2A	88	61.714	ENSSLDG00000023518	cracr2ab	94	48.798	Seriola_lalandi_dorsalis
ENSG00000130038	CRACR2A	93	36.240	ENSSLDG00000022995	cracr2b	89	46.632	Seriola_lalandi_dorsalis
ENSG00000130038	CRACR2A	72	55.789	ENSSPUG00000010462	-	59	50.917	Sphenodon_punctatus
ENSG00000130038	CRACR2A	89	79.096	ENSSPUG00000017268	CRACR2A	95	61.966	Sphenodon_punctatus
ENSG00000130038	CRACR2A	91	62.222	ENSSPAG00000012064	CRACR2A	94	55.367	Stegastes_partitus
ENSG00000130038	CRACR2A	91	61.667	ENSSPAG00000022330	cracr2ab	99	47.928	Stegastes_partitus
ENSG00000130038	CRACR2A	98	83.357	ENSSSCG00000000732	CRACR2A	100	84.897	Sus_scrofa
ENSG00000130038	CRACR2A	99	55.238	ENSTRUG00000023284	CRACR2A	92	53.957	Takifugu_rubripes
ENSG00000130038	CRACR2A	100	80.874	ENSUAMG00000021584	CRACR2A	100	80.601	Ursus_americanus
ENSG00000130038	CRACR2A	100	80.601	ENSUMAG00000014780	CRACR2A	100	80.328	Ursus_maritimus
ENSG00000130038	CRACR2A	100	82.923	ENSVVUG00000018097	CRACR2A	100	82.650	Vulpes_vulpes
ENSG00000130038	CRACR2A	88	59.770	ENSXCOG00000007494	CRACR2A	96	51.631	Xiphophorus_couchianus
ENSG00000130038	CRACR2A	91	60.000	ENSXCOG00000013604	cracr2ab	97	52.096	Xiphophorus_couchianus
ENSG00000130038	CRACR2A	90	58.659	ENSXMAG00000021050	CRACR2A	94	53.333	Xiphophorus_maculatus
ENSG00000130038	CRACR2A	91	59.444	ENSXMAG00000011202	cracr2ab	97	51.020	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002115	store-operated calcium entry	20418871.	IMP	Process
GO:0002250	adaptive immune response	-	IEA	Process
GO:0005509	calcium ion binding	20418871.	IDA	Function
GO:0005515	protein binding	20418871.23088713.25416956.	IPI	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005737	cytoplasm	20418871.	IDA	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0032237	activation of store-operated calcium channel activity	20418871.	IMP	Process
GO:0035580	specific granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0051928	positive regulation of calcium ion transport	20418871.	IMP	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr12	3696833	Missense_Mutation	novel	Q56L	0.24
ACC	chr12	3627459	Missense_Mutation	rs746523323	R637W	0.18
BLCA	chr12	3656317	Silent	novel	Q284Q	0.29
BLCA	chr12	3680268	Missense_Mutation	NA	L104V	0.15
BLCA	chr12	3648534	Missense_Mutation	rs758562218	G376S	0.15
BLCA	chr12	3696837	Missense_Mutation	NA	A55S	0.2
BRCA	chr12	3615432	Frame_Shift_Del	novel	*F705Rfs7**	0.04
BRCA	chr12	3656396	Missense_Mutation	NA	R258K	0.12
BRCA	chr12	3648514	Silent	NA	L382L	0.33
BRCA	chr12	3627438	Missense_Mutation	novel	E644K	0.09
CESC	chr12	3673517	Missense_Mutation	NA	F200L	0.41
CESC	chr12	3638240	Missense_Mutation	novel	E496K	0.29
CESC	chr12	3648522	Missense_Mutation	NA	P380A	0.29
CESC	chr12	3696968	Missense_Mutation	novel	R11T	0.11
CESC	chr12	3654348	Nonsense_Mutation	NA	E304*	0.46
CESC	chr12	3633634	Missense_Mutation	rs563950130	R569W	0.29	MMR_HSR1
CESC	chr12	3627545	Missense_Mutation	rs758305378	R608Q	0.36	MMR_HSR1
COAD	chr12	3654254	Missense_Mutation	NA	S335N	0.34
COAD	chr12	3615288	3'Flank	novel		0.18
COAD	chr12	3615397	Silent	novel	I718I	0.04
COAD	chr12	3633675	Missense_Mutation	NA	A555V	0.47	MMR_HSR1
COAD	chr12	3640516	Intron	novel		0.33
COAD	chr12	3696792	Missense_Mutation	NA	I70F	0.22
COAD	chr12	3627642	Silent	novel	D600D	0.13
COAD	chr12	3679101	Splice_Region	NA		0.21
COAD	chr12	3638196	Silent	rs777429692	P510P	0.52
COAD	chr12	3679101	Splice_Region	NA		0.23
ESCA	chr12	3648487	Silent	rs149287496	S391S	0.14
ESCA	chr12	3638407	Missense_Mutation	novel	S440F	0.51
ESCA	chr12	3633689	Silent	rs149047355	F550F	0.38
ESCA	chr12	3627657	Silent	novel	A595A	0.05
ESCA	chr12	3673480	Missense_Mutation	novel	E213K	0.07
GBM	chr12	3679028	Silent	novel	E137E	0.06
GBM	chr12	3654358	Missense_Mutation	novel	E300D	0.42
GBM	chr12	3697003	5'UTR	rs374966789		0.24
GBM	chr12	3678939	Missense_Mutation	NA	L167P	0.04
HNSC	chr12	3654278	Missense_Mutation	novel	Q327L	0.33
HNSC	chr12	3648581	Missense_Mutation	rs773874892	R360H	0.19
HNSC	chr12	3648514	Silent	rs765872014	L382L	0.25
HNSC	chr12	3648614	Splice_Site	novel	X349_splice	0.28
HNSC	chr12	3696813	Missense_Mutation	novel	D63Y	0.28
HNSC	chr12	3679017	Missense_Mutation	novel	Y141F	0.13
KIRP	chr12	3638161	Missense_Mutation	novel	P522L	0.35
KIRP	chr12	3656379	Missense_Mutation	NA	Q264K	0.35
LAML	chr12	3656367	Nonsense_Mutation	novel	Q268*	0.11
LGG	chr12	3678925	Missense_Mutation	rs199641669	V172M	0.05
LGG	chr12	3696867	Missense_Mutation	novel	T45A	0.06
LIHC	chr12	3697006	5'UTR	novel		0.35
LIHC	chr12	3627678	Missense_Mutation	NA	N588K	0.28	MMR_HSR1
LUAD	chr12	3696996	Missense_Mutation	novel	A2P	0.24
LUAD	chr12	3648481	Silent	novel	G393G	0.08
LUAD	chr12	3654300	Nonsense_Mutation	NA	E320*	0.36
LUAD	chr12	3673573	Missense_Mutation	rs757430649	L182F	0.29
LUAD	chr12	3696853	Silent	novel	L49L	0.08
LUAD	chr12	3654218	Missense_Mutation	rs771537326	K347R	0.09
LUAD	chr12	3678998	Silent	NA	E147E	0.15
LUAD	chr12	3696815	Missense_Mutation	NA	C62S	0.38
LUAD	chr12	3697019	5'UTR	novel		0.67
LUSC	chr12	3696853	Silent	novel	L49L	0.36
LUSC	chr12	3654279	Nonsense_Mutation	NA	Q327*	0.05
LUSC	chr12	3673457	Silent	novel	C220C	0.11
LUSC	chr12	3673462	Nonsense_Mutation	NA	E219*	0.52
LUSC	chr12	3678973	Missense_Mutation	novel	E156Q	0.06
LUSC	chr12	3648441	3'UTR	rs750735904		0.37
LUSC	chr12	3659627	Silent	novel	I233I	0.26
LUSC	chr12	3648501	Missense_Mutation	novel	R387G	0.46
LUSC	chr12	3679034	Silent	NA	R135R	0.24
LUSC	chr12	3696979	Missense_Mutation	NA	R7S	0.73
LUSC	chr12	3696980	Missense_Mutation	NA	R7M	0.73
LUSC	chr12	3654307	Silent	novel	R317R	0.43
LUSC	chr12	3696948	Missense_Mutation	NA	G18W	0.32
LUSC	chr12	3680330	Missense_Mutation	rs377375003	P83L	0.23
LUSC	chr12	3654301	Silent	novel	L319L	0.47
LUSC	chr12	3678947	Missense_Mutation	novel	M164I	0.24
OV	chr12	3659618	Silent	NA	L236L	0.42
OV	chr12	3673590	Missense_Mutation	novel	E176G	0.49
OV	chr12	3648384	3'UTR	novel		0.21
OV	chr12	3673460	Missense_Mutation	novel	E219D	0.27
OV	chr12	3648590	Missense_Mutation	novel	S357T	0.25
OV	chr12	3697020	5'UTR	novel		0.26
OV	chr12	3615248	3'Flank	novel		0.55
OV	chr12	3696797	Missense_Mutation	novel	G68D	0.08
OV	chr12	3656337	Missense_Mutation	NA	E278Q	0.14
PAAD	chr12	3680273	Missense_Mutation	novel	G102D	0.17
PRAD	chr12	3654277	Missense_Mutation	novel	Q327H	0.15
READ	chr12	3654381	Missense_Mutation	NA	A293S	0.07
READ	chr12	3617000	Missense_Mutation	NA	A689T	0.15
READ	chr12	3673495	Missense_Mutation	NA	L208F	0.63
SARC	chr12	3638338	Missense_Mutation	novel	P463Q	0.23
SARC	chr12	3659649	Missense_Mutation	novel	I226S	0.55
SARC	chr12	3696971	Missense_Mutation	NA	S10F	0.14
SKCM	chr12	3696926	Missense_Mutation	NA	G25E	0.33
SKCM	chr12	3696906	Missense_Mutation	NA	P32S	0.33
SKCM	chr12	3678916	Missense_Mutation	novel	D175N	0.28
SKCM	chr12	3648491	Missense_Mutation	rs764589720	G390E	0.24
SKCM	chr12	3673559	Silent	NA	L186L	0.32
SKCM	chr12	3679040	Silent	NA	A133A	0.15
SKCM	chr12	3696982	Silent	rs774995333	G6G	0.41
SKCM	chr12	3679072	Missense_Mutation	NA	P123S	0.6
SKCM	chr12	3680298	Missense_Mutation	novel	D94N	0.5
SKCM	chr12	3679030	Missense_Mutation	NA	E137K	0.26
SKCM	chr12	3696927	Missense_Mutation	novel	G25R	0.41
SKCM	chr12	3680319	Missense_Mutation	NA	E87K	0.47
SKCM	chr12	3696790	Silent	rs139345952	I70I	0.13
SKCM	chr12	3648449	3'UTR	novel		0.1
SKCM	chr12	3648547	Silent	NA	F371F	0.25
SKCM	chr12	3654225	Nonsense_Mutation	NA	Q345*	0.45
STAD	chr12	3654308	Missense_Mutation	NA	R317L	0.21
STAD	chr12	3659590	Missense_Mutation	NA	S246G	0.51
STAD	chr12	3678980	Silent	rs754763063	G153G	0.42
STAD	chr12	3696984	Missense_Mutation	rs768277859	G6R	0.36
STAD	chr12	3648538	Silent	rs769781947	C374C	0.43
STAD	chr12	3679057	Missense_Mutation	novel	A128S	0.06
THCA	chr12	3678985	Missense_Mutation	NA	M152V	0.38
UCEC	chr12	3640419	Intron	novel		1
UCEC	chr12	3640628	Intron	novel		0.4
UCEC	chr12	3673572	Missense_Mutation	novel	L182P	0.11
UCEC	chr12	3644621	3'Flank	rs761233575		0.36
UCEC	chr12	3633632	Silent	novel	R569R	0.12
UCEC	chr12	3654214	Splice_Region	NA	E348E	0.32
UCEC	chr12	3659655	Splice_Site	NA	X224_splice	0.42
UCEC	chr12	3678958	Missense_Mutation	rs148261182	R161W	0.3
UCEC	chr12	3638153	Missense_Mutation	NA	Q525K	0.46
UCEC	chr12	3619371	Missense_Mutation	novel	E645V	0.07
UCEC	chr12	3640700	Intron	novel		0.3
UCEC	chr12	3627459	Missense_Mutation	rs746523323	R637W	0.48
UCEC	chr12	3678988	Missense_Mutation	rs755977858	D151N	0.43
UCEC	chr12	3673576	Nonsense_Mutation	rs201392258	Q181*	0.07
UCEC	chr12	3659582	Missense_Mutation	NA	K248N	0.22
UCEC	chr12	3640462	Intron	novel		0.4
UCEC	chr12	3640779	Intron	NA		0.35
UCEC	chr12	3679035	Missense_Mutation	rs781207239	R135H	0.18
UCEC	chr12	3615244	3'Flank	novel		0.56
UCEC	chr12	3654254	Missense_Mutation	NA	S335I	0.38
UCEC	chr12	3619345	Missense_Mutation	novel	L654F	0.47
UCEC	chr12	3678984	Missense_Mutation	novel	M152T	0.17
UCEC	chr12	3648582	Missense_Mutation	rs545817495	R360C	0.22
UCEC	chr12	3638254	Missense_Mutation	novel	L491P	0.17
UCEC	chr12	3641839	Splice_Site	novel	X389_splice	0.26
UCEC	chr12	3633729	Missense_Mutation	novel	S537N	0.47
UCEC	chr12	3641820	Missense_Mutation	novel	A395T	0.37
UCEC	chr12	3641739	Missense_Mutation	rs756529583	L422I	0.43
UCEC	chr12	3678989	Silent	rs150361390	G150G	0.44
UCEC	chr12	3640539	Intron	novel		0.18
UCEC	chr12	3648343	3'UTR	novel		0.42
UCEC	chr12	3648406	3'UTR	novel		0.1
UCEC	chr12	3678980	Silent	rs754763063	G153G	0.52
UCEC	chr12	3615204	3'Flank	novel		0.82
UCEC	chr12	3638451	Missense_Mutation	novel	Q425H	0.43
UCEC	chr12	3656381	Missense_Mutation	novel	S263N	0.07
UCEC	chr12	3680329	Silent	rs761692679	P83P	0.29
UCEC	chr12	3673512	Missense_Mutation	novel	T202I	0.14
UCEC	chr12	3615402	Missense_Mutation	novel	T717A	0.24
UCEC	chr12	3679029	Missense_Mutation	novel	E137G	0.33
UCEC	chr12	3627502	Silent	rs151337991	I622I	0.29
UCEC	chr12	3638226	Silent	rs552177056	V500V	0.43
UCEC	chr12	3615391	Silent	novel	V720V	0.32
UCEC	chr12	3648414	3'UTR	novel		0.39
UCEC	chr12	3659579	Silent	NA	E249E	0.45
UCEC	chr12	3615391	Silent	novel	V720V	0.49
UCEC	chr12	3633614	Silent	novel	A575A	0.41
UCEC	chr12	3638308	Missense_Mutation	novel	S473F	0.4
UCEC	chr12	3640695	Intron	novel		0.43
UCEC	chr12	3673495	Missense_Mutation	NA	L208F	0.27
UCEC	chr12	3648564	Missense_Mutation	novel	L366I	0.09
UCEC	chr12	3656396	Missense_Mutation	NA	R258K	0.35
UCEC	chr12	3696842	Missense_Mutation	novel	R53M	0.32
UCEC	chr12	3696916	Silent	novel	A28A	0.26
UCEC	chr12	3638158	Frame_Shift_Ins	NA	*R523Pfs12**	0.36
UCEC	chr12	3659619	Missense_Mutation	NA	L236R	0.37
UCEC	chr12	3615134	3'Flank	novel		0.29
UCEC	chr12	3638313	Silent	NA	I471I	0.36
UCEC	chr12	3627707	Splice_Site	NA	X579_splice	0.25
UCEC	chr12	3633644	Missense_Mutation	novel	F565L	0.15	MMR_HSR1
UCEC	chr12	3644611	3'Flank	novel		0.49
UCEC	chr12	3615320	3'Flank	novel		0.52
UCEC	chr12	3627636	Silent	novel	A602A	0.38
UCEC	chr12	3679036	Missense_Mutation	rs375574366	R135C	0.3
UCEC	chr12	3640577	Intron	novel		0.45

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
COAD	AMP	0.2151	2.8622e-08
DLBC	DEL	0.0833	0.11856
PAAD	AMP	0.1413	0.0041088
READ	AMP	0.2121	0.027505
TGCT	AMP	0.9333	3.5918e-21
THYM	AMP	0.0325	0.24554

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0043	Kaplan-Meier Survival Analysis
KIRC	0.038	Kaplan-Meier Survival Analysis
UCS	0.012	Kaplan-Meier Survival Analysis
SKCM	0.0068	Kaplan-Meier Survival Analysis
PRAD	0.022	Kaplan-Meier Survival Analysis
GBM	0.0066	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.038	Kaplan-Meier Survival Analysis
UVM	0.00055	Kaplan-Meier Survival Analysis