EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130254 (Gene tree)
Gene ID: 9667
Gene Symbol: SAFB2
Alias: KIAA0138
Full Name: scaffold attachment factor B2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 37,054 bases
Position: chr19:5,586,993-5,624,046
Accession: 21605
RBP type: canonical RBP
Summary: The protein encoded by this gene, along with its paralog (scaffold attachment factor B1), is a repressor of estrogen receptor alpha. The encoded protein binds scaffold/matrix attachment region (S/MAR) DNA and is involved in cell cycle regulation, apoptosis, differentiation, the stress response, and regulation of immune genes. [provided by RefSeq, May 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000252542	RRM_1	PF00076.22	1.7e-13	1	1
ENSP00000252542	SAP	PF02037.27	6.4e-10	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26273616	Unravelling the RNA-Binding Properties of SAFB Proteins in Breast Cancer Cells.	Biomed Res Int	2015	Hong E	doi: 10.1155/2015/395816
17200140	Alternative RNA splicing complexes containing the scaffold attachment factor SAFB2.	J Cell Sci	2007 Jan 15	Sergeant KA	-
27888239	The increasing diversity of functions attributed to the SAFB family of RNA-/DNA-binding proteins.	Biochem J	2016 Dec 1	Norman M	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000252542	SAFB2-201	3371	XM_011528449	ENSP00000252542	953 (aa)	XP_011526751	Q14151
ENST00000585449	SAFB2-202	443	-	-	- (aa)	-	-
ENST00000589925	SAFB2-204	506	-	-	- (aa)	-	-
ENST00000590262	SAFB2-206	564	-	ENSP00000468454	124 (aa)	-	K7ERX3
ENST00000591101	SAFB2-207	551	-	-	- (aa)	-	-
ENST00000591310	SAFB2-210	722	-	-	- (aa)	-	-
ENST00000590000	SAFB2-205	633	-	-	- (aa)	-	-
ENST00000587802	SAFB2-203	583	-	-	- (aa)	-	-
ENST00000592599	SAFB2-211	2260	-	-	- (aa)	-	-
ENST00000591120	SAFB2-208	1298	-	ENSP00000468505	115 (aa)	-	Q14151
ENST00000591123	SAFB2-209	836	-	ENSP00000467981	87 (aa)	-	K7EQU4

Gene Model

Click here to download ENSG00000130254's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130254	Blood Pressure	5.6630000E-005	-
ENSG00000130254	Blood Pressure	7.3950000E-005	-
ENSG00000130254	Obsessive-Compulsive Disorder	7E-6	26859814

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130254	rs113123495	19	5587529	C	Obsessive-compulsive symptoms	26859814	unit increase	10.582	EFO_0007802

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130254's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000130254	SAFB2	57	50.769	ENSG00000137776	SLTM	88	47.561
ENSG00000130254	SAFB2	98	69.313	ENSG00000160633	SAFB	100	69.874

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130254	SAFB2	100	86.254	ENSAMEG00000012146	SAFB2	100	86.149	Ailuropoda_melanoleuca
ENSG00000130254	SAFB2	100	96.642	ENSANAG00000031936	SAFB2	100	96.642	Aotus_nancymaae
ENSG00000130254	SAFB2	100	84.067	ENSBTAG00000001790	SAFB2	99	84.509	Bos_taurus
ENSG00000130254	SAFB2	100	92.742	ENSCJAG00000017205	-	97	92.093	Callithrix_jacchus
ENSG00000130254	SAFB2	100	88.796	ENSCAFG00000018814	SAFB2	100	88.796	Canis_familiaris
ENSG00000130254	SAFB2	100	88.796	ENSCAFG00020018939	SAFB2	100	88.796	Canis_lupus_dingo
ENSG00000130254	SAFB2	100	83.648	ENSCHIG00000024547	SAFB2	100	83.648	Capra_hircus
ENSG00000130254	SAFB2	93	67.245	ENSCAPG00000011771	SAFB2	100	67.795	Cavia_aperea
ENSG00000130254	SAFB2	100	79.124	ENSCPOG00000011394	SAFB2	100	79.226	Cavia_porcellus
ENSG00000130254	SAFB2	100	96.747	ENSCCAG00000017348	SAFB2	100	96.747	Cebus_capucinus
ENSG00000130254	SAFB2	100	97.272	ENSCATG00000039497	SAFB2	100	97.272	Cercocebus_atys
ENSG00000130254	SAFB2	100	98.321	ENSCSAG00000009959	SAFB2	100	98.321	Chlorocebus_sabaeus
ENSG00000130254	SAFB2	87	77.778	ENSCHOG00000010684	SAFB2	99	76.412	Choloepus_hoffmanni
ENSG00000130254	SAFB2	100	95.908	ENSCANG00000024675	SAFB2	100	95.908	Colobus_angolensis_palliatus
ENSG00000130254	SAFB2	100	70.080	ENSCGRG00001015833	Safb2	100	69.779	Cricetulus_griseus_chok1gshd
ENSG00000130254	SAFB2	100	70.080	ENSCGRG00000011131	Safb2	100	69.779	Cricetulus_griseus_crigri
ENSG00000130254	SAFB2	88	74.312	ENSDNOG00000045791	-	99	81.321	Dasypus_novemcinctus
ENSG00000130254	SAFB2	95	75.840	ENSDORG00000016199	Safb2	100	76.056	Dipodomys_ordii
ENSG00000130254	SAFB2	80	79.348	ENSETEG00000016756	-	50	85.650	Echinops_telfairi
ENSG00000130254	SAFB2	86	83.636	ENSEASG00005022952	SAFB2	91	83.135	Equus_asinus_asinus
ENSG00000130254	SAFB2	98	83.565	ENSECAG00000018978	SAFB2	100	83.721	Equus_caballus
ENSG00000130254	SAFB2	100	87.631	ENSFCAG00000011834	SAFB2	100	87.631	Felis_catus
ENSG00000130254	SAFB2	93	82.780	ENSFDAG00000020009	SAFB2	93	83.065	Fukomys_damarensis
ENSG00000130254	SAFB2	56	62.500	ENSGAGG00000008422	-	86	62.500	Gopherus_agassizii
ENSG00000130254	SAFB2	100	96.455	ENSGGOG00000015093	SAFB2	100	96.455	Gorilla_gorilla
ENSG00000130254	SAFB2	100	85.905	ENSHGLG00000017442	SAFB2	100	86.550	Heterocephalus_glaber_female
ENSG00000130254	SAFB2	98	82.632	ENSLAFG00000003836	SAFB2	99	81.770	Loxodonta_africana
ENSG00000130254	SAFB2	100	98.531	ENSMFAG00000039706	SAFB2	100	98.531	Macaca_fascicularis
ENSG00000130254	SAFB2	100	98.636	ENSMMUG00000017968	SAFB2	100	98.636	Macaca_mulatta
ENSG00000130254	SAFB2	100	92.476	ENSMNEG00000032042	SAFB2	100	92.092	Macaca_nemestrina
ENSG00000130254	SAFB2	100	98.741	ENSMLEG00000034562	SAFB2	100	98.741	Mandrillus_leucophaeus
ENSG00000130254	SAFB2	82	75.784	ENSMAUG00000011573	Safb2	92	76.302	Mesocricetus_auratus
ENSG00000130254	SAFB2	100	91.004	ENSMICG00000008711	SAFB2	100	91.004	Microcebus_murinus
ENSG00000130254	SAFB2	100	69.122	ENSMOCG00000006827	Safb2	100	68.681	Microtus_ochrogaster
ENSG00000130254	SAFB2	98	72.334	ENSMODG00000001178	SAFB2	100	71.813	Monodelphis_domestica
ENSG00000130254	SAFB2	100	69.384	MGP_CAROLIEiJ_G0021779	Safb2	100	69.085	Mus_caroli
ENSG00000130254	SAFB2	100	69.552	ENSMUSG00000042625	Safb2	100	69.353	Mus_musculus
ENSG00000130254	SAFB2	100	69.000	MGP_PahariEiJ_G0020768	Safb2	100	68.700	Mus_pahari
ENSG00000130254	SAFB2	100	64.121	MGP_SPRETEiJ_G0022690	Safb2	100	62.157	Mus_spretus
ENSG00000130254	SAFB2	100	87.120	ENSMPUG00000006106	SAFB2	93	87.016	Mustela_putorius_furo
ENSG00000130254	SAFB2	100	82.884	ENSMLUG00000001050	SAFB2	100	81.224	Myotis_lucifugus
ENSG00000130254	SAFB2	100	97.692	ENSNLEG00000013514	SAFB2	100	97.692	Nomascus_leucogenys
ENSG00000130254	SAFB2	93	68.568	ENSMEUG00000002456	SAFB2	100	68.233	Notamacropus_eugenii
ENSG00000130254	SAFB2	100	75.495	ENSOPRG00000011523	-	100	75.600	Ochotona_princeps
ENSG00000130254	SAFB2	100	82.280	ENSODEG00000014751	SAFB2	100	82.176	Octodon_degus
ENSG00000130254	SAFB2	97	49.587	ENSOANG00000011319	-	97	53.881	Ornithorhynchus_anatinus
ENSG00000130254	SAFB2	98	50.820	ENSOANG00000013644	-	100	53.531	Ornithorhynchus_anatinus
ENSG00000130254	SAFB2	97	60.833	ENSOCUG00000001592	-	98	77.622	Oryctolagus_cuniculus
ENSG00000130254	SAFB2	100	89.749	ENSOGAG00000006855	SAFB2	100	88.935	Otolemur_garnettii
ENSG00000130254	SAFB2	97	74.689	ENSOARG00000007982	SAFB2	67	84.976	Ovis_aries
ENSG00000130254	SAFB2	100	99.790	ENSPPAG00000043392	SAFB2	100	99.790	Pan_paniscus
ENSG00000130254	SAFB2	100	87.526	ENSPPRG00000011310	SAFB2	100	87.526	Panthera_pardus
ENSG00000130254	SAFB2	82	87.862	ENSPTIG00000015120	SAFB2	91	87.862	Panthera_tigris_altaica
ENSG00000130254	SAFB2	100	100.000	ENSPTRG00000010334	SAFB2	100	93.704	Pan_troglodytes
ENSG00000130254	SAFB2	100	98.636	ENSPANG00000007004	SAFB2	100	98.636	Papio_anubis
ENSG00000130254	SAFB2	100	67.697	ENSPEMG00000016015	Safb2	100	67.398	Peromyscus_maniculatus_bairdii
ENSG00000130254	SAFB2	64	75.000	ENSPCIG00000009518	-	99	78.637	Phascolarctos_cinereus
ENSG00000130254	SAFB2	100	99.056	ENSPPYG00000009427	SAFB2	100	99.056	Pongo_abelii
ENSG00000130254	SAFB2	100	80.104	ENSPCAG00000006352	SAFB2	99	81.654	Procavia_capensis
ENSG00000130254	SAFB2	100	87.631	ENSPCOG00000023260	SAFB2	100	85.879	Propithecus_coquereli
ENSG00000130254	SAFB2	98	74.380	ENSPVAG00000004902	-	71	86.957	Pteropus_vampyrus
ENSG00000130254	SAFB2	82	69.417	ENSRNOG00000049511	AABR07066522.1	100	67.476	Rattus_norvegicus
ENSG00000130254	SAFB2	94	94.872	ENSRBIG00000033446	SAFB2	100	99.124	Rhinopithecus_bieti
ENSG00000130254	SAFB2	100	98.426	ENSRROG00000006606	SAFB2	100	98.426	Rhinopithecus_roxellana
ENSG00000130254	SAFB2	100	95.278	ENSSBOG00000032315	SAFB2	100	96.231	Saimiri_boliviensis_boliviensis
ENSG00000130254	SAFB2	98	71.932	ENSSHAG00000012703	SAFB2	100	70.668	Sarcophilus_harrisii
ENSG00000130254	SAFB2	81	72.165	ENSSARG00000000649	SAFB2	100	72.165	Sorex_araneus
ENSG00000130254	SAFB2	100	88.901	ENSSSCG00000013523	SAFB2	100	88.901	Sus_scrofa
ENSG00000130254	SAFB2	89	75.455	ENSTBEG00000012709	SAFB2	86	78.937	Tupaia_belangeri
ENSG00000130254	SAFB2	93	80.493	ENSTTRG00000013585	SAFB2	93	80.269	Tursiops_truncatus
ENSG00000130254	SAFB2	98	88.260	ENSUAMG00000024695	SAFB2	97	88.260	Ursus_americanus
ENSG00000130254	SAFB2	86	86.144	ENSUMAG00000009585	SAFB2	90	86.144	Ursus_maritimus
ENSG00000130254	SAFB2	89	78.182	ENSVPAG00000012041	SAFB2	89	90.625	Vicugna_pacos
ENSG00000130254	SAFB2	100	88.691	ENSVVUG00000013695	SAFB2	100	88.691	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	12660241.20562859.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	21873635.	IBA	Process
GO:0016604	nuclear body	-	IDA	Component
GO:0042802	identical protein binding	19674106.	IPI	Function
GO:0043231	intracellular membrane-bounded organelle	-	IDA	Component
GO:0043565	sequence-specific DNA binding	21873635.	IBA	Function
GO:0050684	regulation of mRNA processing	21873635.	IBA	Process
GO:0060008	Sertoli cell differentiation	-	IEA	Process
GO:0060765	regulation of androgen receptor signaling pathway	21873635.	IBA	Process
GO:0070062	extracellular exosome	18570454.	HDA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
14587024	Scaffold attachment factors SAFB1 and SAFB2: Innocent bystanders or critical players in breast tumorigenesis?	J Cell Biochem	2003 Nov 1	Oesterreich S	-
19137425	Low SAFB levels are associated with worse outcome in breast cancer patients.	Breast Cancer Res Treat	2010 Jun	Hammerich-Hille S	doi: 10.1007/s10549-008-0297-6
19077293	No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.	BMC Med Genet	2008 Dec 13	Bergman A	doi: 10.1186/1471-2350-9-108.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr19	5600261	Splice_Site	NA	X520_splice	0.18
BLCA	chr19	5591765	Missense_Mutation	NA	D793H	0.21
BLCA	chr19	5604838	Missense_Mutation	novel	I465M	0.4
BLCA	chr19	5613490	Nonsense_Mutation	NA	S194*	0.2
BLCA	chr19	5616282	Missense_Mutation	novel	M131I	0.3
BLCA	chr19	5622590	Silent	novel	L42L	0.16
BLCA	chr19	5604858	Missense_Mutation	NA	D459N	0.16
BRCA	chr19	5604858	Missense_Mutation	NA	D459N	0.33
BRCA	chr19	5590377	Missense_Mutation	NA	G809E	0.75
BRCA	chr19	5591782	Missense_Mutation	rs777512759	S787L	0.07
BRCA	chr19	5616145	Missense_Mutation	novel	P177H	0.27
BRCA	chr19	5621362	Missense_Mutation	NA	I74T	0.15
BRCA	chr19	5621329	Missense_Mutation	NA	S85L	0.28
BRCA	chr19	5616307	Splice_Site	novel	X114_splice	0.19
BRCA	chr19	5595478	Missense_Mutation	NA	R601L	0.2
BRCA	chr19	5604634	Missense_Mutation	novel	E503G	0.13
BRCA	chr19	5587281	Missense_Mutation	NA	H942Y	0.41
BRCA	chr19	5612366	Intron	novel		0.27
CESC	chr19	5622688	Missense_Mutation	novel	D10Y	0.12
CESC	chr19	5600236	Missense_Mutation	NA	K528N	0.37
COAD	chr19	5610087	Missense_Mutation	novel	G402S	0.16
COAD	chr19	5604647	Missense_Mutation	rs776973053	E499K	0.34
COAD	chr19	5616312	Silent	novel	E121E	0.07
COAD	chr19	5590327	Missense_Mutation	rs143019060	G826S	0.15
COAD	chr19	5604874	Silent	novel	V453V	0.19
COAD	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.55
COAD	chr19	5604790	Missense_Mutation	novel	E481D	0.19
COAD	chr19	5604654	Missense_Mutation	novel	K496N	0.05
COAD	chr19	5604655	Missense_Mutation	novel	K496R	0.04
COAD	chr19	5616183	Missense_Mutation	novel	E164D	0.12
COAD	chr19	5592831	Missense_Mutation	rs547264084	R755H	0.28
COAD	chr19	5594097	Silent	NA	R667R	0.5
COAD	chr19	5604905	Missense_Mutation	NA	R443H	0.45
COAD	chr19	5587271	Frame_Shift_Del	NA	*P945Vfs24**	0.48
COAD	chr19	5590287	Frame_Shift_Del	novel	*P839Lfs16**	0.2
COAD	chr19	5616256	Missense_Mutation	NA	A140V	0.25
COAD	chr19	5616428	Silent	rs150398727	D111D	0.06
COAD	chr19	5590295	Frame_Shift_Del	NA	*L837Cfs18**	0.13
COAD	chr19	5610029	Missense_Mutation	novel	T421M	0.35
COAD	chr19	5611336	Missense_Mutation	novel	P310H	0.43
COAD	chr19	5590295	Frame_Shift_Del	NA	*L837Cfs18**	0.18
COAD	chr19	5616305	Nonsense_Mutation	NA	Q124*	0.1
COAD	chr19	5590332	Frame_Shift_Del	rs765699897	*G824Afs8**	0.24
COAD	chr19	5592806	Silent	novel	H763H	0.06
COAD	chr19	5587089	3'UTR	novel		0.22
COAD	chr19	5592833	Silent	rs199536778	Y754Y	0.16
COAD	chr19	5604807	Nonsense_Mutation	NA	R476*	0.06
COAD	chr19	5613465	Splice_Region	rs775548479	P202P	0.39
COAD	chr19	5587722	Missense_Mutation	NA	A895V	0.52
COAD	chr19	5598844	Silent	rs552698976	S577S	0.3
COAD	chr19	5612447	Intron	novel		0.24
COAD	chr19	5611137	Silent	rs554620400	G376G	0.38
COAD	chr19	5590332	Frame_Shift_Del	rs765699897	*G824Afs8**	0.19
ESCA	chr19	5587766	Splice_Site	novel	X880_splice	0.17
ESCA	chr19	5612497	Intron	novel		0.29
ESCA	chr19	5622759	5'UTR	rs540292495		0.3
ESCA	chr19	5622873	5'UTR	novel		1
GBM	chr19	5587927	Missense_Mutation	rs770444467	R860H	0.1
GBM	chr19	5604931	Silent	rs540916569	V434V	0.14
GBM	chr19	5595469	Missense_Mutation	novel	E604G	0.39
GBM	chr19	5587905	Silent	rs372249286	D867D	0.48
GBM	chr19	5616219	Silent	novel	T152T	0.12
GBM	chr19	5592770	Missense_Mutation	novel	Q775H	0.23
HNSC	chr19	5622600	Missense_Mutation	novel	R39Q	0.15	RRM_1
HNSC	chr19	5593965	Silent	novel	E711E	0.36
HNSC	chr19	5598865	Silent	novel	R570R	0.36
HNSC	chr19	5622544	Missense_Mutation	novel	E58Q	0.4	RRM_1
HNSC	chr19	5604912	Missense_Mutation	novel	N441D	0.14
HNSC	chr19	5587176	3'UTR	novel		0.45
KIRC	chr19	5613483	Silent	NA	L196L	0.23
KIRP	chr19	5587261	Missense_Mutation	novel	H948Q	0.42
KIRP	chr19	5622904	5'UTR	novel		0.72
LGG	chr19	5594164	Missense_Mutation	novel	R645Q	0.29
LGG	chr19	5587928	Missense_Mutation	rs376399865	R860C	0.18
LGG	chr19	5612477	Intron	novel		0.42
LGG	chr19	5590361	Silent	rs773820152	H814H	0.23
LIHC	chr19	5604851	Missense_Mutation	rs142026681	A461V	0.29
LIHC	chr19	5592856	Missense_Mutation	rs772797669	R747C	0.13
LIHC	chr19	5594089	Missense_Mutation	rs747436889	L670R	0.37
LIHC	chr19	5587208	3'UTR	rs771486818		0.47
LIHC	chr19	5621370	Silent	NA	P71P	0.05
LUAD	chr19	5616176	Missense_Mutation	novel	A167S	0.07
LUAD	chr19	5616177	Silent	novel	V166V	0.07
LUAD	chr19	5604644	Missense_Mutation	novel	V500L	0.1
LUAD	chr19	5612554	Missense_Mutation	NA	S207Y	0.17
LUAD	chr19	5587927	Missense_Mutation	NA	R860L	0.45
LUAD	chr19	5600180	Missense_Mutation	novel	Q547L	0.43
LUAD	chr19	5610681	Missense_Mutation	NA	K385Q	0.43
LUSC	chr19	5592799	Missense_Mutation	novel	H766N	0.36
LUSC	chr19	5604933	Missense_Mutation	novel	V434I	0.11
LUSC	chr19	5622635	Silent	novel	T27T	0.26
LUSC	chr19	5622558	Missense_Mutation	NA	K53M	0.37	RRM_1
LUSC	chr19	5590363	Missense_Mutation	novel	H814Y	0.24
LUSC	chr19	5590365	Missense_Mutation	novel	R813L	0.25
LUSC	chr19	5616171	Silent	novel	A168A	0.28
LUSC	chr19	5587247	Missense_Mutation	NA	Y953F	0.14
OV	chr19	5611171	Missense_Mutation	NA	P365R	0.44
OV	chr19	5592801	Missense_Mutation	novel	F765S	0.18
OV	chr19	5592829	Missense_Mutation	novel	A756P	0.32
OV	chr19	5616280	Missense_Mutation	NA	S132N	0.23
OV	chr19	5610088	Silent	novel	V401V	0.07
OV	chr19	5604654	Silent	novel	K496K	0.67
OV	chr19	5604668	Frame_Shift_Ins	novel	*L492Sfs28**	0.29
PAAD	chr19	5592838	Nonsense_Mutation	novel	R753*	0.04
PAAD	chr19	5612375	Intron	novel		0.21
PRAD	chr19	5598859	Silent	NA	V572V	0.29
READ	chr19	5612472	Intron	novel		0.18
READ	chr19	5592751	Missense_Mutation	rs745620862	D782N	0.44
READ	chr19	5604617	Missense_Mutation	novel	D509N	0.32
READ	chr19	5613518	Nonsense_Mutation	NA	E185*	0.38
SARC	chr19	5610660	Missense_Mutation	novel	P392T	0.14
SARC	chr19	5616440	Silent	rs770714831	D107D	0.2
SKCM	chr19	5612423	Intron	novel		0.17
SKCM	chr19	5590331	Frame_Shift_Ins	rs759920279	*Y825Lfs9**	0.3
SKCM	chr19	5593995	Silent	NA	E701E	0.45
SKCM	chr19	5591782	Missense_Mutation	rs777512759	S787L	0.43
SKCM	chr19	5612387	Intron	novel		0.5
SKCM	chr19	5612553	Silent	NA	S207S	0.09
SKCM	chr19	5590294	Silent	NA	L837L	0.43
SKCM	chr19	5595493	Missense_Mutation	NA	S596F	0.23
SKCM	chr19	5590294	Silent	NA	L837L	0.2
SKCM	chr19	5594139	Silent	NA	A653A	0.1
SKCM	chr19	5610010	Silent	NA	F427F	0.23
SKCM	chr19	5610012	Missense_Mutation	NA	F427V	0.23
SKCM	chr19	5610051	Silent	NA	L414L	0.18
SKCM	chr19	5616236	Missense_Mutation	NA	F147I	0.24
SKCM	chr19	5590283	Silent	NA	P840P	0.27
SKCM	chr19	5587878	Silent	NA	A876A	0.17
SKCM	chr19	5616131	Splice_Site	novel	X181_splice	0.06
SKCM	chr19	5616132	Splice_Region	novel	A181A	0.06
STAD	chr19	5590287	Frame_Shift_Del	novel	*P839Lfs16**	0.38
STAD	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.75
STAD	chr19	5590332	Frame_Shift_Del	rs765699897	*G824Afs8**	0.78
STAD	chr19	5590295	Frame_Shift_Del	NA	*L837Cfs18**	0.55
STAD	chr19	5587926	Silent	rs374459619	R860R	0.33
STAD	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.6
STAD	chr19	5622596	In_Frame_Del	novel	I36_A40del	0.78	RRM_1
STAD	chr19	5587112	3'UTR	novel		0.19
STAD	chr19	5592832	Missense_Mutation	rs367861196	R755C	0.11
STAD	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.45
STAD	chr19	5600213	Frame_Shift_Del	NA	*K536Sfs15**	0.16
STAD	chr19	5587345	Silent	rs747451273	G920G	0.58
STAD	chr19	5590391	Silent	rs767805977	R804R	0.13
STAD	chr19	5587282	Silent	rs761926149	P941P	0.15
STAD	chr19	5592752	Silent	rs371347316	I781I	0.23
STAD	chr19	5587254	Missense_Mutation	rs201263017	R951C	0.3
STAD	chr19	5587131	3'UTR	novel		0.15
STAD	chr19	5590352	Silent	NA	D817D	0.67
THYM	chr19	5591750	Missense_Mutation	novel	Q798E	0.53
UCEC	chr19	5616206	Missense_Mutation	rs779944871	D157N	0.33
UCEC	chr19	5590375	Missense_Mutation	rs201737192	P810S	0.18
UCEC	chr19	5604647	Missense_Mutation	rs776973053	E499K	0.26
UCEC	chr19	5592796	Missense_Mutation	rs771872975	D767N	0.42
UCEC	chr19	5595478	Missense_Mutation	rs749273357	R601H	0.17
UCEC	chr19	5604617	Missense_Mutation	novel	D509N	0.18
UCEC	chr19	5612393	Intron	novel		0.5
UCEC	chr19	5622896	5'UTR	novel		0.33
UCEC	chr19	5604597	Missense_Mutation	rs147906448	E515D	0.28
UCEC	chr19	5612386	Intron	novel		0.42
UCEC	chr19	5592800	Silent	novel	F765F	0.69
UCEC	chr19	5595389	Missense_Mutation	novel	R631W	0.36
UCEC	chr19	5600247	Missense_Mutation	novel	K525E	0.42
UCEC	chr19	5604905	Missense_Mutation	NA	R443H	0.43
UCEC	chr19	5613527	Missense_Mutation	novel	V182M	0.46
UCEC	chr19	5604647	Missense_Mutation	rs776973053	E499K	0.44
UCEC	chr19	5604653	Nonsense_Mutation	novel	E497*	0.04
UCEC	chr19	5604891	Nonsense_Mutation	NA	R448*	0.14
UCEC	chr19	5612458	Intron	novel		0.1
UCEC	chr19	5595441	Silent	rs547528626	S613S	0.22
UCEC	chr19	5587253	Missense_Mutation	rs777236403	R951H	0.16
UCEC	chr19	5587703	Splice_Region	NA	A901A	0.16
UCEC	chr19	5598844	Silent	rs552698976	S577S	0.5
UCEC	chr19	5587075	3'UTR	novel		0.46
UCEC	chr19	5587337	Missense_Mutation	novel	E923G	0.14
UCEC	chr19	5591792	Missense_Mutation	rs368944878	R784W	0.31
UCEC	chr19	5600171	Missense_Mutation	novel	L550P	0.11
UCEC	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.45
UCEC	chr19	5587924	Missense_Mutation	novel	A861V	0.24
UCEC	chr19	5590381	Missense_Mutation	novel	G808R	0.4
UCEC	chr19	5604865	Silent	rs370774462	S456S	0.56
UCEC	chr19	5621326	Missense_Mutation	rs372273402	A86V	0.36
UCEC	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.48
UCEC	chr19	5604647	Missense_Mutation	rs776973053	E499K	0.19
UCEC	chr19	5604647	Missense_Mutation	rs776973053	E499K	0.48
UCEC	chr19	5604824	Missense_Mutation	novel	R470I	0.34
UCEC	chr19	5612534	Splice_Region	novel		0.45
UCEC	chr19	5621375	Missense_Mutation	novel	D70Y	0.4
UCEC	chr19	5595478	Missense_Mutation	rs749273357	R601H	0.34
UCEC	chr19	5612538	Splice_Site	NA	X212_splice	0.38
UCEC	chr19	5616439	Missense_Mutation	rs369736320	D108N	0.48
UCEC	chr19	5587038	3'UTR	novel		0.64
UCEC	chr19	5587234	3'UTR	novel		0.42
UCEC	chr19	5621314	Missense_Mutation	novel	V90A	0.24
UCEC	chr19	5600163	Missense_Mutation	rs147832323	G553R	0.26
UCEC	chr19	5616206	Missense_Mutation	rs779944871	D157N	0.12
UCEC	chr19	5595378	Silent	rs371849776	R634R	0.24
UCEC	chr19	5592751	Missense_Mutation	rs745620862	D782N	0.4
UCEC	chr19	5600168	Missense_Mutation	novel	K551R	0.31
UCEC	chr19	5616457	Missense_Mutation	novel	D102Y	0.29
UCEC	chr19	5621322	Missense_Mutation	novel	K87N	0.22
UCEC	chr19	5621379	Silent	novel	G68G	0.49
UCEC	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.4
UCEC	chr19	5587250	Missense_Mutation	rs747865364	R952H	0.14
UCEC	chr19	5616206	Missense_Mutation	rs779944871	D157N	0.25
UCEC	chr19	5604905	Missense_Mutation	NA	R443H	0.71
UCEC	chr19	5590332	Frame_Shift_Del	rs765699897	*G824Afs8**	0.27
UCEC	chr19	5600128	Splice_Site	novel	X564_splice	0.18
UCEC	chr19	5616270	Silent	rs756499003	D135D	0.32
UCEC	chr19	5591793	Splice_Region	NA	R783R	0.08
UCEC	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.5
UCEC	chr19	5590300	Missense_Mutation	rs533605559	R835W	0.18
UCEC	chr19	5616465	Missense_Mutation	NA	G99D	0.04
UCEC	chr19	5610669	Missense_Mutation	NA	D389Y	0.4
UCEC	chr19	5604590	Missense_Mutation	NA	I518V	0.32
UCEC	chr19	5610670	Missense_Mutation	novel	K388N	0.07
UCEC	chr19	5587110	3'UTR	novel		0.26
UCEC	chr19	5611878	Intron	novel		0.33
UCEC	chr19	5600261	Splice_Site	novel	X520_splice	0.32
UCS	chr19	5587271	Frame_Shift_Del	rs779760860	*P945Rfs49**	0.36
UCS	chr19	5594041	In_Frame_Del	rs748161277	M682_R686del	0.67

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
PAAD	DEL	0.1359	0.0060878
READ	DEL	0.1152	0.23023
THCA	DEL	0.012	0.10598

Survival Analysis

Cancer	P-value	Q-value
STAD	0.0035	Kaplan-Meier Survival Analysis
MESO	0.029	Kaplan-Meier Survival Analysis
ACC	0.0029	Kaplan-Meier Survival Analysis
HNSC	0.029	Kaplan-Meier Survival Analysis
PRAD	0.024	Kaplan-Meier Survival Analysis
LUSC	0.013	Kaplan-Meier Survival Analysis
KIRP	0.02	Kaplan-Meier Survival Analysis
COAD	0.047	Kaplan-Meier Survival Analysis
PAAD	0.0002	Kaplan-Meier Survival Analysis
BLCA	0.00033	Kaplan-Meier Survival Analysis
UCEC	0.015	Kaplan-Meier Survival Analysis
LIHC	0.049	Kaplan-Meier Survival Analysis
UVM	0.0033	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742