EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130312 (Gene tree)
Gene ID: 64981
Gene Symbol: MRPL34
Alias: L34mt|MGC2633|MGC24974
Full Name: mitochondrial ribosomal protein L34
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 14,239 bases
Position: chr19:17,292,609-17,306,847
Accession: 14488
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000252602	Ribosomal_L34	PF00468.17	1.3e-17	1	1
ENSP00000469581	Ribosomal_L34	PF00468.17	1.3e-17	1	1
ENSP00000471820	Ribosomal_L34	PF00468.17	1.3e-17	1	1
ENSP00000472266	Ribosomal_L34	PF00468.17	8.3e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000594999	MRPL34-202	555	XM_011528189	ENSP00000471820	92 (aa)	XP_011526491	Q9BQ48
ENST00000600434	MRPL34-205	793	-	ENSP00000469581	92 (aa)	-	Q9BQ48
ENST00000595444	MRPL34-203	863	-	ENSP00000472266	184 (aa)	-	M0R226
ENST00000597996	MRPL34-204	404	-	-	- (aa)	-	-
ENST00000252602	MRPL34-201	968	-	ENSP00000252602	92 (aa)	-	Q9BQ48
ENST00000602206	MRPL34-206	603	-	ENSP00000471089	36 (aa)	-	M0R093

Gene Model

Click here to download ENSG00000130312's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130312	rs10424198	19	17298862	T	Mitochondrial DNA copy number	30704525	[0.2-0.33] unit decrease	0.262	EFO_0006312

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130312's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130312	MRPL34	77	85.915	ENSAMEG00000010483	MRPL34	87	85.915	Ailuropoda_melanoleuca
ENSG00000130312	MRPL34	100	90.217	ENSANAG00000020983	-	100	83.696	Aotus_nancymaae
ENSG00000130312	MRPL34	96	79.775	ENSBTAG00000014579	MRPL34	93	79.775	Bos_taurus
ENSG00000130312	MRPL34	100	91.304	ENSCJAG00000047204	MRPL34	100	91.304	Callithrix_jacchus
ENSG00000130312	MRPL34	91	73.810	ENSCAFG00000028802	MRPL34	96	73.810	Canis_familiaris
ENSG00000130312	MRPL34	92	74.118	ENSCAFG00020010412	MRPL34	97	74.118	Canis_lupus_dingo
ENSG00000130312	MRPL34	96	79.775	ENSCHIG00000014263	MRPL34	93	79.775	Capra_hircus
ENSG00000130312	MRPL34	76	82.857	ENSTSYG00000028788	MRPL34	85	82.857	Carlito_syrichta
ENSG00000130312	MRPL34	100	76.087	ENSCPOG00000038177	MRPL34	100	76.087	Cavia_porcellus
ENSG00000130312	MRPL34	100	90.217	ENSCCAG00000031745	-	100	88.172	Cebus_capucinus
ENSG00000130312	MRPL34	100	96.739	ENSCATG00000032681	-	100	94.565	Cercocebus_atys
ENSG00000130312	MRPL34	100	79.348	ENSCLAG00000008278	MRPL34	100	79.348	Chinchilla_lanigera
ENSG00000130312	MRPL34	100	95.652	ENSCSAG00000005626	MRPL34	100	95.652	Chlorocebus_sabaeus
ENSG00000130312	MRPL34	100	51.064	ENSCPBG00000012424	MRPL34	67	51.064	Chrysemys_picta_bellii
ENSG00000130312	MRPL34	100	97.826	ENSCANG00000039994	-	100	97.826	Colobus_angolensis_palliatus
ENSG00000130312	MRPL34	100	78.261	ENSCGRG00001014234	Mrpl34	100	78.261	Cricetulus_griseus_chok1gshd
ENSG00000130312	MRPL34	100	78.261	ENSCGRG00000007085	Mrpl34	100	78.261	Cricetulus_griseus_crigri
ENSG00000130312	MRPL34	100	80.000	ENSDNOG00000033349	MRPL34	100	80.000	Dasypus_novemcinctus
ENSG00000130312	MRPL34	100	65.217	ENSDORG00000025245	Mrpl34	100	65.217	Dipodomys_ordii
ENSG00000130312	MRPL34	100	80.000	ENSETEG00000010854	MRPL34	100	80.000	Echinops_telfairi
ENSG00000130312	MRPL34	100	82.105	ENSEASG00005002874	MRPL34	100	82.105	Equus_asinus_asinus
ENSG00000130312	MRPL34	100	82.105	ENSECAG00000011693	MRPL34	100	82.105	Equus_caballus
ENSG00000130312	MRPL34	100	73.469	ENSFCAG00000043549	MRPL34	100	73.469	Felis_catus
ENSG00000130312	MRPL34	63	67.241	ENSFALG00000014997	MRPL34	95	67.241	Ficedula_albicollis
ENSG00000130312	MRPL34	100	100.000	ENSGGOG00000005799	-	100	100.000	Gorilla_gorilla
ENSG00000130312	MRPL34	100	72.917	ENSHGLG00000003238	MRPL34	100	72.917	Heterocephalus_glaber_female
ENSG00000130312	MRPL34	100	72.917	ENSHGLG00100013043	MRPL34	100	72.917	Heterocephalus_glaber_male
ENSG00000130312	MRPL34	100	85.870	ENSSTOG00000006247	MRPL34	100	85.870	Ictidomys_tridecemlineatus
ENSG00000130312	MRPL34	100	76.087	ENSJJAG00000018808	Mrpl34	100	76.087	Jaculus_jaculus
ENSG00000130312	MRPL34	93	87.500	ENSLAFG00000012255	MRPL34	93	87.500	Loxodonta_africana
ENSG00000130312	MRPL34	100	97.826	ENSMFAG00000044117	-	100	94.565	Macaca_fascicularis
ENSG00000130312	MRPL34	100	97.826	ENSMMUG00000009657	-	100	93.514	Macaca_mulatta
ENSG00000130312	MRPL34	100	97.826	ENSMNEG00000041354	-	100	94.565	Macaca_nemestrina
ENSG00000130312	MRPL34	100	96.739	ENSMLEG00000039501	MRPL34	100	82.065	Mandrillus_leucophaeus
ENSG00000130312	MRPL34	87	60.714	ENSMGAG00000003912	MRPL34	98	60.714	Meleagris_gallopavo
ENSG00000130312	MRPL34	100	78.261	ENSMAUG00000001884	Mrpl34	100	78.261	Mesocricetus_auratus
ENSG00000130312	MRPL34	100	84.043	ENSMICG00000043112	MRPL34	100	84.043	Microcebus_murinus
ENSG00000130312	MRPL34	100	74.194	ENSMOCG00000004117	Mrpl34	100	74.194	Microtus_ochrogaster
ENSG00000130312	MRPL34	73	79.104	ENSMODG00000015047	MRPL34	100	79.104	Monodelphis_domestica
ENSG00000130312	MRPL34	100	76.087	MGP_CAROLIEiJ_G0031185	Mrpl34	100	76.087	Mus_caroli
ENSG00000130312	MRPL34	100	75.000	ENSMUSG00000034880	Mrpl34	100	75.000	Mus_musculus
ENSG00000130312	MRPL34	100	72.826	MGP_PahariEiJ_G0021650	Mrpl34	100	72.826	Mus_pahari
ENSG00000130312	MRPL34	100	73.913	MGP_SPRETEiJ_G0032304	Mrpl34	100	73.913	Mus_spretus
ENSG00000130312	MRPL34	100	75.000	ENSMPUG00000015905	MRPL34	100	75.000	Mustela_putorius_furo
ENSG00000130312	MRPL34	100	76.087	ENSNGAG00000018101	Mrpl34	100	76.087	Nannospalax_galili
ENSG00000130312	MRPL34	100	98.913	ENSNLEG00000005736	-	100	98.913	Nomascus_leucogenys
ENSG00000130312	MRPL34	55	88.235	ENSMEUG00000002379	-	100	88.235	Notamacropus_eugenii
ENSG00000130312	MRPL34	53	87.755	ENSOPRG00000004567	-	77	87.755	Ochotona_princeps
ENSG00000130312	MRPL34	100	78.261	ENSODEG00000001492	MRPL34	100	78.261	Octodon_degus
ENSG00000130312	MRPL34	55	78.431	ENSOANG00000011901	-	75	65.217	Ornithorhynchus_anatinus
ENSG00000130312	MRPL34	100	89.130	ENSOGAG00000028616	MRPL34	100	89.130	Otolemur_garnettii
ENSG00000130312	MRPL34	96	80.899	ENSOARG00000017239	MRPL34	93	80.899	Ovis_aries
ENSG00000130312	MRPL34	100	100.000	ENSPPAG00000032716	MRPL34	100	100.000	Pan_paniscus
ENSG00000130312	MRPL34	100	73.469	ENSPPRG00000015405	MRPL34	100	73.469	Panthera_pardus
ENSG00000130312	MRPL34	100	73.469	ENSPTIG00000011413	MRPL34	100	73.469	Panthera_tigris_altaica
ENSG00000130312	MRPL34	100	100.000	ENSPTRG00000029090	MRPL34	100	99.457	Pan_troglodytes
ENSG00000130312	MRPL34	100	97.826	ENSPANG00000030930	-	100	94.565	Papio_anubis
ENSG00000130312	MRPL34	55	74.510	ENSPSIG00000001128	MRPL34	74	74.510	Pelodiscus_sinensis
ENSG00000130312	MRPL34	100	100.000	ENSPPYG00000009709	MRPL34	100	100.000	Pongo_abelii
ENSG00000130312	MRPL34	100	85.870	ENSPCOG00000020760	-	100	70.745	Propithecus_coquereli
ENSG00000130312	MRPL34	93	80.233	ENSPVAG00000007874	MRPL34	91	80.233	Pteropus_vampyrus
ENSG00000130312	MRPL34	55	66.667	ENSPNAG00000019266	mrpl34	54	66.667	Pygocentrus_nattereri
ENSG00000130312	MRPL34	100	73.913	ENSRNOG00000017552	Mrpl34	100	73.913	Rattus_norvegicus
ENSG00000130312	MRPL34	100	94.565	ENSRBIG00000005154	-	100	94.565	Rhinopithecus_bieti
ENSG00000130312	MRPL34	100	97.826	ENSRBIG00000010999	-	100	95.109	Rhinopithecus_bieti
ENSG00000130312	MRPL34	100	96.739	ENSRROG00000028622	-	100	94.565	Rhinopithecus_roxellana
ENSG00000130312	MRPL34	100	90.217	ENSSBOG00000031590	-	100	89.840	Saimiri_boliviensis_boliviensis
ENSG00000130312	MRPL34	62	77.193	ENSSHAG00000014757	MRPL34	84	77.193	Sarcophilus_harrisii
ENSG00000130312	MRPL34	100	82.105	ENSSSCG00000039295	MRPL34	100	82.105	Sus_scrofa
ENSG00000130312	MRPL34	62	68.421	ENSTGUG00000015926	MRPL34	93	68.421	Taeniopygia_guttata
ENSG00000130312	MRPL34	100	90.217	ENSTBEG00000012656	MRPL34	100	90.217	Tupaia_belangeri
ENSG00000130312	MRPL34	96	87.500	ENSTTRG00000003137	MRPL34	93	87.500	Tursiops_truncatus
ENSG00000130312	MRPL34	100	72.826	ENSUAMG00000011536	-	100	72.826	Ursus_americanus
ENSG00000130312	MRPL34	100	70.652	ENSUAMG00000023002	-	100	70.652	Ursus_americanus
ENSG00000130312	MRPL34	100	72.826	ENSUMAG00000011847	-	100	72.826	Ursus_maritimus
ENSG00000130312	MRPL34	100	70.652	ENSUMAG00000004918	-	100	70.652	Ursus_maritimus
ENSG00000130312	MRPL34	96	85.227	ENSVPAG00000011826	MRPL34	93	85.227	Vicugna_pacos
ENSG00000130312	MRPL34	91	82.143	ENSVVUG00000016159	MRPL34	93	82.143	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	11543634.	NAS	Function
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	11543634.	NAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0006412	translation	11543634.	NAS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process