EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130749 (Gene tree)
Gene ID: 23211
Gene Symbol: ZC3H4
Alias: KIAA1064|C19orf7
Full Name: zinc finger CCCH-type containing 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 49,566 bases
Position: chr19:47,064,187-47,113,752
Accession: 17808
RBP type: canonical RBP
Summary: This gene encodes a member of a family of CCCH (C-x8-C-x5-C-x3-H type) zinc finger domain-containing proteins. These zinc finger domains, which coordinate zinc finger binding and are characterized by three cysteine residues and one histidine residue, are nucleic acid-binding. Other family members are known to function in post-transcriptional regulation. [provided by RefSeq, Aug 2011]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000469684	zf-CCCH	PF00642.24	5.3e-13	1	1
ENSP00000253048	zf-CCCH	PF00642.24	1.7e-12	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000595341	ZC3H4-203	431	-	-	- (aa)	-	-
ENST00000253048	ZC3H4-201	6119	XM_005258676	ENSP00000253048	1303 (aa)	XP_005258733	Q9UPT8
ENST00000594019	ZC3H4-202	3259	-	-	- (aa)	-	-
ENST00000597069	ZC3H4-204	664	-	-	- (aa)	-	-
ENST00000601973	ZC3H4-205	4895	XM_017026531	ENSP00000469684	910 (aa)	XP_016882020	M0QY97

Gene Model

Click here to download ENSG00000130749's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130749	Body Mass Index	9E-7	24861553
ENSG00000130749	Body Mass Index	5E-15	25673413
ENSG00000130749	Body Mass Index	7E-9	25673413
ENSG00000130749	Hormones	2E-6	23251661
ENSG00000130749	Body Mass Index	3E-10	25673413
ENSG00000130749	Waist Circumference	2E-10	25673412
ENSG00000130749	Waist Circumference	8E-8	25673412
ENSG00000130749	Body Mass Index	2E-12	20935630
ENSG00000130749	Body Mass Index	6E-16	25673413
ENSG00000130749	Hip	2E-8	25673412

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130749	rs113125564	19	47092874	C	Red blood cell count	27863252	[0.046-0.08] unit increase	0.06323484	EFO_0004305
ENSG00000130749	rs3810291	19	47065746	A	Hip circumference	25673412	[0.015-0.031] unit increase	0.023	EFO_0005093
ENSG00000130749	rs3810291	19	47065746	A	Body mass index	24861553	[0.02-0.047] unit increase	0.0333	EFO_0004340
ENSG00000130749	rs3745618	19	47072459	A	Obesity-related traits	23251661	[NR] pg/mL increase	0.04	EFO_0004730
ENSG00000130749	rs2241388	19	47069730	C	Hematocrit	27863252	[0.019-0.034] unit decrease	0.02632552	EFO_0004348
ENSG00000130749	rs2241388	19	47069730	C	Hemoglobin concentration	27863252	[0.017-0.033] unit decrease	0.02488376	EFO_0004509
ENSG00000130749	rs145775149	19	47103510	G	Monocyte chemoattractant protein-1 levels	27989323	[0.32-0.81] SD units increase	0.5645	EFO_0004749
ENSG00000130749	rs3810291	19	47065746	A	Body mass index	20935630	[0.05-0.13] kg/m2 increase	0.09	EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Body mass index in physically active individuals	28448500	[0.016-0.033] kg/m2 increase	0.0245	EFO_0008002\|EFO_0004340
ENSG00000130749	rs2303108	19	47086638	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Waist circumference	25673412	[0.018-0.034] unit increase	0.0259	EFO_0004342
ENSG00000130749	rs3810291	19	47065746	A	Waist circumference	25673412	[0.018-0.038] unit increase	0.0278	EFO_0004342
ENSG00000130749	rs3810291	19	47065746	A	BMI (adjusted for smoking behaviour)	28443625	[0.019-0.033] kg/m2 increase	0.0259	EFO_0004318\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	BMI (adjusted for smoking behaviour)	28443625	[0.02-0.039] kg/m2 increase	0.0292	EFO_0004318\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Body mass index (joint analysis main effects and smoking interaction)	28443625			EFO_0004318\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	BMI in smokers	28443625	[0.022-0.052] kg/m2 increase	0.0371	EFO_0004318\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	BMI in smokers	28443625	[0.029-0.07] kg/m2 increase	0.0495	EFO_0004318\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	BMI in non-smokers	28443625	[0.017-0.033] kg/m2 increase	0.0247	EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	BMI in non-smokers	28443625	[0.017-0.037] kg/m2 increase	0.0269	EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Body mass index	28448500	[0.016-0.032] kg/m2 increase	0.024	EFO_0008002\|EFO_0004340
ENSG00000130749	rs2303108	19	47086638	C	Body mass index	28448500	[0.017-0.033] kg/m2 increase	0.0246	EFO_0008002\|EFO_0004340
ENSG00000130749	rs2303108	19	47086638	C	Body mass index	28448500	[0.017-0.038] kg/m2 increase	0.0272	EFO_0008002\|EFO_0004340
ENSG00000130749	rs10408163	19	47093845	C	Body mass index	28448500	[0.017-0.037] kg/m2 increase	0.0268	EFO_0008002\|EFO_0004340
ENSG00000130749	rs2303108	19	47086638	C	Body mass index in physically active individuals	28448500	[0.013-0.031] kg/m2 increase	0.022	EFO_0008002\|EFO_0004340
ENSG00000130749	rs2303108	19	47086638	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000130749	rs10408163	19	47093845	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000130749	rs10408163	19	47093845	?	Body mass index (joint analysis main effects and physical activity interaction)	28448500			EFO_0008002\|EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Body mass index	26426971	unit increase	0.02794018	EFO_0004340
ENSG00000130749	rs3810291	19	47065746	G	Body mass index	30108127	[NR] unit decrease	0.026	EFO_0004340
ENSG00000130749	rs3810291	19	47065746	A	Body mass index	26961502	[0.02-0.036] unit increase	0.028	EFO_0004340
ENSG00000130749	rs3810291	19	47065746	?	Menarche (age at onset)	30595370			EFO_0004703
ENSG00000130749	rs3810291	19	47065746	?	Body mass index	30595370			EFO_0004340
ENSG00000130749	rs12973221	19	47111403	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000130749	rs17716478	19	47097336	?	Red blood cell count	30595370			EFO_0004305
ENSG00000130749	rs10408163	19	47093845	?	Lipid traits (pleiotropy) (HIPO component 1)	30289880			EFO_0004574\|EFO_0004530\|EFO_0004611\|EFO_0004612
ENSG00000130749	rs3810291	19	47065746	?	Fat-free mass	30593698	[0.081-0.182] unit increase	0.13155	EFO_0004995
ENSG00000130749	rs3810291	19	47065746	?	Fat-free mass	30593698	[0.099-0.191] unit increase	0.14536	EFO_0004995
ENSG00000130749	rs3810291	19	47065746	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0043-0.0089] unit increase	0.00656934	EFO_0006527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130749's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000130749	ZC3H4	89	41.141	ENSG00000188177	ZC3H6	56	47.685

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130749	ZC3H4	93	59.850	ENSACAG00000003986	ZC3H4	95	62.983	Anolis_carolinensis
ENSG00000130749	ZC3H4	100	95.939	ENSANAG00000023963	ZC3H4	100	95.939	Aotus_nancymaae
ENSG00000130749	ZC3H4	71	50.842	ENSAMXG00000009037	zc3h4	54	86.923	Astyanax_mexicanus
ENSG00000130749	ZC3H4	99	94.175	ENSBTAG00000009286	ZC3H4	97	92.060	Bos_taurus
ENSG00000130749	ZC3H4	99	96.867	ENSCJAG00000011601	ZC3H4	100	94.950	Callithrix_jacchus
ENSG00000130749	ZC3H4	100	90.091	ENSCAFG00000004182	ZC3H4	97	89.593	Canis_familiaris
ENSG00000130749	ZC3H4	99	90.361	ENSCHIG00000013956	ZC3H4	95	90.089	Capra_hircus
ENSG00000130749	ZC3H4	87	91.852	ENSTSYG00000000926	ZC3H4	94	91.852	Carlito_syrichta
ENSG00000130749	ZC3H4	100	97.699	ENSCCAG00000037597	ZC3H4	100	97.699	Cebus_capucinus
ENSG00000130749	ZC3H4	100	97.698	ENSCATG00000039046	ZC3H4	100	97.698	Cercocebus_atys
ENSG00000130749	ZC3H4	91	97.647	ENSCLAG00000001032	ZC3H4	84	95.388	Chinchilla_lanigera
ENSG00000130749	ZC3H4	99	98.054	ENSCSAG00000002989	ZC3H4	99	98.479	Chlorocebus_sabaeus
ENSG00000130749	ZC3H4	71	94.406	ENSCPBG00000001719	ZC3H4	100	70.517	Chrysemys_picta_bellii
ENSG00000130749	ZC3H4	99	88.652	ENSCGRG00001016116	Zc3h4	97	88.280	Cricetulus_griseus_chok1gshd
ENSG00000130749	ZC3H4	99	94.928	ENSDNOG00000003764	ZC3H4	98	86.651	Dasypus_novemcinctus
ENSG00000130749	ZC3H4	99	88.171	ENSDORG00000002726	Zc3h4	98	87.328	Dipodomys_ordii
ENSG00000130749	ZC3H4	77	96.591	ENSETEG00000005763	ZC3H4	77	96.552	Echinops_telfairi
ENSG00000130749	ZC3H4	99	94.417	ENSECAG00000024342	ZC3H4	99	93.215	Equus_caballus
ENSG00000130749	ZC3H4	86	84.298	ENSEEUG00000000519	ZC3H4	77	96.552	Erinaceus_europaeus
ENSG00000130749	ZC3H4	99	91.667	ENSFCAG00000004835	ZC3H4	100	93.645	Felis_catus
ENSG00000130749	ZC3H4	93	73.770	ENSGAGG00000019319	ZC3H4	98	68.621	Gopherus_agassizii
ENSG00000130749	ZC3H4	100	99.693	ENSGGOG00000013071	ZC3H4	100	99.693	Gorilla_gorilla
ENSG00000130749	ZC3H4	87	97.330	ENSSTOG00000016249	ZC3H4	83	88.583	Ictidomys_tridecemlineatus
ENSG00000130749	ZC3H4	95	87.863	ENSJJAG00000019068	Zc3h4	98	89.022	Jaculus_jaculus
ENSG00000130749	ZC3H4	99	95.854	ENSLAFG00000001586	ZC3H4	100	90.666	Loxodonta_africana
ENSG00000130749	ZC3H4	100	98.465	ENSMFAG00000041518	ZC3H4	100	98.465	Macaca_fascicularis
ENSG00000130749	ZC3H4	99	97.324	ENSMLEG00000007946	ZC3H4	100	98.479	Mandrillus_leucophaeus
ENSG00000130749	ZC3H4	99	88.416	ENSMAUG00000000068	Zc3h4	98	88.693	Mesocricetus_auratus
ENSG00000130749	ZC3H4	99	96.359	ENSMICG00000008786	ZC3H4	100	94.491	Microcebus_murinus
ENSG00000130749	ZC3H4	88	80.051	ENSMODG00000008978	ZC3H4	95	80.440	Monodelphis_domestica
ENSG00000130749	ZC3H4	93	90.808	ENSMUSG00000059273	Zc3h4	98	89.014	Mus_musculus
ENSG00000130749	ZC3H4	95	87.229	MGP_PahariEiJ_G0021089	Zc3h4	98	87.772	Mus_pahari
ENSG00000130749	ZC3H4	93	88.219	MGP_SPRETEiJ_G0030312	Zc3h4	98	88.329	Mus_spretus
ENSG00000130749	ZC3H4	96	95.686	ENSMPUG00000005065	ZC3H4	63	82.790	Mustela_putorius_furo
ENSG00000130749	ZC3H4	99	85.681	ENSNGAG00000020090	Zc3h4	100	85.143	Nannospalax_galili
ENSG00000130749	ZC3H4	77	82.648	ENSMEUG00000009167	ZC3H4	80	82.134	Notamacropus_eugenii
ENSG00000130749	ZC3H4	94	90.148	ENSOPRG00000014889	ZC3H4	88	94.721	Ochotona_princeps
ENSG00000130749	ZC3H4	92	95.614	ENSODEG00000008320	ZC3H4	100	89.218	Octodon_degus
ENSG00000130749	ZC3H4	71	79.167	ENSOANG00000001794	ZC3H4	59	61.415	Ornithorhynchus_anatinus
ENSG00000130749	ZC3H4	99	86.248	ENSOCUG00000026069	ZC3H4	72	95.148	Oryctolagus_cuniculus
ENSG00000130749	ZC3H4	99	96.602	ENSOGAG00000031123	ZC3H4	100	94.870	Otolemur_garnettii
ENSG00000130749	ZC3H4	99	69.579	ENSOARG00000010932	ZC3H4	80	79.554	Ovis_aries
ENSG00000130749	ZC3H4	95	91.034	ENSPPRG00000023272	ZC3H4	95	91.599	Panthera_pardus
ENSG00000130749	ZC3H4	82	98.462	ENSPTIG00000014229	ZC3H4	93	98.305	Panthera_tigris_altaica
ENSG00000130749	ZC3H4	100	99.463	ENSPTRG00000011201	ZC3H4	100	99.463	Pan_troglodytes
ENSG00000130749	ZC3H4	100	98.772	ENSPANG00000021115	ZC3H4	100	98.772	Papio_anubis
ENSG00000130749	ZC3H4	95	79.625	ENSPSIG00000002241	ZC3H4	99	71.223	Pelodiscus_sinensis
ENSG00000130749	ZC3H4	93	88.643	ENSPEMG00000009762	Zc3h4	98	85.886	Peromyscus_maniculatus_bairdii
ENSG00000130749	ZC3H4	92	96.683	ENSPPYG00000010167	ZC3H4	97	100.000	Pongo_abelii
ENSG00000130749	ZC3H4	75	90.142	ENSPCAG00000014919	ZC3H4	97	90.000	Procavia_capensis
ENSG00000130749	ZC3H4	99	96.602	ENSPCOG00000017169	ZC3H4	97	94.418	Propithecus_coquereli
ENSG00000130749	ZC3H4	99	93.447	ENSPVAG00000005687	ZC3H4	89	89.301	Pteropus_vampyrus
ENSG00000130749	ZC3H4	99	86.971	ENSRNOG00000015229	Zc3h4	78	85.559	Rattus_norvegicus
ENSG00000130749	ZC3H4	100	89.885	ENSRBIG00000027984	ZC3H4	100	93.170	Rhinopithecus_bieti
ENSG00000130749	ZC3H4	100	97.391	ENSRROG00000032920	ZC3H4	100	97.391	Rhinopithecus_roxellana
ENSG00000130749	ZC3H4	89	97.170	ENSSBOG00000030914	ZC3H4	100	87.141	Saimiri_boliviensis_boliviensis
ENSG00000130749	ZC3H4	88	85.443	ENSSARG00000014146	ZC3H4	76	92.647	Sorex_araneus
ENSG00000130749	ZC3H4	73	95.808	ENSSSCG00000003110	ZC3H4	57	93.703	Sus_scrofa
ENSG00000130749	ZC3H4	94	93.623	ENSVVUG00000000208	ZC3H4	78	88.470	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding	21873635.	IBA	Function
GO:0003700	DNA-binding transcription factor activity	21873635.	IBA	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0045892	negative regulation of transcription, DNA-templated	21873635.	IBA	Process
GO:0046872	metal ion binding	-	IEA	Function