EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130818 (Gene tree)
Gene ID: 79088
Gene Symbol: ZNF426
Alias: MGC2663
Full Name: zinc finger protein 426
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 15,422 bases
Position: chr19:9,523,224-9,538,645
Accession: 20725
RBP type: canonical RBP
Summary: Kaposi's sarcoma-associated herpesvirus (KSHV) can be reactivated from latency by the viral protein RTA. The protein encoded by this gene is a zinc finger transcriptional repressor that interacts with RTA to modulate RTA-mediated reactivation of KSHV. While the encoded protein can repress KSHV reactivation, RTA can induce degradation of this protein through the ubiquitin-proteasome pathway to overcome the repression. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	1	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	2	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	3	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	4	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	5	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	6	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	7	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	8	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	9	10
ENSP00000468100	zf-C2H2	PF00096.26	2.9e-61	10	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	1	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	2	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	3	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	4	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	5	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	6	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	7	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	8	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	9	10
ENSP00000253115	zf-C2H2	PF00096.26	7.6e-61	10	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	1	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	2	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	3	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	4	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	5	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	6	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	7	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	8	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	9	10
ENSP00000439017	zf-C2H2	PF00096.26	7.6e-61	10	10
ENSP00000468100	zf-met	PF12874.7	6.4e-05	1	1
ENSP00000253115	zf-met	PF12874.7	0.00015	1	1
ENSP00000439017	zf-met	PF12874.7	0.00015	1	1
ENSP00000468100	zf-C2H2_jaz	PF12171.8	2.5e-16	1	1
ENSP00000253115	zf-C2H2_jaz	PF12171.8	6.6e-16	1	1
ENSP00000439017	zf-C2H2_jaz	PF12171.8	6.6e-16	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000253115	ZNF426-201	7085	XM_024451702	ENSP00000253115	554 (aa)	XP_024307470	Q9BUY5
ENST00000593003	ZNF426-204	2402	XM_017027293	ENSP00000468100	516 (aa)	XP_016882782	K7ER43
ENST00000589289	ZNF426-203	919	XM_024451705	ENSP00000466469	118 (aa)	XP_024307473	K7EME3
ENST00000535489	ZNF426-202	2375	-	ENSP00000439017	554 (aa)	-	Q9BUY5
ENST00000635810	ZNF426-205	582	-	ENSP00000490091	47 (aa)	-	A0A1B0GUG0

Gene Model

Click here to download ENSG00000130818's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa05168	Herpes simplex virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130818	Intelligence Tests	3.4837300E-005	-
ENSG00000130818	Intelligence Tests	3.4837300E-005	-
ENSG00000130818	Intelligence Tests	3.4837300E-005	-
ENSG00000130818	Child Development Disorders, Pervasive	4.1482000E-005	-
ENSG00000130818	Child Development Disorders, Pervasive	4.1482000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130818's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130818	ZNF426	100	91.336	ENSCANG00000042536	ZNF426	100	91.336	Colobus_angolensis_palliatus
ENSG00000130818	ZNF426	100	98.837	ENSGGOG00000014083	ZNF426	100	98.837	Gorilla_gorilla
ENSG00000130818	ZNF426	100	99.225	ENSPPAG00000027305	ZNF426	100	99.225	Pan_paniscus
ENSG00000130818	ZNF426	100	99.225	ENSPTRG00000010447	ZNF426	100	99.225	Pan_troglodytes
ENSG00000130818	ZNF426	100	97.653	ENSPPYG00000009529	ZNF426	100	97.653	Pongo_abelii

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	-	ISA	Function
GO:0003677	DNA binding	-	IEA	Function
GO:0005515	protein binding	23414517.25416956.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0006357	regulation of transcription by RNA polymerase II	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function