EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130921 (Gene tree)
Gene ID: 91574
Gene Symbol: C12orf65
Alias: FLJ38663|SPG55
Full Name: chromosome 12 open reading frame 65
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 25,044 bases
Position: chr12:123,232,916-123,257,959
Accession: 26784
RBP type: canonical RBP
Summary: This nuclear gene encodes a mitochondrial matrix protein that appears to contribute to peptide chain termination in the mitochondrial translation machinery. Two different 1 bp deletions (resulting in the same premature stop codon)result in decreased mitochondrial translation, decreased levels of oxidative phosphorylation complexes and encepthalomyopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000253233	RF-1	PF00472.20	7.1e-22	1	1
ENSP00000390647	RF-1	PF00472.20	7.1e-22	1	1
ENSP00000391513	RF-1	PF00472.20	7.1e-22	1	1
ENSP00000444843	RF-1	PF00472.20	3e-20	1	1
ENSP00000441796	RF-1	PF00472.20	1.3e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000253233	C12orf65-201	2073	XM_011538980	ENSP00000253233	166 (aa)	XP_011537282	Q9H3J6
ENST00000543139	C12orf65-207	3733	-	ENSP00000444843	138 (aa)	-	F5H4X5
ENST00000536130	C12orf65-205	604	-	ENSP00000443072	36 (aa)	-	F5H5V8
ENST00000425637	C12orf65-203	1632	-	-	- (aa)	-	-
ENST00000429587	C12orf65-204	1326	-	ENSP00000391513	166 (aa)	-	Q9H3J6
ENST00000546132	C12orf65-208	573	-	ENSP00000441796	96 (aa)	-	F5GWJ6
ENST00000366329	C12orf65-202	1901	XM_005253630	ENSP00000390647	166 (aa)	XP_005253687	Q9H3J6
ENST00000538888	C12orf65-206	727	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000130921's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130921	Schizophrenia	2E-8	23974872

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130921	rs11532322	12	123246876	A	Schizophrenia	23974872	[1.06-1.13]	1.094	EFO_0000692
ENSG00000130921	rs4268544	12	123250227	T	Self-reported math ability	30038396	[0.01-0.019] unit increase	0.0146	EFO_0004875
ENSG00000130921	rs1969355	12	123257514	A	Cognitive performance (MTAG)	30038396	[0.017-0.027] unit decrease	0.0223	EFO_0008354

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130921's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130921	C12orf65	78	65.741	ENSAPOG00000000995	si:ch211-275j6.5	70	64.348	Acanthochromis_polyacanthus
ENSG00000130921	C12orf65	93	71.875	ENSAMEG00000015144	C12orf65	98	76.364	Ailuropoda_melanoleuca
ENSG00000130921	C12orf65	80	66.667	ENSACIG00000001644	si:ch211-275j6.5	74	65.254	Amphilophus_citrinellus
ENSG00000130921	C12orf65	78	66.667	ENSAOCG00000005589	si:ch211-275j6.5	73	65.217	Amphiprion_ocellaris
ENSG00000130921	C12orf65	78	66.667	ENSAPEG00000024618	si:ch211-275j6.5	70	65.217	Amphiprion_percula
ENSG00000130921	C12orf65	78	64.220	ENSATEG00000011661	si:ch211-275j6.5	62	62.931	Anabas_testudineus
ENSG00000130921	C12orf65	70	75.214	ENSAPLG00000016073	C12orf65	85	78.431	Anas_platyrhynchos
ENSG00000130921	C12orf65	99	60.976	ENSACAG00000015561	C12orf65	74	61.379	Anolis_carolinensis
ENSG00000130921	C12orf65	100	96.377	ENSANAG00000022881	C12orf65	100	95.758	Aotus_nancymaae
ENSG00000130921	C12orf65	80	64.545	ENSACLG00000023906	si:ch211-275j6.5	72	63.248	Astatotilapia_calliptera
ENSG00000130921	C12orf65	68	65.957	ENSAMXG00000031765	si:ch211-275j6.5	64	63.462	Astyanax_mexicanus
ENSG00000130921	C12orf65	99	85.455	ENSBTAG00000020503	C17H12orf65	96	85.455	Bos_taurus
ENSG00000130921	C12orf65	98	94.681	ENSCJAG00000016579	C12orf65	100	94.512	Callithrix_jacchus
ENSG00000130921	C12orf65	100	77.108	ENSCAFG00000007512	C26H12orf65	69	77.108	Canis_familiaris
ENSG00000130921	C12orf65	100	77.108	ENSCAFG00020016169	C12orf65	100	77.108	Canis_lupus_dingo
ENSG00000130921	C12orf65	98	84.049	ENSCHIG00000022229	C12orf65	82	82.759	Capra_hircus
ENSG00000130921	C12orf65	96	75.000	ENSCAPG00000014691	C12orf65	79	76.552	Cavia_aperea
ENSG00000130921	C12orf65	96	75.758	ENSCPOG00000007583	C12orf65	79	77.241	Cavia_porcellus
ENSG00000130921	C12orf65	99	96.970	ENSCATG00000040685	C12orf65	99	96.951	Cercocebus_atys
ENSG00000130921	C12orf65	96	78.030	ENSCLAG00000014329	C12orf65	78	79.310	Chinchilla_lanigera
ENSG00000130921	C12orf65	99	96.970	ENSCSAG00000002068	C12orf65	98	96.970	Chlorocebus_sabaeus
ENSG00000130921	C12orf65	99	63.415	ENSCPBG00000025970	C12orf65	88	63.448	Chrysemys_picta_bellii
ENSG00000130921	C12orf65	95	77.863	ENSCGRG00001013424	2810006K23Rik	79	75.862	Cricetulus_griseus_chok1gshd
ENSG00000130921	C12orf65	95	77.863	ENSCGRG00000003037	2810006K23Rik	79	75.862	Cricetulus_griseus_crigri
ENSG00000130921	C12orf65	87	60.331	ENSCSEG00000014536	si:ch211-275j6.5	72	60.305	Cynoglossus_semilaevis
ENSG00000130921	C12orf65	77	62.500	ENSCVAG00000023000	si:ch211-275j6.5	69	62.712	Cyprinodon_variegatus
ENSG00000130921	C12orf65	69	68.421	ENSDARG00000097803	si:ch211-275j6.5	74	65.347	Danio_rerio
ENSG00000130921	C12orf65	96	81.203	ENSDNOG00000034728	C12orf65	87	81.379	Dasypus_novemcinctus
ENSG00000130921	C12orf65	97	79.851	ENSDORG00000026069	2810006K23Rik	83	80.556	Dipodomys_ordii
ENSG00000130921	C12orf65	72	48.485	FBgn0050100	CG30100	73	48.113	Drosophila_melanogaster
ENSG00000130921	C12orf65	84	79.310	ENSETEG00000005627	C12orf65	84	79.412	Echinops_telfairi
ENSG00000130921	C12orf65	98	84.043	ENSEASG00005012587	C12orf65	100	87.952	Equus_asinus_asinus
ENSG00000130921	C12orf65	98	82.979	ENSECAG00000001057	C8H12orf65	100	87.349	Equus_caballus
ENSG00000130921	C12orf65	98	81.053	ENSEEUG00000007231	C12orf65	100	82.036	Erinaceus_europaeus
ENSG00000130921	C12orf65	92	54.430	ENSELUG00000015178	lg13h12orf65	81	54.745	Esox_lucius
ENSG00000130921	C12orf65	100	82.635	ENSFCAG00000015328	C12orf65	100	82.635	Felis_catus
ENSG00000130921	C12orf65	100	58.696	ENSFALG00000009261	C12orf65	88	59.310	Ficedula_albicollis
ENSG00000130921	C12orf65	83	61.345	ENSFHEG00000017567	si:ch211-275j6.5	74	61.600	Fundulus_heteroclitus
ENSG00000130921	C12orf65	71	66.327	ENSGMOG00000012139	si:ch211-275j6.5	71	65.714	Gadus_morhua
ENSG00000130921	C12orf65	95	57.862	ENSGALG00000029390	C15H12ORF65	87	57.534	Gallus_gallus
ENSG00000130921	C12orf65	86	63.333	ENSGACG00000008255	si:ch211-275j6.5	79	61.417	Gasterosteus_aculeatus
ENSG00000130921	C12orf65	98	60.638	ENSGAGG00000000823	C12orf65	98	64.583	Gopherus_agassizii
ENSG00000130921	C12orf65	100	99.398	ENSGGOG00000012850	C12orf65	100	99.398	Gorilla_gorilla
ENSG00000130921	C12orf65	80	64.545	ENSHBUG00000007273	si:ch211-275j6.5	72	63.248	Haplochromis_burtoni
ENSG00000130921	C12orf65	98	71.277	ENSHGLG00000010966	C12orf65	78	77.241	Heterocephalus_glaber_female
ENSG00000130921	C12orf65	98	71.277	ENSHGLG00100018631	C12orf65	78	77.241	Heterocephalus_glaber_male
ENSG00000130921	C12orf65	91	60.145	ENSHCOG00000019848	si:ch211-275j6.5	85	58.621	Hippocampus_comes
ENSG00000130921	C12orf65	80	58.333	ENSIPUG00000020793	si:ch211-275j6.5	58	65.263	Ictalurus_punctatus
ENSG00000130921	C12orf65	98	85.106	ENSSTOG00000016463	C12orf65	83	87.586	Ictidomys_tridecemlineatus
ENSG00000130921	C12orf65	99	78.788	ENSJJAG00000023360	2810006K23Rik	89	78.788	Jaculus_jaculus
ENSG00000130921	C12orf65	78	63.393	ENSKMAG00000018733	si:ch211-275j6.5	74	61.345	Kryptolebias_marmoratus
ENSG00000130921	C12orf65	100	60.284	ENSLACG00000017355	C12orf65	88	58.784	Latimeria_chalumnae
ENSG00000130921	C12orf65	72	67.000	ENSLOCG00000005702	si:ch211-275j6.5	88	65.421	Lepisosteus_oculatus
ENSG00000130921	C12orf65	100	78.313	ENSLAFG00000002134	C12orf65	87	78.621	Loxodonta_africana
ENSG00000130921	C12orf65	99	96.970	ENSMMUG00000031495	C12orf65	99	96.951	Macaca_mulatta
ENSG00000130921	C12orf65	99	96.364	ENSMNEG00000044673	C12orf65	99	96.341	Macaca_nemestrina
ENSG00000130921	C12orf65	99	96.970	ENSMLEG00000044309	C12orf65	99	96.951	Mandrillus_leucophaeus
ENSG00000130921	C12orf65	78	67.290	ENSMAMG00000017366	si:ch211-275j6.5	66	65.789	Mastacembelus_armatus
ENSG00000130921	C12orf65	80	64.545	ENSMZEG00005000938	si:ch211-275j6.5	72	63.248	Maylandia_zebra
ENSG00000130921	C12orf65	78	65.891	ENSMGAG00000003354	C12orf65	82	67.568	Meleagris_gallopavo
ENSG00000130921	C12orf65	98	70.213	ENSMAUG00000010304	2810006K23Rik	97	76.230	Mesocricetus_auratus
ENSG00000130921	C12orf65	98	85.106	ENSMICG00000037138	C12orf65	100	87.952	Microcebus_murinus
ENSG00000130921	C12orf65	97	79.104	ENSMOCG00000017477	2810006K23Rik	79	78.621	Microtus_ochrogaster
ENSG00000130921	C12orf65	76	64.762	ENSMMOG00000017134	si:ch211-275j6.5	65	63.393	Mola_mola
ENSG00000130921	C12orf65	95	67.722	ENSMODG00000012450	C12orf65	84	65.517	Monodelphis_domestica
ENSG00000130921	C12orf65	72	67.000	ENSMALG00000012291	si:ch211-275j6.5	63	65.421	Monopterus_albus
ENSG00000130921	C12orf65	94	77.863	MGP_CAROLIEiJ_G0027747	2810006K23Rik	78	76.552	Mus_caroli
ENSG00000130921	C12orf65	83	83.478	ENSMUSG00000047635	2810006K23Rik	78	78.472	Mus_musculus
ENSG00000130921	C12orf65	83	82.609	MGP_SPRETEiJ_G0028745	2810006K23Rik	78	77.778	Mus_spretus
ENSG00000130921	C12orf65	100	73.913	ENSMPUG00000001679	C12orf65	83	75.172	Mustela_putorius_furo
ENSG00000130921	C12orf65	95	78.981	ENSMLUG00000007001	C12orf65	84	77.698	Myotis_lucifugus
ENSG00000130921	C12orf65	99	76.970	ENSNGAG00000010625	2810006K23Rik	79	77.241	Nannospalax_galili
ENSG00000130921	C12orf65	80	64.545	ENSNBRG00000008082	si:ch211-275j6.5	72	63.248	Neolamprologus_brichardi
ENSG00000130921	C12orf65	100	98.795	ENSNLEG00000001470	C12orf65	100	98.795	Nomascus_leucogenys
ENSG00000130921	C12orf65	95	68.153	ENSMEUG00000009430	C12orf65	92	66.207	Notamacropus_eugenii
ENSG00000130921	C12orf65	100	78.261	ENSOPRG00000011029	C12orf65	90	78.621	Ochotona_princeps
ENSG00000130921	C12orf65	98	79.141	ENSODEG00000011382	-	83	79.310	Octodon_degus
ENSG00000130921	C12orf65	71	69.388	ENSONIG00000013298	si:ch211-275j6.5	63	67.619	Oreochromis_niloticus
ENSG00000130921	C12orf65	97	72.388	ENSOANG00000012866	C12orf65	84	70.345	Ornithorhynchus_anatinus
ENSG00000130921	C12orf65	99	74.453	ENSOCUG00000011888	C12orf65	88	78.740	Oryctolagus_cuniculus
ENSG00000130921	C12orf65	86	61.667	ENSORLG00000006153	si:ch211-275j6.5	74	59.843	Oryzias_latipes
ENSG00000130921	C12orf65	86	61.667	ENSORLG00020017188	si:ch211-275j6.5	74	59.843	Oryzias_latipes_hni
ENSG00000130921	C12orf65	86	61.667	ENSORLG00015005780	c9h12orf65	74	59.843	Oryzias_latipes_hsok
ENSG00000130921	C12orf65	76	67.619	ENSOMEG00000001663	si:ch211-275j6.5	55	71.277	Oryzias_melastigma
ENSG00000130921	C12orf65	98	82.979	ENSOGAG00000010778	C12orf65	89	86.897	Otolemur_garnettii
ENSG00000130921	C12orf65	98	84.049	ENSOARG00000005214	C12orf65	86	82.759	Ovis_aries
ENSG00000130921	C12orf65	100	99.398	ENSPPAG00000029654	C12orf65	100	99.398	Pan_paniscus
ENSG00000130921	C12orf65	100	80.838	ENSPPRG00000024772	C12orf65	100	80.838	Panthera_pardus
ENSG00000130921	C12orf65	100	80.838	ENSPTIG00000011744	C12orf65	100	80.838	Panthera_tigris_altaica
ENSG00000130921	C12orf65	100	98.193	ENSPTRG00000005595	C12H12orf65	100	98.193	Pan_troglodytes
ENSG00000130921	C12orf65	99	96.970	ENSPANG00000015388	C12orf65	99	96.970	Papio_anubis
ENSG00000130921	C12orf65	86	61.017	ENSPKIG00000001571	si:ch211-275j6.5	74	60.800	Paramormyrops_kingsleyae
ENSG00000130921	C12orf65	99	60.976	ENSPSIG00000013010	C12orf65	78	61.379	Pelodiscus_sinensis
ENSG00000130921	C12orf65	76	64.545	ENSPMGG00000018342	si:ch211-275j6.5	69	62.069	Periophthalmus_magnuspinnatus
ENSG00000130921	C12orf65	61	63.095	ENSPMAG00000000514	si:ch211-275j6.5	66	71.233	Petromyzon_marinus
ENSG00000130921	C12orf65	95	67.089	ENSPCIG00000010996	C12orf65	84	64.828	Phascolarctos_cinereus
ENSG00000130921	C12orf65	83	61.345	ENSPLAG00000001661	si:ch211-275j6.5	74	61.600	Poecilia_latipinna
ENSG00000130921	C12orf65	83	61.345	ENSPMEG00000018566	si:ch211-275j6.5	75	61.111	Poecilia_mexicana
ENSG00000130921	C12orf65	83	61.345	ENSPMEG00000009201	si:ch211-275j6.5	75	61.111	Poecilia_mexicana
ENSG00000130921	C12orf65	68	69.149	ENSPREG00000021268	si:ch211-275j6.5	74	60.000	Poecilia_reticulata
ENSG00000130921	C12orf65	100	98.193	ENSPPYG00000005082	C12orf65	100	98.193	Pongo_abelii
ENSG00000130921	C12orf65	88	75.207	ENSPCAG00000016193	C12orf65	87	71.724	Procavia_capensis
ENSG00000130921	C12orf65	98	87.234	ENSPCOG00000021574	C12orf65	93	90.964	Propithecus_coquereli
ENSG00000130921	C12orf65	100	83.133	ENSPVAG00000015301	C12orf65	99	83.133	Pteropus_vampyrus
ENSG00000130921	C12orf65	80	64.545	ENSPNYG00000014456	si:ch211-275j6.5	72	63.248	Pundamilia_nyererei
ENSG00000130921	C12orf65	75	59.677	ENSPNAG00000019769	si:ch211-275j6.5	60	61.765	Pygocentrus_nattereri
ENSG00000130921	C12orf65	95	80.153	ENSRNOG00000001073	RGD1563482	80	77.241	Rattus_norvegicus
ENSG00000130921	C12orf65	100	95.181	ENSRBIG00000040789	C12orf65	100	95.181	Rhinopithecus_bieti
ENSG00000130921	C12orf65	100	94.578	ENSRROG00000031384	C12orf65	98	94.578	Rhinopithecus_roxellana
ENSG00000130921	C12orf65	100	97.101	ENSSBOG00000026629	C12orf65	96	95.732	Saimiri_boliviensis_boliviensis
ENSG00000130921	C12orf65	99	61.818	ENSSHAG00000014988	C12orf65	79	60.690	Sarcophilus_harrisii
ENSG00000130921	C12orf65	80	64.035	ENSSFOG00015019122	si:ch211-275j6.5	69	63.333	Scleropages_formosus
ENSG00000130921	C12orf65	76	64.286	ENSSMAG00000016770	si:ch211-275j6.5	68	65.812	Scophthalmus_maximus
ENSG00000130921	C12orf65	96	54.887	ENSSDUG00000020401	si:ch211-275j6.5	84	55.714	Seriola_dumerili
ENSG00000130921	C12orf65	99	56.934	ENSSLDG00000017638	si:ch211-275j6.5	76	57.639	Seriola_lalandi_dorsalis
ENSG00000130921	C12orf65	99	56.707	ENSSPUG00000012613	C12orf65	88	57.241	Sphenodon_punctatus
ENSG00000130921	C12orf65	77	60.000	ENSSPAG00000023476	si:ch211-275j6.5	72	59.016	Stegastes_partitus
ENSG00000130921	C12orf65	100	77.465	ENSSSCG00000009774	C12orf65	86	82.031	Sus_scrofa
ENSG00000130921	C12orf65	77	63.780	ENSTGUG00000005440	C12orf65	82	67.619	Taeniopygia_guttata
ENSG00000130921	C12orf65	83	58.772	ENSTNIG00000015832	si:ch211-275j6.5	70	57.025	Tetraodon_nigroviridis
ENSG00000130921	C12orf65	98	78.723	ENSTBEG00000012500	C12orf65	100	85.542	Tupaia_belangeri
ENSG00000130921	C12orf65	100	86.232	ENSTTRG00000015880	C12orf65	88	86.897	Tursiops_truncatus
ENSG00000130921	C12orf65	93	72.656	ENSUAMG00000019669	C12orf65	100	76.506	Ursus_americanus
ENSG00000130921	C12orf65	93	72.656	ENSUMAG00000004025	C12orf65	100	77.108	Ursus_maritimus
ENSG00000130921	C12orf65	100	76.506	ENSVVUG00000027811	C12orf65	100	76.506	Vulpes_vulpes
ENSG00000130921	C12orf65	83	61.345	ENSXCOG00000000975	si:ch211-275j6.5	74	61.600	Xiphophorus_couchianus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003747	translation release factor activity	-	IEA	Function
GO:0005739	mitochondrion	20186120.	NAS	Component
GO:0005762	mitochondrial large ribosomal subunit	21873635.	IBA	Component
GO:0006415	translational termination	-	IEA	Process