EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000130939 (Gene tree)
Gene ID: 10277
Gene Symbol: UBE4B
Alias: UBOX3|E4|UFD2|KIAA0684
Full Name: ubiquitination factor E4B
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 148,408 bases
Position: chr1:10,032,832-10,181,239
Accession: 12500
RBP type: non-canonical RBP
Summary: The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000253251	UBE4B-201	4772	XM_017000036	ENSP00000253251	1173 (aa)	XP_016855525	O95155
ENST00000462658	UBE4B-204	573	-	-	- (aa)	-	-
ENST00000377153	UBE4B-203	1273	-	ENSP00000366358	100 (aa)	-	B1AQ61
ENST00000488228	UBE4B-210	560	-	ENSP00000468178	98 (aa)	-	K7ERA7
ENST00000487244	UBE4B-209	818	-	-	- (aa)	-	-
ENST00000466379	UBE4B-206	2299	-	-	- (aa)	-	-
ENST00000343090	UBE4B-202	5267	XM_005263422	ENSP00000343001	1302 (aa)	XP_005263479	O95155
ENST00000465408	UBE4B-205	355	-	-	- (aa)	-	-
ENST00000470736	UBE4B-207	827	-	ENSP00000467258	276 (aa)	-	K7EP75
ENST00000475795	UBE4B-208	871	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000130939's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000130939	Coronary Artery Disease	1.1790000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000130939	rs187585530	1	10107367	A	Atrial fibrillation	29892015	[1.36-1.77]	1.55	EFO_0000275
ENSG00000130939	rs187585530	1	10107367	A	Atrial fibrillation	29892015	[1.36-1.77]	1.55	EFO_0000275
ENSG00000130939	rs12144133	1	10144128	?	White blood cell count	30595370			EFO_0004308

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130939's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000151	ubiquitin ligase complex	11802788.	TAS	Component
GO:0000209	protein polyubiquitination	21873635.	IBA	Process
GO:0003222	ventricular trabecula myocardium morphogenesis	-	IEA	Process
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0006511	ubiquitin-dependent protein catabolic process	11802788.	TAS	Process
GO:0006513	protein monoubiquitination	-	IEA	Process
GO:0008626	granzyme-mediated apoptotic signaling pathway	11802788.	IDA	Process
GO:0009411	response to UV	11802788.	IDA	Process
GO:0019899	enzyme binding	-	ISS	Function
GO:0030433	ubiquitin-dependent ERAD pathway	21873635.	IBA	Process
GO:0031175	neuron projection development	-	IEA	Process
GO:0034450	ubiquitin-ubiquitin ligase activity	21873635.	IBA	Function
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	23509263.	IDA	Process
GO:0051117	ATPase binding	-	IEA	Function
GO:0051865	protein autoubiquitination	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28483517	MicroRNA-1301 suppresses tumor cell migration and invasion by targeting the p53/UBE4B pathway in multiple human cancer cells.	Cancer Lett	2017 Aug 10	Wang B	doi: 10.1016/j.canlet.2017.04.038
12700669	Screening for gene mutations in a 500 kb neuroblastoma tumor suppressor candidate region in chromosome 1p; mutation and stage-specific expression in UBE4B/UFD2.	Oncogene	2003 Apr 17	Krona C	-
24587254	Regulation of p53 level by UBE4B in breast cancer.	PLoS One	2014 Feb 26	Zhang Y	doi: 10.1371/journal.pone.0090154

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	10130727	Missense_Mutation	novel	E609K	0.39
ACC	chr1	10137106	Missense_Mutation	novel	T755M	0.86
BLCA	chr1	10033682	Silent	novel	L4L	0.18
BLCA	chr1	10151485	Silent	novel	Q950Q	0.28
BLCA	chr1	10033621	5'UTR	novel		0.28
BLCA	chr1	10151396	Missense_Mutation	NA	N921D	0.12
BLCA	chr1	10171032	Intron	novel		0.39
BLCA	chr1	10101167	Missense_Mutation	rs760809804	R136Q	0.41
BLCA	chr1	10106233	Silent	novel	F282F	0.44
BLCA	chr1	10171251	Missense_Mutation	novel	K1149N	0.42
BLCA	chr1	10106455	Silent	rs758645417	L356L	0.23
BLCA	chr1	10137071	Silent	rs371708780	G743G	0.18
BLCA	chr1	10072073	Nonsense_Mutation	NA	Q24*	0.19
BLCA	chr1	10171308	Silent	novel	A1168A	0.28
BLCA	chr1	10119583	Missense_Mutation	novel	L470S	0.24
BLCA	chr1	10130559	Silent	novel	L585L	0.34
BLCA	chr1	10106490	Missense_Mutation	NA	S368F	0.16
BLCA	chr1	10179432	Silent	NA	T1239T	0.16
BLCA	chr1	10147073	Silent	novel	L858L	0.31
BLCA	chr1	10106200	Silent	NA	L271L	0.64
BLCA	chr1	10135020	Missense_Mutation	NA	F686L	0.18
BLCA	chr1	10171123	Intron	novel		0.39
BLCA	chr1	10158368	Missense_Mutation	novel	T980I	0.38
BRCA	chr1	10106378	Missense_Mutation	rs372819662	R331C	0.09
BRCA	chr1	10103081	Missense_Mutation	NA	N190S	0.35
BRCA	chr1	10130568	Silent	rs777413135	L588L	0.36
BRCA	chr1	10106200	Silent	NA	L271L	0.23
BRCA	chr1	10033647	5'UTR	novel		0.09
BRCA	chr1	10171306	Missense_Mutation	NA	A1168T	0.28
BRCA	chr1	10117583	Frame_Shift_Ins	NA	*A444Sfs52**	0.29
BRCA	chr1	10101167	Missense_Mutation	rs760809804	R136Q	0.17
BRCA	chr1	10145019	Missense_Mutation	rs750897247	R815C	0.67
BRCA	chr1	10102973	Missense_Mutation	NA	S154C	0.6
BRCA	chr1	10137175	Missense_Mutation	rs781407095	R778H	0.26
BRCA	chr1	10103011	Missense_Mutation	NA	R167S	0.42
BRCA	chr1	10161149	Missense_Mutation	NA	K1021E	0.21
BRCA	chr1	10126862	Silent	rs762850040	F541F	0.29
CESC	chr1	10103030	Missense_Mutation	NA	R173Q	0.26
CESC	chr1	10180870	3'UTR	novel		0.29
CESC	chr1	10135106	Missense_Mutation	rs752526141	R715T	0.28
CESC	chr1	10158375	Frame_Shift_Ins	novel	*T983Nfs3**	0.08
CESC	chr1	10158377	Missense_Mutation	novel	T983S	0.08
CESC	chr1	10137071	Silent	rs371708780	G743G	0.45
CESC	chr1	10132460	Missense_Mutation	novel	N668I	0.44
CESC	chr1	10137163	Missense_Mutation	rs546373910	R774H	0.44
CESC	chr1	10171272	Silent	rs142901446	T1156T	0.15
CESC	chr1	10180317	3'UTR	novel		0.56
CESC	chr1	10033532	5'Flank	novel		0.25
CESC	chr1	10105523	Silent	rs145640349	S196S	0.33
CESC	chr1	10137143	Silent	novel	L767L	0.28
CHOL	chr1	10137166	Missense_Mutation	novel	R775P	0.2
CHOL	chr1	10144976	Nonsense_Mutation	novel	W800*	0.65
CHOL	chr1	10180802	3'UTR	novel		0.4
COAD	chr1	10151561	Missense_Mutation	NA	D976N	0.4
COAD	chr1	10103089	Nonsense_Mutation	NA	E193*	0.38
COAD	chr1	10130514	Silent	NA	R570R	0.07
COAD	chr1	10106531	Missense_Mutation	rs548707778	A382T	0.4
COAD	chr1	10137175	Missense_Mutation	rs781407095	R778H	0.21
COAD	chr1	10103094	Splice_Site	NA	X194_splice	0.33
COAD	chr1	10171178	Missense_Mutation	NA	L1125H	0.6
COAD	chr1	10171246	Missense_Mutation	NA	P1148S	0.3
COAD	chr1	10132410	Silent	NA	G651G	0.33
COAD	chr1	10146972	Missense_Mutation	novel	R825W	0.37
COAD	chr1	10168178	Missense_Mutation	novel	R1081C	0.22
COAD	chr1	10072034	Missense_Mutation	rs761955109	R11W	0.37
COAD	chr1	10137205	Missense_Mutation	NA	R788I	0.46
COAD	chr1	10106374	Silent	NA	R329R	0.34
COAD	chr1	10171152	Frame_Shift_Ins	NA	*L1117Ffs8**	0.36
COAD	chr1	10178690	Missense_Mutation	novel	R1191Q	0.2
COAD	chr1	10179536	Missense_Mutation	rs758014435	T1274M	0.41
COAD	chr1	10137165	Missense_Mutation	NA	R775C	0.1
COAD	chr1	10161163	Silent	novel	R1025R	0.09
COAD	chr1	10132449	Silent	NA	V664V	0.2
COAD	chr1	10119510	Splice_Region	novel		0.39
COAD	chr1	10117555	Silent	rs749053336	I431I	0.18
COAD	chr1	10161220	Silent	NA	S1044S	0.16
COAD	chr1	10149269	Frame_Shift_Del	NA	*F894Lfs19**	0.23
COAD	chr1	10105631	Silent	NA	I232I	0.34
COAD	chr1	10105734	Missense_Mutation	NA	S267P	0.37
COAD	chr1	10147066	Missense_Mutation	rs148514322	R856H	0.36
COAD	chr1	10149282	Splice_Region	novel	Q897delinsHQTTR	0.1
COAD	chr1	10151491	Missense_Mutation	NA	F952L	0.29
COAD	chr1	10130513	Missense_Mutation	rs541907403	R570Q	0.22
ESCA	chr1	10158429	Missense_Mutation	novel	F1000L	0.06
ESCA	chr1	10072050	Missense_Mutation	novel	R16P	0.14
ESCA	chr1	10171204	Missense_Mutation	rs1801442	R1134C	0.35
GBM	chr1	10171108	Intron	novel		0.15
GBM	chr1	10161227	Nonsense_Mutation	NA	R1047*	0.28
GBM	chr1	10132385	Missense_Mutation	novel	I643N	0.15
GBM	chr1	10178808	Silent	novel	D1230D	0.31
GBM	chr1	10132410	Silent	NA	G651G	0.23
GBM	chr1	10106497	Silent	novel	Q370Q	0.5
GBM	chr1	10137158	Missense_Mutation	novel	S772R	0.38
GBM	chr1	10161233	Missense_Mutation	novel	H1049N	0.47
GBM	chr1	10179494	Missense_Mutation	novel	R1260Q	0.15
GBM	chr1	10179476	Missense_Mutation	novel	D1254G	0.08
GBM	chr1	10179961	3'UTR	novel		0.12
HNSC	chr1	10171266	Silent	novel	Q1154Q	0.23
HNSC	chr1	10134991	Missense_Mutation	novel	D677H	0.07
HNSC	chr1	10072166	Missense_Mutation	novel	L55V	0.12
HNSC	chr1	10151460	Missense_Mutation	novel	N942I	0.13
HNSC	chr1	10072099	Silent	novel	P32P	0.29
HNSC	chr1	10033587	5'Flank	novel		0.2
HNSC	chr1	10179935	Silent	NA	E1296E	0.16
HNSC	chr1	10149228	Missense_Mutation	rs770338844	A879V	0.14
HNSC	chr1	10147019	Silent	rs546274495	L840L	0.13
HNSC	chr1	10106389	Silent	novel	T334T	0.23
KIRC	chr1	10161284	Missense_Mutation	rs371058351	R1066W	0.09
KIRC	chr1	10179973	3'UTR	rs778733607		0.43
KIRC	chr1	10178698	In_Frame_Del	novel	G1194del	0.31
KIRC	chr1	10103003	Missense_Mutation	NA	K164T	0.19
KIRC	chr1	10102968	Missense_Mutation	NA	E152D	0.24
KIRC	chr1	10106499	Missense_Mutation	rs375249164	R371K	0.28
KIRP	chr1	10117582	Missense_Mutation	novel	E440D	0.44
KIRP	chr1	10117568	Silent	NA	R436R	0.1
LAML	chr1	10171169	Missense_Mutation	novel	N1122T	0.25
LGG	chr1	10122021	Missense_Mutation	NA	G500D	0.15
LIHC	chr1	10130590	Missense_Mutation	novel	S596C	0.25
LIHC	chr1	10151366	Missense_Mutation	novel	I911V	0.87
LIHC	chr1	10161174	Missense_Mutation	NA	M1029T	0.4
LIHC	chr1	10135147	Missense_Mutation	novel	A729P	0.44
LIHC	chr1	10137147	Missense_Mutation	rs761724316	I769V	0.45
LUAD	chr1	10137083	Silent	NA	P747P	0.42
LUAD	chr1	10180001	3'UTR	rs775930352		0.11
LUAD	chr1	10179542	Frame_Shift_Del	novel	*E1277Cfs8**	0.37
LUAD	chr1	10178714	Missense_Mutation	NA	I1199T	0.26
LUAD	chr1	10130798	Splice_Site	novel	X632_splice	0.2
LUAD	chr1	10171113	Intron	novel		0.19
LUAD	chr1	10106524	Silent	NA	L379L	0.1
LUAD	chr1	10178697	Silent	NA	A1193A	0.43
LUAD	chr1	10151500	Missense_Mutation	novel	M955I	0.23
LUAD	chr1	10033639	5'UTR	novel		0.7
LUAD	chr1	10072181	Missense_Mutation	rs376582075	M60V	0.15
LUAD	chr1	10171052	Intron	novel		0.45
LUAD	chr1	10149226	Silent	NA	A878A	0.2
LUAD	chr1	10137178	Missense_Mutation	NA	R779T	0.17
LUAD	chr1	10168199	Missense_Mutation	NA	A1088S	0.11
LUAD	chr1	10151538	Missense_Mutation	NA	P968L	0.22
LUAD	chr1	10147008	Nonsense_Mutation	NA	E837*	0.27
LUAD	chr1	10135065	Missense_Mutation	novel	I701M	0.22
LUAD	chr1	10147054	Missense_Mutation	NA	Q852L	0.27
LUAD	chr1	10171081	Intron	novel		0.71
LUAD	chr1	10095567	Missense_Mutation	NA	M106I	0.34
LUAD	chr1	10178779	Missense_Mutation	NA	A1221S	0.08
LUAD	chr1	10095551	Nonsense_Mutation	novel	S101*	0.38
LUAD	chr1	10137118	Missense_Mutation	NA	F759C	0.08
LUSC	chr1	10095495	Silent	novel	V82V	0.38
LUSC	chr1	10171037	Intron	novel		0.3
LUSC	chr1	10106324	Missense_Mutation	novel	H313Y	0.27
LUSC	chr1	10105533	Missense_Mutation	novel	D200Y	0.25
LUSC	chr1	10179530	Missense_Mutation	novel	R1272L	0.24
LUSC	chr1	10119590	Silent	rs778728074	L472L	0.47
LUSC	chr1	10180043	3'UTR	novel		0.18
LUSC	chr1	10106219	Missense_Mutation	novel	P278A	0.15
LUSC	chr1	10072168	Silent	novel	L55L	0.18
LUSC	chr1	10168268	Missense_Mutation	novel	P1111A	0.35
LUSC	chr1	10130751	Missense_Mutation	rs374640200	I617V	0.1
LUSC	chr1	10179905	Silent	novel	L1286L	0.42
LUSC	chr1	10168189	Silent	novel	R1084R	0.21
OV	chr1	10178719	Missense_Mutation	novel	I1201L	0.18
OV	chr1	10033643	5'UTR	novel		0.25
OV	chr1	10137120	Missense_Mutation	novel	L760F	0.1
OV	chr1	10179983	3'UTR	novel		0.1
OV	chr1	10151502	Missense_Mutation	novel	I956T	0.06
OV	chr1	10126833	Frame_Shift_Del	novel	*K532Rfs7**	0.22
OV	chr1	10103000	Missense_Mutation	novel	C163S	0.06
OV	chr1	10178700	Silent	NA	G1194G	0.56
OV	chr1	10179960	3'UTR	rs751211114		0.2
OV	chr1	10180005	3'UTR	novel		0.17
PAAD	chr1	10144992	Missense_Mutation	novel	A806T	0.08
PAAD	chr1	10179479	Missense_Mutation	rs767677267	R1255H	0.11
PAAD	chr1	10180098	3'UTR	novel		0.27
PRAD	chr1	10171272	Silent	rs142901446	T1156T	0.26
PRAD	chr1	10171308	Silent	novel	A1168A	0.3
READ	chr1	10171150	Nonsense_Mutation	NA	R1116*	0.44
READ	chr1	10072206	Missense_Mutation	NA	G68D	0.18
READ	chr1	10072132	Silent	rs774747080	A43A	0.24
READ	chr1	10168166	Frame_Shift_Ins	novel	*Q1078Lfs45**	0.43
READ	chr1	10101167	Missense_Mutation	rs760809804	R136Q	0.41
READ	chr1	10117564	Silent	rs762901445	F434F	0.42
READ	chr1	10171090	Intron	novel		0.36
READ	chr1	10105526	Missense_Mutation	NA	D197E	0.31
READ	chr1	10161189	Missense_Mutation	NA	T1034M	0.43
SKCM	chr1	10126843	Missense_Mutation	NA	S535F	0.5
SKCM	chr1	10168202	Silent	NA	L1089L	0.23
SKCM	chr1	10106274	Missense_Mutation	NA	P296L	0.42
SKCM	chr1	10135032	Silent	NA	F690F	0.43
SKCM	chr1	10095516	Silent	NA	P89P	0.06
SKCM	chr1	10121983	Silent	novel	F487F	0.06
SKCM	chr1	10168169	Nonsense_Mutation	NA	Q1078*	0.23
SKCM	chr1	10171305	Silent	rs757111718	F1167F	0.3
SKCM	chr1	10130531	Missense_Mutation	rs755327612	S576F	0.68
SKCM	chr1	10144937	Splice_Region	novel		0.23
SKCM	chr1	10179522	Silent	novel	P1269P	0.47
SKCM	chr1	10171185	Silent	rs147245303	Q1127Q	0.18
SKCM	chr1	10122045	Missense_Mutation	NA	T508I	0.34
SKCM	chr1	10171247	Missense_Mutation	novel	P1148L	0.51
SKCM	chr1	10179953	Missense_Mutation	NA	H1302Q	0.26
SKCM	chr1	10137081	Missense_Mutation	NA	P747S	0.25
SKCM	chr1	10137082	Missense_Mutation	novel	P747L	0.25
SKCM	chr1	10106444	Missense_Mutation	NA	P353S	0.43
SKCM	chr1	10101166	Nonsense_Mutation	NA	R136*	0.37
SKCM	chr1	10171023	Intron	novel		0.21
SKCM	chr1	10168202	Silent	NA	L1089L	0.32
SKCM	chr1	10135099	Missense_Mutation	NA	H713Y	0.71
SKCM	chr1	10119510	Splice_Region	novel		0.57
SKCM	chr1	10168198	Silent	rs758182185	L1087L	0.23
SKCM	chr1	10146973	Missense_Mutation	rs761228558	R825Q	0.35
SKCM	chr1	10151541	Missense_Mutation	NA	S969F	0.96
SKCM	chr1	10135015	Missense_Mutation	novel	G685R	0.47
SKCM	chr1	10144986	Missense_Mutation	rs775692397	P804S	0.09
SKCM	chr1	10106259	Missense_Mutation	rs199643842	P291L	0.17
SKCM	chr1	10168249	Silent	novel	V1104V	0.38
SKCM	chr1	10158423	Silent	NA	T998T	0.93
SKCM	chr1	10106308	Silent	NA	S307S	0.36
SKCM	chr1	10106502	Missense_Mutation	novel	P372L	0.51
SKCM	chr1	10101182	Missense_Mutation	rs374692148	S141N	0.42
SKCM	chr1	10161212	Silent	novel	L1042L	0.39
SKCM	chr1	10179967	3'UTR	rs374151375		0.08
STAD	chr1	10095534	Silent	NA	T95T	0.25
STAD	chr1	10130761	Frame_Shift_Del	novel	*N621Tfs13**	0.29
STAD	chr1	10147007	Silent	rs765004153	D836D	0.3
STAD	chr1	10095533	Missense_Mutation	rs749630439	T95M	0.23
STAD	chr1	10151340	Missense_Mutation	rs200375353	A902V	0.2
STAD	chr1	10179965	3'UTR	rs764484000		0.39
STAD	chr1	10130525	Missense_Mutation	rs754119546	P574L	0.29
STAD	chr1	10106407	Silent	rs762532676	A340A	0.3
STAD	chr1	10117584	Frame_Shift_Del	rs758215455	*A444Hfs14**	0.45
STAD	chr1	10106456	Missense_Mutation	rs772803836	A357T	0.1
STAD	chr1	10119555	Missense_Mutation	rs751961761	R461C	0.2
STAD	chr1	10102956	Silent	NA	S148S	0.3
STAD	chr1	10180018	3'UTR	novel		0.35
STAD	chr1	10137162	Missense_Mutation	rs765404233	R774C	0.24
STAD	chr1	10179419	Missense_Mutation	novel	P1235H	0.15
STAD	chr1	10147007	Silent	rs765004153	D836D	0.48
STAD	chr1	10171151	Missense_Mutation	NA	R1116Q	0.27
STAD	chr1	10132447	Missense_Mutation	novel	V664I	0.12
STAD	chr1	10135137	Silent	rs146689339	T725T	0.44
STAD	chr1	10095525	Missense_Mutation	novel	S92R	0.3
STAD	chr1	10122035	Silent	novel	L505L	0.54
STAD	chr1	10171246	Missense_Mutation	NA	P1148A	0.43
STAD	chr1	10178735	Missense_Mutation	NA	L1206R	0.09
STAD	chr1	10179966	3'UTR	novel		0.44
STAD	chr1	10179426	Missense_Mutation	NA	M1237I	0.4
STAD	chr1	10171223	Missense_Mutation	NA	N1140T	0.29
STAD	chr1	10151558	Missense_Mutation	NA	T975A	0.11
STAD	chr1	10072034	Missense_Mutation	rs761955109	R11W	0.26
STAD	chr1	10072131	Missense_Mutation	NA	A43V	0.17
STAD	chr1	10168189	Silent	novel	R1084R	0.16
STAD	chr1	10106455	Silent	rs758645417	L356L	0.28
STAD	chr1	10095513	Silent	NA	S88S	0.35
STAD	chr1	10137175	Missense_Mutation	rs781407095	R778H	0.09
THCA	chr1	10149282	Splice_Region	novel	Q897delinsHQTTR	0.08
UCEC	chr1	10101175	Missense_Mutation	NA	K139Q	0.31
UCEC	chr1	10145007	Missense_Mutation	NA	E811K	0.38
UCEC	chr1	10171150	Nonsense_Mutation	NA	R1116*	0.08
UCEC	chr1	10180794	3'UTR	novel		0.24
UCEC	chr1	10161174	In_Frame_Ins	novel	L1030_T1035dup	0.19
UCEC	chr1	10106280	Missense_Mutation	rs772153110	R298H	0.48
UCEC	chr1	10106391	Missense_Mutation	NA	V335A	0.23
UCEC	chr1	10181116	3'UTR	novel		0.5
UCEC	chr1	10117556	Missense_Mutation	novel	E432K	0.18
UCEC	chr1	10121992	Silent	rs768817664	P490P	0.33
UCEC	chr1	10102956	Silent	NA	S148S	0.08
UCEC	chr1	10178796	Silent	rs753144500	S1226S	0.3
UCEC	chr1	10180402	3'UTR	novel		0.17
UCEC	chr1	10132445	Missense_Mutation	rs766800561	A663V	0.39
UCEC	chr1	10171028	Intron	novel		0.23
UCEC	chr1	10129404	Missense_Mutation	NA	L551F	0.23
UCEC	chr1	10146997	Missense_Mutation	NA	G833D	0.26
UCEC	chr1	10178688	Missense_Mutation	novel	M1190I	0.08
UCEC	chr1	10103089	Nonsense_Mutation	NA	E193*	0.28
UCEC	chr1	10144970	Missense_Mutation	NA	S798R	0.2
UCEC	chr1	10130513	Missense_Mutation	rs541907403	R570Q	0.19
UCEC	chr1	10151485	Missense_Mutation	novel	Q950H	0.17
UCEC	chr1	10130807	Silent	rs141707832	L635L	0.4
UCEC	chr1	10158406	Missense_Mutation	novel	R993C	0.46
UCEC	chr1	10180802	3'UTR	novel		0.41
UCEC	chr1	10106405	Missense_Mutation	novel	A340T	0.26
UCEC	chr1	10072031	Nonsense_Mutation	novel	R10*	0.48
UCEC	chr1	10101166	Nonsense_Mutation	NA	R136*	0.11
UCEC	chr1	10180681	3'UTR	novel		0.42
UCEC	chr1	10130769	Missense_Mutation	rs777007475	R623C	0.47
UCEC	chr1	10132475	Missense_Mutation	novel	Q673R	0.36
UCEC	chr1	10130551	Missense_Mutation	NA	R583W	0.21
UCEC	chr1	10101179	Missense_Mutation	rs759485063	R140Q	0.29
UCEC	chr1	10179515	Missense_Mutation	rs766812302	T1267M	0.23
UCEC	chr1	10137071	Silent	rs371708780	G743G	0.21
UCEC	chr1	10171205	Missense_Mutation	rs201844344	R1134H	0.35
UCEC	chr1	10180000	3'UTR	rs549045105		0.25
UCEC	chr1	10117584	Frame_Shift_Del	rs758215455	*A444Hfs14**	0.4
UCEC	chr1	10180922	3'UTR	novel		0.47
UCEC	chr1	10095534	Silent	NA	T95T	0.49
UCEC	chr1	10137113	Nonsense_Mutation	novel	C757*	0.41
UCEC	chr1	10180547	3'UTR	novel		0.39
UCEC	chr1	10180648	3'UTR	novel		0.37
UCEC	chr1	10180802	3'UTR	novel		0.41
UCEC	chr1	10103016	Silent	novel	V168V	0.3
UCEC	chr1	10130605	Missense_Mutation	NA	A601T	0.43
UCEC	chr1	10180098	3'UTR	novel		0.2
UCEC	chr1	10151341	Silent	novel	A902A	0.35
UCEC	chr1	10149274	Silent	novel	F894F	0.21
UCEC	chr1	10178797	Missense_Mutation	novel	D1227N	0.35
UCEC	chr1	10180548	3'UTR	novel		0.17
UCEC	chr1	10106469	Missense_Mutation	novel	Q361R	0.35
UCEC	chr1	10106379	Missense_Mutation	rs180983516	R331H	0.41
UCEC	chr1	10161186	Missense_Mutation	novel	D1033G	0.12
UCEC	chr1	10171251	Missense_Mutation	novel	K1149N	0.18
UCEC	chr1	10181080	3'UTR	novel		0.27
UCEC	chr1	10106557	Silent	novel	R390R	0.2
UCEC	chr1	10135089	Silent	rs776093046	T709T	0.19
UCEC	chr1	10151429	Missense_Mutation	novel	A932T	0.07
UCEC	chr1	10179947	Silent	rs140883136	S1300S	0.08
UCEC	chr1	10179519	Frame_Shift_Del	novel	*F1270Sfs6**	0.32
UCEC	chr1	10147037	Missense_Mutation	NA	F846L	0.4
UCEC	chr1	10130744	Silent	NA	G614G	0.38
UCEC	chr1	10171305	Silent	rs757111718	F1167F	0.09
UCEC	chr1	10102975	Missense_Mutation	novel	E155K	0.13
UCEC	chr1	10106383	Silent	NA	P332P	0.38
UCEC	chr1	10180323	3'UTR	novel		0.46
UCEC	chr1	10181059	3'UTR	novel		0.36
UCEC	chr1	10095534	Silent	NA	T95T	0.34
UCEC	chr1	10179490	Missense_Mutation	novel	L1259M	0.34
UCEC	chr1	10180149	3'UTR	novel		0.23
UCEC	chr1	10105601	Silent	novel	F222F	0.48
UCEC	chr1	10106309	Missense_Mutation	novel	T308A	0.39
UCEC	chr1	10105732	Missense_Mutation	novel	S266I	0.1
UCEC	chr1	10146966	Missense_Mutation	novel	L823M	0.29
UCEC	chr1	10171313	Missense_Mutation	novel	A1170D	0.45
UCEC	chr1	10105679	Silent	rs201265548	G248G	0.31
UCEC	chr1	10121980	Silent	novel	S486S	0.36

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.1051	0.00029523
CHOL	DEL	0.8056	3.3987e-23
DLBC	DEL	0.1042	0.011841
HNSC	DEL	0.1379	7.0766e-07
KIRC	DEL	0.1458	2.3538e-09
KIRP	DEL	0.1736	1.462e-09
LUAD	DEL	0.1415	0.0024765
LUSC	DEL	0.3573	2.5882e-07
MESO	DEL	0.3448	2.434e-07
READ	DEL	0.3879	2.1758e-10
TGCT	DEL	0.18	0.00046313
UCS	DEL	0.3036	0.0051125

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
SARC	0.0005	Kaplan-Meier Survival Analysis
ACC	0.0045	Kaplan-Meier Survival Analysis
SKCM	0.027	Kaplan-Meier Survival Analysis
BRCA	0.039	Kaplan-Meier Survival Analysis
CESC	0.047	Kaplan-Meier Survival Analysis
KICH	0.049	Kaplan-Meier Survival Analysis
LIHC	0.0054	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742