EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000130985 (Gene tree)
Gene ID: 7317
Gene Symbol: UBA1
Alias: UBE1X|POC20|CFAP124|A1S9T|GXP1|UBE1
Full Name: ubiquitin like modifier activating enzyme 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 24,329 bases
Position: chrX:47,190,800-47,215,128
Accession: 12469
RBP type: non-canonical RBP
Summary: The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23241214	Putative molecular mechanism underlying sperm chromatin remodelling is regulated by reproductive hormones.	Clin Epigenetics	2012 Dec 17	Gill-Sharma MK	doi: 10.1186/1868-7083-4-23.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000377351	UBA1-203	3466	-	ENSP00000366568	1058 (aa)	-	P22314
ENST00000427561	UBA1-205	671	-	ENSP00000397816	173 (aa)	-	Q5JRS1
ENST00000335972	UBA1-201	3559	XM_005272649	ENSP00000338413	1058 (aa)	XP_005272706	P22314
ENST00000451702	UBA1-207	1706	-	ENSP00000401101	234 (aa)	-	Q5JRS2
ENST00000377269	UBA1-202	2497	-	ENSP00000366481	506 (aa)	-	Q5JRR6
ENST00000442035	UBA1-206	1054	-	ENSP00000389583	284 (aa)	-	Q5JRS0
ENST00000412206	UBA1-204	1148	-	ENSP00000415033	270 (aa)	-	Q5JRR9
ENST00000490869	UBA1-209	917	-	-	- (aa)	-	-
ENST00000457753	UBA1-208	809	-	ENSP00000404796	195 (aa)	-	Q5JRS3

Gene Model

Click here to download ENSG00000130985's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04120	Ubiquitin mediated proteolysis	KEGG
hsa05012	Parkinson disease	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000130985's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000130985	UBA1	100	95.558	ENSMUSG00000001924	Uba1	100	95.558	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000792	heterochromatin	1376922.	IDA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004839	ubiquitin activating enzyme activity	21873635.	IBA	Function
GO:0004839	ubiquitin activating enzyme activity	12629039.21685362.	IDA	Function
GO:0004839	ubiquitin activating enzyme activity	-	TAS	Function
GO:0005515	protein binding	16227972.17956732.22190034.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	1376922.22456334.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	1376922.	IDA	Component
GO:0005739	mitochondrion	1376922.	IDA	Component
GO:0005765	lysosomal membrane	1376922.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006974	cellular response to DNA damage stimulus	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	22456334.	IDA	Process
GO:0010008	endosome membrane	1376922.	IDA	Component
GO:0016567	protein ubiquitination	21873635.	IBA	Process
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0016567	protein ubiquitination	-	TAS	Process
GO:0030057	desmosome	1376922.	IDA	Component
GO:0030867	rough endoplasmic reticulum membrane	1376922.	IDA	Component
GO:0032446	protein modification by small protein conjugation	21873635.	IBA	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.23533145.	HDA	Component