EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000131013 (Gene tree)
Gene ID: 85313
Gene Symbol: PPIL4
Alias: N
Full Name: peptidylprolyl isomerase like 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 41,608 bases
Position: chr6:149,504,495-149,546,102
Accession: 15702
RBP type: canonical RBP
Summary: This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000253329	RRM_1	PF00076.22	7.9e-17	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
11978968	Molecular cloning, structure and expression of a novel nuclear RNA-binding cyclophilin-like gene (PPIL4) from human fetal brain.	Cytogenet Cell Genet	2001	Zeng L	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000253329	PPIL4-201	2232	-	ENSP00000253329	492 (aa)	-	Q8WUA2
ENST00000340881	PPIL4-202	1089	-	ENSP00000344128	127 (aa)	-	Q5T4S2

Gene Model

Click here to download ENSG00000131013's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000131013	Arthritis, Rheumatoid	5E-8	24390342
ENSG00000131013	Arthritis, Rheumatoid	3E-9	24390342

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131013	rs9373594	6	149513438	T	Rheumatoid arthritis	24390342	[1.06-1.12]	1.09	EFO_0000685
ENSG00000131013	rs9373594	6	149513438	T	Rheumatoid arthritis	24390342	[1.07-1.15]	1.11	EFO_0000685
ENSG00000131013	rs9373594	6	149513438	T	Rheumatoid arthritis	30423114	[0.069-0.174] unit increase	0.12164	EFO_0000685
ENSG00000131013	rs9373594	6	149513438	T	Rheumatoid arthritis	30423114	[0.042-0.148] unit increase	0.0949502	EFO_0000685

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131013's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000131013	PPIL4	76	84.140	ENSAPOG00000005904	ppil4	78	84.140	Acanthochromis_polyacanthus
ENSG00000131013	PPIL4	100	97.571	ENSAMEG00000018278	PPIL4	100	97.571	Ailuropoda_melanoleuca
ENSG00000131013	PPIL4	73	86.389	ENSACIG00000006837	ppil4	81	86.389	Amphilophus_citrinellus
ENSG00000131013	PPIL4	77	83.598	ENSAOCG00000014541	ppil4	86	84.409	Amphiprion_ocellaris
ENSG00000131013	PPIL4	100	71.429	ENSAPEG00000004245	ppil4	79	84.409	Amphiprion_percula
ENSG00000131013	PPIL4	81	81.000	ENSATEG00000013141	ppil4	98	86.689	Anabas_testudineus
ENSG00000131013	PPIL4	95	80.384	ENSAPLG00000008437	PPIL4	100	79.531	Anas_platyrhynchos
ENSG00000131013	PPIL4	100	77.846	ENSACAG00000006936	PPIL4	100	77.439	Anolis_carolinensis
ENSG00000131013	PPIL4	100	98.780	ENSANAG00000006499	PPIL4	100	98.780	Aotus_nancymaae
ENSG00000131013	PPIL4	77	82.850	ENSACLG00000018467	ppil4	80	84.722	Astatotilapia_calliptera
ENSG00000131013	PPIL4	74	84.573	ENSAMXG00000014167	ppil4	98	84.228	Astyanax_mexicanus
ENSG00000131013	PPIL4	100	97.561	ENSBTAG00000016980	PPIL4	100	97.561	Bos_taurus
ENSG00000131013	PPIL4	67	60.000	WBGene00000890	sig-7	75	60.748	Caenorhabditis_elegans
ENSG00000131013	PPIL4	100	98.374	ENSCJAG00000019613	PPIL4	100	98.374	Callithrix_jacchus
ENSG00000131013	PPIL4	100	98.171	ENSCAFG00000000379	PPIL4	94	98.171	Canis_familiaris
ENSG00000131013	PPIL4	100	98.171	ENSCAFG00020013550	PPIL4	100	98.171	Canis_lupus_dingo
ENSG00000131013	PPIL4	100	97.764	ENSCHIG00000010600	PPIL4	96	97.764	Capra_hircus
ENSG00000131013	PPIL4	100	97.358	ENSTSYG00000009860	PPIL4	100	97.358	Carlito_syrichta
ENSG00000131013	PPIL4	86	80.541	ENSCAPG00000004550	PPIL4	97	68.103	Cavia_aperea
ENSG00000131013	PPIL4	100	96.545	ENSCPOG00000032871	PPIL4	100	96.545	Cavia_porcellus
ENSG00000131013	PPIL4	100	98.374	ENSCCAG00000022598	PPIL4	100	98.374	Cebus_capucinus
ENSG00000131013	PPIL4	100	98.780	ENSCATG00000039936	PPIL4	100	98.780	Cercocebus_atys
ENSG00000131013	PPIL4	100	96.545	ENSCLAG00000003991	PPIL4	100	96.545	Chinchilla_lanigera
ENSG00000131013	PPIL4	100	98.780	ENSCSAG00000017219	PPIL4	100	98.780	Chlorocebus_sabaeus
ENSG00000131013	PPIL4	66	95.673	ENSCHOG00000000236	PPIL4	74	94.872	Choloepus_hoffmanni
ENSG00000131013	PPIL4	100	81.339	ENSCPBG00000016612	PPIL4	100	81.339	Chrysemys_picta_bellii
ENSG00000131013	PPIL4	97	53.416	ENSCING00000006773	-	71	71.077	Ciona_intestinalis
ENSG00000131013	PPIL4	66	70.821	ENSCSAVG00000010619	-	72	65.538	Ciona_savignyi
ENSG00000131013	PPIL4	100	97.154	ENSCGRG00001019623	Ppil4	100	97.154	Cricetulus_griseus_chok1gshd
ENSG00000131013	PPIL4	100	97.154	ENSCGRG00000003980	Ppil4	100	97.154	Cricetulus_griseus_crigri
ENSG00000131013	PPIL4	100	68.889	ENSCSEG00000015812	ppil4	97	66.388	Cynoglossus_semilaevis
ENSG00000131013	PPIL4	76	85.215	ENSCVAG00000001078	ppil4	79	85.215	Cyprinodon_variegatus
ENSG00000131013	PPIL4	98	70.041	ENSDARG00000043854	ppil4	82	83.914	Danio_rerio
ENSG00000131013	PPIL4	100	97.358	ENSDNOG00000040219	PPIL4	100	97.358	Dasypus_novemcinctus
ENSG00000131013	PPIL4	100	96.545	ENSDORG00000007186	Ppil4	100	96.545	Dipodomys_ordii
ENSG00000131013	PPIL4	100	98.577	ENSEASG00005008935	PPIL4	100	98.577	Equus_asinus_asinus
ENSG00000131013	PPIL4	100	98.374	ENSECAG00000021819	PPIL4	100	98.374	Equus_caballus
ENSG00000131013	PPIL4	95	93.348	ENSEEUG00000000959	PPIL4	100	93.089	Erinaceus_europaeus
ENSG00000131013	PPIL4	100	70.588	ENSELUG00000018746	ppil4	99	67.708	Esox_lucius
ENSG00000131013	PPIL4	100	97.764	ENSFCAG00000046720	PPIL4	100	97.764	Felis_catus
ENSG00000131013	PPIL4	88	78.851	ENSFALG00000013130	PPIL4	99	78.391	Ficedula_albicollis
ENSG00000131013	PPIL4	100	97.154	ENSFDAG00000008146	PPIL4	100	97.154	Fukomys_damarensis
ENSG00000131013	PPIL4	77	83.113	ENSFHEG00000011503	ppil4	80	83.651	Fundulus_heteroclitus
ENSG00000131013	PPIL4	75	79.620	ENSGMOG00000006191	ppil4	92	79.032	Gadus_morhua
ENSG00000131013	PPIL4	100	80.081	ENSGALG00000012364	PPIL4	95	80.488	Gallus_gallus
ENSG00000131013	PPIL4	77	83.069	ENSGAFG00000009521	ppil4	87	83.871	Gambusia_affinis
ENSG00000131013	PPIL4	93	74.348	ENSGACG00000006639	ppil4	99	70.348	Gasterosteus_aculeatus
ENSG00000131013	PPIL4	100	81.339	ENSGAGG00000005926	PPIL4	100	81.339	Gopherus_agassizii
ENSG00000131013	PPIL4	100	99.593	ENSGGOG00000009686	PPIL4	100	99.593	Gorilla_gorilla
ENSG00000131013	PPIL4	77	82.850	ENSHBUG00000021518	ppil4	79	84.530	Haplochromis_burtoni
ENSG00000131013	PPIL4	100	97.764	ENSHGLG00000007609	PPIL4	100	97.764	Heterocephalus_glaber_female
ENSG00000131013	PPIL4	100	97.764	ENSHGLG00100008308	PPIL4	100	97.764	Heterocephalus_glaber_male
ENSG00000131013	PPIL4	100	68.651	ENSIPUG00000006626	PPIL4	98	70.564	Ictalurus_punctatus
ENSG00000131013	PPIL4	100	97.561	ENSSTOG00000013980	PPIL4	100	97.561	Ictidomys_tridecemlineatus
ENSG00000131013	PPIL4	100	91.886	ENSJJAG00000017619	Ppil4	100	91.886	Jaculus_jaculus
ENSG00000131013	PPIL4	76	82.353	ENSKMAG00000014367	ppil4	97	69.182	Kryptolebias_marmoratus
ENSG00000131013	PPIL4	100	69.309	ENSLBEG00000012172	ppil4	95	70.332	Labrus_bergylta
ENSG00000131013	PPIL4	99	74.343	ENSLACG00000016551	PPIL4	97	75.726	Latimeria_chalumnae
ENSG00000131013	PPIL4	85	79.665	ENSLOCG00000017002	ppil4	97	73.849	Lepisosteus_oculatus
ENSG00000131013	PPIL4	100	90.467	ENSLAFG00000026804	PPIL4	100	90.467	Loxodonta_africana
ENSG00000131013	PPIL4	100	98.780	ENSMFAG00000032721	PPIL4	100	98.780	Macaca_fascicularis
ENSG00000131013	PPIL4	100	98.780	ENSMMUG00000023067	PPIL4	100	98.780	Macaca_mulatta
ENSG00000131013	PPIL4	100	98.780	ENSMNEG00000042362	PPIL4	100	98.780	Macaca_nemestrina
ENSG00000131013	PPIL4	100	98.780	ENSMLEG00000041942	PPIL4	100	98.780	Mandrillus_leucophaeus
ENSG00000131013	PPIL4	100	73.022	ENSMAMG00000004525	ppil4	79	84.140	Mastacembelus_armatus
ENSG00000131013	PPIL4	77	82.850	ENSMZEG00005015546	ppil4	80	84.722	Maylandia_zebra
ENSG00000131013	PPIL4	95	78.981	ENSMGAG00000012596	PPIL4	100	79.406	Meleagris_gallopavo
ENSG00000131013	PPIL4	100	97.358	ENSMAUG00000015059	Ppil4	100	97.358	Mesocricetus_auratus
ENSG00000131013	PPIL4	100	89.024	ENSMICG00000006287	PPIL4	100	89.024	Microcebus_murinus
ENSG00000131013	PPIL4	100	97.154	ENSMOCG00000012720	-	100	97.154	Microtus_ochrogaster
ENSG00000131013	PPIL4	100	81.707	ENSMOCG00000000256	-	98	82.114	Microtus_ochrogaster
ENSG00000131013	PPIL4	75	82.016	ENSMMOG00000014859	ppil4	82	82.016	Mola_mola
ENSG00000131013	PPIL4	100	86.179	ENSMODG00000016825	PPIL4	100	86.179	Monodelphis_domestica
ENSG00000131013	PPIL4	100	70.385	ENSMALG00000018887	ppil4	78	84.140	Monopterus_albus
ENSG00000131013	PPIL4	95	96.137	MGP_CAROLIEiJ_G0015103	Ppil4	100	96.138	Mus_caroli
ENSG00000131013	PPIL4	100	96.748	ENSMUSG00000015757	Ppil4	100	96.748	Mus_musculus
ENSG00000131013	PPIL4	100	97.154	MGP_PahariEiJ_G0023722	Ppil4	100	97.154	Mus_pahari
ENSG00000131013	PPIL4	100	96.545	MGP_SPRETEiJ_G0015910	Ppil4	100	96.545	Mus_spretus
ENSG00000131013	PPIL4	100	98.171	ENSMPUG00000018073	PPIL4	100	98.171	Mustela_putorius_furo
ENSG00000131013	PPIL4	100	95.951	ENSMLUG00000002766	PPIL4	100	95.951	Myotis_lucifugus
ENSG00000131013	PPIL4	100	96.748	ENSNGAG00000008801	Ppil4	100	96.748	Nannospalax_galili
ENSG00000131013	PPIL4	77	82.850	ENSNBRG00000010947	ppil4	79	83.871	Neolamprologus_brichardi
ENSG00000131013	PPIL4	83	99.511	ENSNLEG00000015316	PPIL4	96	99.511	Nomascus_leucogenys
ENSG00000131013	PPIL4	79	94.118	ENSOPRG00000005619	PPIL4	80	94.118	Ochotona_princeps
ENSG00000131013	PPIL4	100	96.341	ENSODEG00000002499	PPIL4	100	96.341	Octodon_degus
ENSG00000131013	PPIL4	77	81.510	ENSONIG00000011400	ppil4	92	82.493	Oreochromis_niloticus
ENSG00000131013	PPIL4	99	77.530	ENSOANG00000001063	PPIL4	97	77.500	Ornithorhynchus_anatinus
ENSG00000131013	PPIL4	100	96.748	ENSOCUG00000007696	PPIL4	100	96.748	Oryctolagus_cuniculus
ENSG00000131013	PPIL4	76	85.753	ENSORLG00000015310	ppil4	85	80.978	Oryzias_latipes
ENSG00000131013	PPIL4	76	86.022	ENSORLG00020008558	ppil4	92	89.310	Oryzias_latipes_hni
ENSG00000131013	PPIL4	76	86.022	ENSORLG00015003655	ppil4	92	89.310	Oryzias_latipes_hsok
ENSG00000131013	PPIL4	77	84.433	ENSOMEG00000011713	ppil4	96	88.276	Oryzias_melastigma
ENSG00000131013	PPIL4	93	97.403	ENSOGAG00000014153	-	100	97.403	Otolemur_garnettii
ENSG00000131013	PPIL4	99	82.688	ENSOGAG00000025753	-	96	83.054	Otolemur_garnettii
ENSG00000131013	PPIL4	100	97.764	ENSOARG00000002675	PPIL4	100	97.764	Ovis_aries
ENSG00000131013	PPIL4	100	99.797	ENSPPAG00000042154	PPIL4	100	99.797	Pan_paniscus
ENSG00000131013	PPIL4	100	97.764	ENSPPRG00000004682	PPIL4	100	97.764	Panthera_pardus
ENSG00000131013	PPIL4	98	97.292	ENSPTIG00000014238	PPIL4	81	97.292	Panthera_tigris_altaica
ENSG00000131013	PPIL4	100	99.797	ENSPTRG00000018692	PPIL4	100	99.797	Pan_troglodytes
ENSG00000131013	PPIL4	100	98.780	ENSPANG00000017996	PPIL4	100	98.780	Papio_anubis
ENSG00000131013	PPIL4	99	70.000	ENSPKIG00000019748	ppil4	95	85.172	Paramormyrops_kingsleyae
ENSG00000131013	PPIL4	81	77.889	ENSPSIG00000016651	PPIL4	96	77.865	Pelodiscus_sinensis
ENSG00000131013	PPIL4	91	72.222	ENSPMGG00000002277	ppil4	82	82.927	Periophthalmus_magnuspinnatus
ENSG00000131013	PPIL4	100	97.154	ENSPEMG00000010912	Ppil4	100	97.154	Peromyscus_maniculatus_bairdii
ENSG00000131013	PPIL4	100	85.425	ENSPCIG00000025561	PPIL4	100	85.569	Phascolarctos_cinereus
ENSG00000131013	PPIL4	89	76.765	ENSPFOG00000004145	ppil4	99	70.902	Poecilia_formosa
ENSG00000131013	PPIL4	77	82.895	ENSPLAG00000001207	ppil4	79	84.409	Poecilia_latipinna
ENSG00000131013	PPIL4	77	82.895	ENSPMEG00000009249	ppil4	98	86.254	Poecilia_mexicana
ENSG00000131013	PPIL4	77	82.368	ENSPREG00000020355	ppil4	78	83.871	Poecilia_reticulata
ENSG00000131013	PPIL4	74	98.898	ENSPPYG00000029525	-	99	98.898	Pongo_abelii
ENSG00000131013	PPIL4	95	81.237	ENSPPYG00000017785	-	97	79.515	Pongo_abelii
ENSG00000131013	PPIL4	80	98.795	ENSPCAG00000008203	PPIL4	85	98.795	Procavia_capensis
ENSG00000131013	PPIL4	100	98.780	ENSPCOG00000016997	PPIL4	100	98.780	Propithecus_coquereli
ENSG00000131013	PPIL4	100	97.561	ENSPVAG00000000746	PPIL4	100	97.561	Pteropus_vampyrus
ENSG00000131013	PPIL4	77	82.850	ENSPNYG00000010608	ppil4	80	84.722	Pundamilia_nyererei
ENSG00000131013	PPIL4	100	69.715	ENSPNAG00000002199	ppil4	78	84.946	Pygocentrus_nattereri
ENSG00000131013	PPIL4	100	97.561	ENSRNOG00000015552	Ppil4	100	97.561	Rattus_norvegicus
ENSG00000131013	PPIL4	100	95.935	ENSRBIG00000043467	PPIL4	100	95.935	Rhinopithecus_bieti
ENSG00000131013	PPIL4	100	98.780	ENSRROG00000002923	PPIL4	100	98.780	Rhinopithecus_roxellana
ENSG00000131013	PPIL4	100	98.577	ENSSBOG00000004498	PPIL4	100	98.577	Saimiri_boliviensis_boliviensis
ENSG00000131013	PPIL4	100	84.990	ENSSHAG00000017140	PPIL4	97	85.386	Sarcophilus_harrisii
ENSG00000131013	PPIL4	100	71.660	ENSSFOG00015020750	ppil4	100	71.992	Scleropages_formosus
ENSG00000131013	PPIL4	100	71.341	ENSSMAG00000017653	ppil4	97	85.862	Scophthalmus_maximus
ENSG00000131013	PPIL4	100	70.683	ENSSDUG00000010647	ppil4	81	84.444	Seriola_dumerili
ENSG00000131013	PPIL4	100	70.732	ENSSLDG00000021975	ppil4	81	83.889	Seriola_lalandi_dorsalis
ENSG00000131013	PPIL4	100	90.707	ENSSARG00000011244	PPIL4	100	90.505	Sorex_araneus
ENSG00000131013	PPIL4	67	90.060	ENSSPUG00000005655	PPIL4	72	90.938	Sphenodon_punctatus
ENSG00000131013	PPIL4	100	69.838	ENSSPAG00000017442	ppil4	84	84.722	Stegastes_partitus
ENSG00000131013	PPIL4	100	97.561	ENSSSCG00000028867	PPIL4	100	97.561	Sus_scrofa
ENSG00000131013	PPIL4	100	80.691	ENSTGUG00000010655	-	100	80.285	Taeniopygia_guttata
ENSG00000131013	PPIL4	93	69.584	ENSTRUG00000006670	ppil4	91	84.247	Takifugu_rubripes
ENSG00000131013	PPIL4	78	74.419	ENSTNIG00000002706	ppil4	94	76.882	Tetraodon_nigroviridis
ENSG00000131013	PPIL4	95	74.359	ENSTBEG00000001467	PPIL4	100	74.359	Tupaia_belangeri
ENSG00000131013	PPIL4	100	86.789	ENSTTRG00000006014	PPIL4	100	86.789	Tursiops_truncatus
ENSG00000131013	PPIL4	95	97.868	ENSUMAG00000002774	PPIL4	98	97.868	Ursus_maritimus
ENSG00000131013	PPIL4	100	88.821	ENSVPAG00000005157	PPIL4	100	88.821	Vicugna_pacos
ENSG00000131013	PPIL4	100	97.967	ENSVVUG00000005119	PPIL4	94	97.967	Vulpes_vulpes
ENSG00000131013	PPIL4	100	70.994	ENSXETG00000021385	ppil4	79	85.135	Xenopus_tropicalis
ENSG00000131013	PPIL4	100	69.636	ENSXCOG00000001316	ppil4	81	84.444	Xiphophorus_couchianus
ENSG00000131013	PPIL4	100	69.838	ENSXMAG00000004998	ppil4	83	83.333	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000413	protein peptidyl-prolyl isomerization	-	IEA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain	21873635.	IBA	Process