EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000131368 (Gene tree)
Gene ID: 64432
Gene Symbol: MRPS25
Alias: MRP-S25|FLJ00023|DKFZp313H0817|RPMS25
Full Name: mitochondrial ribosomal protein S25
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 23,085 bases
Position: chr3:15,042,251-15,065,335
Accession: 14511
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000390882	L51_S25_CI-B8	PF05047.16	1.6e-10	1	1
ENSP00000253686	L51_S25_CI-B8	PF05047.16	2.1e-10	1	1
ENSP00000407733	L51_S25_CI-B8	PF05047.16	1.5e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000444840	MRPS25-203	1281	-	ENSP00000407733	129 (aa)	-	P82663
ENST00000253686	MRPS25-201	4586	-	ENSP00000253686	173 (aa)	-	P82663
ENST00000496484	MRPS25-207	823	-	-	- (aa)	-	-
ENST00000447299	MRPS25-204	723	-	ENSP00000402068	110 (aa)	-	E7EPW2
ENST00000449354	MRPS25-205	1119	-	ENSP00000390882	145 (aa)	-	P82663
ENST00000420267	MRPS25-202	590	-	ENSP00000396828	110 (aa)	-	E7EPW2
ENST00000474866	MRPS25-206	540	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000131368's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131368's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000131368	MRPS25	100	80.000	ENSAPOG00000022005	mrps25	100	75.723	Acanthochromis_polyacanthus
ENSG00000131368	MRPS25	99	94.495	ENSAMEG00000004349	MRPS25	100	89.595	Ailuropoda_melanoleuca
ENSG00000131368	MRPS25	100	79.091	ENSACIG00000007796	mrps25	100	74.419	Amphilophus_citrinellus
ENSG00000131368	MRPS25	100	80.000	ENSAOCG00000017022	mrps25	100	75.000	Amphiprion_ocellaris
ENSG00000131368	MRPS25	100	80.000	ENSAPEG00000016566	mrps25	100	75.000	Amphiprion_percula
ENSG00000131368	MRPS25	100	80.909	ENSATEG00000009141	mrps25	100	75.581	Anabas_testudineus
ENSG00000131368	MRPS25	100	97.273	ENSANAG00000036121	MRPS25	100	97.110	Aotus_nancymaae
ENSG00000131368	MRPS25	99	85.321	ENSAMXG00000019894	mrps25	100	75.723	Astyanax_mexicanus
ENSG00000131368	MRPS25	100	95.455	ENSBTAG00000013723	MRPS25	100	88.439	Bos_taurus
ENSG00000131368	MRPS25	100	40.179	WBGene00021920	mrps-25	96	39.759	Caenorhabditis_elegans
ENSG00000131368	MRPS25	100	97.273	ENSCJAG00000017160	MRPS25	100	96.532	Callithrix_jacchus
ENSG00000131368	MRPS25	99	96.330	ENSCAFG00000028683	MRPS25	100	90.751	Canis_familiaris
ENSG00000131368	MRPS25	99	96.330	ENSCAFG00020006345	MRPS25	100	90.751	Canis_lupus_dingo
ENSG00000131368	MRPS25	100	94.545	ENSCHIG00000009931	MRPS25	100	88.439	Capra_hircus
ENSG00000131368	MRPS25	100	97.273	ENSTSYG00000037222	MRPS25	100	93.642	Carlito_syrichta
ENSG00000131368	MRPS25	73	85.827	ENSCAPG00000006099	MRPS25	100	85.827	Cavia_aperea
ENSG00000131368	MRPS25	100	90.909	ENSCPOG00000020398	MRPS25	100	87.283	Cavia_porcellus
ENSG00000131368	MRPS25	100	97.273	ENSCCAG00000029293	MRPS25	100	96.532	Cebus_capucinus
ENSG00000131368	MRPS25	100	99.091	ENSCATG00000042651	MRPS25	100	97.674	Cercocebus_atys
ENSG00000131368	MRPS25	100	89.091	ENSCLAG00000008381	MRPS25	100	85.549	Chinchilla_lanigera
ENSG00000131368	MRPS25	100	99.091	ENSCSAG00000009193	MRPS25	100	97.110	Chlorocebus_sabaeus
ENSG00000131368	MRPS25	100	91.818	ENSCHOG00000006975	-	99	76.744	Choloepus_hoffmanni
ENSG00000131368	MRPS25	100	87.273	ENSCPBG00000014615	MRPS25	99	84.211	Chrysemys_picta_bellii
ENSG00000131368	MRPS25	96	47.706	ENSCING00000004797	-	79	46.667	Ciona_intestinalis
ENSG00000131368	MRPS25	100	99.091	ENSCANG00000037875	MRPS25	100	97.674	Colobus_angolensis_palliatus
ENSG00000131368	MRPS25	97	94.393	ENSCGRG00001016556	Mrps25	100	90.643	Cricetulus_griseus_chok1gshd
ENSG00000131368	MRPS25	97	94.393	ENSCGRG00000014568	Mrps25	100	90.643	Cricetulus_griseus_crigri
ENSG00000131368	MRPS25	100	80.000	ENSCSEG00000021392	mrps25	100	71.512	Cynoglossus_semilaevis
ENSG00000131368	MRPS25	100	80.000	ENSCVAG00000012389	mrps25	100	74.566	Cyprinodon_variegatus
ENSG00000131368	MRPS25	100	80.909	ENSDARG00000041306	mrps25	100	73.988	Danio_rerio
ENSG00000131368	MRPS25	72	93.548	ENSDNOG00000048066	-	98	93.548	Dasypus_novemcinctus
ENSG00000131368	MRPS25	73	88.976	ENSDORG00000026838	Mrps25	100	88.976	Dipodomys_ordii
ENSG00000131368	MRPS25	98	55.963	FBgn0030572	mRpS25	98	54.819	Drosophila_melanogaster
ENSG00000131368	MRPS25	100	97.273	ENSEASG00005015419	MRPS25	72	93.064	Equus_asinus_asinus
ENSG00000131368	MRPS25	100	95.556	ENSECAG00000020841	MRPS25	55	95.556	Equus_caballus
ENSG00000131368	MRPS25	100	77.273	ENSELUG00000023537	mrps25	98	72.781	Esox_lucius
ENSG00000131368	MRPS25	100	93.636	ENSFCAG00000027687	MRPS25	100	90.751	Felis_catus
ENSG00000131368	MRPS25	100	86.364	ENSFALG00000013684	MRPS25	100	82.456	Ficedula_albicollis
ENSG00000131368	MRPS25	100	91.818	ENSFDAG00000006252	MRPS25	100	87.209	Fukomys_damarensis
ENSG00000131368	MRPS25	91	77.000	ENSFHEG00000003470	mrps25	92	73.006	Fundulus_heteroclitus
ENSG00000131368	MRPS25	100	75.455	ENSGMOG00000017071	mrps25	99	72.727	Gadus_morhua
ENSG00000131368	MRPS25	99	85.321	ENSGALG00000008506	MRPS25	99	80.117	Gallus_gallus
ENSG00000131368	MRPS25	100	78.182	ENSGAFG00000021080	mrps25	100	75.723	Gambusia_affinis
ENSG00000131368	MRPS25	100	76.364	ENSGACG00000002961	mrps25	99	74.251	Gasterosteus_aculeatus
ENSG00000131368	MRPS25	100	89.091	ENSGAGG00000012589	MRPS25	99	84.211	Gopherus_agassizii
ENSG00000131368	MRPS25	100	100.000	ENSGGOG00000011005	MRPS25	100	100.000	Gorilla_gorilla
ENSG00000131368	MRPS25	100	78.182	ENSHBUG00000022813	mrps25	100	74.419	Haplochromis_burtoni
ENSG00000131368	MRPS25	100	87.273	ENSHGLG00100005267	MRPS25	100	84.302	Heterocephalus_glaber_male
ENSG00000131368	MRPS25	100	80.000	ENSHCOG00000010210	mrps25	100	73.837	Hippocampus_comes
ENSG00000131368	MRPS25	100	80.909	ENSIPUG00000022462	mrps25	100	72.832	Ictalurus_punctatus
ENSG00000131368	MRPS25	100	93.636	ENSSTOG00000030962	MRPS25	100	87.283	Ictidomys_tridecemlineatus
ENSG00000131368	MRPS25	100	98.182	ENSJJAG00000013413	Mrps25	100	98.182	Jaculus_jaculus
ENSG00000131368	MRPS25	100	80.000	ENSKMAG00000015394	mrps25	100	73.988	Kryptolebias_marmoratus
ENSG00000131368	MRPS25	100	77.273	ENSLBEG00000005216	mrps25	100	73.837	Labrus_bergylta
ENSG00000131368	MRPS25	100	79.091	ENSLACG00000009006	MRPS25	99	73.837	Latimeria_chalumnae
ENSG00000131368	MRPS25	100	75.455	ENSLOCG00000011170	mrps25	100	71.676	Lepisosteus_oculatus
ENSG00000131368	MRPS25	99	88.889	ENSLAFG00000022178	MRPS25	100	88.889	Loxodonta_africana
ENSG00000131368	MRPS25	100	99.091	ENSMFAG00000035383	MRPS25	100	97.674	Macaca_fascicularis
ENSG00000131368	MRPS25	100	99.091	ENSMMUG00000005157	MRPS25	100	97.674	Macaca_mulatta
ENSG00000131368	MRPS25	100	99.091	ENSMNEG00000034531	MRPS25	100	97.674	Macaca_nemestrina
ENSG00000131368	MRPS25	100	99.091	ENSMLEG00000031574	MRPS25	100	97.674	Mandrillus_leucophaeus
ENSG00000131368	MRPS25	100	77.273	ENSMAMG00000013121	mrps25	100	73.256	Mastacembelus_armatus
ENSG00000131368	MRPS25	100	78.182	ENSMZEG00005000200	mrps25	100	74.419	Maylandia_zebra
ENSG00000131368	MRPS25	98	69.412	ENSMGAG00000010421	MRPS25	99	69.412	Meleagris_gallopavo
ENSG00000131368	MRPS25	100	85.455	ENSMICG00000040033	-	99	82.249	Microcebus_murinus
ENSG00000131368	MRPS25	75	87.805	ENSMICG00000045033	-	99	90.123	Microcebus_murinus
ENSG00000131368	MRPS25	97	94.393	ENSMOCG00000000775	Mrps25	100	90.643	Microtus_ochrogaster
ENSG00000131368	MRPS25	100	81.818	ENSMMOG00000021174	mrps25	100	81.818	Mola_mola
ENSG00000131368	MRPS25	100	90.000	ENSMODG00000007018	MRPS25	75	86.705	Monodelphis_domestica
ENSG00000131368	MRPS25	100	74.545	ENSMALG00000021413	mrps25	100	70.349	Monopterus_albus
ENSG00000131368	MRPS25	97	93.458	MGP_CAROLIEiJ_G0028662	Mrps25	100	89.474	Mus_caroli
ENSG00000131368	MRPS25	97	93.458	ENSMUSG00000014551	Mrps25	100	89.474	Mus_musculus
ENSG00000131368	MRPS25	97	93.458	MGP_PahariEiJ_G0022409	Mrps25	100	89.474	Mus_pahari
ENSG00000131368	MRPS25	100	97.273	ENSMPUG00000017248	MRPS25	100	92.486	Mustela_putorius_furo
ENSG00000131368	MRPS25	100	94.545	ENSMLUG00000017504	-	100	91.329	Myotis_lucifugus
ENSG00000131368	MRPS25	100	91.071	ENSMLUG00000022193	-	100	89.565	Myotis_lucifugus
ENSG00000131368	MRPS25	100	94.545	ENSNGAG00000021861	Mrps25	99	91.124	Nannospalax_galili
ENSG00000131368	MRPS25	100	78.182	ENSNBRG00000019573	mrps25	100	74.419	Neolamprologus_brichardi
ENSG00000131368	MRPS25	91	98.734	ENSNLEG00000031537	MRPS25	100	98.734	Nomascus_leucogenys
ENSG00000131368	MRPS25	100	93.636	ENSOPRG00000009370	MRPS25	100	91.908	Ochotona_princeps
ENSG00000131368	MRPS25	100	92.727	ENSODEG00000001966	MRPS25	100	88.439	Octodon_degus
ENSG00000131368	MRPS25	100	78.182	ENSONIG00000017238	mrps25	100	74.419	Oreochromis_niloticus
ENSG00000131368	MRPS25	100	89.091	ENSOANG00000021369	MRPS25	100	86.127	Ornithorhynchus_anatinus
ENSG00000131368	MRPS25	100	94.545	ENSOCUG00000006984	MRPS25	100	91.908	Oryctolagus_cuniculus
ENSG00000131368	MRPS25	100	78.182	ENSORLG00000010890	mrps25	100	72.832	Oryzias_latipes
ENSG00000131368	MRPS25	100	77.273	ENSORLG00020020489	mrps25	100	72.254	Oryzias_latipes_hni
ENSG00000131368	MRPS25	100	78.182	ENSORLG00015015827	mrps25	100	73.410	Oryzias_latipes_hsok
ENSG00000131368	MRPS25	100	78.182	ENSOMEG00000009352	mrps25	100	71.676	Oryzias_melastigma
ENSG00000131368	MRPS25	100	90.909	ENSOGAG00000014041	MRPS25	100	89.595	Otolemur_garnettii
ENSG00000131368	MRPS25	100	94.545	ENSOARG00000017225	MRPS25	100	94.545	Ovis_aries
ENSG00000131368	MRPS25	100	100.000	ENSPPAG00000039324	MRPS25	100	100.000	Pan_paniscus
ENSG00000131368	MRPS25	99	94.495	ENSPPRG00000013901	MRPS25	100	91.329	Panthera_pardus
ENSG00000131368	MRPS25	99	94.495	ENSPTIG00000016698	MRPS25	100	91.329	Panthera_tigris_altaica
ENSG00000131368	MRPS25	100	100.000	ENSPTRG00000014658	MRPS25	100	100.000	Pan_troglodytes
ENSG00000131368	MRPS25	100	99.091	ENSPANG00000029339	MRPS25	100	97.674	Papio_anubis
ENSG00000131368	MRPS25	100	80.000	ENSPKIG00000011826	mrps25	100	73.837	Paramormyrops_kingsleyae
ENSG00000131368	MRPS25	100	90.000	ENSPSIG00000008882	MRPS25	100	81.977	Pelodiscus_sinensis
ENSG00000131368	MRPS25	100	78.182	ENSPMGG00000019549	mrps25	100	73.837	Periophthalmus_magnuspinnatus
ENSG00000131368	MRPS25	97	93.458	ENSPEMG00000015595	Mrps25	100	90.058	Peromyscus_maniculatus_bairdii
ENSG00000131368	MRPS25	99	65.455	ENSPMAG00000001827	mrps25	99	62.791	Petromyzon_marinus
ENSG00000131368	MRPS25	97	87.850	ENSPCIG00000023530	-	100	84.393	Phascolarctos_cinereus
ENSG00000131368	MRPS25	100	79.279	ENSPFOG00000011720	mrps25	100	75.287	Poecilia_formosa
ENSG00000131368	MRPS25	100	80.000	ENSPLAG00000013689	mrps25	100	75.723	Poecilia_latipinna
ENSG00000131368	MRPS25	100	80.000	ENSPMEG00000019743	mrps25	100	75.723	Poecilia_mexicana
ENSG00000131368	MRPS25	100	80.000	ENSPREG00000016711	mrps25	100	75.723	Poecilia_reticulata
ENSG00000131368	MRPS25	100	98.266	ENSPPYG00000013409	MRPS25	100	98.266	Pongo_abelii
ENSG00000131368	MRPS25	100	95.455	ENSPCAG00000011135	MRPS25	100	92.486	Procavia_capensis
ENSG00000131368	MRPS25	100	78.182	ENSPNYG00000010498	mrps25	100	74.419	Pundamilia_nyererei
ENSG00000131368	MRPS25	100	80.000	ENSPNAG00000000160	mrps25	100	72.832	Pygocentrus_nattereri
ENSG00000131368	MRPS25	97	91.589	ENSRNOG00000010912	Mrps25	100	88.304	Rattus_norvegicus
ENSG00000131368	MRPS25	100	99.091	ENSRBIG00000012859	MRPS25	100	97.674	Rhinopithecus_bieti
ENSG00000131368	MRPS25	100	99.091	ENSRROG00000034718	MRPS25	100	97.674	Rhinopithecus_roxellana
ENSG00000131368	MRPS25	100	96.364	ENSSBOG00000035105	-	100	96.124	Saimiri_boliviensis_boliviensis
ENSG00000131368	MRPS25	100	87.283	ENSSBOG00000032606	-	100	87.283	Saimiri_boliviensis_boliviensis
ENSG00000131368	MRPS25	100	90.000	ENSSHAG00000016039	MRPS25	100	87.861	Sarcophilus_harrisii
ENSG00000131368	MRPS25	98	81.481	ENSSFOG00015016016	mrps25	100	75.000	Scleropages_formosus
ENSG00000131368	MRPS25	100	79.091	ENSSMAG00000012013	mrps25	100	73.837	Scophthalmus_maximus
ENSG00000131368	MRPS25	100	79.091	ENSSDUG00000012983	mrps25	100	72.674	Seriola_dumerili
ENSG00000131368	MRPS25	100	79.091	ENSSLDG00000004856	mrps25	100	72.674	Seriola_lalandi_dorsalis
ENSG00000131368	MRPS25	100	82.727	ENSSPUG00000017201	MRPS25	100	78.613	Sphenodon_punctatus
ENSG00000131368	MRPS25	100	79.091	ENSSPAG00000011672	mrps25	100	73.256	Stegastes_partitus
ENSG00000131368	MRPS25	99	95.413	ENSSSCG00000034318	MRPS25	100	92.486	Sus_scrofa
ENSG00000131368	MRPS25	100	87.273	ENSTGUG00000010579	MRPS25	100	81.871	Taeniopygia_guttata
ENSG00000131368	MRPS25	100	79.091	ENSTRUG00000011566	mrps25	100	72.093	Takifugu_rubripes
ENSG00000131368	MRPS25	100	75.455	ENSTNIG00000017920	mrps25	100	70.930	Tetraodon_nigroviridis
ENSG00000131368	MRPS25	72	86.400	ENSTBEG00000002596	MRPS25	98	86.400	Tupaia_belangeri
ENSG00000131368	MRPS25	99	92.661	ENSTTRG00000009881	MRPS25	100	90.751	Tursiops_truncatus
ENSG00000131368	MRPS25	99	94.495	ENSUAMG00000002002	MRPS25	80	89.595	Ursus_americanus
ENSG00000131368	MRPS25	99	94.495	ENSUMAG00000017301	MRPS25	80	89.595	Ursus_maritimus
ENSG00000131368	MRPS25	99	95.413	ENSVVUG00000013846	MRPS25	100	90.751	Vulpes_vulpes
ENSG00000131368	MRPS25	100	84.545	ENSXETG00000004816	mrps25	99	79.651	Xenopus_tropicalis
ENSG00000131368	MRPS25	70	83.471	ENSXETG00000000318	-	99	78.906	Xenopus_tropicalis
ENSG00000131368	MRPS25	100	80.000	ENSXCOG00000001254	mrps25	100	80.000	Xiphophorus_couchianus
ENSG00000131368	MRPS25	100	79.091	ENSXMAG00000023324	mrps25	100	76.301	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	21873635.	IBA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005840	ribosome	-	IEA	Component
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process