EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000131473 (Gene tree)
Gene ID: 47
Gene Symbol: ACLY
Alias: ATPCL|CLATP|ACL
Full Name: ATP citrate lyase
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 63,635 bases
Position: chr17:41,866,908-41,930,542
Accession: 115
RBP type: non-canonical RBP
Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21204617	Ionising radiation triggers fat accumulation in white adipose tissue.	Int J Radiat Biol	2011 Mar	Jo SK	doi: 10.3109/09553002.2010.537429
31137884	Cyanidin-3-O-galactoside-enriched Aronia melanocarpa extract attenuates weight gain and adipogenic pathways in high-fat diet-induced obese C57BL/6 mice.	Nutrients	2019 May 27	Lim SM	doi: 10.3390/nu11051190.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000592970	ACLY-210	540	-	ENSP00000468705	109 (aa)	-	K7ESG8
ENST00000590151	ACLY-207	4309	XM_005257395	ENSP00000466259	1101 (aa)	XP_005257452	P53396
ENST00000590735	ACLY-208	586	-	-	- (aa)	-	-
ENST00000537919	ACLY-204	2974	-	ENSP00000445349	830 (aa)	-	P53396
ENST00000588547	ACLY-205	471	-	-	- (aa)	-	-
ENST00000588779	ACLY-206	783	-	-	- (aa)	-	-
ENST00000393896	ACLY-203	3682	-	ENSP00000377474	1091 (aa)	-	P53396
ENST00000352035	ACLY-201	4339	-	ENSP00000253792	1101 (aa)	-	P53396
ENST00000353196	ACLY-202	4318	XM_017024688	ENSP00000345398	1091 (aa)	XP_016880177	P53396
ENST00000590770	ACLY-209	583	-	ENSP00000464717	133 (aa)	-	K7EIE7

Gene Model

Click here to download ENSG00000131473's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00020	Citrate cycle (TCA cycle)	KEGG
hsa01100	Metabolic pathways	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131473	rs4796622	17	41921971	G	High light scatter reticulocyte percentage of red cells	27863252	[0.043-0.068] unit increase	0.05538642	EFO_0007986
ENSG00000131473	rs7209507	17	41871398	?	Mean corpuscular hemoglobin	30595370			EFO_0004527

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131473's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000131473	ACLY	99	65.676	WBGene00016995	acly-1	99	60.270	Caenorhabditis_elegans
ENSG00000131473	ACLY	99	72.297	FBgn0020236	ATPCL	99	70.228	Drosophila_melanogaster
ENSG00000131473	ACLY	100	99.248	ENSMUSG00000020917	Acly	100	98.093	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003878	ATP citrate synthase activity	21873635.	IBA	Function
GO:0003878	ATP citrate synthase activity	1371749.	IDA	Function
GO:0003878	ATP citrate synthase activity	23932781.	TAS	Function
GO:0005515	protein binding	23932781.	IPI	Function
GO:0005524	ATP binding	1371749.	TAS	Function
GO:0005576	extracellular region	-	TAS	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006085	acetyl-CoA biosynthetic process	21873635.	IBA	Process
GO:0006085	acetyl-CoA biosynthetic process	1371749.	IDA	Process
GO:0006101	citrate metabolic process	1371749.	IDA	Process
GO:0006107	oxaloacetate metabolic process	1371749.	IDA	Process
GO:0006633	fatty acid biosynthetic process	21873635.	IBA	Process
GO:0006695	cholesterol biosynthetic process	1371749.	TAS	Process
GO:0008610	lipid biosynthetic process	23932781.	IDA	Process
GO:0009346	citrate lyase complex	21873635.	IBA	Component
GO:0015936	coenzyme A metabolic process	1371749.	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0031325	positive regulation of cellular metabolic process	-	TAS	Process
GO:0035578	azurophil granule lumen	-	TAS	Component
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0046949	fatty-acyl-CoA biosynthetic process	-	TAS	Process
GO:0048037	cofactor binding	-	IEA	Function
GO:0070062	extracellular exosome	19056867.20458337.23533145.	HDA	Component
GO:1904813	ficolin-1-rich granule lumen	-	TAS	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
26928812	Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells.	Cancer Res	2016 Apr 15	Lucenay KS	doi: 10.1158/0008-5472.CAN-15-1646
28443474	ATP citrate lyase is increased in human breast cancer, depletion of which promotes apoptosis.	Tumour Biol	2017 Apr	Wang D	doi: 10.1177/1010428317698338.
28901466	miR-133b acts as a tumor suppressor and negatively regulates ATP citrate lyase via PPARγ in gastric cancer.	Oncol Rep	2017 Nov	Cheng Y	doi: 10.3892/or.2017.5944
21726077	The lipogenesis pathway as a cancer target.	J Med Chem	2011 Aug 25	Abramson HN	doi: 10.1021/jm2005805
24132143	ATP citrate lyase mediates resistance of colorectal cancer cells to SN38.	Mol Cancer Ther	2013 Dec	Zhou Y	doi: 10.1158/1535-7163.MCT-13-0098
23807225	ATP citrate lyase knockdown impacts cancer stem cells in vitro.	Cell Death Dis	2013 Jun 27	Hanai JI	doi: 10.1038/cddis.2013.215.
22718913	ATP citrate lyase knockdown induces growth arrest and apoptosis through different cell- and environment-dependent mechanisms.	Mol Cancer Ther	2012 Sep	Zaidi N	doi: 10.1158/1535-7163.MCT-12-0095
22787121	ATP-citrate lyase: a key player in cancer metabolism.	Cancer Res	2012 Aug 1	Zaidi N	doi: 10.1158/0008-5472.CAN-11-4112
25890184	Functional polymorphisms of ATP citrate lyase gene predicts clinical outcome of patients with advanced colorectal cancer.	World J Surg Oncol	2015 Feb 12	Xie S	doi: 10.1186/s12957-015-0440-x.
18922930	ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.	Cancer Res	2008 Oct 15	Migita T	doi: 10.1158/0008-5472.CAN-08-1235.
22266777	Prognostic and therapeutic implications of increased ATP citrate lyase expression in human epithelial ovarian cancer.	Oncol Rep	2012 Apr	Wang Y	doi: 10.3892/or.2012.1638

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	41897786	Silent	novel	V464V	0.5
BLCA	chr17	41869478	Missense_Mutation	novel	S1016L	0.3
BLCA	chr17	41898769	Silent	novel	I400I	0.22
BLCA	chr17	41901755	Missense_Mutation	novel	I375S	0.53
BLCA	chr17	41893119	Silent	novel	Q505Q	0.11
BLCA	chr17	41886174	Silent	novel	L670L	0.25
BLCA	chr17	41869111	Missense_Mutation	NA	I1022M	0.05
BLCA	chr17	41884256	Silent	novel	F697F	0.2
BLCA	chr17	41905530	Missense_Mutation	novel	H332L	0.35
BLCA	chr17	41912447	Silent	NA	L85L	0.21
BLCA	chr17	41913820	Silent	NA	F18F	0.13
BLCA	chr17	41878853	Silent	novel	L779L	0.07
BLCA	chr17	41913777	Missense_Mutation	rs148951948	R33G	0.44
BLCA	chr17	41869495	Silent	NA	V1010V	0.31
BLCA	chr17	41883233	Splice_Site	NA	X719_splice	0.41
BLCA	chr17	41913772	Silent	novel	V34V	0.07
BLCA	chr17	41871719	Silent	novel	L969L	0.29
BLCA	chr17	41886194	Nonsense_Mutation	novel	G664*	0.16
BRCA	chr17	41909632	Silent	rs782319779	G138G	0.1
BRCA	chr17	41871828	Missense_Mutation	novel	D933G	0.12
BRCA	chr17	41873910	Missense_Mutation	NA	R848Q	0.36
BRCA	chr17	41909001	Missense_Mutation	NA	I202F	0.34
BRCA	chr17	41886111	Splice_Site	NA	X691_splice	0.4
BRCA	chr17	41869529	Missense_Mutation	NA	P999L	0.29
CESC	chr17	41897794	Missense_Mutation	rs782078720	D462N	0.14
CESC	chr17	41909555	Missense_Mutation	novel	D164V	0.08
CESC	chr17	41893150	Missense_Mutation	rs387907386	R495H	0.47
CESC	chr17	41872081	Missense_Mutation	novel	R915Q	0.2
CESC	chr17	41886131	Missense_Mutation	novel	V685M	0.18
CESC	chr17	41913852	Missense_Mutation	novel	E8Q	0.18
CESC	chr17	41898705	Missense_Mutation	NA	R422W	0.17
CESC	chr17	41905553	Silent	NA	L324L	0.58
CESC	chr17	41913869	Missense_Mutation	rs781941291	S2L	0.35
CESC	chr17	41869108	Silent	NA	L1023L	0.39
CESC	chr17	41867174	3'UTR	novel		0.31
CHOL	chr17	41893137	Silent	novel	A499A	0.6
COAD	chr17	41867610	3'UTR	novel		0.56
COAD	chr17	41905546	Missense_Mutation	NA	M327V	0.19
COAD	chr17	41893039	Missense_Mutation	novel	P532H	0.3
COAD	chr17	41901812	Missense_Mutation	novel	G356D	0.26
COAD	chr17	41901801	Missense_Mutation	novel	A360T	0.06
COAD	chr17	41872124	Missense_Mutation	NA	G901R	0.37
COAD	chr17	41884268	Silent	rs140674334	P693P	0.24
COAD	chr17	41869571	Missense_Mutation	NA	M985T	0.42
COAD	chr17	41913845	Missense_Mutation	rs200879681	T10M	0.42
COAD	chr17	41867610	3'UTR	novel		0.53
COAD	chr17	41886227	Missense_Mutation	rs565573136	R653C	0.11
COAD	chr17	41907462	Missense_Mutation	novel	G243W	0.07
COAD	chr17	41907459	Missense_Mutation	NA	R244W	0.47
COAD	chr17	41886194	Missense_Mutation	NA	G664R	0.29
COAD	chr17	41867795	3'UTR	novel		0.7
COAD	chr17	41867820	Missense_Mutation	NA	M1099T	0.37
COAD	chr17	41905635	Frame_Shift_Del	novel	*G297Vfs31**	0.32
COAD	chr17	41867833	Missense_Mutation	novel	L1095I	0.07
COAD	chr17	41897814	Missense_Mutation	NA	S455Y	0.24
COAD	chr17	41868754	Missense_Mutation	NA	A1056T	0.19
COAD	chr17	41901756	Missense_Mutation	rs188073019	I375V	0.2
COAD	chr17	41886194	Missense_Mutation	NA	G664R	0.47
ESCA	chr17	41871731	Missense_Mutation	novel	K965N	0.21
GBM	chr17	41878856	Silent	novel	A778A	0.05
GBM	chr17	41871826	Missense_Mutation	novel	R934W	0.38
GBM	chr17	41910223	Missense_Mutation	novel	Q115L	0.09
GBM	chr17	41892388	Missense_Mutation	novel	K554R	0.09
GBM	chr17	41907498	Missense_Mutation	novel	V231L	0.16
HNSC	chr17	41896640	Missense_Mutation	novel	P480R	0.24
HNSC	chr17	41878814	Silent	novel	E792E	0.13
HNSC	chr17	41907463	Silent	rs782400219	F242F	0.06
HNSC	chr17	41886191	Missense_Mutation	novel	G665S	0.18
HNSC	chr17	41901769	Silent	novel	E370E	0.23
KICH	chr17	41893173	Splice_Region	novel	G487G	0.73
KIRC	chr17	41871781	Missense_Mutation	novel	A949T	0.3
KIRC	chr17	41897806	Nonsense_Mutation	NA	E458*	0.1
KIRC	chr17	41904789	Splice_Region	NA	G335G	0.17
KIRC	chr17	41893042	Missense_Mutation	NA	Y531S	0.28
KIRP	chr17	41906549	Missense_Mutation	novel	G282V	0.28
KIRP	chr17	41892408	Missense_Mutation	NA	E547D	0.38
KIRP	chr17	41868770	Silent	NA	E1050E	0.24
KIRP	chr17	41897837	Splice_Region	novel	T447T	0.41
LAML	chr17	41871737	Missense_Mutation	novel	M963I	0.04
LGG	chr17	41873905	Nonsense_Mutation	NA	Q850*	0.21
LGG	chr17	41884256	Missense_Mutation	NA	F697L	0.46
LGG	chr17	41904736	Missense_Mutation	novel	T353M	0.4
LGG	chr17	41909605	Silent	NA	A147A	0.13
LIHC	chr17	41872147	Missense_Mutation	NA	C893Y	0.2
LIHC	chr17	41873825	Silent	novel	L876L	0.18
LIHC	chr17	41893107	Silent	novel	V509V	0.27
LIHC	chr17	41907556	Frame_Shift_Ins	novel	*V212Sfs5**	0.43
LIHC	chr17	41868736	Missense_Mutation	NA	V1062M	0.4
LUAD	chr17	41907466	Silent	NA	P241P	0.23
LUAD	chr17	41913791	Missense_Mutation	novel	R28L	0.05
LUAD	chr17	41913858	Missense_Mutation	rs367736290	I6V	0.11
LUAD	chr17	41873904	Missense_Mutation	NA	Q850L	0.1
LUAD	chr17	41878186	Missense_Mutation	novel	E802K	0.09
LUSC	chr17	41892323	Missense_Mutation	novel	R576C	0.5
LUSC	chr17	41906625	Missense_Mutation	novel	D257H	0.19
LUSC	chr17	41884236	Missense_Mutation	rs782683248	Y704S	0.47
LUSC	chr17	41873910	Missense_Mutation	NA	R848Q	0.28
LUSC	chr17	41873816	Silent	NA	Q879Q	0.18
LUSC	chr17	41892377	Missense_Mutation	NA	D558N	0.24
LUSC	chr17	41893070	Missense_Mutation	novel	D522H	0.28
OV	chr17	41913745	Missense_Mutation	NA	L43F	0.72
OV	chr17	41912442	Frame_Shift_Del	novel	*P87Hfs20**	0.08
OV	chr17	41909039	Missense_Mutation	novel	F189S	0.11
OV	chr17	41913841	Silent	novel	G11G	0.31
OV	chr17	41883137	Silent	novel	T750T	0.12
OV	chr17	41906535	Missense_Mutation	rs369798437	V287M	0.04
OV	chr17	41907523	Silent	rs782814333	D222D	0.49
OV	chr17	41868777	Missense_Mutation	NA	A1048G	0.45
OV	chr17	41867809	3'UTR	novel		0.08
PAAD	chr17	41873937	Missense_Mutation	rs782729574	S839L	0.37
PAAD	chr17	41884239	Missense_Mutation	novel	R703H	0.21
PAAD	chr17	41892322	Missense_Mutation	novel	R576H	0.15
PAAD	chr17	41906536	Silent	rs115877497	V286V	0.17
PCPG	chr17	41892289	Missense_Mutation	novel	N587I	0.19
PRAD	chr17	41878178	Silent	rs35022178	L804L	0.19
PRAD	chr17	41906615	Missense_Mutation	novel	S260N	0.41
READ	chr17	41869546	Silent	rs144346203	Y993Y	0.4
READ	chr17	41907463	Silent	rs782400219	F242F	0.46
READ	chr17	41872029	Splice_Region	NA		0.32
READ	chr17	41878145	Silent	novel	E815E	0.3
SARC	chr17	41909006	Missense_Mutation	novel	L200R	0.17
SARC	chr17	41878173	Missense_Mutation	novel	A806D	0.11
SARC	chr17	41892410	Missense_Mutation	novel	E547K	0.54
SARC	chr17	41918985	5'UTR	novel		0.26
SARC	chr17	41869480	Silent	novel	T1015T	0.38
SKCM	chr17	41887693	Missense_Mutation	NA	I594S	0.39
SKCM	chr17	41907470	Missense_Mutation	novel	P240L	0.1
SKCM	chr17	41907471	Missense_Mutation	novel	P240S	0.1
SKCM	chr17	41913854	Missense_Mutation	NA	S7L	0.3
SKCM	chr17	41907447	Missense_Mutation	NA	P248S	0.18
SKCM	chr17	41886257	Silent	NA	L643L	0.18
SKCM	chr17	41887670	Missense_Mutation	NA	P602S	0.63
SKCM	chr17	41909649	Silent	NA	L133L	0.14
SKCM	chr17	41905576	Frame_Shift_Del	novel	*Y317Mfs11**	0.06
SKCM	chr17	41905578	Frame_Shift_Del	novel	*A310Lfs2**	0.05
SKCM	chr17	41913754	Nonsense_Mutation	novel	W40*	0.07
SKCM	chr17	41869513	Silent	NA	L1004L	0.42
SKCM	chr17	41886165	Silent	NA	I673I	0.52
SKCM	chr17	41873830	Missense_Mutation	NA	L875F	0.07
SKCM	chr17	41913820	Silent	NA	F18F	0.05
SKCM	chr17	41907481	Silent	rs374252025	I236I	0.27
SKCM	chr17	41887692	Silent	novel	I594I	0.25
SKCM	chr17	41892324	Silent	novel	L575L	0.43
SKCM	chr17	41909020	Silent	NA	L195L	0.12
SKCM	chr17	41883167	Silent	rs782181799	I740I	0.98
SKCM	chr17	41909032	Missense_Mutation	NA	F191L	0.09
SKCM	chr17	41873905	Nonsense_Mutation	NA	Q850*	0.1
SKCM	chr17	41913832	Silent	novel	L14L	0.08
STAD	chr17	41893073	Nonsense_Mutation	NA	R521*	0.24
STAD	chr17	41871828	Frame_Shift_Ins	NA	*D933Gfs16**	0.26
STAD	chr17	41883151	Missense_Mutation	NA	G746R	0.28
STAD	chr17	41909046	Missense_Mutation	NA	G187S	0.59
STAD	chr17	41886279	Silent	novel	K635K	0.74
STAD	chr17	41905522	Missense_Mutation	novel	G335R	0.06
STAD	chr17	41873886	Frame_Shift_Del	novel	*G856Afs39**	0.22
STAD	chr17	41909603	Missense_Mutation	NA	K148T	0.15
STAD	chr17	41912457	Missense_Mutation	NA	K82R	0.08
STAD	chr17	41906549	Frame_Shift_Del	novel	*G282Vfs14**	0.11
STAD	chr17	41913814	Silent	NA	C20C	0.18
STAD	chr17	41905593	Missense_Mutation	NA	P311L	0.48
TGCT	chr17	41871759	Missense_Mutation	novel	P956L	0.18
THYM	chr17	41867610	3'UTR	novel		0.35
UCEC	chr17	41867352	3'UTR	novel		0.27
UCEC	chr17	41907463	Silent	rs782400219	F242F	0.37
UCEC	chr17	41897790	Missense_Mutation	novel	E463A	0.32
UCEC	chr17	41912450	Nonsense_Mutation	novel	W84*	0.33
UCEC	chr17	41905658	Splice_Region	NA	S289S	0.19
UCEC	chr17	41869052	Missense_Mutation	NA	S1042F	0.07
UCEC	chr17	41901795	Nonsense_Mutation	NA	R362*	0.39
UCEC	chr17	41869079	Missense_Mutation	NA	F1033C	0.38
UCEC	chr17	41883204	Missense_Mutation	NA	C728Y	0.07
UCEC	chr17	41867855	Silent	rs367827410	P1087P	0.46
UCEC	chr17	41907521	Missense_Mutation	novel	A223G	0.48
UCEC	chr17	41892300	Missense_Mutation	novel	M583I	0.41
UCEC	chr17	41892411	Missense_Mutation	novel	K546N	0.17
UCEC	chr17	41884252	Missense_Mutation	novel	D699N	0.42
UCEC	chr17	41909702	Splice_Site	novel	X116_splice	0.27
UCEC	chr17	41867900	Silent	NA	H1072H	0.19
UCEC	chr17	41869477	Silent	rs376532911	S1016S	0.2
UCEC	chr17	41872125	Silent	NA	H900H	0.16
UCEC	chr17	41869052	Missense_Mutation	NA	S1042F	0.23
UCEC	chr17	41871714	Missense_Mutation	NA	M971T	0.13
UCEC	chr17	41872165	Missense_Mutation	novel	C887Y	0.2
UCEC	chr17	41872084	Missense_Mutation	rs375650392	A914V	0.12
UCEC	chr17	41867216	3'UTR	novel		0.25
UCEC	chr17	41878180	Missense_Mutation	NA	L804I	0.41
UCEC	chr17	41909064	Silent	NA	L181L	0.4
UCEC	chr17	41905658	Splice_Region	NA	S289S	0.28
UCEC	chr17	41918967	5'UTR	novel		0.23
UCEC	chr17	41867673	3'UTR	rs73307729		0.36
UCEC	chr17	41904747	Silent	rs201366190	N349N	0.37
UCEC	chr17	41873936	Silent	rs117473633	S839S	0.51
UCEC	chr17	41905592	Frame_Shift_Del	novel	*S312Afs16**	0.11
UCEC	chr17	41909054	Missense_Mutation	novel	F184C	0.83
UCEC	chr17	41906626	Silent	rs373894224	L256L	0.41
UCEC	chr17	41867102	3'UTR	novel		0.61
UCEC	chr17	41869546	Silent	rs144346203	Y993Y	0.22
UCEC	chr17	41905642	Missense_Mutation	novel	L295I	0.52
UCEC	chr17	41905549	Missense_Mutation	NA	L326I	0.13
UCEC	chr17	41909652	Missense_Mutation	rs781804168	V132I	0.31
UCEC	chr17	41869551	Missense_Mutation	novel	D992Y	0.1
UCEC	chr17	41901765	Missense_Mutation	rs782226163	E372K	0.13
UCEC	chr17	41905657	Missense_Mutation	novel	D290N	0.42
UCEC	chr17	41867634	3'UTR	novel		0.13
UCEC	chr17	41867610	3'UTR	novel		0.47
UCEC	chr17	41886242	Missense_Mutation	novel	A648T	0.07
UCEC	chr17	41904786	Silent	rs782141417	K336K	0.27
UCEC	chr17	41884269	Missense_Mutation	rs532952188	P693L	0.44
UCEC	chr17	41868754	Missense_Mutation	novel	A1056S	0.24
UCEC	chr17	41871790	Missense_Mutation	novel	F946I	0.06
UCEC	chr17	41905566	Missense_Mutation	novel	A320D	0.31
UCEC	chr17	41887636	Missense_Mutation	rs142738500	A613V	0.17
UCEC	chr17	41867731	3'UTR	novel		0.24
UCEC	chr17	41867829	Missense_Mutation	rs148640026	P1096L	0.35
UCEC	chr17	41869569	Nonsense_Mutation	rs782631078	R986*	0.43
UCEC	chr17	41919002	5'Flank	novel		0.33
UCEC	chr17	41868751	Missense_Mutation	novel	L1057I	0.18
UCEC	chr17	41873961	Missense_Mutation	novel	L831R	0.18
UCEC	chr17	41904761	Missense_Mutation	rs782746157	A345T	0.28
UCEC	chr17	41907458	Missense_Mutation	rs183942395	R244Q	0.49
UCEC	chr17	41913759	Missense_Mutation	novel	D39Y	0.18
UCEC	chr17	41867345	3'UTR	novel		0.5
UCEC	chr17	41909657	Missense_Mutation	novel	D130G	0.4
UCEC	chr17	41867673	3'UTR	rs73307729		0.44
UCEC	chr17	41867862	Missense_Mutation	NA	R1085H	0.41
UCEC	chr17	41869512	Missense_Mutation	novel	D1005N	0.35
UCEC	chr17	41906535	Missense_Mutation	rs369798437	V287M	0.39
UCS	chr17	41907481	Silent	rs374252025	I236I	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.2778	0.0017784
DLBC	DEL	0	0.18166
THCA	DEL	0.002	0.221
UCEC	DEL	0.1967	5.8317e-06
UCS	DEL	0.3571	0.19877
UVM	DEL	0.0375	0.22482

Survival Analysis

Cancer	P-value	Q-value
THYM	0.013	Kaplan-Meier Survival Analysis
SARC	0.0023	Kaplan-Meier Survival Analysis
MESO	0.00011	Kaplan-Meier Survival Analysis
ACC	0.00065	Kaplan-Meier Survival Analysis
HNSC	0.0034	Kaplan-Meier Survival Analysis
PRAD	0.026	Kaplan-Meier Survival Analysis
KIRP	0.044	Kaplan-Meier Survival Analysis
BLCA	0.0009	Kaplan-Meier Survival Analysis
CESC	0.00012	Kaplan-Meier Survival Analysis
LAML	0.041	Kaplan-Meier Survival Analysis
KICH	0.0024	Kaplan-Meier Survival Analysis
UCEC	0.016	Kaplan-Meier Survival Analysis
LIHC	0.0012	Kaplan-Meier Survival Analysis
LUAD	0.043	Kaplan-Meier Survival Analysis
UVM	0.002	Kaplan-Meier Survival Analysis
OV	0.0099	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742