EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000131504 (Gene tree)
Gene ID: 1729
Gene Symbol: DIAPH1
Alias: hDIA1|LFHL1|DFNA1
Full Name: diaphanous related formin 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 104,040 bases
Position: chr5:141,515,016-141,619,055
Accession: 2876
RBP type: non-canonical RBP
Summary: This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000491754	DIAPH1-209	557	-	-	- (aa)	-	-
ENST00000494967	DIAPH1-210	629	-	-	- (aa)	-	-
ENST00000523100	DIAPH1-213	1180	-	ENSP00000428208	201 (aa)	-	B4E2I7
ENST00000448451	DIAPH1-205	2090	-	ENSP00000408159	74 (aa)	-	H7C2W8
ENST00000647330	DIAPH1-217	1795	-	ENSP00000494308	249 (aa)	-	A0A2R8YEF8
ENST00000472516	DIAPH1-207	508	-	-	- (aa)	-	-
ENST00000643312	DIAPH1-215	583	-	ENSP00000495191	74 (aa)	-	H7C2W8
ENST00000518484	DIAPH1-212	546	-	-	- (aa)	-	-
ENST00000476339	DIAPH1-208	2606	-	-	- (aa)	-	-
ENST00000468119	DIAPH1-206	619	-	ENSP00000493546	74 (aa)	-	H7C2W8
ENST00000253811	DIAPH1-201	5789	-	ENSP00000253811	1228 (aa)	-	H9KV28
ENST00000518047	DIAPH1-211	4668	XM_024454385	ENSP00000428268	1263 (aa)	XP_024310153	O60610
ENST00000524301	DIAPH1-214	561	-	-	- (aa)	-	-
ENST00000389057	DIAPH1-203	5762	-	ENSP00000373709	1263 (aa)	-	A0A140T8Z0
ENST00000389054	DIAPH1-202	5795	XM_024454384	ENSP00000373706	1272 (aa)	XP_024310152	O60610
ENST00000643718	DIAPH1-216	2228	-	-	- (aa)	-	-
ENST00000398557	DIAPH1-204	5789	-	ENSP00000381565	1272 (aa)	-	A0A0G2JH68
ENST00000647433	DIAPH1-218	5843	-	ENSP00000494675	1250 (aa)	-	A0A2R8Y5N1

Gene Model

Click here to download ENSG00000131504's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04510	Focal adhesion	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa04933	AGE-RAGE signaling pathway in diabetic complications	KEGG
hsa05131	Shigellosis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000131504	Intelligence Tests	2.5117900E-005	-
ENSG00000131504	Intelligence Tests	3.3894200E-005	-
ENSG00000131504	Child Development Disorders, Pervasive	4.2719000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131504	rs72792324	5	141604894	A	Mean platelet volume	27863252	[0.044-0.085] unit increase	0.06435557	EFO_0004584
ENSG00000131504	rs10066420	5	141594912	A	Educational attainment (MTAG)	30038396	[0.0063-0.0117] unit decrease	0.009	EFO_0004784
ENSG00000131504	rs4912763	5	141592550	T	Self-reported math ability (MTAG)	30038396	[0.0076-0.0158] unit decrease	0.0117	EFO_0004875
ENSG00000131504	rs6881581	5	141566788	A	Educational attainment (years of education)	30038396	[0.0067-0.0125] unit decrease	0.0096	EFO_0004784
ENSG00000131504	rs10063055	5	141610541	?	Body mass index	30595370			EFO_0004340
ENSG00000131504	rs7712601	5	141538221	?	Eczema	30595370			HP_0000964

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131504's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0003779	actin binding	-	IEA	Function
GO:0005102	signaling receptor binding	9360932.	NAS	Function
GO:0005515	protein binding	18218625.18230650.18922799.22190034.	IPI	Function
GO:0005634	nucleus	-	ISS	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005815	microtubule organizing center	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0007010	cytoskeleton organization	21834987.	IMP	Process
GO:0007010	cytoskeleton organization	-	ISS	Process
GO:0007605	sensory perception of sound	-	IEA	Process
GO:0008360	regulation of cell shape	21834987.	IMP	Process
GO:0017048	Rho GTPase binding	-	IEA	Function
GO:0030036	actin cytoskeleton organization	-	ISS	Process
GO:0030041	actin filament polymerization	-	ISS	Process
GO:0030335	positive regulation of cell migration	-	IEA	Process
GO:0030667	secretory granule membrane	-	TAS	Component
GO:0032587	ruffle membrane	-	IEA	Component
GO:0032886	regulation of microtubule-based process	20937854.	IMP	Process
GO:0035372	protein localization to microtubule	15123714.	IMP	Process
GO:0043312	neutrophil degranulation	-	TAS	Process
GO:0044325	ion channel binding	15123714.	IPI	Function
GO:0051279	regulation of release of sequestered calcium ion into cytosol	15123714.	IMP	Process
GO:0051493	regulation of cytoskeleton organization	26912466.	IMP	Process
GO:0071420	cellular response to histamine	15123714.	IMP	Process
GO:0072686	mitotic spindle	15123714.	IDA	Component
GO:0101003	ficolin-1-rich granule membrane	-	TAS	Component
GO:2000145	regulation of cell motility	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24317603	Mammalian diaphanous-related formin 1 is required for motility and invadopodia formation in human U87 glioblastoma cells.	Int J Mol Med	2014 Feb	Li Z	doi: 10.3892/ijmm.2013.1577
26893363	mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization.	Oncotarget	2016 Apr 5	Kim D	doi: 10.18632/oncotarget.7429.
27177153	Matrix metalloproteinase2 regulates MDAMB231 breast cancer cell invasion induced by active mammalian diaphanous-related formin1.	Mol Med Rep	2016 Jul	Kim D	doi: 10.3892/mmr.2016.5282
27911711	Diaphanous-related formin 1 as a target for tumor therapy.	Biochem Soc Trans	2016 Oct 15	Lin YN	-

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr5	141578605	Silent	novel	I318I	0.27
BLCA	chr5	141526442	Missense_Mutation	novel	Q1098P	0.19
BLCA	chr5	141578319	Missense_Mutation	novel	D357N	0.39
BLCA	chr5	141524229	Missense_Mutation	novel	E1192V	0.44
BLCA	chr5	141580777	Missense_Mutation	NA	S264C	0.19
BLCA	chr5	141573605	Missense_Mutation	NA	P749S	0.3
BRCA	chr5	141577482	Nonsense_Mutation	novel	E425*	0.09
BRCA	chr5	141582321	Missense_Mutation	novel	M225I	0.05
BRCA	chr5	141578322	Nonsense_Mutation	novel	E356*	0.06
BRCA	chr5	141524212	In_Frame_Del	NA	E1195_G1197del	0.32
BRCA	chr5	141573632	Missense_Mutation	NA	P740A	0.17
BRCA	chr5	141580810	Missense_Mutation	novel	P253L	0.08
BRCA	chr5	141583506	Missense_Mutation	NA	S171F	0.15
BRCA	chr5	141580798	Missense_Mutation	NA	I257S	0.46
BRCA	chr5	141579131	Missense_Mutation	rs201927388	P297L	0.1
BRCA	chr5	141580777	Missense_Mutation	NA	S264F	0.33
CESC	chr5	141573711	Missense_Mutation	novel	M713I	0.31
CESC	chr5	141574099	Missense_Mutation	novel	P584H	0.33
CESC	chr5	141528894	Missense_Mutation	novel	F942L	0.21
CESC	chr5	141573815	Missense_Mutation	novel	P679T	0.29
CESC	chr5	141515145	3'UTR	novel		0.2
CESC	chr5	141515147	3'UTR	novel		0.2
CESC	chr5	141515132	3'UTR	novel		0.48
CESC	chr5	141528795	Frame_Shift_Del	novel	*L976Sfs2**	0.1
CESC	chr5	141524224	Missense_Mutation	novel	D1194N	0.22
CESC	chr5	141584134	Missense_Mutation	NA	T131I	0.37
COAD	chr5	141573820	Frame_Shift_Del	NA	*P677Hfs91**	0.28
COAD	chr5	141583513	Missense_Mutation	novel	R169C	0.35
COAD	chr5	141526310	Missense_Mutation	rs200419320	R1142Q	0.2
COAD	chr5	141573842	Missense_Mutation	novel	P670S	0.16
COAD	chr5	141573742	Frame_Shift_Del	rs776958288	*P703Hfs65**	0.56
COAD	chr5	141573742	Frame_Shift_Del	rs776958288	*P703Hfs65**	0.46
COAD	chr5	141574035	Silent	NA	S605S	0.36
COAD	chr5	141529205	Silent	novel	D915D	0.14
COAD	chr5	141576797	Missense_Mutation	novel	F452S	0.13
COAD	chr5	141524229	Missense_Mutation	novel	E1192A	0.15
COAD	chr5	141528578	Missense_Mutation	novel	R1008Q	0.12
COAD	chr5	141528461	Missense_Mutation	NA	A1047G	0.23
COAD	chr5	141573783	Silent	novel	P689P	0.22
ESCA	chr5	141515148	3'UTR	novel		0.8
ESCA	chr5	141577578	Missense_Mutation	novel	V393I	0.97
GBM	chr5	141528492	Missense_Mutation	novel	F1037V	0.07
GBM	chr5	141571990	Missense_Mutation	novel	E803D	0.04
GBM	chr5	141524202	Missense_Mutation	novel	S1201N	0.55
GBM	chr5	141577493	Missense_Mutation	rs754559074	R421Q	0.44
GBM	chr5	141577504	Silent	novel	L417L	0.06
GBM	chr5	141528560	Missense_Mutation	novel	D1014A	0.04
HNSC	chr5	141578246	Missense_Mutation	novel	D381V	0.19
HNSC	chr5	141578308	Silent	novel	V360V	0.32
HNSC	chr5	141524147	Silent	novel	R1219R	0.17
HNSC	chr5	141583260	Missense_Mutation	novel	A189V	0.04
HNSC	chr5	141526357	Silent	novel	P1126P	0.26
HNSC	chr5	141528485	Missense_Mutation	novel	D1039V	0.53
HNSC	chr5	141580833	Silent	novel	V245V	0.07
HNSC	chr5	141576266	Missense_Mutation	novel	E475D	0.2
HNSC	chr5	141573515	Missense_Mutation	novel	L779F	0.38
HNSC	chr5	141529218	Missense_Mutation	novel	K911R	0.1
KIRC	chr5	141527693	Frame_Shift_Del	novel	*A1052Lfs8**	0.21
KIRC	chr5	141517007	Splice_Region	NA	A1221A	0.37
KIRC	chr5	141574982	Silent	NA	S542S	0.23
KIRP	chr5	141573884	Missense_Mutation	NA	P656T	0.48
KIRP	chr5	141574127	Missense_Mutation	novel	S575P	0.49
KIRP	chr5	141573753	Silent	novel	G699G	0.19
KIRP	chr5	141529639	Missense_Mutation	novel	E880D	0.44
LAML	chr5	141516970	Missense_Mutation	novel	A1234T	0.07
LGG	chr5	141529177	Missense_Mutation	rs773243948	V925M	0.1
LGG	chr5	141580861	Missense_Mutation	novel	E236G	0.33
LGG	chr5	141577524	Missense_Mutation	novel	L411I	0.36
LGG	chr5	141588239	Silent	novel	R43R	0.13
LIHC	chr5	141576273	Missense_Mutation	novel	K473T	0.4
LIHC	chr5	141573514	In_Frame_Del	novel	Y773_L779del	0.18
LIHC	chr5	141528862	Missense_Mutation	novel	I953S	0.45
LIHC	chr5	141579142	Silent	novel	E293E	0.45
LUAD	chr5	141526153	Silent	novel	Q1153Q	0.15
LUAD	chr5	141579135	Nonsense_Mutation	novel	Q296*	0.32
LUAD	chr5	141580817	Missense_Mutation	novel	A251S	0.11
LUAD	chr5	141573732	Silent	NA	P706P	0.75
LUSC	chr5	141578557	Silent	rs748386464	I334I	0.23
LUSC	chr5	141524148	Missense_Mutation	novel	R1219L	0.13
LUSC	chr5	141526134	Missense_Mutation	novel	E1160Q	0.15
LUSC	chr5	141571927	Missense_Mutation	novel	K824N	0.35
LUSC	chr5	141527585	Silent	novel	V1087V	0.44
LUSC	chr5	141573651	Silent	rs368848606	P733P	0.15
LUSC	chr5	141587059	Missense_Mutation	NA	L95V	0.34
LUSC	chr5	141578528	Missense_Mutation	novel	H344R	0.23
LUSC	chr5	141576807	Missense_Mutation	novel	D449N	0.33
LUSC	chr5	141574126	Missense_Mutation	novel	S575F	0.15
LUSC	chr5	141571438	Splice_Site	novel	X825_splice	0.22
MESO	chr5	141587145	Missense_Mutation	NA	S66F	0.22
OV	chr5	141587133	Frame_Shift_Ins	novel	*N70Rfs15**	0.09
OV	chr5	141576872	Splice_Site	NA	X427_splice	0.35
OV	chr5	141573995	Missense_Mutation	novel	P619S	0.07
OV	chr5	141516987	Missense_Mutation	novel	A1228V	0.1
OV	chr5	141529658	Missense_Mutation	novel	I874T	0.1
OV	chr5	141529659	Missense_Mutation	novel	I874L	0.09
OV	chr5	141572007	Missense_Mutation	novel	W798R	0.03
PAAD	chr5	141528498	Missense_Mutation	novel	L1035V	0.14
PAAD	chr5	141524148	Missense_Mutation	rs750059700	R1219H	0.19
PAAD	chr5	141534426	Missense_Mutation	novel	K830N	0.19
PAAD	chr5	141583261	Missense_Mutation	novel	A189T	0.21
PRAD	chr5	141575124	Missense_Mutation	novel	R495Q	0.09
READ	chr5	141527675	Missense_Mutation	NA	K1057N	0.17
READ	chr5	141534402	Missense_Mutation	rs761209182	K838N	0.19
READ	chr5	141579172	Missense_Mutation	novel	M283I	0.07
READ	chr5	141573816	Silent	novel	P678P	0.14
SARC	chr5	141516824	3'UTR	novel		0.4
SARC	chr5	141534460	Intron	rs559271636		0.53
SKCM	chr5	141578562	Missense_Mutation	NA	H333Y	0.47
SKCM	chr5	141577503	Missense_Mutation	novel	L418F	0.21
SKCM	chr5	141571963	Silent	rs185113837	F812F	0.2
SKCM	chr5	141528791	Silent	novel	L977L	0.36
SKCM	chr5	141528792	Silent	novel	L976L	0.35
SKCM	chr5	141575055	Missense_Mutation	novel	G518E	0.22
SKCM	chr5	141575056	Missense_Mutation	novel	G518R	0.21
SKCM	chr5	141573554	Missense_Mutation	rs769148092	G766R	0.27
SKCM	chr5	141576259	Missense_Mutation	NA	E478K	0.32
SKCM	chr5	141516813	3'UTR	rs368620770		0.23
SKCM	chr5	141582341	Missense_Mutation	NA	R219C	0.34
SKCM	chr5	141516878	Silent	novel	A1264A	0.43
SKCM	chr5	141516879	Missense_Mutation	novel	A1264V	0.42
SKCM	chr5	141587164	Missense_Mutation	NA	E60K	0.36
SKCM	chr5	141574999	Silent	NA	L537L	0.34
SKCM	chr5	141516747	3'UTR	novel		0.44
SKCM	chr5	141573597	Silent	novel	P751P	0.42
SKCM	chr5	141516848	3'UTR	novel		0.4
SKCM	chr5	141573710	Missense_Mutation	NA	P714S	0.42
SKCM	chr5	141573672	Silent	NA	I726I	0.66
SKCM	chr5	141524171	Silent	NA	A1211A	0.31
SKCM	chr5	141574153	Missense_Mutation	rs755863519	S566F	0.41
SKCM	chr5	141529623	Silent	NA	L886L	0.81
SKCM	chr5	141582341	Missense_Mutation	NA	R219C	0.57
SKCM	chr5	141529670	Missense_Mutation	novel	P870L	0.41
SKCM	chr5	141529671	Missense_Mutation	novel	P870S	0.41
SKCM	chr5	141573625	Missense_Mutation	NA	P742L	0.36
SKCM	chr5	141528861	Silent	novel	I953I	0.31
STAD	chr5	141528754	Missense_Mutation	NA	A989V	0.34
STAD	chr5	141528773	Missense_Mutation	novel	V983I	0.14
STAD	chr5	141516966	Missense_Mutation	rs761387295	S1235L	0.29
STAD	chr5	141574035	Silent	NA	S605S	0.63
STAD	chr5	141571985	Missense_Mutation	rs752824698	R805H	0.35
STAD	chr5	141528841	Missense_Mutation	novel	V960A	0.07
STAD	chr5	141575097	Missense_Mutation	novel	K504T	0.36
STAD	chr5	141571962	Missense_Mutation	rs147203145	A813T	0.39
STAD	chr5	141578541	Missense_Mutation	NA	R340C	0.28
STAD	chr5	141516988	Missense_Mutation	NA	A1228T	0.2
STAD	chr5	141571923	Splice_Site	novel	X825_splice	0.76
STAD	chr5	141528496	Silent	novel	L1035L	0.07
STAD	chr5	141580758	Silent	rs745385668	P270P	0.41
STAD	chr5	141526434	Missense_Mutation	NA	Y1101H	0.26
STAD	chr5	141528819	Missense_Mutation	NA	L967F	0.23
STAD	chr5	141576281	Silent	NA	D470D	0.14
STAD	chr5	141528921	Silent	NA	L933L	0.2
TGCT	chr5	141582373	Missense_Mutation	novel	S208I	0.2
THCA	chr5	141528505	Silent	NA	P1032P	0.4
UCEC	chr5	141583250	Missense_Mutation	NA	L192F	0.27
UCEC	chr5	141527675	Missense_Mutation	NA	K1057N	0.07
UCEC	chr5	141528547	Silent	rs727502960	T1018T	0.05
UCEC	chr5	141526422	Missense_Mutation	rs781577050	R1105W	0.33
UCEC	chr5	141583604	Missense_Mutation	novel	Q138H	0.15
UCEC	chr5	141515147	3'UTR	novel		0.88
UCEC	chr5	141528925	Missense_Mutation	rs370578225	R932Q	0.37
UCEC	chr5	141518994	Intron	novel		0.48
UCEC	chr5	141534418	Missense_Mutation	novel	E833G	0.23
UCEC	chr5	141516760	3'UTR	novel		0.38
UCEC	chr5	141515155	3'UTR	novel		0.39
UCEC	chr5	141528832	Missense_Mutation	novel	A963V	0.16
UCEC	chr5	141534402	Missense_Mutation	rs761209182	K838N	0.31
UCEC	chr5	141516692	3'UTR	novel		0.21
UCEC	chr5	141526383	Silent	rs777586861	L1118L	0.25
UCEC	chr5	141528919	Missense_Mutation	rs758893826	R934Q	0.14
UCEC	chr5	141578312	Missense_Mutation	NA	R359I	0.29
UCEC	chr5	141583596	Missense_Mutation	NA	S141I	0.13
UCEC	chr5	141573795	Silent	NA	A685A	0.19
UCEC	chr5	141583236	Missense_Mutation	rs763948267	R197Q	0.45
UCEC	chr5	141527577	Frame_Shift_Ins	novel	*M1090Nfs13**	0.41
UCEC	chr5	141528504	Missense_Mutation	novel	D1033N	0.37
UCEC	chr5	141578584	Silent	rs774957853	A325A	0.33
UCEC	chr5	141529213	Nonsense_Mutation	novel	E913*	0.46
UCEC	chr5	141534410	Missense_Mutation	novel	E836K	0.49
UCEC	chr5	141516889	Missense_Mutation	novel	L1261I	0.4
UCEC	chr5	141573516	Silent	novel	Q778Q	0.35
UCEC	chr5	141573811	Missense_Mutation	novel	P680H	0.21
UCEC	chr5	141516995	Silent	rs371385202	A1225A	0.38
UCEC	chr5	141583564	Silent	novel	L152L	0.29
UCEC	chr5	141573784	Frame_Shift_Del	novel	*P689Hfs79**	0.26
UCEC	chr5	141528808	Missense_Mutation	NA	E971V	0.42
UCEC	chr5	141515151	3'UTR	novel		0.36
UCEC	chr5	141515147	3'UTR	novel		0.42
UCEC	chr5	141534402	Missense_Mutation	rs761209182	K838N	0.41
UCEC	chr5	141579188	Missense_Mutation	novel	R278M	0.13
UCEC	chr5	141571985	Missense_Mutation	rs752824698	R805H	0.38
UCEC	chr5	141516966	Missense_Mutation	rs761387295	S1235L	0.55
UCEC	chr5	141587086	Missense_Mutation	novel	D86Y	0.16
UCEC	chr5	141518961	Intron	novel		0.52
UCEC	chr5	141526141	Frame_Shift_Ins	novel	*T1158Pfs9**	0.06
UCEC	chr5	141573742	Frame_Shift_Del	rs776958288	*P703Hfs65**	0.54
UCEC	chr5	141515148	3'UTR	novel		0.33
UCEC	chr5	141572034	Missense_Mutation	NA	A789T	0.32
UCEC	chr5	141526316	Missense_Mutation	novel	N1140T	0.3
UCEC	chr5	141574169	Nonsense_Mutation	novel	E561*	0.23
UCEC	chr5	141515147	3'UTR	novel		0.3
UCEC	chr5	141526415	Missense_Mutation	novel	M1107T	0.32
UCEC	chr5	141573820	Frame_Shift_Del	NA	*P677Hfs91**	0.5
UCEC	chr5	141576864	Missense_Mutation	novel	Y430H	0.21
UCEC	chr5	141529676	Missense_Mutation	novel	R868H	0.17
UCEC	chr5	141573741	Frame_Shift_Ins	rs771360300	*P704Tfs71**	0.48
UCEC	chr5	141515147	3'UTR	novel		0.54
UCEC	chr5	141575124	Missense_Mutation	novel	R495Q	0.42
UCEC	chr5	141578237	Missense_Mutation	rs200927557	R384H	0.46
UCEC	chr5	141583236	Missense_Mutation	rs763948267	R197Q	0.44
UCEC	chr5	141529173	Missense_Mutation	novel	V926A	0.06
UCEC	chr5	141571971	Nonsense_Mutation	novel	E810*	0.45
UCEC	chr5	141575072	Silent	novel	K512K	0.18
UCEC	chr5	141582340	Missense_Mutation	novel	R219H	0.09
UCEC	chr5	141528941	Frame_Shift_Ins	novel	*M927Lfs52**	0.09
UCEC	chr5	141573742	Frame_Shift_Del	rs776958288	*P703Hfs65**	0.38
UCEC	chr5	141574116	Silent	novel	S578S	0.18
UCEC	chr5	141576800	Missense_Mutation	novel	D451G	0.5
UCEC	chr5	141574159	Nonsense_Mutation	novel	*S564Yfs6**	0.05
UCEC	chr5	141516715	3'UTR	novel		0.58
UCEC	chr5	141576272	Silent	novel	K473K	0.41
UCEC	chr5	141576788	Missense_Mutation	rs200004048	R455Q	0.1
UCEC	chr5	141534402	Missense_Mutation	rs761209182	K838N	0.13
UCEC	chr5	141573741	Frame_Shift_Ins	rs771360300	*P704Tfs71**	0.56
UCEC	chr5	141575017	Missense_Mutation	novel	A531S	0.43
UCEC	chr5	141526141	Frame_Shift_Ins	novel	*T1158Pfs9**	0.04
UCEC	chr5	141575097	Missense_Mutation	novel	K504T	0.23
UCEC	chr5	141587136	Missense_Mutation	novel	R69I	0.4
UCEC	chr5	141571988	Missense_Mutation	novel	D804V	0.36
UCEC	chr5	141575117	Silent	novel	E497E	0.38
UCEC	chr5	141579197	Splice_Site	NA	X275_splice	0.28
UCEC	chr5	141528925	Missense_Mutation	rs370578225	R932Q	0.13
UCEC	chr5	141571992	Missense_Mutation	novel	E803K	0.37
UCEC	chr5	141578336	Missense_Mutation	rs201545942	R351Q	0.23
UCEC	chr5	141516526	3'UTR	novel		0.12
UCEC	chr5	141518967	Intron	novel		0.53
UCS	chr5	141571978	Silent	novel	E807E	0.37

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
KIRP	AMP	0.1076	0.069756
KIRP	DEL	0.0382	0.11554
LAML	DEL	0.089	1.2971e-07
LUSC	DEL	0.6208	0.002071
MESO	DEL	0.1379	0.20184
PRAD	AMP	0.0305	0.16448
SKCM	DEL	0.3134	2.2081e-08
THCA	AMP	0.0361	0.075436
THCA	DEL	0	0.23456

Survival Analysis

Cancer	P-value	Q-value
THYM	0.021	Kaplan-Meier Survival Analysis
ACC	0.039	Kaplan-Meier Survival Analysis
UCS	0.021	Kaplan-Meier Survival Analysis
SKCM	0.038	Kaplan-Meier Survival Analysis
PRAD	0.04	Kaplan-Meier Survival Analysis
LUSC	0.046	Kaplan-Meier Survival Analysis
TGCT	0.049	Kaplan-Meier Survival Analysis
COAD	0.0036	Kaplan-Meier Survival Analysis
PAAD	0.00048	Kaplan-Meier Survival Analysis
UCEC	0.049	Kaplan-Meier Survival Analysis
LGG	0.00011	Kaplan-Meier Survival Analysis
LUAD	0.047	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

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Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742