EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000131558 (Gene tree)
Gene ID: 60412
Gene Symbol: EXOC4
Alias: KIAA1699|MGC27170|SEC8|Sec8p|SEC8L1
Full Name: exocyst complex component 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 813,523 bases
Position: chr7:133,253,067-134,066,589
Accession: 30389
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462055	EXOC4-205	2364	-	-	- (aa)	-	-
ENST00000253861	EXOC4-201	4185	-	ENSP00000253861	974 (aa)	-	Q96A65
ENST00000481074	EXOC4-215	568	-	-	- (aa)	-	-
ENST00000482089	EXOC4-216	628	-	-	- (aa)	-	-
ENST00000478265	EXOC4-211	595	-	-	- (aa)	-	-
ENST00000472020	EXOC4-210	492	-	-	- (aa)	-	-
ENST00000468932	EXOC4-208	753	-	-	- (aa)	-	-
ENST00000459626	EXOC4-203	592	-	-	- (aa)	-	-
ENST00000486013	EXOC4-219	1600	-	-	- (aa)	-	-
ENST00000460346	EXOC4-204	762	-	-	- (aa)	-	-
ENST00000469115	EXOC4-209	755	-	-	- (aa)	-	-
ENST00000480840	EXOC4-214	388	-	-	- (aa)	-	-
ENST00000393161	EXOC4-202	1604	XM_005250523	ENSP00000376868	473 (aa)	XP_005250580	Q96A65
ENST00000463150	EXOC4-206	526	-	-	- (aa)	-	-
ENST00000466000	EXOC4-207	555	-	-	- (aa)	-	-
ENST00000492326	EXOC4-222	549	-	-	- (aa)	-	-
ENST00000489931	EXOC4-221	578	-	-	- (aa)	-	-
ENST00000480337	EXOC4-213	429	-	-	- (aa)	-	-
ENST00000498024	EXOC4-224	329	-	-	- (aa)	-	-
ENST00000494685	EXOC4-223	313	-	-	- (aa)	-	-
ENST00000479839	EXOC4-212	543	-	-	- (aa)	-	-
ENST00000486409	EXOC4-220	605	-	-	- (aa)	-	-
ENST00000484397	EXOC4-218	502	-	-	- (aa)	-	-
ENST00000483800	EXOC4-217	559	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000131558's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000131558	Body Weights and Measures	2.74543388689708E-6	17903300
ENSG00000131558	Body Weights and Measures	2.64010451545005E-6	17903300
ENSG00000131558	Body Weight	3.78872399011687E-5	17903300
ENSG00000131558	Body Weight	6.57952803608122E-5	17903300
ENSG00000131558	Body Weight	4.60143470570884E-5	17903300
ENSG00000131558	Body Weight	5.81981414238621E-5	17903300
ENSG00000131558	Body Weight	6.14948630972556E-5	17903300
ENSG00000131558	Body Weight	9.5007702671585E-5	17903300
ENSG00000131558	Body Weight	7.4013781725224E-5	17903300
ENSG00000131558	Body Weight	8.96577488028938E-5	17903300
ENSG00000131558	Blood Pressure	5.57018727390859E-6	17903302
ENSG00000131558	Neuropsychological Tests	9.86046491937564E-5	17903297
ENSG00000131558	Platelet Function Tests	2.2318900E-005	-
ENSG00000131558	Platelet Function Tests	1.2510189E-006	-
ENSG00000131558	Platelet Function Tests	1.7692142E-006	-
ENSG00000131558	Platelet Function Tests	1.6058800E-005	-
ENSG00000131558	Platelet Function Tests	4.9345164E-006	-
ENSG00000131558	Platelet Function Tests	2.3633315E-006	-
ENSG00000131558	Platelet Function Tests	1.7922479E-006	-
ENSG00000131558	Platelet Function Tests	1.6598300E-005	-
ENSG00000131558	Blood Pressure	8E-6	17903302
ENSG00000131558	Alzheimer Disease	5E-7	23535033
ENSG00000131558	Education	2E-12	27225129
ENSG00000131558	Education	3E-9	27225129

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000131558	rs12707116	7	133740156	?	Cognitive ability	29186694	z score decrease	6.227	EFO_0004337
ENSG00000131558	rs1362739	7	133746181	?	Cognitive ability	29186694	z score increase	6.239	EFO_0004337
ENSG00000131558	rs12707116	7	133740156	?	Cognitive ability (MTAG)	29186694	z score decrease	7.12	EFO_0004337\|EFO_0004784
ENSG00000131558	rs17167170	7	133617591	A	Educational attainment (years of education)	27225129	NR unit increase	0.01948004	EFO_0004784
ENSG00000131558	rs7781266	7	133820348	?	Educational attainment (college completion)	27225129	[NR]	1.042923	EFO_0004784
ENSG00000131558	rs11770757	7	134063193	?	Alzheimer's disease (cognitive decline)	23535033	unit decrease	0.16	EFO_0000249
ENSG00000131558	rs6975094	7	133494486	A	QT interval	29213071	[6.11-13.87] ms decrease	9.99	EFO_0004682
ENSG00000131558	rs6973256	7	133370849	T	Intelligence (MTAG)	29326435	[0.013-0.025] unit increase	0.01915792	EFO_0004337
ENSG00000131558	rs10254118	7	133473599	A	Intelligence (MTAG)	29326435	[0.015-0.027] unit increase	0.02070377	EFO_0004337
ENSG00000131558	rs1030268	7	133921878	A	Intelligence (MTAG)	29326435	[0.013-0.026] unit decrease	0.019503407	EFO_0004337
ENSG00000131558	rs11765450	7	133384928	T	Intelligence (MTAG)	29326435	[0.016-0.031] unit decrease	0.023339247	EFO_0004337
ENSG00000131558	rs12707116	7	133740156	T	Intelligence (MTAG)	29326435	[0.018-0.03] unit decrease	0.024088169	EFO_0004337
ENSG00000131558	rs1882538	7	133276984	A	Intelligence (MTAG)	29326435	[0.015-0.027] unit increase	0.0211912	EFO_0004337
ENSG00000131558	rs2346268	7	133957989	A	Intelligence (MTAG)	29326435	[0.015-0.027] unit increase	0.02131768	EFO_0004337
ENSG00000131558	rs2971970	7	133959025	T	Intelligence (MTAG)	29326435	[0.017-0.031] unit decrease	0.024300301	EFO_0004337
ENSG00000131558	rs4728302	7	133945710	T	Intelligence (MTAG)	29326435	[0.018-0.03] unit decrease	0.023831645	EFO_0004337
ENSG00000131558	rs17167210	7	133654590	A	Intelligence (MTAG)	29326435	[0.017-0.029] unit decrease	0.02312524	EFO_0004337
ENSG00000131558	rs10215367	7	133260999	T	Intelligence (MTAG)	29326435	[0.013-0.025] unit increase	0.019046552	EFO_0004337
ENSG00000131558	rs12707087	7	133269778	T	Intelligence (MTAG)	29326435	[0.015-0.03] unit decrease	0.022929119	EFO_0004337
ENSG00000131558	rs3823572	7	133995848	A	Intelligence (MTAG)	29326435	[0.017-0.029] unit increase	0.02299677	EFO_0004337
ENSG00000131558	rs4422723	7	133921405	A	Intelligence (MTAG)	29326435	[0.015-0.027] unit decrease	0.020883946	EFO_0004337
ENSG00000131558	rs13243553	7	133822202	G	Vigorous physical activity	29899525		1.04	EFO_0008002
ENSG00000131558	rs6956293	7	133445424	T	Cognitive performance	30038396	[0.013-0.026] unit increase	0.0197	EFO_0008354
ENSG00000131558	rs6975134	7	133846679	T	Cognitive performance	30038396	[0.016-0.028] unit decrease	0.0219	EFO_0008354
ENSG00000131558	rs6951416	7	133407524	A	Educational attainment (MTAG)	30038396	[0.0053-0.0107] unit decrease	0.008	EFO_0004784
ENSG00000131558	rs57352738	7	133619940	A	Educational attainment (MTAG)	30038396	[0.015-0.021] unit decrease	0.0177	EFO_0004784
ENSG00000131558	rs17597230	7	133468245	G	Self-reported math ability	30038396	[0.027-0.056] unit increase	0.0413	EFO_0004875
ENSG00000131558	rs4728298	7	133752015	T	Self-reported math ability	30038396	[0.013-0.023] unit increase	0.0177	EFO_0004875
ENSG00000131558	rs12707134	7	134045571	C	Self-reported math ability	30038396	[0.01-0.0182] unit decrease	0.0141	EFO_0004875
ENSG00000131558	rs1149558	7	133363002	T	Highest math class taken	30038396	[0.009-0.018] unit increase	0.0135	EFO_0004875
ENSG00000131558	rs6949760	7	133991348	C	Highest math class taken	30038396	[0.019-0.028] unit decrease	0.0236	EFO_0004875
ENSG00000131558	rs11772444	7	133769121	A	Self-reported math ability (MTAG)	30038396	[0.017-0.026] unit decrease	0.0212	EFO_0004875
ENSG00000131558	rs6467512	7	133977679	T	Self-reported math ability (MTAG)	30038396	[0.011-0.019] unit decrease	0.0151	EFO_0004875
ENSG00000131558	rs57352738	7	133619940	A	Highest math class taken (MTAG)	30038396	[0.02-0.028] unit decrease	0.0237	EFO_0004875
ENSG00000131558	rs6467512	7	133977679	T	Highest math class taken (MTAG)	30038396	[0.01-0.017] unit decrease	0.0139	EFO_0004875
ENSG00000131558	rs4728302	7	133945710	T	Intelligence	28530673	z score decrease	5.08	EFO_0004337
ENSG00000131558	rs4728302	7	133945710	T	Intelligence	28530673	z score decrease	5.967	EFO_0004337
ENSG00000131558	rs7804463	7	133762898	T	Moderate to vigorous physical activity levels	29899525	unit increase	0.015	EFO_0008002
ENSG00000131558	rs6978272	7	133403285	?	Response to selective serotonin reuptake inhibitors in depression	30034349	[2-5.88]	3.448276	EFO_0003761\|EFO_0005658
ENSG00000131558	rs10488172	7	133650423	?	Tonometry	17903302			EFO_0004325
ENSG00000131558	rs57352738	7	133619940	A	Cognitive performance (MTAG)	30038396	[0.021-0.032] unit decrease	0.0267	EFO_0008354
ENSG00000131558	rs6467512	7	133977679	T	Cognitive performance (MTAG)	30038396	[0.012-0.022] unit decrease	0.0168	EFO_0008354
ENSG00000131558	rs12707116	7	133740156	T	General cognitive ability	29844566	z-score decrease	6.616	EFO_0004337
ENSG00000131558	rs11977339	7	133285920	T	General cognitive ability	29844566	z-score increase	6.055	EFO_0004337
ENSG00000131558	rs6950324	7	133369958	T	General cognitive ability	29844566	z-score decrease	5.661	EFO_0004337
ENSG00000131558	rs3823572	7	133995848	A	General cognitive ability	29844566	z-score increase	5.654	EFO_0004337
ENSG00000131558	rs2346449	7	134049164	T	General cognitive ability	29844566	z-score increase	5.578	EFO_0004337
ENSG00000131558	rs10281827	7	133397056	A	General cognitive ability	29844566	z-score decrease	5.519	EFO_0004337
ENSG00000131558	rs4731992	7	134017344	A	General cognitive ability	29844566	z-score decrease	5.493	EFO_0004337
ENSG00000131558	rs12707093	7	133516063	?	General cognitive ability	29844566	z-score increase	5.45	EFO_0004337
ENSG00000131558	rs17167170	7	133617591	?	General cognitive ability	29844566	z-score increase	5.281	EFO_0004337
ENSG00000131558	rs6972284	7	133850961	?	General cognitive ability	29844566	z-score decrease	5.191	EFO_0004337
ENSG00000131558	rs1362739	7	133746181	A	Intelligence	29942086	z-score increase	7.662	EFO_0004337
ENSG00000131558	rs35284403	7	133264129	T	Intelligence	29942086	z-score decrease	5.692	EFO_0004337
ENSG00000131558	rs6949831	7	133396716	C	Intelligence	29942086	z-score increase	6.133	EFO_0004337
ENSG00000131558	rs10954428	7	133703303	A	Intelligence	29942086	z-score increase	6.476	EFO_0004337
ENSG00000131558	rs6973256	7	133370849	T	Intelligence	29942086	z-score increase	7.145	EFO_0004337
ENSG00000131558	rs2971963	7	133956752	A	Intelligence	29942086	z-score increase	6.36	EFO_0004337
ENSG00000131558	rs6949760	7	133991348	A	Intelligence	29942086	z-score increase	5.763	EFO_0004337
ENSG00000131558	rs149142052	7	133610309	?	DNA methylation variation (age effect)	30348214			GO_0006306
ENSG00000131558	rs57352738	7	133619940	A	Educational attainment (years of education)	30038396	[0.012-0.019] unit decrease	0.0152	EFO_0004784
ENSG00000131558	rs4731992	7	134017344	?	Educational attainment (years of education)	30595370			EFO_0004784
ENSG00000131558	rs10279261	7	133905093	A	Smoking status (ever vs never smokers)	30643258	[0.0073-0.0154] unit decrease	0.01130086	EFO_0004318
ENSG00000131558	rs4728302	7	133945710	T	Extremely high intelligence	29520040	NR z score decrease decrease	5.66	EFO_0004337
ENSG00000131558	rs2345667	7	133559395	G	Age of smoking initiation (MTAG)	30643251	[0.0091-0.0163] unit decrease	0.0126869	EFO_0005670
ENSG00000131558	rs10279261	7	133905093	A	Smoking initiation (ever regular vs never regular) (MTAG)	30643251	[0.0074-0.0118] unit decrease	0.00958076	EFO_0006527
ENSG00000131558	rs10279261	7	133905093	A	Smoking initiation (ever regular vs never regular)	30643251	[0.014-0.024] unit decrease	0.018872635	EFO_0006527
ENSG00000131558	rs6958557	7	133901041	T	Chronotype	30696823		1.0264436	EFO_0008328

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000131558's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000145	exocyst	21873635.	IBA	Component
GO:0005515	protein binding	17043677.18329369.19885391.20579884.21241894.21658605.25244576.25594178.26760201.27173435.	IPI	Function
GO:0005737	cytoplasm	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	-	TAS	Component
GO:0005902	microvillus	-	IEA	Component
GO:0006612	protein targeting to membrane	21873635.	IBA	Process
GO:0006887	exocytosis	21873635.	IBA	Process
GO:0006893	Golgi to plasma membrane transport	21873635.	IBA	Process
GO:0006904	vesicle docking involved in exocytosis	-	IEA	Process
GO:0007268	chemical synaptic transmission	21873635.	IBA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016241	regulation of macroautophagy	21241894.	TAS	Process
GO:0017160	Ral GTPase binding	24056301.	IPI	Function
GO:0030165	PDZ domain binding	-	IEA	Function
GO:0032584	growth cone membrane	21873635.	IBA	Component
GO:0035748	myelin sheath abaxonal region	-	IEA	Component
GO:0045202	synapse	21873635.	IBA	Component
GO:0047485	protein N-terminus binding	18480549.	IPI	Function
GO:0048341	paraxial mesoderm formation	-	IEA	Process
GO:0090522	vesicle tethering involved in exocytosis	-	IEA	Process
GO:0090543	Flemming body	-	IEA	Component