EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132275 (Gene tree)
Gene ID: 23378
Gene Symbol: RRP8
Alias: NML|KIAA0409
Full Name: ribosomal RNA processing 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 88,849 bases
Position: chr11:6,514,830-6,603,678
Accession: 29030
RBP type: canonical RBP
Summary: (Ribosomal RNA Processing 8) is a Protein Coding gene. Diseases associated with RRP8 include Breast Abscess and Bowen-Conradi Syndrome. Among its related pathways are Chromatin Regulation / Acetylation and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. Gene Ontology (GO) annotations related to this gene include methylated histone binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000254605	Methyltransf_8	PF05148.15	5.3e-106	1	1
ENSP00000436960	Methyltransf_8	PF05148.15	2.6e-47	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
23897426	Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability.	Mol Cell Biol	2013 Oct	Yang L	doi: 10.1128/MCB.00476-13
26505814	Nucleolar repression facilitates initiation and maintenance of senescence.	Cell Cycle	2015	Yang L	doi: 10.1080/15384101.2015.1100777.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000533907	RRP8-204	1989	-	ENSP00000436246	306 (aa)	-	E9PPY3
ENST00000534343	RRP8-205	726	-	ENSP00000436960	140 (aa)	-	E9PPP6
ENST00000530762	RRP8-203	956	-	ENSP00000435873	78 (aa)	-	E9PS87
ENST00000526352	RRP8-202	1126	-	-	- (aa)	-	-
ENST00000254605	RRP8-201	6560	XM_011519955	ENSP00000254605	456 (aa)	XP_011518257	O43159

Gene Model

Click here to download ENSG00000132275's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132275's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132275	RRP8	100	82.276	ENSAMEG00000016307	RRP8	100	82.495	Ailuropoda_melanoleuca
ENSG00000132275	RRP8	76	58.716	ENSACIG00000019896	rrp8	50	54.918	Amphilophus_citrinellus
ENSG00000132275	RRP8	100	96.296	ENSANAG00000028524	RRP8	100	96.296	Aotus_nancymaae
ENSG00000132275	RRP8	76	62.037	ENSAMXG00000005164	rrp8	52	54.909	Astyanax_mexicanus
ENSG00000132275	RRP8	100	79.039	ENSBTAG00000000697	RRP8	100	78.384	Bos_taurus
ENSG00000132275	RRP8	78	45.872	WBGene00020296	T07A9.8	80	39.863	Caenorhabditis_elegans
ENSG00000132275	RRP8	100	95.370	ENSCJAG00000014012	RRP8	100	95.370	Callithrix_jacchus
ENSG00000132275	RRP8	100	80.306	ENSCAFG00000006476	RRP8	68	80.306	Canis_familiaris
ENSG00000132275	RRP8	100	80.306	ENSCAFG00020009685	RRP8	100	80.306	Canis_lupus_dingo
ENSG00000132275	RRP8	100	78.166	ENSCHIG00000019002	RRP8	94	78.384	Capra_hircus
ENSG00000132275	RRP8	100	90.714	ENSTSYG00000003391	RRP8	100	94.444	Carlito_syrichta
ENSG00000132275	RRP8	84	76.486	ENSCAPG00000013284	RRP8	100	75.969	Cavia_aperea
ENSG00000132275	RRP8	100	79.085	ENSCPOG00000012515	RRP8	100	77.996	Cavia_porcellus
ENSG00000132275	RRP8	100	95.370	ENSCCAG00000035197	RRP8	100	95.370	Cebus_capucinus
ENSG00000132275	RRP8	100	96.296	ENSCATG00000029344	RRP8	100	96.296	Cercocebus_atys
ENSG00000132275	RRP8	100	90.741	ENSCLAG00000016099	RRP8	100	77.778	Chinchilla_lanigera
ENSG00000132275	RRP8	100	95.370	ENSCSAG00000004345	RRP8	100	91.667	Chlorocebus_sabaeus
ENSG00000132275	RRP8	77	71.296	ENSCPBG00000000945	-	83	69.492	Chrysemys_picta_bellii
ENSG00000132275	RRP8	77	57.798	ENSCSAVG00000006435	-	60	50.628	Ciona_savignyi
ENSG00000132275	RRP8	100	95.370	ENSCANG00000040771	RRP8	100	95.370	Colobus_angolensis_palliatus
ENSG00000132275	RRP8	100	75.711	ENSCGRG00001003103	Rrp8	100	75.711	Cricetulus_griseus_chok1gshd
ENSG00000132275	RRP8	100	75.274	ENSCGRG00000014009	Rrp8	100	75.274	Cricetulus_griseus_crigri
ENSG00000132275	RRP8	76	59.813	ENSCSEG00000007330	rrp8	69	53.623	Cynoglossus_semilaevis
ENSG00000132275	RRP8	77	60.000	ENSCVAG00000012032	rrp8	69	56.466	Cyprinodon_variegatus
ENSG00000132275	RRP8	100	51.773	ENSDARG00000071652	rrp8	100	51.773	Danio_rerio
ENSG00000132275	RRP8	100	82.135	ENSDNOG00000000812	RRP8	91	81.046	Dasypus_novemcinctus
ENSG00000132275	RRP8	100	92.593	ENSDORG00000000103	Rrp8	100	80.349	Dipodomys_ordii
ENSG00000132275	RRP8	86	41.322	FBgn0034422	CG7137	63	41.485	Drosophila_melanogaster
ENSG00000132275	RRP8	100	79.694	ENSETEG00000008877	RRP8	100	77.462	Echinops_telfairi
ENSG00000132275	RRP8	100	90.000	ENSEASG00005001761	RRP8	100	90.000	Equus_asinus_asinus
ENSG00000132275	RRP8	100	78.502	ENSECAG00000006612	RRP8	83	83.254	Equus_caballus
ENSG00000132275	RRP8	100	89.286	ENSFCAG00000015384	RRP8	100	89.286	Felis_catus
ENSG00000132275	RRP8	100	87.963	ENSFDAG00000008872	RRP8	100	77.560	Fukomys_damarensis
ENSG00000132275	RRP8	76	59.813	ENSGMOG00000007188	rrp8	81	49.671	Gadus_morhua
ENSG00000132275	RRP8	100	57.857	ENSGALG00000048769	-	100	57.857	Gallus_gallus
ENSG00000132275	RRP8	59	54.878	ENSGAFG00000012308	-	74	54.878	Gambusia_affinis
ENSG00000132275	RRP8	76	57.798	ENSGACG00000011343	rrp8	72	53.623	Gasterosteus_aculeatus
ENSG00000132275	RRP8	84	48.571	ENSGAGG00000005261	RRP8	63	56.401	Gopherus_agassizii
ENSG00000132275	RRP8	100	99.342	ENSGGOG00000000389	RRP8	100	99.342	Gorilla_gorilla
ENSG00000132275	RRP8	100	91.667	ENSHGLG00000003980	RRP8	100	77.342	Heterocephalus_glaber_female
ENSG00000132275	RRP8	97	91.667	ENSHGLG00100015659	RRP8	100	77.342	Heterocephalus_glaber_male
ENSG00000132275	RRP8	81	60.177	ENSIPUG00000017733	rrp8	72	43.008	Ictalurus_punctatus
ENSG00000132275	RRP8	100	79.212	ENSSTOG00000016272	RRP8	100	79.212	Ictidomys_tridecemlineatus
ENSG00000132275	RRP8	77	87.037	ENSJJAG00000021889	-	100	77.143	Jaculus_jaculus
ENSG00000132275	RRP8	100	80.786	ENSJJAG00000020608	-	100	80.349	Jaculus_jaculus
ENSG00000132275	RRP8	76	59.813	ENSLBEG00000019937	rrp8	85	46.131	Labrus_bergylta
ENSG00000132275	RRP8	76	63.551	ENSLACG00000001252	-	60	59.322	Latimeria_chalumnae
ENSG00000132275	RRP8	66	44.086	ENSLOCG00000013776	-	95	45.339	Lepisosteus_oculatus
ENSG00000132275	RRP8	100	82.057	ENSLAFG00000000112	RRP8	100	82.057	Loxodonta_africana
ENSG00000132275	RRP8	100	96.296	ENSMFAG00000046084	RRP8	100	96.296	Macaca_fascicularis
ENSG00000132275	RRP8	100	96.296	ENSMMUG00000007738	RRP8	100	96.296	Macaca_mulatta
ENSG00000132275	RRP8	100	96.296	ENSMNEG00000029648	RRP8	100	96.296	Macaca_nemestrina
ENSG00000132275	RRP8	100	96.296	ENSMLEG00000035110	RRP8	100	96.296	Mandrillus_leucophaeus
ENSG00000132275	RRP8	100	71.706	ENSMAUG00000000324	Rrp8	100	71.058	Mesocricetus_auratus
ENSG00000132275	RRP8	100	88.571	ENSMICG00000038472	RRP8	100	88.571	Microcebus_murinus
ENSG00000132275	RRP8	100	74.179	ENSMOCG00000002486	Rrp8	100	74.179	Microtus_ochrogaster
ENSG00000132275	RRP8	100	76.638	MGP_CAROLIEiJ_G0030236	Rrp8	100	76.419	Mus_caroli
ENSG00000132275	RRP8	100	75.983	ENSMUSG00000030888	Rrp8	100	75.764	Mus_musculus
ENSG00000132275	RRP8	100	75.109	MGP_PahariEiJ_G0013451	Rrp8	100	74.891	Mus_pahari
ENSG00000132275	RRP8	100	75.546	MGP_SPRETEiJ_G0031348	Rrp8	100	75.328	Mus_spretus
ENSG00000132275	RRP8	100	91.667	ENSMPUG00000005510	RRP8	100	81.619	Mustela_putorius_furo
ENSG00000132275	RRP8	98	93.519	ENSMLUG00000008938	RRP8	100	82.713	Myotis_lucifugus
ENSG00000132275	RRP8	100	90.741	ENSNGAG00000012450	Rrp8	100	79.431	Nannospalax_galili
ENSG00000132275	RRP8	88	59.055	ENSNBRG00000023416	rrp8	100	55.319	Neolamprologus_brichardi
ENSG00000132275	RRP8	100	97.222	ENSNLEG00000017445	RRP8	100	94.518	Nomascus_leucogenys
ENSG00000132275	RRP8	84	56.410	ENSMEUG00000004945	-	100	67.033	Notamacropus_eugenii
ENSG00000132275	RRP8	100	77.342	ENSOPRG00000008052	RRP8	100	77.778	Ochotona_princeps
ENSG00000132275	RRP8	100	88.889	ENSODEG00000011209	RRP8	100	77.124	Octodon_degus
ENSG00000132275	RRP8	100	91.667	ENSOCUG00000027619	RRP8	100	82.495	Oryctolagus_cuniculus
ENSG00000132275	RRP8	100	80.921	ENSOGAG00000007184	RRP8	100	80.921	Otolemur_garnettii
ENSG00000132275	RRP8	100	78.603	ENSOARG00000017435	RRP8	70	78.821	Ovis_aries
ENSG00000132275	RRP8	100	100.000	ENSPPAG00000040792	RRP8	100	100.000	Pan_paniscus
ENSG00000132275	RRP8	100	89.286	ENSPPRG00000022654	RRP8	100	89.286	Panthera_pardus
ENSG00000132275	RRP8	100	89.286	ENSPTIG00000011321	RRP8	100	89.286	Panthera_tigris_altaica
ENSG00000132275	RRP8	100	100.000	ENSPTRG00000003297	RRP8	100	100.000	Pan_troglodytes
ENSG00000132275	RRP8	100	96.296	ENSPANG00000006537	RRP8	100	96.296	Papio_anubis
ENSG00000132275	RRP8	77	65.741	ENSPMGG00000000968	-	83	65.766	Periophthalmus_magnuspinnatus
ENSG00000132275	RRP8	100	76.368	ENSPEMG00000017257	Rrp8	100	75.930	Peromyscus_maniculatus_bairdii
ENSG00000132275	RRP8	100	98.465	ENSPPYG00000003538	RRP8	100	98.465	Pongo_abelii
ENSG00000132275	RRP8	100	78.118	ENSPCAG00000016176	RRP8	100	78.118	Procavia_capensis
ENSG00000132275	RRP8	100	90.000	ENSPCOG00000024627	RRP8	100	90.000	Propithecus_coquereli
ENSG00000132275	RRP8	100	81.360	ENSPVAG00000002420	RRP8	100	80.482	Pteropus_vampyrus
ENSG00000132275	RRP8	100	74.728	ENSRNOG00000018766	Rrp8	100	92.093	Rattus_norvegicus
ENSG00000132275	RRP8	100	94.444	ENSRBIG00000044485	RRP8	100	94.444	Rhinopithecus_bieti
ENSG00000132275	RRP8	100	93.519	ENSRROG00000045322	RRP8	100	93.519	Rhinopithecus_roxellana
ENSG00000132275	RRP8	76	36.296	YDR083W	-	84	33.141	Saccharomyces_cerevisiae
ENSG00000132275	RRP8	100	96.296	ENSSBOG00000035280	RRP8	100	95.714	Saimiri_boliviensis_boliviensis
ENSG00000132275	RRP8	77	72.727	ENSSHAG00000009273	-	56	70.567	Sarcophilus_harrisii
ENSG00000132275	RRP8	99	92.593	ENSSARG00000007949	RRP8	100	76.754	Sorex_araneus
ENSG00000132275	RRP8	99	58.696	ENSSPAG00000006664	rrp8	99	58.696	Stegastes_partitus
ENSG00000132275	RRP8	100	77.342	ENSSSCG00000023880	RRP8	100	76.906	Sus_scrofa
ENSG00000132275	RRP8	77	62.281	ENSTGUG00000000591	RRP8	100	64.602	Taeniopygia_guttata
ENSG00000132275	RRP8	93	82.979	ENSTBEG00000000237	RRP8	100	84.397	Tupaia_belangeri
ENSG00000132275	RRP8	100	81.917	ENSTTRG00000004867	RRP8	100	81.699	Tursiops_truncatus
ENSG00000132275	RRP8	100	89.286	ENSUAMG00000025756	RRP8	100	89.286	Ursus_americanus
ENSG00000132275	RRP8	100	82.713	ENSUMAG00000000528	RRP8	96	82.932	Ursus_maritimus
ENSG00000132275	RRP8	100	81.128	ENSVPAG00000008019	RRP8	100	81.779	Vicugna_pacos
ENSG00000132275	RRP8	100	76.956	ENSVVUG00000024346	RRP8	100	76.956	Vulpes_vulpes
ENSG00000132275	RRP8	77	62.963	ENSXCOG00000006156	rrp8	65	56.627	Xiphophorus_couchianus
ENSG00000132275	RRP8	77	63.889	ENSXMAG00000005011	rrp8	51	57.831	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000183	chromatin silencing at rDNA	21873635.	IBA	Process
GO:0000183	chromatin silencing at rDNA	18485871.	IDA	Process
GO:0000183	chromatin silencing at rDNA	-	TAS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	18485871.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005677	chromatin silencing complex	21873635.	IBA	Component
GO:0005677	chromatin silencing complex	18485871.	IDA	Component
GO:0005730	nucleolus	21873635.	IBA	Component
GO:0005730	nucleolus	18485871.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005886	plasma membrane	-	IDA	Component
GO:0006364	rRNA processing	-	IEA	Process
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	18485871.	TAS	Function
GO:0032259	methylation	-	IEA	Process
GO:0033553	rDNA heterochromatin	21873635.	IBA	Component
GO:0033553	rDNA heterochromatin	18485871.	IDA	Component
GO:0035064	methylated histone binding	21873635.	IBA	Function
GO:0035064	methylated histone binding	18485871.	IDA	Function
GO:0042149	cellular response to glucose starvation	21873635.	IBA	Process
GO:0042149	cellular response to glucose starvation	21471221.	IMP	Process
GO:0046015	regulation of transcription by glucose	21873635.	IBA	Process
GO:0046015	regulation of transcription by glucose	21471221.	IMP	Process
GO:0071158	positive regulation of cell cycle arrest	21471221.	IMP	Process
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator	21471221.	IMP	Process