EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132313 (Gene tree)
Gene ID: 51318
Gene Symbol: MRPL35
Alias: N
Full Name: mitochondrial ribosomal protein L35
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 14,440 bases
Position: chr2:86,199,355-86,213,794
Accession: 14489
RBP type: canonical RBP
Summary: Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000254644	Ribosomal_L35p	PF01632.19	6.6e-15	1	1
ENSP00000386255	Ribosomal_L35p	PF01632.19	7e-15	1	1
ENSP00000338389	Ribosomal_L35p	PF01632.19	7.9e-15	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000605125	MRPL35-204	833	-	ENSP00000473925	95 (aa)	-	S4R348
ENST00000337109	MRPL35-202	3727	-	ENSP00000338389	188 (aa)	-	Q9NZE8
ENST00000254644	MRPL35-201	1061	-	ENSP00000254644	170 (aa)	-	Q9NZE8
ENST00000409180	MRPL35-203	651	XM_005264361	ENSP00000386255	177 (aa)	XP_005264418	D3YTC1

Gene Model

Click here to download ENSG00000132313's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03010	Ribosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000132313	Vascular Diseases	5.8830000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132313	rs2241432	2	86211023	?	Systolic blood pressure	30595370			EFO_0006335
ENSG00000132313	rs2059352	2	86200698	A	Systolic blood pressure	30578418	[0.16-0.31] mmHg decrease	0.2359	EFO_0006335

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132313's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132313	MRPL35	96	50.296	ENSAPOG00000014486	mrpl35	85	50.296	Acanthochromis_polyacanthus
ENSG00000132313	MRPL35	100	80.319	ENSAMEG00000005978	MRPL35	100	80.319	Ailuropoda_melanoleuca
ENSG00000132313	MRPL35	96	54.839	ENSACIG00000024315	mrpl35	98	54.839	Amphilophus_citrinellus
ENSG00000132313	MRPL35	96	53.763	ENSAOCG00000000336	mrpl35	98	53.763	Amphiprion_ocellaris
ENSG00000132313	MRPL35	96	53.763	ENSAPEG00000023364	mrpl35	98	53.763	Amphiprion_percula
ENSG00000132313	MRPL35	96	56.593	ENSATEG00000021800	mrpl35	99	56.593	Anabas_testudineus
ENSG00000132313	MRPL35	57	75.926	ENSACAG00000025298	MRPL35	81	75.926	Anolis_carolinensis
ENSG00000132313	MRPL35	100	91.489	ENSANAG00000030616	MRPL35	100	91.489	Aotus_nancymaae
ENSG00000132313	MRPL35	96	56.989	ENSACLG00000021543	mrpl35	98	56.989	Astatotilapia_calliptera
ENSG00000132313	MRPL35	97	57.143	ENSAMXG00000040020	mrpl35	99	57.143	Astyanax_mexicanus
ENSG00000132313	MRPL35	100	83.511	ENSBTAG00000004823	MRPL35	100	83.511	Bos_taurus
ENSG00000132313	MRPL35	100	91.489	ENSCJAG00000022808	-	100	91.489	Callithrix_jacchus
ENSG00000132313	MRPL35	100	91.489	ENSCJAG00000019467	-	100	91.489	Callithrix_jacchus
ENSG00000132313	MRPL35	100	78.191	ENSCAFG00000007553	MRPL35	100	78.191	Canis_familiaris
ENSG00000132313	MRPL35	100	77.660	ENSCAFG00020016017	MRPL35	100	77.660	Canis_lupus_dingo
ENSG00000132313	MRPL35	93	81.143	ENSCHIG00000016097	MRPL35	100	81.915	Capra_hircus
ENSG00000132313	MRPL35	100	86.702	ENSTSYG00000007713	MRPL35	100	86.702	Carlito_syrichta
ENSG00000132313	MRPL35	93	80.000	ENSCAPG00000016674	MRPL35	100	80.000	Cavia_aperea
ENSG00000132313	MRPL35	100	78.723	ENSCPOG00000012387	MRPL35	100	78.723	Cavia_porcellus
ENSG00000132313	MRPL35	100	91.489	ENSCCAG00000034626	MRPL35	100	91.489	Cebus_capucinus
ENSG00000132313	MRPL35	100	95.745	ENSCATG00000037137	MRPL35	100	95.745	Cercocebus_atys
ENSG00000132313	MRPL35	100	78.191	ENSCLAG00000004489	MRPL35	100	78.191	Chinchilla_lanigera
ENSG00000132313	MRPL35	100	95.213	ENSCSAG00000000626	-	100	95.213	Chlorocebus_sabaeus
ENSG00000132313	MRPL35	93	61.143	ENSCHOG00000003797	MRPL35	100	62.766	Choloepus_hoffmanni
ENSG00000132313	MRPL35	98	63.043	ENSCPBG00000001213	MRPL35	99	63.043	Chrysemys_picta_bellii
ENSG00000132313	MRPL35	77	41.447	ENSCSAVG00000009271	-	65	41.447	Ciona_savignyi
ENSG00000132313	MRPL35	99	70.414	ENSCANG00000028695	-	100	70.414	Colobus_angolensis_palliatus
ENSG00000132313	MRPL35	100	96.277	ENSCANG00000042841	MRPL35	100	96.277	Colobus_angolensis_palliatus
ENSG00000132313	MRPL35	100	79.412	ENSCGRG00001016701	Mrpl35	100	79.255	Cricetulus_griseus_chok1gshd
ENSG00000132313	MRPL35	100	79.412	ENSCGRG00000007088	Mrpl35	100	79.255	Cricetulus_griseus_crigri
ENSG00000132313	MRPL35	73	62.857	ENSCSEG00000001344	mrpl35	80	62.857	Cynoglossus_semilaevis
ENSG00000132313	MRPL35	91	58.046	ENSCVAG00000005521	mrpl35	88	58.046	Cyprinodon_variegatus
ENSG00000132313	MRPL35	97	57.065	ENSDARG00000070589	mrpl35	92	57.065	Danio_rerio
ENSG00000132313	MRPL35	93	80.571	ENSDNOG00000045624	-	99	79.032	Dasypus_novemcinctus
ENSG00000132313	MRPL35	94	78.531	ENSDORG00000012391	Mrpl35	96	78.531	Dipodomys_ordii
ENSG00000132313	MRPL35	50	54.255	FBgn0038923	mRpL35	53	54.255	Drosophila_melanogaster
ENSG00000132313	MRPL35	92	53.757	ENSETEG00000009350	-	100	53.757	Echinops_telfairi
ENSG00000132313	MRPL35	100	82.979	ENSEASG00005001655	MRPL35	90	82.979	Equus_asinus_asinus
ENSG00000132313	MRPL35	100	82.979	ENSECAG00000024527	MRPL35	90	82.979	Equus_caballus
ENSG00000132313	MRPL35	97	53.846	ENSELUG00000010029	mrpl35	99	53.846	Esox_lucius
ENSG00000132313	MRPL35	89	78.146	ENSFCAG00000025565	-	97	77.844	Felis_catus
ENSG00000132313	MRPL35	93	82.759	ENSFCAG00000040448	-	100	82.979	Felis_catus
ENSG00000132313	MRPL35	61	74.783	ENSFALG00000010096	MRPL35	100	74.783	Ficedula_albicollis
ENSG00000132313	MRPL35	100	74.118	ENSFDAG00000001484	MRPL35	99	71.910	Fukomys_damarensis
ENSG00000132313	MRPL35	60	73.214	ENSFHEG00000009211	mrpl35	64	73.214	Fundulus_heteroclitus
ENSG00000132313	MRPL35	59	74.545	ENSGMOG00000010615	mrpl35	92	74.545	Gadus_morhua
ENSG00000132313	MRPL35	93	59.091	ENSGALG00000022950	MRPL35	99	57.754	Gallus_gallus
ENSG00000132313	MRPL35	96	54.945	ENSGAFG00000009819	mrpl35	99	54.945	Gambusia_affinis
ENSG00000132313	MRPL35	93	57.386	ENSGACG00000008269	mrpl35	93	75.455	Gasterosteus_aculeatus
ENSG00000132313	MRPL35	100	61.376	ENSGAGG00000020090	MRPL35	91	61.376	Gopherus_agassizii
ENSG00000132313	MRPL35	100	98.936	ENSGGOG00000026769	MRPL35	100	98.936	Gorilla_gorilla
ENSG00000132313	MRPL35	87	77.703	ENSGGOG00000043392	-	97	77.703	Gorilla_gorilla
ENSG00000132313	MRPL35	96	56.989	ENSHBUG00000022325	mrpl35	98	56.989	Haplochromis_burtoni
ENSG00000132313	MRPL35	92	79.191	ENSHGLG00100012873	MRPL35	99	79.191	Heterocephalus_glaber_male
ENSG00000132313	MRPL35	64	69.167	ENSHCOG00000020369	mrpl35	97	52.222	Hippocampus_comes
ENSG00000132313	MRPL35	96	56.354	ENSIPUG00000023891	mrpl35	99	56.354	Ictalurus_punctatus
ENSG00000132313	MRPL35	100	77.660	ENSSTOG00000030233	MRPL35	100	77.660	Ictidomys_tridecemlineatus
ENSG00000132313	MRPL35	97	54.545	ENSKMAG00000005185	mrpl35	99	54.545	Kryptolebias_marmoratus
ENSG00000132313	MRPL35	97	57.979	ENSLBEG00000021581	mrpl35	99	57.754	Labrus_bergylta
ENSG00000132313	MRPL35	97	57.609	ENSLACG00000002159	MRPL35	100	57.609	Latimeria_chalumnae
ENSG00000132313	MRPL35	97	57.368	ENSLOCG00000010848	mrpl35	100	57.368	Lepisosteus_oculatus
ENSG00000132313	MRPL35	100	79.255	ENSLAFG00000001319	MRPL35	100	79.255	Loxodonta_africana
ENSG00000132313	MRPL35	100	95.480	ENSMFAG00000002964	MRPL35	100	95.480	Macaca_fascicularis
ENSG00000132313	MRPL35	92	82.166	ENSMFAG00000000104	-	100	78.212	Macaca_fascicularis
ENSG00000132313	MRPL35	100	94.915	ENSMMUG00000020932	MRPL35	100	94.915	Macaca_mulatta
ENSG00000132313	MRPL35	92	82.803	ENSMMUG00000030529	-	100	78.771	Macaca_mulatta
ENSG00000132313	MRPL35	92	82.803	ENSMNEG00000036011	-	100	78.771	Macaca_nemestrina
ENSG00000132313	MRPL35	93	97.126	ENSMNEG00000043851	MRPL35	92	97.126	Macaca_nemestrina
ENSG00000132313	MRPL35	100	72.941	ENSMLEG00000033271	-	100	72.340	Mandrillus_leucophaeus
ENSG00000132313	MRPL35	100	95.294	ENSMLEG00000034130	MRPL35	100	95.294	Mandrillus_leucophaeus
ENSG00000132313	MRPL35	96	56.216	ENSMAMG00000002561	mrpl35	99	56.216	Mastacembelus_armatus
ENSG00000132313	MRPL35	96	56.989	ENSMZEG00005008064	mrpl35	98	56.989	Maylandia_zebra
ENSG00000132313	MRPL35	100	77.059	ENSMAUG00000009361	Mrpl35	100	76.596	Mesocricetus_auratus
ENSG00000132313	MRPL35	100	86.170	ENSMICG00000000776	MRPL35	100	86.170	Microcebus_murinus
ENSG00000132313	MRPL35	100	78.824	ENSMOCG00000008652	Mrpl35	100	78.723	Microtus_ochrogaster
ENSG00000132313	MRPL35	93	57.609	ENSMMOG00000013882	mrpl35	95	57.609	Mola_mola
ENSG00000132313	MRPL35	93	69.714	ENSMODG00000009393	MRPL35	100	69.714	Monodelphis_domestica
ENSG00000132313	MRPL35	97	59.783	ENSMALG00000008539	mrpl35	99	59.783	Monopterus_albus
ENSG00000132313	MRPL35	100	76.596	MGP_CAROLIEiJ_G0028491	Mrpl35	100	76.596	Mus_caroli
ENSG00000132313	MRPL35	100	76.596	ENSMUSG00000052962	Mrpl35	100	76.596	Mus_musculus
ENSG00000132313	MRPL35	100	77.660	MGP_PahariEiJ_G0022227	Mrpl35	100	77.660	Mus_pahari
ENSG00000132313	MRPL35	100	75.532	MGP_SPRETEiJ_G0029496	Mrpl35	100	75.532	Mus_spretus
ENSG00000132313	MRPL35	100	78.191	ENSMPUG00000009217	MRPL35	100	78.191	Mustela_putorius_furo
ENSG00000132313	MRPL35	100	80.851	ENSMLUG00000014531	MRPL35	100	80.851	Myotis_lucifugus
ENSG00000132313	MRPL35	100	81.383	ENSNGAG00000012550	Mrpl35	100	81.383	Nannospalax_galili
ENSG00000132313	MRPL35	96	56.150	ENSNBRG00000008083	mrpl35	99	57.062	Neolamprologus_brichardi
ENSG00000132313	MRPL35	99	77.381	ENSNLEG00000029266	-	100	77.381	Nomascus_leucogenys
ENSG00000132313	MRPL35	91	92.208	ENSNLEG00000028410	-	99	92.208	Nomascus_leucogenys
ENSG00000132313	MRPL35	100	96.809	ENSNLEG00000028560	MRPL35	100	96.809	Nomascus_leucogenys
ENSG00000132313	MRPL35	92	68.208	ENSMEUG00000004773	MRPL35	100	68.208	Notamacropus_eugenii
ENSG00000132313	MRPL35	92	75.145	ENSOPRG00000016834	MRPL35	100	75.145	Ochotona_princeps
ENSG00000132313	MRPL35	100	76.596	ENSODEG00000003180	MRPL35	100	76.596	Octodon_degus
ENSG00000132313	MRPL35	96	56.684	ENSONIG00000020132	mrpl35	98	56.684	Oreochromis_niloticus
ENSG00000132313	MRPL35	100	60.317	ENSOANG00000013423	MRPL35	100	60.317	Ornithorhynchus_anatinus
ENSG00000132313	MRPL35	100	81.383	ENSOCUG00000010193	MRPL35	100	81.383	Oryctolagus_cuniculus
ENSG00000132313	MRPL35	93	56.250	ENSORLG00000015918	mrpl35	95	56.250	Oryzias_latipes
ENSG00000132313	MRPL35	63	70.588	ENSORLG00020009134	mrpl35	68	70.588	Oryzias_latipes_hni
ENSG00000132313	MRPL35	63	72.034	ENSORLG00015000228	mrpl35	61	72.034	Oryzias_latipes_hsok
ENSG00000132313	MRPL35	61	76.316	ENSOMEG00000006008	mrpl35	65	76.316	Oryzias_melastigma
ENSG00000132313	MRPL35	100	81.915	ENSOGAG00000004048	MRPL35	100	81.915	Otolemur_garnettii
ENSG00000132313	MRPL35	93	81.034	ENSOARG00000020642	MRPL35	82	81.034	Ovis_aries
ENSG00000132313	MRPL35	98	75.449	ENSPPAG00000034076	-	97	75.449	Pan_paniscus
ENSG00000132313	MRPL35	100	98.936	ENSPPAG00000042773	MRPL35	100	98.936	Pan_paniscus
ENSG00000132313	MRPL35	93	82.759	ENSPPRG00000006561	-	100	82.979	Panthera_pardus
ENSG00000132313	MRPL35	93	81.034	ENSPPRG00000015141	-	100	81.383	Panthera_pardus
ENSG00000132313	MRPL35	93	82.184	ENSPTIG00000019867	-	100	82.447	Panthera_tigris_altaica
ENSG00000132313	MRPL35	93	81.609	ENSPTIG00000006319	-	100	81.383	Panthera_tigris_altaica
ENSG00000132313	MRPL35	100	98.936	ENSPTRG00000012152	MRPL35	100	98.936	Pan_troglodytes
ENSG00000132313	MRPL35	92	83.439	ENSPANG00000022075	-	100	79.330	Papio_anubis
ENSG00000132313	MRPL35	100	94.915	ENSPANG00000025906	MRPL35	100	94.915	Papio_anubis
ENSG00000132313	MRPL35	94	56.667	ENSPKIG00000018550	mrpl35	97	57.377	Paramormyrops_kingsleyae
ENSG00000132313	MRPL35	98	63.587	ENSPSIG00000008612	MRPL35	99	63.587	Pelodiscus_sinensis
ENSG00000132313	MRPL35	93	54.286	ENSPMGG00000010485	mrpl35	94	54.286	Periophthalmus_magnuspinnatus
ENSG00000132313	MRPL35	100	76.596	ENSPEMG00000021175	Mrpl35	100	76.596	Peromyscus_maniculatus_bairdii
ENSG00000132313	MRPL35	53	68.687	ENSPMAG00000002898	mrpl35	95	68.687	Petromyzon_marinus
ENSG00000132313	MRPL35	92	65.385	ENSPCIG00000004298	-	91	65.318	Phascolarctos_cinereus
ENSG00000132313	MRPL35	96	54.054	ENSPFOG00000001115	mrpl35	99	54.054	Poecilia_formosa
ENSG00000132313	MRPL35	96	54.054	ENSPLAG00000011281	mrpl35	99	54.054	Poecilia_latipinna
ENSG00000132313	MRPL35	96	54.054	ENSPMEG00000004702	mrpl35	99	54.054	Poecilia_mexicana
ENSG00000132313	MRPL35	62	71.552	ENSPREG00000014850	mrpl35	69	71.552	Poecilia_reticulata
ENSG00000132313	MRPL35	100	98.235	ENSPPYG00000012214	-	82	98.235	Pongo_abelii
ENSG00000132313	MRPL35	100	77.128	ENSPCAG00000012141	MRPL35	100	77.128	Procavia_capensis
ENSG00000132313	MRPL35	100	86.702	ENSPCOG00000007856	MRPL35	100	86.702	Propithecus_coquereli
ENSG00000132313	MRPL35	100	85.638	ENSPVAG00000012679	MRPL35	100	85.638	Pteropus_vampyrus
ENSG00000132313	MRPL35	96	56.989	ENSPNYG00000022623	mrpl35	98	56.989	Pundamilia_nyererei
ENSG00000132313	MRPL35	96	55.738	ENSPNAG00000018009	mrpl35	98	55.738	Pygocentrus_nattereri
ENSG00000132313	MRPL35	100	77.128	ENSRNOG00000008546	Mrpl35	100	77.128	Rattus_norvegicus
ENSG00000132313	MRPL35	100	95.745	ENSRBIG00000043270	-	100	95.745	Rhinopithecus_bieti
ENSG00000132313	MRPL35	100	66.489	ENSRBIG00000034504	-	91	76.871	Rhinopithecus_bieti
ENSG00000132313	MRPL35	100	95.213	ENSRBIG00000030640	-	100	95.213	Rhinopithecus_bieti
ENSG00000132313	MRPL35	99	77.976	ENSRROG00000008868	-	98	76.136	Rhinopithecus_roxellana
ENSG00000132313	MRPL35	100	95.745	ENSRROG00000045417	MRPL35	100	95.745	Rhinopithecus_roxellana
ENSG00000132313	MRPL35	92	93.064	ENSSBOG00000022291	MRPL35	100	93.064	Saimiri_boliviensis_boliviensis
ENSG00000132313	MRPL35	93	67.241	ENSSHAG00000014416	MRPL35	93	67.241	Sarcophilus_harrisii
ENSG00000132313	MRPL35	95	56.284	ENSSFOG00015004266	mrpl35	97	56.284	Scleropages_formosus
ENSG00000132313	MRPL35	61	76.316	ENSSMAG00000002498	mrpl35	65	76.316	Scophthalmus_maximus
ENSG00000132313	MRPL35	95	54.348	ENSSDUG00000001120	mrpl35	97	54.348	Seriola_dumerili
ENSG00000132313	MRPL35	97	54.545	ENSSLDG00000006561	mrpl35	99	54.545	Seriola_lalandi_dorsalis
ENSG00000132313	MRPL35	100	73.016	ENSSARG00000006229	MRPL35	100	73.016	Sorex_araneus
ENSG00000132313	MRPL35	92	64.740	ENSSPUG00000004765	MRPL35	99	63.388	Sphenodon_punctatus
ENSG00000132313	MRPL35	97	54.545	ENSSPAG00000012265	mrpl35	99	54.545	Stegastes_partitus
ENSG00000132313	MRPL35	100	80.319	ENSSSCG00000021746	MRPL35	100	80.319	Sus_scrofa
ENSG00000132313	MRPL35	57	78.505	ENSTGUG00000010799	MRPL35	100	78.505	Taeniopygia_guttata
ENSG00000132313	MRPL35	97	53.476	ENSTRUG00000019782	mrpl35	99	52.688	Takifugu_rubripes
ENSG00000132313	MRPL35	96	55.914	ENSTNIG00000017358	mrpl35	98	55.914	Tetraodon_nigroviridis
ENSG00000132313	MRPL35	100	81.481	ENSTBEG00000015366	MRPL35	100	81.481	Tupaia_belangeri
ENSG00000132313	MRPL35	100	81.383	ENSTTRG00000010371	MRPL35	100	81.383	Tursiops_truncatus
ENSG00000132313	MRPL35	100	79.787	ENSUAMG00000025275	MRPL35	100	79.787	Ursus_americanus
ENSG00000132313	MRPL35	100	80.319	ENSUMAG00000007891	MRPL35	100	80.319	Ursus_maritimus
ENSG00000132313	MRPL35	100	84.706	ENSVPAG00000012004	MRPL35	100	84.043	Vicugna_pacos
ENSG00000132313	MRPL35	91	73.548	ENSVVUG00000000063	MRPL35	77	67.442	Vulpes_vulpes
ENSG00000132313	MRPL35	98	58.163	ENSXETG00000028100	mrpl35	94	58.163	Xenopus_tropicalis
ENSG00000132313	MRPL35	61	71.053	ENSXCOG00000008830	mrpl35	64	71.053	Xiphophorus_couchianus
ENSG00000132313	MRPL35	61	71.930	ENSXMAG00000013548	mrpl35	64	71.930	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003735	structural constituent of ribosome	11543634.	NAS	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0005739	mitochondrion	28892042.	IDA	Component
GO:0005743	mitochondrial inner membrane	-	TAS	Component
GO:0005761	mitochondrial ribosome	11543634.	NAS	Component
GO:0005762	mitochondrial large ribosomal subunit	25278503.28892042.	IDA	Component
GO:0006412	translation	11543634.	NAS	Process
GO:0070125	mitochondrial translational elongation	-	TAS	Process
GO:0070126	mitochondrial translational termination	-	TAS	Process