EuRBPDB

Description

Ensembl ID: ENSG00000132323 (Gene tree)
Gene ID: 80895
Gene Symbol: ILKAP
Alias: DKFZP434J2031|FLJ10181|PPM1O
Full Name: ILK associated serine/threonine phosphatase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 33,329 bases
Position: chr2:238,170,401-238,203,729
Accession: 15566
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a protein serine/threonine phosphatase of the PP2C family. This protein can interact with integrin-linked kinase (ILK/ILK1), a regulator of integrin mediated signaling, and regulate the kinase activity of ILK. Through the interaction with ILK, this protein may selectively affect the signaling process of ILK-mediated glycogen synthase kinase 3 beta (GSK3beta), and thus participate in Wnt signaling pathway. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000490837	ILKAP-209	557	-	-	- (aa)	-	-
ENST00000450411	ILKAP-202	1024	-	ENSP00000406254	203 (aa)	-	H7C2I8
ENST00000254654	ILKAP-201	1490	XM_005246106	ENSP00000254654	392 (aa)	XP_005246163	Q9H0C8
ENST00000463129	ILKAP-204	1861	-	-	- (aa)	-	-
ENST00000479400	ILKAP-208	690	-	-	- (aa)	-	-
ENST00000612675	ILKAP-211	1335	-	ENSP00000477533	162 (aa)	-	F8SNU6
ENST00000622223	ILKAP-212	1088	-	ENSP00000477542	274 (aa)	-	F8SNU7
ENST00000465131	ILKAP-205	750	-	-	- (aa)	-	-
ENST00000467133	ILKAP-207	618	-	-	- (aa)	-	-
ENST00000498727	ILKAP-210	587	-	-	- (aa)	-	-
ENST00000457149	ILKAP-203	793	-	ENSP00000395301	212 (aa)	-	E9PC05
ENST00000466468	ILKAP-206	2651	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000132323	Phospholipids	2E-8	22359512

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132323	rs35676364	2	238184733	GT	Mean corpuscular hemoglobin	27863252	[0.022-0.036] unit increase	0.02864316	EFO_0004527
ENSG00000132323	rs35676364	2	238184733	GT	Mean corpuscular volume	27863252	[0.015-0.029] unit increase	0.02197751	EFO_0004526
ENSG00000132323	rs35113840	2	238193016	GA	Red cell distribution width	27863252	[0.018-0.035] unit decrease	0.02636336	EFO_0005192
ENSG00000132323	rs12472274	2	238186781	?	Phospholipid levels (plasma)	22359512	[NR] % increase	0.8	EFO_0004639

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004722	protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity	21873635.	IBA	Function
GO:0005515	protein binding	11331582.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006470	protein dephosphorylation	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function