EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132376 (Gene tree)
Gene ID: 51763
Gene Symbol: INPP5K
Alias: SKIP
Full Name: inositol polyphosphate-5-phosphatase K
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 22,318 bases
Position: chr17:1,494,571-1,516,888
Accession: 33882
RBP type: canonical RBP
Summary: This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000413937	Exo_endo_phos	PF03372.23	3.3e-08	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000445774	INPP5K-205	565	-	ENSP00000389334	52 (aa)	-	C9JQW8
ENST00000571274	INPP5K-215	571	-	ENSP00000458413	84 (aa)	-	I3L0Y0
ENST00000449479	INPP5K-206	949	-	ENSP00000413259	229 (aa)	-	C9JZB0
ENST00000575172	INPP5K-219	594	-	ENSP00000459758	158 (aa)	-	I3L2L1
ENST00000487039	INPP5K-212	482	-	-	- (aa)	-	-
ENST00000477910	INPP5K-210	739	-	ENSP00000467376	50 (aa)	-	K7EPG6
ENST00000460733	INPP5K-207	554	-	-	- (aa)	-	-
ENST00000574561	INPP5K-217	591	-	ENSP00000461105	154 (aa)	-	I3L4A5
ENST00000461552	INPP5K-208	581	-	-	- (aa)	-	-
ENST00000576646	INPP5K-220	629	-	ENSP00000466632	38 (aa)	-	K7EMS8
ENST00000574955	INPP5K-218	566	-	ENSP00000459029	51 (aa)	-	I3L1R1
ENST00000498390	INPP5K-214	622	-	ENSP00000466929	23 (aa)	-	K7ENF7
ENST00000495339	INPP5K-213	406	-	-	- (aa)	-	-
ENST00000477115	INPP5K-209	770	-	-	- (aa)	-	-
ENST00000350761	INPP5K-202	1505	-	ENSP00000254712	63 (aa)	-	J3KN07
ENST00000573790	INPP5K-216	635	-	ENSP00000461846	99 (aa)	-	I3NI31
ENST00000320345	INPP5K-201	2880	XM_005256683	ENSP00000318476	372 (aa)	XP_005256740	Q9BT40
ENST00000406424	INPP5K-203	3194	XM_011523934	ENSP00000385177	372 (aa)	XP_011522236	Q9BT40
ENST00000421807	INPP5K-204	2988	-	ENSP00000413937	448 (aa)	-	Q9BT40
ENST00000481867	INPP5K-211	558	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132376's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00562	Inositol phosphate metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04070	Phosphatidylinositol signaling system	KEGG
hsa04910	Insulin signaling pathway	KEGG

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132376	rs939563	17	1512616	A	Mean platelet volume	27863252	[0.015-0.029] unit increase	0.02163254	EFO_0004584

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132376's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132376	INPP5K	100	62.000	ENSAPOG00000006700	inpp5kb	94	45.349	Acanthochromis_polyacanthus
ENSG00000132376	INPP5K	98	90.625	ENSAMEG00000008066	INPP5K	95	79.372	Ailuropoda_melanoleuca
ENSG00000132376	INPP5K	100	52.000	ENSACIG00000023356	inpp5ka	89	48.028	Amphilophus_citrinellus
ENSG00000132376	INPP5K	100	64.000	ENSACIG00000013422	inpp5kb	95	46.667	Amphilophus_citrinellus
ENSG00000132376	INPP5K	100	50.000	ENSAOCG00000003312	inpp5ka	91	46.966	Amphiprion_ocellaris
ENSG00000132376	INPP5K	100	62.000	ENSAOCG00000023757	inpp5kb	94	46.838	Amphiprion_ocellaris
ENSG00000132376	INPP5K	100	62.500	ENSAPEG00000023074	inpp5kb	95	45.578	Amphiprion_percula
ENSG00000132376	INPP5K	100	50.000	ENSAPEG00000002929	inpp5ka	89	47.489	Amphiprion_percula
ENSG00000132376	INPP5K	88	67.857	ENSATEG00000021792	inpp5kb	90	46.118	Anabas_testudineus
ENSG00000132376	INPP5K	100	52.000	ENSATEG00000020329	inpp5ka	89	48.140	Anabas_testudineus
ENSG00000132376	INPP5K	100	62.000	ENSAPLG00000008625	INPP5K	97	58.469	Anas_platyrhynchos
ENSG00000132376	INPP5K	100	96.875	ENSANAG00000023521	INPP5K	100	89.955	Aotus_nancymaae
ENSG00000132376	INPP5K	94	61.702	ENSACLG00000022330	inpp5kb	95	45.786	Astatotilapia_calliptera
ENSG00000132376	INPP5K	100	54.000	ENSACLG00000015203	inpp5ka	91	46.563	Astatotilapia_calliptera
ENSG00000132376	INPP5K	100	52.000	ENSAMXG00000031383	inpp5ka	90	46.067	Astyanax_mexicanus
ENSG00000132376	INPP5K	100	54.000	ENSAMXG00000016643	inpp5kb	96	42.472	Astyanax_mexicanus
ENSG00000132376	INPP5K	100	88.000	ENSBTAG00000011479	INPP5K	99	71.938	Bos_taurus
ENSG00000132376	INPP5K	100	96.875	ENSCJAG00000022850	-	96	88.837	Callithrix_jacchus
ENSG00000132376	INPP5K	100	96.875	ENSCJAG00000002060	-	100	89.732	Callithrix_jacchus
ENSG00000132376	INPP5K	100	90.625	ENSCHIG00000013342	INPP5K	99	78.842	Capra_hircus
ENSG00000132376	INPP5K	100	95.652	ENSCCAG00000030656	INPP5K	100	89.286	Cebus_capucinus
ENSG00000132376	INPP5K	100	100.000	ENSCATG00000042698	INPP5K	100	96.429	Cercocebus_atys
ENSG00000132376	INPP5K	100	100.000	ENSCSAG00000014042	INPP5K	100	96.205	Chlorocebus_sabaeus
ENSG00000132376	INPP5K	100	60.000	ENSCPBG00000020466	INPP5K	95	50.448	Chrysemys_picta_bellii
ENSG00000132376	INPP5K	100	100.000	ENSCANG00000027991	INPP5K	100	95.982	Colobus_angolensis_palliatus
ENSG00000132376	INPP5K	100	86.957	ENSCGRG00001006776	Inpp5k	97	75.169	Cricetulus_griseus_chok1gshd
ENSG00000132376	INPP5K	100	86.957	ENSCGRG00000011514	Inpp5k	98	75.169	Cricetulus_griseus_crigri
ENSG00000132376	INPP5K	100	50.000	ENSCSEG00000005136	INPP5K	93	45.176	Cynoglossus_semilaevis
ENSG00000132376	INPP5K	100	64.000	ENSCSEG00000009648	inpp5kb	85	46.226	Cynoglossus_semilaevis
ENSG00000132376	INPP5K	95	55.556	ENSCVAG00000014094	INPP5K	94	43.839	Cyprinodon_variegatus
ENSG00000132376	INPP5K	100	62.500	ENSDARG00000078618	inpp5kb	95	44.419	Danio_rerio
ENSG00000132376	INPP5K	100	58.000	ENSDARG00000099563	inpp5ka	91	47.344	Danio_rerio
ENSG00000132376	INPP5K	100	86.957	ENSEEUG00000001746	INPP5K	100	76.392	Erinaceus_europaeus
ENSG00000132376	INPP5K	95	61.111	ENSELUG00000010246	inpp5ka	89	47.945	Esox_lucius
ENSG00000132376	INPP5K	100	60.000	ENSELUG00000000699	inpp5kb	93	45.940	Esox_lucius
ENSG00000132376	INPP5K	100	93.750	ENSFCAG00000006292	INPP5K	99	80.178	Felis_catus
ENSG00000132376	INPP5K	100	62.000	ENSFALG00000006671	INPP5K	78	57.042	Ficedula_albicollis
ENSG00000132376	INPP5K	100	88.095	ENSFDAG00000016697	INPP5K	96	77.728	Fukomys_damarensis
ENSG00000132376	INPP5K	95	55.556	ENSFHEG00000021907	inpp5ka	90	47.907	Fundulus_heteroclitus
ENSG00000132376	INPP5K	100	62.000	ENSFHEG00000017942	inpp5kb	96	45.958	Fundulus_heteroclitus
ENSG00000132376	INPP5K	100	49.580	ENSGMOG00000000770	inpp5kb	100	45.047	Gadus_morhua
ENSG00000132376	INPP5K	91	62.500	ENSGMOG00000009311	inpp5ka	100	51.084	Gadus_morhua
ENSG00000132376	INPP5K	100	60.000	ENSGALG00000002739	INPP5K	91	57.547	Gallus_gallus
ENSG00000132376	INPP5K	100	60.000	ENSGAFG00000000282	inpp5kb	95	46.244	Gambusia_affinis
ENSG00000132376	INPP5K	95	55.556	ENSGAFG00000012439	inpp5ka	83	46.189	Gambusia_affinis
ENSG00000132376	INPP5K	100	52.000	ENSGACG00000005511	inpp5ka	99	47.113	Gasterosteus_aculeatus
ENSG00000132376	INPP5K	100	58.000	ENSGACG00000020608	inpp5kb	100	43.875	Gasterosteus_aculeatus
ENSG00000132376	INPP5K	100	60.000	ENSGAGG00000008365	INPP5K	91	57.547	Gopherus_agassizii
ENSG00000132376	INPP5K	100	100.000	ENSGGOG00000007373	INPP5K	100	98.884	Gorilla_gorilla
ENSG00000132376	INPP5K	100	54.000	ENSHBUG00000008702	inpp5ka	94	47.738	Haplochromis_burtoni
ENSG00000132376	INPP5K	100	60.000	ENSHBUG00000014999	inpp5kb	94	45.080	Haplochromis_burtoni
ENSG00000132376	INPP5K	100	60.000	ENSHCOG00000006985	inpp5kb	87	44.519	Hippocampus_comes
ENSG00000132376	INPP5K	100	54.000	ENSHCOG00000015362	INPP5K	93	46.445	Hippocampus_comes
ENSG00000132376	INPP5K	100	56.000	ENSIPUG00000014228	inpp5ka	89	46.517	Ictalurus_punctatus
ENSG00000132376	INPP5K	100	56.000	ENSIPUG00000005065	inpp5kb	98	40.138	Ictalurus_punctatus
ENSG00000132376	INPP5K	100	95.652	ENSSTOG00000005020	INPP5K	87	78.378	Ictidomys_tridecemlineatus
ENSG00000132376	INPP5K	100	91.667	ENSJJAG00000013918	Inpp5k	99	77.551	Jaculus_jaculus
ENSG00000132376	INPP5K	100	64.000	ENSKMAG00000000659	inpp5kb	96	45.575	Kryptolebias_marmoratus
ENSG00000132376	INPP5K	100	54.000	ENSKMAG00000015448	inpp5ka	90	44.420	Kryptolebias_marmoratus
ENSG00000132376	INPP5K	100	62.000	ENSLBEG00000011848	inpp5kb	90	46.479	Labrus_bergylta
ENSG00000132376	INPP5K	95	58.333	ENSLBEG00000016790	inpp5ka	89	45.414	Labrus_bergylta
ENSG00000132376	INPP5K	100	62.000	ENSLACG00000007138	INPP5K	89	55.714	Latimeria_chalumnae
ENSG00000132376	INPP5K	100	48.800	ENSLOCG00000000846	inpp5kb	91	48.115	Lepisosteus_oculatus
ENSG00000132376	INPP5K	100	88.095	ENSLAFG00000010060	INPP5K	95	80.225	Loxodonta_africana
ENSG00000132376	INPP5K	100	100.000	ENSMFAG00000030338	INPP5K	100	96.429	Macaca_fascicularis
ENSG00000132376	INPP5K	100	100.000	ENSMMUG00000002373	INPP5K	100	90.179	Macaca_mulatta
ENSG00000132376	INPP5K	100	100.000	ENSMNEG00000035408	INPP5K	100	96.205	Macaca_nemestrina
ENSG00000132376	INPP5K	100	100.000	ENSMLEG00000038285	INPP5K	100	96.429	Mandrillus_leucophaeus
ENSG00000132376	INPP5K	100	52.000	ENSMAMG00000004570	inpp5ka	90	47.586	Mastacembelus_armatus
ENSG00000132376	INPP5K	100	58.000	ENSMAMG00000019469	inpp5kb	93	45.154	Mastacembelus_armatus
ENSG00000132376	INPP5K	100	54.000	ENSMZEG00005003900	INPP5K	91	46.563	Maylandia_zebra
ENSG00000132376	INPP5K	94	61.702	ENSMZEG00005019226	inpp5kb	94	44.851	Maylandia_zebra
ENSG00000132376	INPP5K	100	62.000	ENSMGAG00000005047	INPP5K	94	59.005	Meleagris_gallopavo
ENSG00000132376	INPP5K	100	86.957	ENSMAUG00000007460	-	93	80.934	Mesocricetus_auratus
ENSG00000132376	INPP5K	100	91.304	ENSMOCG00000005686	Inpp5k	96	75.112	Microtus_ochrogaster
ENSG00000132376	INPP5K	100	58.000	ENSMMOG00000019517	inpp5kb	99	45.558	Mola_mola
ENSG00000132376	INPP5K	95	58.333	ENSMMOG00000005843	inpp5ka	92	47.222	Mola_mola
ENSG00000132376	INPP5K	100	61.572	ENSMODG00000010327	INPP5K	96	59.036	Monodelphis_domestica
ENSG00000132376	INPP5K	95	55.556	ENSMALG00000021979	inpp5ka	90	47.465	Monopterus_albus
ENSG00000132376	INPP5K	100	91.304	MGP_CAROLIEiJ_G0016745	Inpp5k	96	76.000	Mus_caroli
ENSG00000132376	INPP5K	100	91.304	ENSMUSG00000006127	Inpp5k	96	75.556	Mus_musculus
ENSG00000132376	INPP5K	100	91.304	MGP_SPRETEiJ_G0017588	Inpp5k	96	75.778	Mus_spretus
ENSG00000132376	INPP5K	99	90.625	ENSMPUG00000013429	INPP5K	95	79.866	Mustela_putorius_furo
ENSG00000132376	INPP5K	100	89.286	ENSMLUG00000001819	INPP5K	96	78.876	Myotis_lucifugus
ENSG00000132376	INPP5K	100	58.000	ENSNBRG00000008888	inpp5kb	80	45.619	Neolamprologus_brichardi
ENSG00000132376	INPP5K	100	54.000	ENSNBRG00000023132	inpp5ka	99	42.512	Neolamprologus_brichardi
ENSG00000132376	INPP5K	100	62.000	ENSONIG00000004821	inpp5kb	99	45.517	Oreochromis_niloticus
ENSG00000132376	INPP5K	100	68.000	ENSOANG00000002536	-	98	59.292	Ornithorhynchus_anatinus
ENSG00000132376	INPP5K	100	84.524	ENSOCUG00000000073	INPP5K	96	75.223	Oryctolagus_cuniculus
ENSG00000132376	INPP5K	100	54.000	ENSORLG00000005065	inpp5kb	82	44.626	Oryzias_latipes
ENSG00000132376	INPP5K	100	52.000	ENSORLG00000009637	inpp5ka	88	46.636	Oryzias_latipes
ENSG00000132376	INPP5K	100	56.000	ENSORLG00020010279	inpp5kb	92	44.626	Oryzias_latipes_hni
ENSG00000132376	INPP5K	100	52.000	ENSORLG00020017763	inpp5ka	91	45.249	Oryzias_latipes_hni
ENSG00000132376	INPP5K	100	52.000	ENSORLG00015023137	inpp5ka	91	46.933	Oryzias_latipes_hsok
ENSG00000132376	INPP5K	100	56.000	ENSORLG00015015933	inpp5kb	89	45.199	Oryzias_latipes_hsok
ENSG00000132376	INPP5K	100	54.000	ENSOMEG00000016657	inpp5kb	94	45.662	Oryzias_melastigma
ENSG00000132376	INPP5K	94	62.500	ENSOMEG00000020222	inpp5ka	90	46.697	Oryzias_melastigma
ENSG00000132376	INPP5K	100	88.000	ENSOGAG00000006172	INPP5K	100	79.770	Otolemur_garnettii
ENSG00000132376	INPP5K	100	90.625	ENSOARG00000012783	INPP5K	95	78.097	Ovis_aries
ENSG00000132376	INPP5K	100	100.000	ENSPPAG00000042486	INPP5K	100	99.107	Pan_paniscus
ENSG00000132376	INPP5K	100	93.750	ENSPPRG00000005328	INPP5K	99	80.178	Panthera_pardus
ENSG00000132376	INPP5K	100	93.750	ENSPTIG00000015046	INPP5K	99	79.955	Panthera_tigris_altaica
ENSG00000132376	INPP5K	100	100.000	ENSPTRG00000008525	INPP5K	100	99.107	Pan_troglodytes
ENSG00000132376	INPP5K	100	100.000	ENSPANG00000024602	INPP5K	100	96.429	Papio_anubis
ENSG00000132376	INPP5K	95	63.889	ENSPKIG00000021858	inpp5ka	93	45.964	Paramormyrops_kingsleyae
ENSG00000132376	INPP5K	100	60.000	ENSPKIG00000025592	INPP5K	89	48.113	Paramormyrops_kingsleyae
ENSG00000132376	INPP5K	100	56.000	ENSPSIG00000011689	INPP5K	95	55.000	Pelodiscus_sinensis
ENSG00000132376	INPP5K	95	61.111	ENSPMGG00000001272	-	94	47.806	Periophthalmus_magnuspinnatus
ENSG00000132376	INPP5K	100	60.000	ENSPMGG00000007558	inpp5kb	94	45.727	Periophthalmus_magnuspinnatus
ENSG00000132376	INPP5K	100	91.304	ENSPEMG00000015251	Inpp5k	96	75.893	Peromyscus_maniculatus_bairdii
ENSG00000132376	INPP5K	100	48.235	ENSPMAG00000009891	-	98	43.750	Petromyzon_marinus
ENSG00000132376	INPP5K	99	64.602	ENSPCIG00000017183	INPP5K	96	58.986	Phascolarctos_cinereus
ENSG00000132376	INPP5K	100	52.000	ENSPFOG00000012225	inpp5ka	91	45.928	Poecilia_formosa
ENSG00000132376	INPP5K	100	62.000	ENSPFOG00000018120	inpp5kb	89	46.963	Poecilia_formosa
ENSG00000132376	INPP5K	100	60.000	ENSPLAG00000017064	inpp5kb	83	45.708	Poecilia_latipinna
ENSG00000132376	INPP5K	100	52.000	ENSPLAG00000023959	inpp5ka	91	47.113	Poecilia_latipinna
ENSG00000132376	INPP5K	100	60.000	ENSPMEG00000003151	inpp5kb	83	45.940	Poecilia_mexicana
ENSG00000132376	INPP5K	100	52.000	ENSPMEG00000003654	inpp5ka	91	47.113	Poecilia_mexicana
ENSG00000132376	INPP5K	96	54.167	ENSPREG00000009696	inpp5ka	91	47.113	Poecilia_reticulata
ENSG00000132376	INPP5K	100	62.000	ENSPREG00000015210	inpp5kb	96	45.575	Poecilia_reticulata
ENSG00000132376	INPP5K	100	100.000	ENSPPYG00000007772	INPP5K	100	96.429	Pongo_abelii
ENSG00000132376	INPP5K	98	96.875	ENSPCOG00000028791	INPP5K	99	82.511	Propithecus_coquereli
ENSG00000132376	INPP5K	100	54.000	ENSPNYG00000009955	inpp5ka	91	48.611	Pundamilia_nyererei
ENSG00000132376	INPP5K	94	61.702	ENSPNYG00000020217	inpp5kb	95	46.241	Pundamilia_nyererei
ENSG00000132376	INPP5K	100	52.000	ENSPNAG00000005980	inpp5ka	90	46.313	Pygocentrus_nattereri
ENSG00000132376	INPP5K	100	54.000	ENSPNAG00000025241	inpp5kb	93	43.662	Pygocentrus_nattereri
ENSG00000132376	INPP5K	100	91.304	ENSRNOG00000056954	Inpp5k	99	72.247	Rattus_norvegicus
ENSG00000132376	INPP5K	100	100.000	ENSRBIG00000037118	INPP5K	100	95.982	Rhinopithecus_bieti
ENSG00000132376	INPP5K	100	100.000	ENSRROG00000043460	INPP5K	100	96.205	Rhinopithecus_roxellana
ENSG00000132376	INPP5K	100	95.652	ENSSBOG00000033103	INPP5K	100	88.453	Saimiri_boliviensis_boliviensis
ENSG00000132376	INPP5K	100	64.192	ENSSHAG00000002999	-	85	58.636	Sarcophilus_harrisii
ENSG00000132376	INPP5K	100	56.000	ENSSFOG00015016067	inpp5ka	90	47.597	Scleropages_formosus
ENSG00000132376	INPP5K	100	54.000	ENSSFOG00015003905	inpp5kb	98	49.203	Scleropages_formosus
ENSG00000132376	INPP5K	100	56.000	ENSSMAG00000018090	inpp5ka	91	47.523	Scophthalmus_maximus
ENSG00000132376	INPP5K	100	66.000	ENSSMAG00000009248	inpp5kb	82	47.529	Scophthalmus_maximus
ENSG00000132376	INPP5K	97	67.857	ENSSDUG00000003376	inpp5kb	94	46.591	Seriola_dumerili
ENSG00000132376	INPP5K	100	52.000	ENSSDUG00000022099	inpp5ka	90	47.836	Seriola_dumerili
ENSG00000132376	INPP5K	97	67.857	ENSSLDG00000016366	inpp5kb	96	46.364	Seriola_lalandi_dorsalis
ENSG00000132376	INPP5K	100	52.000	ENSSLDG00000025424	inpp5ka	90	47.836	Seriola_lalandi_dorsalis
ENSG00000132376	INPP5K	100	54.583	ENSSPUG00000007597	INPP5K	93	53.604	Sphenodon_punctatus
ENSG00000132376	INPP5K	100	64.000	ENSSPAG00000013573	inpp5kb	95	45.958	Stegastes_partitus
ENSG00000132376	INPP5K	95	55.556	ENSSPAG00000021330	inpp5ka	89	47.945	Stegastes_partitus
ENSG00000132376	INPP5K	100	90.000	ENSSSCG00000030707	INPP5K	98	80.135	Sus_scrofa
ENSG00000132376	INPP5K	100	62.000	ENSTGUG00000005518	-	93	57.619	Taeniopygia_guttata
ENSG00000132376	INPP5K	100	60.000	ENSTRUG00000019993	inpp5kb	95	45.602	Takifugu_rubripes
ENSG00000132376	INPP5K	95	58.333	ENSTRUG00000012655	inpp5ka	83	45.958	Takifugu_rubripes
ENSG00000132376	INPP5K	100	60.000	ENSTNIG00000009970	inpp5kb	99	47.907	Tetraodon_nigroviridis
ENSG00000132376	INPP5K	95	55.556	ENSTNIG00000014293	inpp5ka	98	47.294	Tetraodon_nigroviridis
ENSG00000132376	INPP5K	100	90.625	ENSUAMG00000013248	INPP5K	99	79.510	Ursus_americanus
ENSG00000132376	INPP5K	100	90.625	ENSUMAG00000009644	INPP5K	99	79.287	Ursus_maritimus
ENSG00000132376	INPP5K	100	56.710	ENSXETG00000022881	inpp5k	95	55.435	Xenopus_tropicalis
ENSG00000132376	INPP5K	100	60.000	ENSXCOG00000017924	inpp5kb	83	45.476	Xiphophorus_couchianus
ENSG00000132376	INPP5K	95	55.556	ENSXCOG00000004555	inpp5ka	92	46.136	Xiphophorus_couchianus
ENSG00000132376	INPP5K	100	62.000	ENSXMAG00000010655	inpp5kb	95	45.372	Xiphophorus_maculatus
ENSG00000132376	INPP5K	95	58.333	ENSXMAG00000002328	inpp5ka	91	46.189	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0001726	ruffle	21873635.	IBA	Component
GO:0001726	ruffle	12536145.	IDA	Component
GO:0001933	negative regulation of protein phosphorylation	-	ISS	Process
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	21873635.	IBA	Function
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	28190456.	IMP	Function
GO:0004445	inositol-polyphosphate 5-phosphatase activity	-	IEA	Function
GO:0005000	vasopressin receptor activity	-	ISS	Function
GO:0005515	protein binding	16002321.16189514.21712384.25416956.26940976.	IPI	Function
GO:0005634	nucleus	18774950.	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	-	ISS	Component
GO:0005783	endoplasmic reticulum	21873635.	IBA	Component
GO:0005783	endoplasmic reticulum	12536145.18774950.26940976.28190456.	IDA	Component
GO:0005802	trans-Golgi network	12556481.	IDA	Component
GO:0005829	cytosol	10753883.21712384.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005886	plasma membrane	21873635.	IBA	Component
GO:0005886	plasma membrane	12556481.21712384.	IDA	Component
GO:0005979	regulation of glycogen biosynthetic process	-	ISS	Process
GO:0006469	negative regulation of protein kinase activity	12556481.	IDA	Process
GO:0006661	phosphatidylinositol biosynthetic process	-	TAS	Process
GO:0007186	G protein-coupled receptor signaling pathway	-	ISS	Process
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	12556481.	IDA	Process
GO:0010829	negative regulation of glucose transmembrane transport	12556481.	IDA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016020	membrane	12536145.	IDA	Component
GO:0016311	dephosphorylation	21712384.	IDA	Process
GO:0016311	dephosphorylation	18774950.	IMP	Process
GO:0016312	inositol bisphosphate phosphatase activity	21873635.	IBA	Function
GO:0016312	inositol bisphosphate phosphatase activity	10753883.	IDA	Function
GO:0030036	actin cytoskeleton organization	10753883.	NAS	Process
GO:0032587	ruffle membrane	12556481.	IDA	Component
GO:0032869	cellular response to insulin stimulus	12556481.	IDA	Process
GO:0032870	cellular response to hormone stimulus	-	ISS	Process
GO:0033137	negative regulation of peptidyl-serine phosphorylation	21873635.	IBA	Process
GO:0033137	negative regulation of peptidyl-serine phosphorylation	12556481.	IDA	Process
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	21873635.	IBA	Function
GO:0034485	phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity	21712384.	IDA	Function
GO:0034594	phosphatidylinositol trisphosphate phosphatase activity	12556481.	IDA	Function
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	18774950.	IMP	Function
GO:0035305	negative regulation of dephosphorylation	-	ISS	Process
GO:0035810	positive regulation of urine volume	-	ISS	Process
GO:0042577	lipid phosphatase activity	10753883.	NAS	Function
GO:0042593	glucose homeostasis	-	ISS	Process
GO:0043005	neuron projection	10753883.	IDA	Component
GO:0043407	negative regulation of MAP kinase activity	12556481.	IDA	Process
GO:0043922	negative regulation by host of viral transcription	18774950.	IDA	Process
GO:0045719	negative regulation of glycogen biosynthetic process	21873635.	IBA	Process
GO:0045719	negative regulation of glycogen biosynthetic process	12556481.	IDA	Process
GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	18774950.	IDA	Process
GO:0045892	negative regulation of transcription, DNA-templated	-	ISS	Process
GO:0045893	positive regulation of transcription, DNA-templated	-	ISS	Process
GO:0046030	inositol trisphosphate phosphatase activity	10753883.	IDA	Function
GO:0046627	negative regulation of insulin receptor signaling pathway	21873635.	IBA	Process
GO:0046627	negative regulation of insulin receptor signaling pathway	12556481.	IDA	Process
GO:0046855	inositol phosphate dephosphorylation	21873635.	IBA	Process
GO:0046855	inositol phosphate dephosphorylation	12536145.	IDA	Process
GO:0046856	phosphatidylinositol dephosphorylation	21873635.	IBA	Process
GO:0046856	phosphatidylinositol dephosphorylation	12536145.12556481.	IDA	Process
GO:0048471	perinuclear region of cytoplasm	18774950.21712384.	IDA	Component
GO:0051497	negative regulation of stress fiber assembly	12556481.	IDA	Process
GO:0051898	negative regulation of protein kinase B signaling	21873635.	IBA	Process
GO:0051898	negative regulation of protein kinase B signaling	12556481.	IDA	Process
GO:0051926	negative regulation of calcium ion transport	12556481.	IDA	Process
GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity	-	IEA	Function
GO:0052659	inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	-	IEA	Function
GO:0071320	cellular response to cAMP	-	ISS	Process
GO:0071356	cellular response to tumor necrosis factor	21712384.	IDA	Process
GO:0071364	cellular response to epidermal growth factor stimulus	21712384.	IDA	Process
GO:0072659	protein localization to plasma membrane	-	ISS	Process
GO:0090315	negative regulation of protein targeting to membrane	12556481.	IDA	Process
GO:0097178	ruffle assembly	12556481.	IDA	Process
GO:2000466	negative regulation of glycogen (starch) synthase activity	-	ISS	Process
GO:2001153	positive regulation of renal water transport	-	ISS	Process

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr17	1496715	Missense_Mutation	novel	S351L	0.19
BLCA	chr17	1496063	Silent	novel	F429F	0.74
BRCA	chr17	1497985	Missense_Mutation	rs79971656	T305M	0.58	Exo_endo_phos
CESC	chr17	1513467	Silent	novel	L83L	0.23
CESC	chr17	1513456	Missense_Mutation	novel	I86M	0.43	Exo_endo_phos
COAD	chr17	1498112	Missense_Mutation	rs751680176	R263C	0.37	Exo_endo_phos
COAD	chr17	1496687	Nonsense_Mutation	novel	W360*	0.17
COAD	chr17	1498090	Missense_Mutation	NA	R270H	0.24	Exo_endo_phos
COAD	chr17	1513943	Silent	rs375141992	A27A	0.4
COAD	chr17	1496091	Missense_Mutation	rs138972043	R420H	0.38
COAD	chr17	1498090	Missense_Mutation	NA	R270H	0.4	Exo_endo_phos
COAD	chr17	1513502	Missense_Mutation	rs779661934	S71L	0.36	Exo_endo_phos
ESCA	chr17	1498033	Missense_Mutation	rs61735262	P289L	0.4	Exo_endo_phos
GBM	chr17	1509276	Silent	novel	P152P	0.07
GBM	chr17	1508160	Silent	novel	E207E	0.24
GBM	chr17	1498050	Silent	rs748453410	P283P	0.78
GBM	chr17	1506990	Missense_Mutation	novel	Y256D	0.07	Exo_endo_phos
GBM	chr17	1513552	Missense_Mutation	novel	E54D	0.1	Exo_endo_phos
GBM	chr17	1516473	Silent	NA	P9P	0.54
GBM	chr17	1513970	Silent	rs752181436	V18V	0.25
KIRP	chr17	1496711	Silent	NA	T352T	0.55
LUAD	chr17	1513943	Silent	novel	A27A	0.14
LUSC	chr17	1495826	Missense_Mutation	novel	I448M	0.39
LUSC	chr17	1496123	Silent	rs200875024	E409E	0.68
LUSC	chr17	1509715	Nonsense_Mutation	novel	S114_K116delins*	0.06	Exo_endo_phos
LUSC	chr17	1509799	Missense_Mutation	novel	V88I	0.33	Exo_endo_phos
OV	chr17	1508199	Missense_Mutation	novel	N194K	0.14	Exo_endo_phos
OV	chr17	1508208	Frame_Shift_Del	novel	*D192Tfs2**	0.1	Exo_endo_phos
OV	chr17	1509745	Missense_Mutation	novel	H106Y	0.08	Exo_endo_phos
OV	chr17	1496382	Missense_Mutation	novel	N374K	0.69
PRAD	chr17	1498090	Missense_Mutation	NA	R270H	0.38	Exo_endo_phos
READ	chr17	1497954	Silent	rs370433971	S315S	0.39
READ	chr17	1513912	Missense_Mutation	NA	L38M	0.21	Exo_endo_phos
READ	chr17	1513513	Silent	novel	A67A	0.64
SKCM	chr17	1508157	Silent	novel	S208S	0.21
SKCM	chr17	1508158	Missense_Mutation	novel	S208F	0.21	Exo_endo_phos
SKCM	chr17	1498018	Missense_Mutation	NA	S294F	0.38	Exo_endo_phos
SKCM	chr17	1496700	Missense_Mutation	novel	P356L	0.68
SKCM	chr17	1496701	Missense_Mutation	novel	P356T	0.68
SKCM	chr17	1508212	Missense_Mutation	novel	F190Y	0.15	Exo_endo_phos
SKCM	chr17	1509225	Silent	novel	E169E	0.48
SKCM	chr17	1513504	Silent	NA	D70D	0.36
SKCM	chr17	1495876	Missense_Mutation	NA	P432S	0.14
SKCM	chr17	1513870	Splice_Site	novel	X51_splice	0.86
SKCM	chr17	1509244	Missense_Mutation	NA	H163R	0.17	Exo_endo_phos
STAD	chr17	1507067	Missense_Mutation	NA	D230G	0.14	Exo_endo_phos
STAD	chr17	1513514	Missense_Mutation	NA	A67D	0.11	Exo_endo_phos
STAD	chr17	1497985	Missense_Mutation	rs79971656	T305M	0.34	Exo_endo_phos
STAD	chr17	1497949	Missense_Mutation	rs754509919	T317M	0.26
STAD	chr17	1513951	Missense_Mutation	NA	S25P	0.34	Exo_endo_phos
STAD	chr17	1495874	Silent	rs142054151	P432P	0.67
STAD	chr17	1496798	Missense_Mutation	novel	K323N	0.27
STAD	chr17	1508195	Missense_Mutation	rs141189913	R196W	0.68	Exo_endo_phos
THCA	chr17	1506994	In_Frame_Del	novel	N254del	0.06	Exo_endo_phos
UCEC	chr17	1496687	Nonsense_Mutation	novel	W360*	0.45
UCEC	chr17	1498064	Missense_Mutation	novel	P279S	0.28	Exo_endo_phos
UCEC	chr17	1498123	Splice_Site	novel	X259_splice	0.39
UCEC	chr17	1496092	Missense_Mutation	rs756203232	R420C	0.22
UCEC	chr17	1498035	Silent	rs138432703	P288P	0.19
UCEC	chr17	1509761	Silent	NA	V100V	0.25
UCEC	chr17	1507024	Silent	rs61733756	P244P	0.43
UCEC	chr17	1495880	Splice_Site	novel	X431_splice	0.36
UCEC	chr17	1496778	Missense_Mutation	novel	L330P	0.22
UCEC	chr17	1495798	3'UTR	rs200005699		0.38
UCEC	chr17	1496091	Missense_Mutation	rs138972043	R420H	0.43
UCEC	chr17	1513544	Missense_Mutation	novel	S57Y	0.41	Exo_endo_phos
UCEC	chr17	1513902	Missense_Mutation	rs774454087	R41Q	0.09	Exo_endo_phos
UCEC	chr17	1496097	Missense_Mutation	novel	S418I	0.19
UCEC	chr17	1513893	Missense_Mutation	novel	N44T	0.32	Exo_endo_phos
UCEC	chr17	1509180	Splice_Region	rs749984324	H184H	0.3
UCEC	chr17	1497952	Missense_Mutation	novel	G316D	0.4
UCEC	chr17	1509786	Missense_Mutation	rs763835790	R92H	0.58	Exo_endo_phos
UCEC	chr17	1495383	3'UTR	novel		0.44
UCEC	chr17	1507003	Silent	novel	R251R	0.42
UCEC	chr17	1498111	Missense_Mutation	NA	R263H	0.32	Exo_endo_phos
UCEC	chr17	1513475	Missense_Mutation	novel	L80P	0.22	Exo_endo_phos
UCEC	chr17	1495535	3'UTR	novel		0.38

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LAML	DEL	0.0733	0.12511
LIHC	DEL	0.5297	3.9592e-10
LUAD	DEL	0.4477	0.00029194
SKCM	DEL	0.2997	0.21028
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
THYM	0.01	Kaplan-Meier Survival Analysis
KIRC	0.00052	Kaplan-Meier Survival Analysis
MESO	0.017	Kaplan-Meier Survival Analysis
PAAD	0.00012	Kaplan-Meier Survival Analysis
CESC	0.00078	Kaplan-Meier Survival Analysis
LAML	0.0074	Kaplan-Meier Survival Analysis
UCEC	0.00014	Kaplan-Meier Survival Analysis
CHOL	0.0035	Kaplan-Meier Survival Analysis
THCA	0.024	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

GWAS

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742