EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132423 (Gene tree)
Gene ID: 51805
Gene Symbol: COQ3
Alias: bA9819.1
Full Name: coenzyme Q3, methyltransferase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 24,819 bases
Position: chr6:99,369,400-99,394,218
Accession: 18175
RBP type: canonical RBP
Summary: Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000254759	MTS	PF05175.14	6.2e-05	1	1
ENSP00000254759	Methyltransf_31	PF13847.6	2e-12	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000369240	COQ3-202	646	-	ENSP00000358243	141 (aa)	-	F6WGP0
ENST00000254759	COQ3-201	1335	XM_005267018	ENSP00000254759	369 (aa)	XP_005267075	Q9NZJ6
ENST00000479163	COQ3-203	686	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132423's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00130	Ubiquinone and other terpenoid-quinone biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132423's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132423	COQ3	75	61.538	ENSAPOG00000018453	coq3	82	61.888	Acanthochromis_polyacanthus
ENSG00000132423	COQ3	100	81.989	ENSAMEG00000011217	COQ3	100	81.989	Ailuropoda_melanoleuca
ENSG00000132423	COQ3	67	66.800	ENSACIG00000002855	coq3	78	67.200	Amphilophus_citrinellus
ENSG00000132423	COQ3	75	61.888	ENSAOCG00000000804	coq3	82	61.888	Amphiprion_ocellaris
ENSG00000132423	COQ3	75	61.538	ENSAPEG00000020804	coq3	82	61.538	Amphiprion_percula
ENSG00000132423	COQ3	87	57.447	ENSATEG00000024719	coq3	95	57.447	Anabas_testudineus
ENSG00000132423	COQ3	74	67.766	ENSAPLG00000006613	COQ3	96	67.766	Anas_platyrhynchos
ENSG00000132423	COQ3	73	66.045	ENSACAG00000010498	COQ3	97	66.045	Anolis_carolinensis
ENSG00000132423	COQ3	100	92.683	ENSANAG00000029640	COQ3	100	92.683	Aotus_nancymaae
ENSG00000132423	COQ3	83	53.846	ENSAMXG00000008641	coq3	88	58.545	Astyanax_mexicanus
ENSG00000132423	COQ3	100	81.081	ENSBTAG00000019729	COQ3	100	81.081	Bos_taurus
ENSG00000132423	COQ3	71	45.000	WBGene00000763	coq-3	95	40.230	Caenorhabditis_elegans
ENSG00000132423	COQ3	100	90.515	ENSCJAG00000001326	COQ3	100	90.515	Callithrix_jacchus
ENSG00000132423	COQ3	91	83.582	ENSCAFG00000003469	COQ3	99	83.582	Canis_familiaris
ENSG00000132423	COQ3	100	79.784	ENSCAFG00020016760	COQ3	100	79.784	Canis_lupus_dingo
ENSG00000132423	COQ3	99	79.946	ENSCHIG00000011202	COQ3	95	85.373	Capra_hircus
ENSG00000132423	COQ3	100	84.865	ENSTSYG00000009149	COQ3	100	84.865	Carlito_syrichta
ENSG00000132423	COQ3	70	80.000	ENSCAPG00000005726	COQ3	100	80.000	Cavia_aperea
ENSG00000132423	COQ3	100	75.676	ENSCPOG00000005688	COQ3	100	75.676	Cavia_porcellus
ENSG00000132423	COQ3	100	91.328	ENSCCAG00000025442	COQ3	100	91.328	Cebus_capucinus
ENSG00000132423	COQ3	100	93.225	ENSCATG00000009558	COQ3	100	93.225	Cercocebus_atys
ENSG00000132423	COQ3	100	83.827	ENSCSAG00000014581	COQ3	100	83.827	Chlorocebus_sabaeus
ENSG00000132423	COQ3	100	75.676	ENSCHOG00000009503	COQ3	100	75.676	Choloepus_hoffmanni
ENSG00000132423	COQ3	93	57.222	ENSCPBG00000003600	COQ3	99	57.222	Chrysemys_picta_bellii
ENSG00000132423	COQ3	67	47.200	ENSCING00000002605	-	82	47.200	Ciona_intestinalis
ENSG00000132423	COQ3	64	48.333	ENSCSAVG00000005853	-	77	48.333	Ciona_savignyi
ENSG00000132423	COQ3	100	82.927	ENSCANG00000034926	COQ3	100	82.927	Colobus_angolensis_palliatus
ENSG00000132423	COQ3	100	72.358	ENSCGRG00001007261	Coq3	100	72.358	Cricetulus_griseus_chok1gshd
ENSG00000132423	COQ3	100	71.816	ENSCGRG00000007329	COQ3	100	71.816	Cricetulus_griseus_crigri
ENSG00000132423	COQ3	80	56.146	ENSCSEG00000008645	coq3	97	56.146	Cynoglossus_semilaevis
ENSG00000132423	COQ3	66	67.742	ENSCVAG00000021341	coq3	73	64.341	Cyprinodon_variegatus
ENSG00000132423	COQ3	69	61.024	ENSDARG00000069857	coq3	80	61.024	Danio_rerio
ENSG00000132423	COQ3	80	82.993	ENSDNOG00000045765	COQ3	99	82.993	Dasypus_novemcinctus
ENSG00000132423	COQ3	69	40.458	FBgn0032922	CG9249	90	40.458	Drosophila_melanogaster
ENSG00000132423	COQ3	70	68.846	ENSETEG00000013822	-	100	68.846	Echinops_telfairi
ENSG00000132423	COQ3	75	47.170	ENSEBUG00000016355	coq3	90	47.191	Eptatretus_burgeri
ENSG00000132423	COQ3	100	79.459	ENSEASG00005006138	COQ3	100	79.459	Equus_asinus_asinus
ENSG00000132423	COQ3	100	79.459	ENSECAG00000016788	COQ3	100	79.459	Equus_caballus
ENSG00000132423	COQ3	100	80.593	ENSFCAG00000018466	COQ3	100	80.593	Felis_catus
ENSG00000132423	COQ3	89	58.730	ENSFALG00000009623	COQ3	96	64.452	Ficedula_albicollis
ENSG00000132423	COQ3	69	65.979	ENSFHEG00000009736	coq3	76	65.600	Fundulus_heteroclitus
ENSG00000132423	COQ3	65	65.934	ENSGMOG00000006023	coq3	97	61.811	Gadus_morhua
ENSG00000132423	COQ3	90	58.268	ENSGALG00000015486	COQ3	98	66.187	Gallus_gallus
ENSG00000132423	COQ3	64	67.778	ENSGAFG00000000680	coq3	76	62.016	Gambusia_affinis
ENSG00000132423	COQ3	72	65.347	ENSGACG00000004983	coq3	91	61.654	Gasterosteus_aculeatus
ENSG00000132423	COQ3	92	57.522	ENSGAGG00000024849	COQ3	94	57.522	Gopherus_agassizii
ENSG00000132423	COQ3	100	96.748	ENSGGOG00000006696	COQ3	100	96.748	Gorilla_gorilla
ENSG00000132423	COQ3	77	62.500	ENSHBUG00000015558	coq3	84	62.500	Haplochromis_burtoni
ENSG00000132423	COQ3	100	77.838	ENSHGLG00000002982	COQ3	100	77.838	Heterocephalus_glaber_female
ENSG00000132423	COQ3	100	77.838	ENSHGLG00100008603	COQ3	100	77.838	Heterocephalus_glaber_male
ENSG00000132423	COQ3	78	58.054	ENSHCOG00000014459	coq3	84	58.054	Hippocampus_comes
ENSG00000132423	COQ3	67	58.635	ENSIPUG00000004833	coq3	75	58.635	Ictalurus_punctatus
ENSG00000132423	COQ3	100	78.591	ENSSTOG00000016562	COQ3	88	78.591	Ictidomys_tridecemlineatus
ENSG00000132423	COQ3	67	67.339	ENSKMAG00000002723	coq3	77	67.339	Kryptolebias_marmoratus
ENSG00000132423	COQ3	70	65.251	ENSLOCG00000017096	coq3	90	65.251	Lepisosteus_oculatus
ENSG00000132423	COQ3	91	79.403	ENSLAFG00000006127	COQ3	100	79.403	Loxodonta_africana
ENSG00000132423	COQ3	100	94.038	ENSMFAG00000034338	COQ3	100	94.038	Macaca_fascicularis
ENSG00000132423	COQ3	100	94.038	ENSMNEG00000030450	COQ3	100	94.038	Macaca_nemestrina
ENSG00000132423	COQ3	100	94.309	ENSMLEG00000031892	COQ3	100	94.309	Mandrillus_leucophaeus
ENSG00000132423	COQ3	77	62.500	ENSMZEG00005011886	coq3	84	62.500	Maylandia_zebra
ENSG00000132423	COQ3	84	61.017	ENSMGAG00000013560	COQ3	99	63.140	Meleagris_gallopavo
ENSG00000132423	COQ3	100	74.797	ENSMAUG00000013286	Coq3	100	74.797	Mesocricetus_auratus
ENSG00000132423	COQ3	100	84.865	ENSMICG00000006818	COQ3	100	84.865	Microcebus_murinus
ENSG00000132423	COQ3	100	75.202	ENSMOCG00000014486	Coq3	100	75.202	Microtus_ochrogaster
ENSG00000132423	COQ3	69	63.918	ENSMMOG00000017865	coq3	80	66.135	Mola_mola
ENSG00000132423	COQ3	99	64.754	ENSMODG00000018116	COQ3	98	64.754	Monodelphis_domestica
ENSG00000132423	COQ3	99	72.973	MGP_CAROLIEiJ_G0025848	Coq3	99	72.973	Mus_caroli
ENSG00000132423	COQ3	99	72.432	ENSMUSG00000028247	Coq3	99	72.432	Mus_musculus
ENSG00000132423	COQ3	96	73.184	MGP_PahariEiJ_G0023971	Coq3	97	73.184	Mus_pahari
ENSG00000132423	COQ3	99	72.432	MGP_SPRETEiJ_G0026797	Coq3	99	72.432	Mus_spretus
ENSG00000132423	COQ3	100	77.507	ENSMPUG00000001569	COQ3	100	77.507	Mustela_putorius_furo
ENSG00000132423	COQ3	88	85.015	ENSMLUG00000005199	COQ3	100	85.015	Myotis_lucifugus
ENSG00000132423	COQ3	100	79.404	ENSNGAG00000018739	Coq3	100	79.404	Nannospalax_galili
ENSG00000132423	COQ3	77	63.194	ENSNBRG00000007451	coq3	84	63.194	Neolamprologus_brichardi
ENSG00000132423	COQ3	100	95.935	ENSNLEG00000013664	COQ3	100	95.935	Nomascus_leucogenys
ENSG00000132423	COQ3	54	71.144	ENSMEUG00000003625	-	97	71.144	Notamacropus_eugenii
ENSG00000132423	COQ3	80	85.841	ENSOPRG00000005386	COQ3	78	78.777	Ochotona_princeps
ENSG00000132423	COQ3	95	73.881	ENSODEG00000001392	COQ3	95	76.716	Octodon_degus
ENSG00000132423	COQ3	78	62.671	ENSONIG00000000124	coq3	100	62.671	Oreochromis_niloticus
ENSG00000132423	COQ3	84	65.595	ENSOANG00000008935	COQ3	77	65.595	Ornithorhynchus_anatinus
ENSG00000132423	COQ3	71	61.852	ENSORLG00000025966	coq3	82	61.852	Oryzias_latipes
ENSG00000132423	COQ3	71	62.687	ENSORLG00020001246	coq3	82	62.687	Oryzias_latipes_hni
ENSG00000132423	COQ3	67	63.492	ENSORLG00015016456	coq3	78	64.286	Oryzias_latipes_hsok
ENSG00000132423	COQ3	67	65.200	ENSOMEG00000005649	coq3	76	65.200	Oryzias_melastigma
ENSG00000132423	COQ3	93	85.965	ENSOGAG00000015139	COQ3	100	85.965	Otolemur_garnettii
ENSG00000132423	COQ3	100	81.081	ENSOARG00000011897	COQ3	100	81.081	Ovis_aries
ENSG00000132423	COQ3	100	98.103	ENSPPAG00000000909	COQ3	100	98.103	Pan_paniscus
ENSG00000132423	COQ3	100	80.054	ENSPPRG00000001796	COQ3	100	80.054	Panthera_pardus
ENSG00000132423	COQ3	100	80.323	ENSPTIG00000014871	COQ3	100	80.323	Panthera_tigris_altaica
ENSG00000132423	COQ3	100	98.374	ENSPTRG00000018441	COQ3	100	98.374	Pan_troglodytes
ENSG00000132423	COQ3	100	94.309	ENSPANG00000020865	COQ3	100	94.309	Papio_anubis
ENSG00000132423	COQ3	70	62.245	ENSPKIG00000022973	coq3	69	60.392	Paramormyrops_kingsleyae
ENSG00000132423	COQ3	89	60.000	ENSPSIG00000002536	COQ3	98	60.000	Pelodiscus_sinensis
ENSG00000132423	COQ3	68	64.231	ENSPMGG00000022094	coq3	79	64.231	Periophthalmus_magnuspinnatus
ENSG00000132423	COQ3	100	76.550	ENSPEMG00000002775	Coq3	100	76.550	Peromyscus_maniculatus_bairdii
ENSG00000132423	COQ3	88	70.909	ENSPCIG00000000455	COQ3	93	70.909	Phascolarctos_cinereus
ENSG00000132423	COQ3	71	62.000	ENSPFOG00000019395	coq3	82	58.333	Poecilia_formosa
ENSG00000132423	COQ3	71	62.000	ENSPLAG00000003598	coq3	79	60.150	Poecilia_latipinna
ENSG00000132423	COQ3	71	62.000	ENSPMEG00000004224	coq3	83	58.423	Poecilia_mexicana
ENSG00000132423	COQ3	71	62.000	ENSPREG00000015754	coq3	82	60.377	Poecilia_reticulata
ENSG00000132423	COQ3	100	95.935	ENSPPYG00000016863	COQ3	100	95.935	Pongo_abelii
ENSG00000132423	COQ3	56	77.295	ENSPCAG00000006367	-	100	77.295	Procavia_capensis
ENSG00000132423	COQ3	80	86.486	ENSPCOG00000005473	COQ3	99	86.486	Propithecus_coquereli
ENSG00000132423	COQ3	100	81.890	ENSPVAG00000001685	COQ3	100	68.649	Pteropus_vampyrus
ENSG00000132423	COQ3	77	62.500	ENSPNYG00000004234	coq3	84	62.500	Pundamilia_nyererei
ENSG00000132423	COQ3	82	55.652	ENSPNAG00000016740	coq3	86	57.664	Pygocentrus_nattereri
ENSG00000132423	COQ3	93	74.203	ENSRNOG00000009974	Coq3	99	74.203	Rattus_norvegicus
ENSG00000132423	COQ3	100	94.580	ENSRBIG00000026935	COQ3	100	94.580	Rhinopithecus_bieti
ENSG00000132423	COQ3	100	94.580	ENSRROG00000037009	COQ3	100	94.580	Rhinopithecus_roxellana
ENSG00000132423	COQ3	90	92.913	ENSSBOG00000020418	COQ3	100	82.656	Saimiri_boliviensis_boliviensis
ENSG00000132423	COQ3	81	73.667	ENSSHAG00000011955	COQ3	97	73.667	Sarcophilus_harrisii
ENSG00000132423	COQ3	70	61.923	ENSSFOG00015011267	coq3	75	61.923	Scleropages_formosus
ENSG00000132423	COQ3	73	63.107	ENSSMAG00000008860	coq3	74	64.961	Scophthalmus_maximus
ENSG00000132423	COQ3	73	65.049	ENSSDUG00000008881	coq3	76	65.399	Seriola_dumerili
ENSG00000132423	COQ3	73	65.049	ENSSLDG00000010913	coq3	76	65.779	Seriola_lalandi_dorsalis
ENSG00000132423	COQ3	90	70.079	ENSSARG00000003539	-	100	75.833	Sorex_araneus
ENSG00000132423	COQ3	88	59.327	ENSSPUG00000002262	COQ3	99	55.738	Sphenodon_punctatus
ENSG00000132423	COQ3	75	61.538	ENSSPAG00000020102	coq3	83	61.538	Stegastes_partitus
ENSG00000132423	COQ3	89	56.349	ENSTGUG00000012290	COQ3	99	66.787	Taeniopygia_guttata
ENSG00000132423	COQ3	70	66.667	ENSTRUG00000000262	coq3	81	65.504	Takifugu_rubripes
ENSG00000132423	COQ3	73	61.165	ENSTNIG00000007012	coq3	83	62.094	Tetraodon_nigroviridis
ENSG00000132423	COQ3	89	66.159	ENSTBEG00000017102	COQ3	100	66.159	Tupaia_belangeri
ENSG00000132423	COQ3	100	81.622	ENSTTRG00000004620	COQ3	100	81.622	Tursiops_truncatus
ENSG00000132423	COQ3	100	81.132	ENSUAMG00000023921	COQ3	100	81.132	Ursus_americanus
ENSG00000132423	COQ3	64	89.076	ENSUMAG00000021586	COQ3	76	89.076	Ursus_maritimus
ENSG00000132423	COQ3	80	78.788	ENSVPAG00000001397	COQ3	100	78.788	Vicugna_pacos
ENSG00000132423	COQ3	100	78.706	ENSVVUG00000015036	COQ3	100	78.706	Vulpes_vulpes
ENSG00000132423	COQ3	79	57.018	ENSXETG00000000799	coq3	100	59.420	Xenopus_tropicalis
ENSG00000132423	COQ3	64	68.889	ENSXMAG00000004124	coq3	77	61.538	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004395	hexaprenyldihydroxybenzoate methyltransferase activity	-	IEA	Function
GO:0005515	protein binding	27499296.	IPI	Function
GO:0005739	mitochondrion	10777520.	IDA	Component
GO:0005759	mitochondrial matrix	-	TAS	Component
GO:0006071	glycerol metabolic process	10777520.	IGI	Process
GO:0006744	ubiquinone biosynthetic process	-	IEA	Process
GO:0006744	ubiquinone biosynthetic process	10777520.	IGI	Process
GO:0006744	ubiquinone biosynthetic process	-	TAS	Process
GO:0008171	O-methyltransferase activity	10777520.	IGI	Function
GO:0008425	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity	-	IEA	Function
GO:0008689	3-demethylubiquinone-9 3-O-methyltransferase activity	-	IEA	Function
GO:0010795	regulation of ubiquinone biosynthetic process	-	IEA	Process
GO:0031314	extrinsic component of mitochondrial inner membrane	-	IEA	Component
GO:0032259	methylation	-	IEA	Process
GO:0044595	decaprenyldihydroxybenzoate methyltransferase activity	-	TAS	Function
GO:0044596	3-demethylubiquinone-10 3-O-methyltransferase activity	-	TAS	Function
GO:1990886	3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity	-	IEA	Function

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr6	99371564	Silent	novel	T251T	0.18
BLCA	chr6	99394182	5'UTR	novel		0.46
BLCA	chr6	99376090	Silent	NA	V193V	0.2
BLCA	chr6	99375981	Missense_Mutation	novel	D230H	0.23	MTS
BLCA	chr6	99371437	Missense_Mutation	novel	L294V	0.26
BLCA	chr6	99369601	Nonstop_Mutation	novel	370Lext26	0.12
BLCA	chr6	99376020	Missense_Mutation	NA	D217H	0.24	MTS
BRCA	chr6	99369712	Missense_Mutation	NA	S333F	0.33
BRCA	chr6	99394146	Missense_Mutation	NA	G12C	0.47
CESC	chr6	99383823	Splice_Region	NA	V36V	0.28
CESC	chr6	99369683	Missense_Mutation	NA	E343K	0.35
CESC	chr6	99380323	Frame_Shift_Ins	novel	*Y85Vfs12**	0.43
CESC	chr6	99380293	Silent	rs562947006	S94S	0.32
COAD	chr6	99371509	Missense_Mutation	novel	I270V	0.29
COAD	chr6	99377486	Splice_Site	novel	X129_splice	0.27
COAD	chr6	99376079	Missense_Mutation	novel	R197K	0.06	MTS
COAD	chr6	99371434	Missense_Mutation	NA	E295K	0.33
GBM	chr6	99380340	Missense_Mutation	novel	Y79H	0.1
HNSC	chr6	99371457	Missense_Mutation	novel	P287L	0.17
HNSC	chr6	99369756	Nonsense_Mutation	rs763813636	W318*	0.47
KIRC	chr6	99371556	Nonsense_Mutation	novel	*N254delinsSED**	0.06	MTS
KIRP	chr6	99375970	Silent	NA	T233T	0.33
KIRP	chr6	99369626	Missense_Mutation	novel	A362S	0.23
LGG	chr6	99369640	Missense_Mutation	NA	A357V	0.19
LGG	chr6	99369801	Frame_Shift_Del	novel	*T303Wfs2**	0.06
LUAD	chr6	99377487	Splice_Site	novel	X129_splice	0.23
LUAD	chr6	99369668	Nonsense_Mutation	novel	G348*	0.3
LUSC	chr6	99376086	Missense_Mutation	novel	D195N	0.16	MTS
LUSC	chr6	99369800	Missense_Mutation	novel	V304L	0.2
LUSC	chr6	99369690	Silent	novel	A340A	0.12
LUSC	chr6	99380292	Missense_Mutation	rs377313779	G95S	0.3
OV	chr6	99369794	Frame_Shift_Ins	novel	*G306Pfs34**	0.06
PAAD	chr6	99383730	Silent	novel	I67I	0.03
PRAD	chr6	99369688	Missense_Mutation	NA	S341F	0.13
READ	chr6	99383730	Silent	NA	I67I	0.18
SARC	chr6	99369623	Missense_Mutation	novel	V363M	0.4
SKCM	chr6	99371541	Missense_Mutation	NA	S259F	0.42	MTS
SKCM	chr6	99369808	Missense_Mutation	NA	V301A	0.17
SKCM	chr6	99380219	Missense_Mutation	NA	S119F	0.3
SKCM	chr6	99376107	Missense_Mutation	NA	K188E	0.14	MTS
STAD	chr6	99371467	Missense_Mutation	NA	F284V	0.18
STAD	chr6	99394141	Missense_Mutation	NA	W13C	0.23
STAD	chr6	99371507	Silent	novel	I270I	0.28
STAD	chr6	99383734	Missense_Mutation	rs149717575	T66M	0.45
STAD	chr6	99377480	Missense_Mutation	rs754375927	N131S	0.31
STAD	chr6	99376173	Missense_Mutation	rs375375802	R166W	0.29	MTS
STAD	chr6	99371585	Splice_Region	rs369408410	P244P	0.24
STAD	chr6	99380327	Missense_Mutation	NA	R83K	0.25
UCEC	chr6	99380205	Missense_Mutation	NA	R124G	0.35
UCEC	chr6	99369606	Missense_Mutation	NA	K368N	0.3
UCEC	chr6	99383800	Missense_Mutation	novel	G44V	0.09
UCEC	chr6	99380299	Silent	rs751957396	V92V	0.27
UCEC	chr6	99369721	Missense_Mutation	NA	A330D	0.2
UCEC	chr6	99375993	Nonsense_Mutation	novel	E226*	0.38	MTS
UCEC	chr6	99376107	Missense_Mutation	NA	K188E	0.17	MTS
UCEC	chr6	99376079	Missense_Mutation	rs771820402	R197I	0.42	MTS
UCEC	chr6	99377388	Nonsense_Mutation	novel	E162*	0.23	MTS
UCEC	chr6	99380299	Silent	rs751957396	V92V	0.43
UCEC	chr6	99380297	Missense_Mutation	NA	D93G	0.24
UCEC	chr6	99369772	Nonsense_Mutation	novel	S313*	0.3
UCEC	chr6	99376173	Missense_Mutation	rs375375802	R166W	0.32	MTS
UCEC	chr6	99371585	Splice_Region	novel	P244P	0.47
UCEC	chr6	99380299	Silent	rs751957396	V92V	0.19
UCEC	chr6	99369580	Missense_Mutation	novel		0.23
UCEC	chr6	99369527	3'UTR	novel		0.16
UCEC	chr6	99376016	Missense_Mutation	NA	A218V	0.25	MTS
UCEC	chr6	99371519	Missense_Mutation	novel	F266L	0.32
UCEC	chr6	99383814	Silent	novel	K39K	0.08

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	DEL	0.3505	3.4915e-05
DLBC	DEL	0.3333	0.00052595
ESCA	DEL	0.2446	0.036953
LUAD	DEL	0.4089	0.0021365
MESO	DEL	0.3908	0.05642
PAAD	DEL	0.3478	0.11274
SARC	DEL	0.2335	0.0021591
SKCM	DEL	0.515	1.5442e-06
STAD	DEL	0.1565	0.0044196
THYM	DEL	0.1301	0.10691

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00037	Kaplan-Meier Survival Analysis
STAD	0.039	Kaplan-Meier Survival Analysis
SARC	0.045	Kaplan-Meier Survival Analysis
MESO	0.04	Kaplan-Meier Survival Analysis
BRCA	0.028	Kaplan-Meier Survival Analysis
ESCA	0.0075	Kaplan-Meier Survival Analysis
PCPG	0.047	Kaplan-Meier Survival Analysis
READ	0.021	Kaplan-Meier Survival Analysis
LIHC	0.0013	Kaplan-Meier Survival Analysis
DLBC	0.044	Kaplan-Meier Survival Analysis
LGG	0.00022	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742