EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132463 (Gene tree)
Gene ID: 2926
Gene Symbol: GRSF1
Alias: N
Full Name: G-rich RNA sequence binding factor 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 27,493 bases
Position: chr4:70,815,782-70,843,274
Accession: 4610
RBP type: canonical RBP
Summary: The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000421789	RRM_1	PF00076.22	5.1e-23	1	1
ENSP00000443380	RRM_1	PF00076.22	5.5e-23	1	1
ENSP00000427354	RRM_1	PF00076.22	7.5e-23	1	1
ENSP00000254799	RRM_1	PF00076.22	9.4e-23	1	1
ENSP00000425430	RRM_1	PF00076.22	4.1e-21	1	2
ENSP00000425430	RRM_1	PF00076.22	4.1e-21	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	NascentRICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
27198227	HuR and GRSF1 modulate the nuclear export and mitochondrial localization of the lncRNA RMRP.	Genes Dev	2016 May 15	Noh JH	doi: 10.1101/gad.276022.115
30753671	Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.	Nucleic Acids Res	2019 Mar 18	Noh JH	doi: 10.1093/nar/gkz082.
29288125	Functional characterization of isolated RNA-binding domains of the GRSF1 protein.	Biochim Biophys Acta Gen Subj	2018 Apr	Sofi S	doi: 10.1016/j.bbagen.2017.12.009
29366917	Functional characterization of naturally occurring genetic variations of the human guanine-rich RNA sequence binding factor 1 (GRSF1).	Biochim Biophys Acta Gen Subj	2018 Apr	Sofi S	doi: 10.1016/j.bbagen.2017.12.008
25184340	Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.	PLoS One	2014 Sep 3	Nieradka A	doi: 10.1371/journal.pone.0104631
31085189	Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production.	Exp Cell Res	2019 Aug 1	Yin W	doi: 10.1016/j.yexcr.2019.05.004
10359774	Regulation of eukaryotic protein synthesis: selective influenza viral mRNA translation is mediated by the cellular RNA-binding protein GRSF-1.	Proc Natl Acad Sci U S A	1999 Jun 8	Park YW	-
22708492	The biology of the RNA binding protein guanine-rich sequence binding factor 1.	Curr Protein Pept Sci	2012 Jun	Ufer C	-
23473033	The mitochondrial RNA-binding protein GRSF1 localizes to RNA granules and is required for posttranscriptional mitochondrial gene expression.	Cell Metab	2013 Mar 5	Antonicka H	doi: 10.1016/j.cmet.2013.02.006.
8036161	GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element.	Nucleic Acids Res	1994 Jun 25	Qian Z	-
12239318	Selective translation of eukaryotic mRNAs: functional molecular analysis of GRSF-1, a positive regulator of influenza virus protein synthesis.	J Virol	2002 Oct	Kash JC	-
15857914	Dissecting Wnt/beta-catenin signaling during gastrulation using RNA interference in mouse embryos.	Development	2005 Jun	Lickert H	-
18462695	A hierarchical network controls protein translation during murine embryonic stem cell self-renewal and differentiation.	Cell Stem Cell	2008 May 8	Sampath P	doi: 10.1016/j.stem.2008.03.013.
26984403	ICP4-induced miR-101 attenuates HSV-1 replication.	Sci Rep	2016 Mar 17	Wang X	doi: 10.1038/srep23205.
23473034	GRSF1 regulates RNA processing in mitochondrial RNA granules.	Cell Metab	2013 Mar 5	Jourdain AA	doi: 10.1016/j.cmet.2013.02.005.
28835257	Long noncoding RNAs coordinate functions between mitochondria and the nucleus.	Epigenetics Chromatin	2017 Aug 23	Dong Y	doi: 10.1186/s13072-017-0149-x.
30944385	GRSF1 is an age-related regulator of senescence.	Sci Rep	2019 Apr 3	Kim SJ	doi: 10.1038/s41598-019-42064-6.
17967896	Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs.	Mol Cell Biol	2008 Jan	Cobbold LC	-
30086537	GRSF1 suppresses cell senescence.	Aging (Albany NY)	2018 Aug 7	Noh JH	doi: 10.18632/aging.101516.
30394198	GRSF1-mediated MIR-G-1 promotes malignant behavior and nuclear autophagy by directly upregulating TMED5 and LMNB1 in cervical cancer cells.	Autophagy	2019 Apr	Yang Z	doi: 10.1080/15548627.2018.1539590
26507454	miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively.	Sci Rep	2015 Oct 28	Song G	doi: 10.1038/srep15793.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000506453	GRSF1-205	925	-	ENSP00000427644	114 (aa)	-	H0YAM1
ENST00000514161	GRSF1-207	1765	-	ENSP00000421789	417 (aa)	-	H0Y8R1
ENST00000499044	GRSF1-202	2491	-	ENSP00000427354	453 (aa)	-	H0YAK1
ENST00000502323	GRSF1-203	1794	XM_011531897	ENSP00000425430	318 (aa)	XP_011530199	Q12849
ENST00000545193	GRSF1-208	2682	-	ENSP00000443380	424 (aa)	-	F5H5I6
ENST00000505068	GRSF1-204	3561	-	-	- (aa)	-	-
ENST00000254799	GRSF1-201	6666	XM_005265681	ENSP00000254799	480 (aa)	XP_005265738	Q12849
ENST00000508091	GRSF1-206	419	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132463's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132463's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000132463	GRSF1	98	59.494	ENSG00000126945	HNRNPH2	61	58.750
ENSG00000132463	GRSF1	98	58.621	ENSG00000169045	HNRNPH1	100	51.485
ENSG00000132463	GRSF1	59	66.234	ENSG00000096746	HNRNPH3	74	42.471
ENSG00000132463	GRSF1	98	41.520	ENSG00000169813	HNRNPF	90	46.591

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132463	GRSF1	100	96.226	ENSAMEG00000005896	GRSF1	100	94.751	Ailuropoda_melanoleuca
ENSG00000132463	GRSF1	99	72.812	ENSACAG00000012921	GRSF1	91	64.944	Anolis_carolinensis
ENSG00000132463	GRSF1	100	97.799	ENSANAG00000022114	GRSF1	100	95.417	Aotus_nancymaae
ENSG00000132463	GRSF1	99	97.222	ENSBTAG00000008577	GRSF1	100	95.028	Bos_taurus
ENSG00000132463	GRSF1	100	97.799	ENSCJAG00000014477	GRSF1	99	98.052	Callithrix_jacchus
ENSG00000132463	GRSF1	88	96.085	ENSCAFG00000002922	GRSF1	100	96.085	Canis_familiaris
ENSG00000132463	GRSF1	99	100.000	ENSCAFG00020027060	GRSF1	100	97.619	Canis_lupus_dingo
ENSG00000132463	GRSF1	99	97.222	ENSCHIG00000021580	GRSF1	100	93.125	Capra_hircus
ENSG00000132463	GRSF1	100	96.855	ENSTSYG00000008487	-	100	96.855	Carlito_syrichta
ENSG00000132463	GRSF1	100	83.962	ENSTSYG00000028860	-	100	79.945	Carlito_syrichta
ENSG00000132463	GRSF1	97	89.286	ENSCAPG00000000156	GRSF1	100	89.286	Cavia_aperea
ENSG00000132463	GRSF1	100	89.308	ENSCPOG00000011662	GRSF1	100	88.366	Cavia_porcellus
ENSG00000132463	GRSF1	100	96.541	ENSCCAG00000028735	-	100	94.167	Cebus_capucinus
ENSG00000132463	GRSF1	81	85.328	ENSCCAG00000024189	-	95	75.161	Cebus_capucinus
ENSG00000132463	GRSF1	100	99.057	ENSCATG00000035808	GRSF1	99	98.710	Cercocebus_atys
ENSG00000132463	GRSF1	100	89.623	ENSCLAG00000003057	GRSF1	100	88.643	Chinchilla_lanigera
ENSG00000132463	GRSF1	100	98.428	ENSCSAG00000004856	GRSF1	100	97.292	Chlorocebus_sabaeus
ENSG00000132463	GRSF1	100	73.041	ENSCPBG00000019502	GRSF1	86	67.423	Chrysemys_picta_bellii
ENSG00000132463	GRSF1	100	99.057	ENSCANG00000037992	GRSF1	100	99.057	Colobus_angolensis_palliatus
ENSG00000132463	GRSF1	98	100.000	ENSCGRG00001019953	Grsf1	100	92.541	Cricetulus_griseus_chok1gshd
ENSG00000132463	GRSF1	100	93.396	ENSCGRG00000005357	Grsf1	100	92.521	Cricetulus_griseus_crigri
ENSG00000132463	GRSF1	100	94.340	ENSDORG00000015145	Grsf1	100	97.810	Dipodomys_ordii
ENSG00000132463	GRSF1	100	94.025	ENSETEG00000013786	GRSF1	100	93.043	Echinops_telfairi
ENSG00000132463	GRSF1	99	100.000	ENSEASG00005016685	GRSF1	94	93.347	Equus_asinus_asinus
ENSG00000132463	GRSF1	99	100.000	ENSECAG00000024208	GRSF1	94	93.542	Equus_caballus
ENSG00000132463	GRSF1	98	46.094	ENSELUG00000011613	-	95	41.755	Esox_lucius
ENSG00000132463	GRSF1	99	100.000	ENSFCAG00000007270	GRSF1	100	93.750	Felis_catus
ENSG00000132463	GRSF1	99	53.231	ENSFALG00000008394	GRSF1	98	53.779	Ficedula_albicollis
ENSG00000132463	GRSF1	65	89.781	ENSFDAG00000008167	-	100	89.781	Fukomys_damarensis
ENSG00000132463	GRSF1	99	52.366	ENSGALG00000031160	GRSF1	84	47.564	Gallus_gallus
ENSG00000132463	GRSF1	100	74.143	ENSGAGG00000006013	GRSF1	99	67.140	Gopherus_agassizii
ENSG00000132463	GRSF1	100	99.686	ENSGGOG00000014852	-	100	99.686	Gorilla_gorilla
ENSG00000132463	GRSF1	100	88.994	ENSHGLG00000000661	GRSF1	100	88.366	Heterocephalus_glaber_female
ENSG00000132463	GRSF1	100	88.994	ENSHGLG00100005974	GRSF1	100	94.161	Heterocephalus_glaber_male
ENSG00000132463	GRSF1	100	95.283	ENSSTOG00000011569	GRSF1	100	97.674	Ictidomys_tridecemlineatus
ENSG00000132463	GRSF1	97	90.397	ENSJJAG00000005325	Grsf1	100	94.891	Jaculus_jaculus
ENSG00000132463	GRSF1	99	54.114	ENSLACG00000009507	GRSF1	97	53.672	Latimeria_chalumnae
ENSG00000132463	GRSF1	98	48.726	ENSLOCG00000011589	GRSF1	80	47.541	Lepisosteus_oculatus
ENSG00000132463	GRSF1	99	100.000	ENSLAFG00000017032	-	100	91.529	Loxodonta_africana
ENSG00000132463	GRSF1	100	98.742	ENSMFAG00000037346	GRSF1	100	97.500	Macaca_fascicularis
ENSG00000132463	GRSF1	100	98.742	ENSMMUG00000000380	GRSF1	99	98.701	Macaca_mulatta
ENSG00000132463	GRSF1	98	100.000	ENSMNEG00000023162	GRSF1	100	91.250	Macaca_nemestrina
ENSG00000132463	GRSF1	100	99.057	ENSMLEG00000007180	GRSF1	100	98.895	Mandrillus_leucophaeus
ENSG00000132463	GRSF1	99	52.997	ENSMGAG00000009940	GRSF1	99	53.550	Meleagris_gallopavo
ENSG00000132463	GRSF1	100	94.654	ENSMICG00000005385	GRSF1	99	93.906	Microcebus_murinus
ENSG00000132463	GRSF1	65	97.080	ENSMOCG00000012769	-	100	97.080	Microtus_ochrogaster
ENSG00000132463	GRSF1	100	84.906	ENSMODG00000019088	GRSF1	90	78.351	Monodelphis_domestica
ENSG00000132463	GRSF1	100	93.396	MGP_CAROLIEiJ_G0027377	Grsf1	100	97.080	Mus_caroli
ENSG00000132463	GRSF1	100	93.396	ENSMUSG00000044221	Grsf1	100	97.080	Mus_musculus
ENSG00000132463	GRSF1	100	90.881	MGP_PahariEiJ_G0017155	Grsf1	100	95.620	Mus_pahari
ENSG00000132463	GRSF1	100	93.082	MGP_SPRETEiJ_G0028374	Grsf1	100	92.541	Mus_spretus
ENSG00000132463	GRSF1	100	95.912	ENSMPUG00000009499	GRSF1	97	94.766	Mustela_putorius_furo
ENSG00000132463	GRSF1	100	93.458	ENSMLUG00000028158	GRSF1	100	92.603	Myotis_lucifugus
ENSG00000132463	GRSF1	64	99.259	ENSNGAG00000022132	-	99	99.259	Nannospalax_galili
ENSG00000132463	GRSF1	99	99.029	ENSNLEG00000007721	-	99	98.710	Nomascus_leucogenys
ENSG00000132463	GRSF1	81	87.891	ENSMEUG00000015942	GRSF1	99	72.626	Notamacropus_eugenii
ENSG00000132463	GRSF1	97	92.218	ENSOPRG00000010148	-	78	91.333	Ochotona_princeps
ENSG00000132463	GRSF1	100	75.786	ENSODEG00000004897	-	100	77.008	Octodon_degus
ENSG00000132463	GRSF1	100	77.987	ENSODEG00000010775	-	100	78.363	Octodon_degus
ENSG00000132463	GRSF1	100	88.994	ENSODEG00000001826	-	100	84.583	Octodon_degus
ENSG00000132463	GRSF1	81	62.602	ENSOANG00000013696	-	100	62.602	Ornithorhynchus_anatinus
ENSG00000132463	GRSF1	100	95.912	ENSOCUG00000010029	GRSF1	100	80.167	Oryctolagus_cuniculus
ENSG00000132463	GRSF1	100	81.447	ENSOGAG00000026370	-	99	74.550	Otolemur_garnettii
ENSG00000132463	GRSF1	100	90.654	ENSOGAG00000000141	-	100	90.685	Otolemur_garnettii
ENSG00000132463	GRSF1	100	94.704	ENSOARG00000011898	GRSF1	100	93.973	Ovis_aries
ENSG00000132463	GRSF1	100	100.000	ENSPPAG00000042456	-	100	100.000	Pan_paniscus
ENSG00000132463	GRSF1	99	100.000	ENSPPRG00000022913	GRSF1	100	93.750	Panthera_pardus
ENSG00000132463	GRSF1	100	95.283	ENSPTIG00000008060	GRSF1	100	94.751	Panthera_tigris_altaica
ENSG00000132463	GRSF1	100	99.686	ENSPTRG00000016136	GRSF1	100	98.718	Pan_troglodytes
ENSG00000132463	GRSF1	100	100.000	ENSPANG00000018597	GRSF1	99	97.742	Papio_anubis
ENSG00000132463	GRSF1	97	80.255	ENSPSIG00000014267	-	96	75.500	Pelodiscus_sinensis
ENSG00000132463	GRSF1	100	94.340	ENSPEMG00000012814	Grsf1	100	93.646	Peromyscus_maniculatus_bairdii
ENSG00000132463	GRSF1	100	87.107	ENSPCIG00000000627	GRSF1	100	79.210	Phascolarctos_cinereus
ENSG00000132463	GRSF1	99	97.297	ENSPPYG00000014812	GRSF1	100	82.328	Pongo_abelii
ENSG00000132463	GRSF1	100	94.654	ENSPCAG00000013949	GRSF1	100	88.209	Procavia_capensis
ENSG00000132463	GRSF1	100	96.226	ENSPVAG00000004338	GRSF1	100	89.262	Pteropus_vampyrus
ENSG00000132463	GRSF1	98	97.297	ENSRNOG00000003392	Grsf1	100	90.208	Rattus_norvegicus
ENSG00000132463	GRSF1	100	99.057	ENSRBIG00000036494	GRSF1	99	98.710	Rhinopithecus_bieti
ENSG00000132463	GRSF1	100	98.742	ENSRROG00000035735	GRSF1	100	97.500	Rhinopithecus_roxellana
ENSG00000132463	GRSF1	100	97.403	ENSSBOG00000032141	GRSF1	100	71.473	Saimiri_boliviensis_boliviensis
ENSG00000132463	GRSF1	100	88.365	ENSSHAG00000018365	GRSF1	100	82.338	Sarcophilus_harrisii
ENSG00000132463	GRSF1	97	95.130	ENSSARG00000011681	GRSF1	100	95.130	Sorex_araneus
ENSG00000132463	GRSF1	97	65.147	ENSSPUG00000007576	GRSF1	99	59.333	Sphenodon_punctatus
ENSG00000132463	GRSF1	99	97.222	ENSSSCG00000008940	GRSF1	100	91.458	Sus_scrofa
ENSG00000132463	GRSF1	99	55.590	ENSTGUG00000001644	GRSF1	99	55.331	Taeniopygia_guttata
ENSG00000132463	GRSF1	97	95.779	ENSTBEG00000010173	GRSF1	100	95.779	Tupaia_belangeri
ENSG00000132463	GRSF1	100	89.623	ENSTTRG00000008405	GRSF1	99	89.003	Tursiops_truncatus
ENSG00000132463	GRSF1	97	97.222	ENSUAMG00000008901	GRSF1	93	96.154	Ursus_americanus
ENSG00000132463	GRSF1	100	96.541	ENSUMAG00000003757	GRSF1	88	95.068	Ursus_maritimus
ENSG00000132463	GRSF1	100	80.189	ENSVPAG00000011889	GRSF1	100	81.717	Vicugna_pacos
ENSG00000132463	GRSF1	100	95.912	ENSVVUG00000004150	GRSF1	100	95.349	Vulpes_vulpes
ENSG00000132463	GRSF1	99	52.632	ENSXETG00000013850	grsf1	100	51.491	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003729	mRNA binding	8036161.	TAS	Function
GO:0005515	protein binding	24338975.	IPI	Function
GO:0005737	cytoplasm	8036161.	TAS	Component
GO:0005739	mitochondrion	-	IDA	Component
GO:0006378	mRNA polyadenylation	8036161.	TAS	Process
GO:0008033	tRNA processing	-	IEA	Process
GO:0009952	anterior/posterior pattern specification	-	IEA	Process
GO:0016331	morphogenesis of embryonic epithelium	-	IEA	Process
GO:0035770	ribonucleoprotein granule	25683715.	IDA	Component
GO:0042645	mitochondrial nucleoid	25683715.	IDA	Component