EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132478 (Gene tree)
Gene ID: 85451
Gene Symbol: UNK
Alias: KIAA1753|ZC3HDC5|ZC3H5
Full Name: unk zinc finger
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 41,035 bases
Position: chr17:75,784,771-75,825,805
Accession: 29369
RBP type: canonical RBP
Summary: (Unk Zinc Finger) is a Protein Coding gene. An important paralog of this gene is UNKL.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000464893	zf-CCCH	PF00642.24	0.00027	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
25737280	Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.	Genes Dev	2015 Mar 1	Murn J	doi: 10.1101/gad.258483.115.
26641712	Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt.	Nat Struct Mol Biol	2016 Jan	Murn J	doi: 10.1038/nsmb.3140

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000589790	UNK-206	549	-	-	- (aa)	-	-
ENST00000587258	UNK-203	660	-	ENSP00000467726	220 (aa)	-	K7EQ93
ENST00000592629	UNK-208	633	-	ENSP00000466431	41 (aa)	-	K7EMB1
ENST00000589666	UNK-205	3925	XM_006722145	ENSP00000464893	810 (aa)	XP_006722208	Q9C0B0
ENST00000586527	UNK-202	1312	-	ENSP00000467849	39 (aa)	-	K7EQJ1
ENST00000587501	UNK-204	984	-	ENSP00000464953	37 (aa)	-	K7EIZ1
ENST00000586217	UNK-201	651	-	ENSP00000466054	69 (aa)	-	K7ELF5
ENST00000592074	UNK-207	573	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132478's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132478	rs9900933	17	75805073	C	Sum eosinophil basophil counts	27863252	[0.016-0.031] unit decrease	0.02316879	EFO_0005090\|EFO_0004842
ENSG00000132478	rs9900933	17	75805073	?	White blood cell count	30595370			EFO_0004308
ENSG00000132478	rs9900933	17	75805073	?	Eosinophil counts	30595370			EFO_0004842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132478's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000132478	UNK	94	63.077	ENSG00000059145	UNKL	92	78.041

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132478	UNK	100	97.901	ENSAMEG00000009769	UNK	92	97.901	Ailuropoda_melanoleuca
ENSG00000132478	UNK	68	87.234	ENSATEG00000004212	unk	94	57.071	Anabas_testudineus
ENSG00000132478	UNK	96	89.575	ENSAPLG00000014891	UNK	100	89.575	Anas_platyrhynchos
ENSG00000132478	UNK	100	86.215	ENSACAG00000007303	UNK	98	87.113	Anolis_carolinensis
ENSG00000132478	UNK	100	99.259	ENSANAG00000017139	UNK	100	99.259	Aotus_nancymaae
ENSG00000132478	UNK	94	68.571	ENSAMXG00000031804	unk	56	61.822	Astyanax_mexicanus
ENSG00000132478	UNK	100	97.531	ENSBTAG00000016287	UNK	100	97.531	Bos_taurus
ENSG00000132478	UNK	100	99.259	ENSCJAG00000014056	UNK	100	99.259	Callithrix_jacchus
ENSG00000132478	UNK	100	98.025	ENSCAFG00000004925	UNK	92	98.025	Canis_familiaris
ENSG00000132478	UNK	100	98.025	ENSCAFG00020004454	UNK	100	98.025	Canis_lupus_dingo
ENSG00000132478	UNK	97	100.000	ENSCHIG00000015385	UNK	100	96.914	Capra_hircus
ENSG00000132478	UNK	100	98.148	ENSTSYG00000008096	UNK	100	98.148	Carlito_syrichta
ENSG00000132478	UNK	96	84.685	ENSCAPG00000008657	UNK	96	84.685	Cavia_aperea
ENSG00000132478	UNK	100	96.543	ENSCPOG00000012679	UNK	100	96.543	Cavia_porcellus
ENSG00000132478	UNK	100	99.383	ENSCCAG00000031100	UNK	100	99.383	Cebus_capucinus
ENSG00000132478	UNK	100	99.506	ENSCATG00000038041	UNK	100	99.506	Cercocebus_atys
ENSG00000132478	UNK	97	100.000	ENSCLAG00000008106	UNK	100	96.420	Chinchilla_lanigera
ENSG00000132478	UNK	100	99.383	ENSCSAG00000004859	UNK	100	99.383	Chlorocebus_sabaeus
ENSG00000132478	UNK	100	86.941	ENSCPBG00000028046	UNK	99	87.894	Chrysemys_picta_bellii
ENSG00000132478	UNK	100	99.630	ENSCANG00000033795	UNK	100	99.630	Colobus_angolensis_palliatus
ENSG00000132478	UNK	97	100.000	ENSCGRG00001024874	Unk	98	94.817	Cricetulus_griseus_chok1gshd
ENSG00000132478	UNK	97	94.804	ENSCGRG00000008631	Unk	98	94.817	Cricetulus_griseus_crigri
ENSG00000132478	UNK	68	91.489	ENSCSEG00000020209	unk	95	58.534	Cynoglossus_semilaevis
ENSG00000132478	UNK	68	87.234	ENSDARG00000000935	unk	94	59.770	Danio_rerio
ENSG00000132478	UNK	100	96.914	ENSDNOG00000038145	UNK	88	96.914	Dasypus_novemcinctus
ENSG00000132478	UNK	97	100.000	ENSDORG00000008133	Unk	100	96.914	Dipodomys_ordii
ENSG00000132478	UNK	97	100.000	ENSETEG00000019640	UNK	97	88.156	Echinops_telfairi
ENSG00000132478	UNK	100	98.519	ENSEASG00005002430	UNK	100	98.519	Equus_asinus_asinus
ENSG00000132478	UNK	100	98.395	ENSECAG00000024672	UNK	100	98.395	Equus_caballus
ENSG00000132478	UNK	97	100.000	ENSEEUG00000013779	UNK	85	100.000	Erinaceus_europaeus
ENSG00000132478	UNK	68	85.106	ENSELUG00000023290	unk	95	57.811	Esox_lucius
ENSG00000132478	UNK	100	98.025	ENSFCAG00000005757	UNK	100	98.025	Felis_catus
ENSG00000132478	UNK	96	89.433	ENSFALG00000001035	UNK	94	89.433	Ficedula_albicollis
ENSG00000132478	UNK	98	95.328	ENSFDAG00000009316	UNK	98	95.328	Fukomys_damarensis
ENSG00000132478	UNK	82	73.795	ENSGMOG00000014314	unk	81	74.174	Gadus_morhua
ENSG00000132478	UNK	100	86.578	ENSGALG00000002278	UNK	98	87.608	Gallus_gallus
ENSG00000132478	UNK	100	86.941	ENSGAGG00000007411	UNK	98	87.980	Gopherus_agassizii
ENSG00000132478	UNK	100	100.000	ENSGGOG00000009203	UNK	100	100.000	Gorilla_gorilla
ENSG00000132478	UNK	100	97.160	ENSHGLG00000007512	UNK	100	97.160	Heterocephalus_glaber_female
ENSG00000132478	UNK	100	97.160	ENSHGLG00100002318	UNK	100	97.160	Heterocephalus_glaber_male
ENSG00000132478	UNK	93	69.565	ENSIPUG00000004291	UNK	94	58.418	Ictalurus_punctatus
ENSG00000132478	UNK	97	100.000	ENSSTOG00000013344	UNK	99	97.368	Ictidomys_tridecemlineatus
ENSG00000132478	UNK	97	100.000	ENSJJAG00000009816	Unk	98	95.322	Jaculus_jaculus
ENSG00000132478	UNK	100	71.829	ENSLACG00000014044	UNK	97	72.864	Latimeria_chalumnae
ENSG00000132478	UNK	99	67.647	ENSLOCG00000011578	unk	95	66.583	Lepisosteus_oculatus
ENSG00000132478	UNK	97	100.000	ENSLAFG00000022662	UNK	100	96.921	Loxodonta_africana
ENSG00000132478	UNK	100	99.383	ENSMFAG00000037148	UNK	100	99.383	Macaca_fascicularis
ENSG00000132478	UNK	100	99.383	ENSMMUG00000013646	UNK	100	99.383	Macaca_mulatta
ENSG00000132478	UNK	100	99.259	ENSMNEG00000036240	UNK	100	99.259	Macaca_nemestrina
ENSG00000132478	UNK	100	99.383	ENSMLEG00000043327	UNK	100	99.383	Mandrillus_leucophaeus
ENSG00000132478	UNK	68	87.234	ENSMAMG00000001390	unk	94	57.503	Mastacembelus_armatus
ENSG00000132478	UNK	96	86.718	ENSMGAG00000004713	UNK	100	86.718	Meleagris_gallopavo
ENSG00000132478	UNK	97	100.000	ENSMAUG00000011025	Unk	98	95.575	Mesocricetus_auratus
ENSG00000132478	UNK	100	97.901	ENSMICG00000007591	UNK	100	97.901	Microcebus_murinus
ENSG00000132478	UNK	97	100.000	ENSMOCG00000021657	Unk	98	95.322	Microtus_ochrogaster
ENSG00000132478	UNK	68	89.362	ENSMMOG00000004874	unk	94	56.980	Mola_mola
ENSG00000132478	UNK	97	100.000	ENSMODG00000007684	UNK	85	86.752	Monodelphis_domestica
ENSG00000132478	UNK	97	100.000	MGP_CAROLIEiJ_G0017427	Unk	98	95.449	Mus_caroli
ENSG00000132478	UNK	97	100.000	ENSMUSG00000020770	Unk	98	95.322	Mus_musculus
ENSG00000132478	UNK	97	100.000	MGP_PahariEiJ_G0018556	Unk	98	94.943	Mus_pahari
ENSG00000132478	UNK	97	100.000	MGP_SPRETEiJ_G0018272	Unk	98	95.322	Mus_spretus
ENSG00000132478	UNK	97	100.000	ENSMPUG00000013806	UNK	100	96.925	Mustela_putorius_furo
ENSG00000132478	UNK	100	97.160	ENSMLUG00000015453	UNK	100	97.160	Myotis_lucifugus
ENSG00000132478	UNK	97	100.000	ENSNGAG00000012366	Unk	100	96.173	Nannospalax_galili
ENSG00000132478	UNK	100	93.580	ENSNLEG00000001120	UNK	98	95.431	Nomascus_leucogenys
ENSG00000132478	UNK	97	100.000	ENSMEUG00000004094	UNK	97	87.628	Notamacropus_eugenii
ENSG00000132478	UNK	100	95.556	ENSOPRG00000012784	UNK	98	95.702	Ochotona_princeps
ENSG00000132478	UNK	97	100.000	ENSODEG00000010183	UNK	98	90.013	Octodon_degus
ENSG00000132478	UNK	100	97.037	ENSOCUG00000014994	UNK	100	97.037	Oryctolagus_cuniculus
ENSG00000132478	UNK	68	85.106	ENSORLG00000028573	unk	94	57.379	Oryzias_latipes
ENSG00000132478	UNK	67	84.783	ENSOMEG00000009977	unk	95	47.804	Oryzias_melastigma
ENSG00000132478	UNK	100	98.025	ENSOGAG00000001922	UNK	92	98.025	Otolemur_garnettii
ENSG00000132478	UNK	97	100.000	ENSOARG00000009548	UNK	97	85.945	Ovis_aries
ENSG00000132478	UNK	100	100.000	ENSPPAG00000032800	UNK	100	100.000	Pan_paniscus
ENSG00000132478	UNK	100	98.272	ENSPPRG00000008948	UNK	100	98.272	Panthera_pardus
ENSG00000132478	UNK	100	97.901	ENSPTIG00000005435	UNK	100	97.901	Panthera_tigris_altaica
ENSG00000132478	UNK	100	100.000	ENSPTRG00000009656	UNK	100	100.000	Pan_troglodytes
ENSG00000132478	UNK	100	99.506	ENSPANG00000020121	UNK	100	99.506	Papio_anubis
ENSG00000132478	UNK	68	89.362	ENSPKIG00000022222	unk	94	58.113	Paramormyrops_kingsleyae
ENSG00000132478	UNK	99	87.615	ENSPSIG00000009640	UNK	100	82.398	Pelodiscus_sinensis
ENSG00000132478	UNK	68	89.362	ENSPMGG00000021574	unk	93	56.875	Periophthalmus_magnuspinnatus
ENSG00000132478	UNK	97	100.000	ENSPEMG00000016145	Unk	98	95.070	Peromyscus_maniculatus_bairdii
ENSG00000132478	UNK	97	97.222	ENSPCIG00000020300	UNK	84	91.465	Phascolarctos_cinereus
ENSG00000132478	UNK	100	99.753	ENSPPYG00000008637	UNK	100	99.753	Pongo_abelii
ENSG00000132478	UNK	97	97.222	ENSPCAG00000004504	UNK	88	89.903	Procavia_capensis
ENSG00000132478	UNK	100	97.778	ENSPCOG00000027411	UNK	100	97.778	Propithecus_coquereli
ENSG00000132478	UNK	97	100.000	ENSPVAG00000008460	UNK	92	99.185	Pteropus_vampyrus
ENSG00000132478	UNK	93	69.565	ENSPNAG00000011973	unk	93	59.613	Pygocentrus_nattereri
ENSG00000132478	UNK	97	100.000	ENSRNOG00000006600	Unk	98	94.817	Rattus_norvegicus
ENSG00000132478	UNK	100	99.753	ENSRBIG00000025523	UNK	100	99.753	Rhinopithecus_bieti
ENSG00000132478	UNK	100	99.877	ENSRROG00000013651	UNK	100	99.877	Rhinopithecus_roxellana
ENSG00000132478	UNK	100	99.383	ENSSBOG00000019483	UNK	100	99.383	Saimiri_boliviensis_boliviensis
ENSG00000132478	UNK	97	91.603	ENSSHAG00000017696	UNK	97	91.603	Sarcophilus_harrisii
ENSG00000132478	UNK	68	87.234	ENSSFOG00015003052	unk	94	55.781	Scleropages_formosus
ENSG00000132478	UNK	68	87.234	ENSSDUG00000012373	unk	94	56.675	Seriola_dumerili
ENSG00000132478	UNK	68	87.234	ENSSLDG00000001990	unk	94	57.035	Seriola_lalandi_dorsalis
ENSG00000132478	UNK	99	83.333	ENSSPUG00000008526	UNK	97	85.899	Sphenodon_punctatus
ENSG00000132478	UNK	100	97.901	ENSSSCG00000017201	UNK	100	97.901	Sus_scrofa
ENSG00000132478	UNK	97	89.031	ENSTGUG00000008279	UNK	98	88.875	Taeniopygia_guttata
ENSG00000132478	UNK	52	90.217	ENSTBEG00000016178	-	53	90.217	Tupaia_belangeri
ENSG00000132478	UNK	97	100.000	ENSTTRG00000015890	UNK	90	99.441	Tursiops_truncatus
ENSG00000132478	UNK	96	93.677	ENSUAMG00000003483	UNK	97	93.677	Ursus_americanus
ENSG00000132478	UNK	96	97.935	ENSUMAG00000010576	UNK	99	97.935	Ursus_maritimus
ENSG00000132478	UNK	56	98.515	ENSVPAG00000011532	-	57	98.515	Vicugna_pacos
ENSG00000132478	UNK	100	97.606	ENSVVUG00000014786	UNK	100	97.606	Vulpes_vulpes
ENSG00000132478	UNK	97	79.140	ENSXETG00000012578	unk	96	79.618	Xenopus_tropicalis

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0001764	neuron migration	21873635.	IBA	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005737	cytoplasm	-	IEA	Component
GO:0005844	polysome	21873635.	IBA	Component
GO:0005844	polysome	25737280.	IDA	Component
GO:0046872	metal ion binding	-	IEA	Function
GO:0048667	cell morphogenesis involved in neuron differentiation	21873635.	IBA	Process
GO:0048667	cell morphogenesis involved in neuron differentiation	25737280.	IMP	Process
GO:1905538	polysome binding	-	IEA	Function
GO:1990715	mRNA CDS binding	21873635.	IBA	Function
GO:1990715	mRNA CDS binding	25737280.	IDA	Function
GO:2000766	negative regulation of cytoplasmic translation	21873635.	IBA	Process
GO:2000766	negative regulation of cytoplasmic translation	25737280.	IMP	Process