EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132485 (Gene tree)
Gene ID: 9406
Gene Symbol: ZRANB2
Alias: ZIS|ZIS1|ZIS2|ZNF265
Full Name: zinc finger RANBP2-type containing 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 18,007 bases
Position: chr1:71,063,291-71,081,297
Accession: 13058
RBP type: canonical RBP
Summary: (Zinc Finger RANBP2-Type Containing 2) is a Protein Coding gene. Diseases associated with ZRANB2 include Syndromic X-Linked Intellectual Disability Snyder Type. Gene Ontology (GO) annotations related to this gene include RNA binding.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000254821	zf-RanBP	PF00641.18	9.3e-13	1	2
ENSP00000254821	zf-RanBP	PF00641.18	9.3e-13	2	2
ENSP00000482026	zf-RanBP	PF00641.18	9.3e-13	1	2
ENSP00000482026	zf-RanBP	PF00641.18	9.3e-13	2	2
ENSP00000359958	zf-RanBP	PF00641.18	1e-12	1	2
ENSP00000359958	zf-RanBP	PF00641.18	1e-12	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21256132	Characterization of a family of RanBP2-type zinc fingers that can recognize single-stranded RNA.	J Mol Biol	2011 Mar 25	Nguyen CD	doi: 10.1016/j.jmb.2010.12.041
19304800	The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences.	Proc Natl Acad Sci U S A	2009 Apr 7	Loughlin FE	doi: 10.1073/pnas.0802466106
9374836	Zis: a developmentally regulated gene expressed in juxtaglomerular cells.	Am J Physiol	1997 Nov	Karginova EA	doi: 10.1152/ajprenal.1997.273.5.F731.
12657633	The structure of the zinc finger domain from human splicing factor ZNF265 fold.	J Biol Chem	2003 Jun 20	Plambeck CA	-
29587120	-	-	-	-	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000479947	ZRANB2-205	470	-	-	- (aa)	-	-
ENST00000487510	ZRANB2-206	579	-	-	- (aa)	-	-
ENST00000473260	ZRANB2-203	482	-	-	- (aa)	-	-
ENST00000611683	ZRANB2-207	1257	-	ENSP00000482026	320 (aa)	-	O95218
ENST00000370920	ZRANB2-202	3078	-	ENSP00000359958	330 (aa)	-	O95218
ENST00000254821	ZRANB2-201	2821	-	ENSP00000254821	320 (aa)	-	O95218
ENST00000477096	ZRANB2-204	3677	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132485's gene model file

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132485	rs66461782	1	71067604	?	Menarche (age at onset)	30595370			EFO_0004703

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132485's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132485	ZRANB2	62	68.182	ENSAPOG00000001338	zranb2	68	69.620	Acanthochromis_polyacanthus
ENSG00000132485	ZRANB2	100	99.394	ENSAMEG00000003845	ZRANB2	100	99.394	Ailuropoda_melanoleuca
ENSG00000132485	ZRANB2	58	78.075	ENSAOCG00000015750	zranb2	92	96.850	Amphiprion_ocellaris
ENSG00000132485	ZRANB2	62	83.415	ENSAPEG00000002999	zranb2	64	79.500	Amphiprion_percula
ENSG00000132485	ZRANB2	60	76.389	ENSATEG00000011416	zranb2	64	72.222	Anabas_testudineus
ENSG00000132485	ZRANB2	50	88.272	ENSAPLG00000011345	ZRANB2	53	90.625	Anas_platyrhynchos
ENSG00000132485	ZRANB2	62	93.434	ENSACAG00000004293	ZRANB2	58	96.891	Anolis_carolinensis
ENSG00000132485	ZRANB2	100	100.000	ENSANAG00000018241	ZRANB2	100	100.000	Aotus_nancymaae
ENSG00000132485	ZRANB2	100	99.688	ENSBTAG00000002627	ZRANB2	100	99.688	Bos_taurus
ENSG00000132485	ZRANB2	100	99.697	ENSCJAG00000006356	ZRANB2	100	99.697	Callithrix_jacchus
ENSG00000132485	ZRANB2	94	100.000	ENSCAFG00000020412	ZRANB2	98	100.000	Canis_familiaris
ENSG00000132485	ZRANB2	100	99.697	ENSCAFG00020017151	ZRANB2	100	99.697	Canis_lupus_dingo
ENSG00000132485	ZRANB2	100	100.000	ENSCHIG00000009410	-	100	100.000	Capra_hircus
ENSG00000132485	ZRANB2	93	94.932	ENSCHIG00000026876	-	90	94.932	Capra_hircus
ENSG00000132485	ZRANB2	95	99.042	ENSTSYG00000008830	ZRANB2	100	100.000	Carlito_syrichta
ENSG00000132485	ZRANB2	96	96.226	ENSCAPG00000007827	ZRANB2	100	96.226	Cavia_aperea
ENSG00000132485	ZRANB2	100	97.879	ENSCPOG00000007829	ZRANB2	100	97.879	Cavia_porcellus
ENSG00000132485	ZRANB2	100	100.000	ENSCCAG00000034005	ZRANB2	100	100.000	Cebus_capucinus
ENSG00000132485	ZRANB2	100	100.000	ENSCATG00000025001	ZRANB2	100	100.000	Cercocebus_atys
ENSG00000132485	ZRANB2	100	98.438	ENSCLAG00000004404	ZRANB2	100	98.438	Chinchilla_lanigera
ENSG00000132485	ZRANB2	100	96.084	ENSCSAG00000010588	-	100	96.084	Chlorocebus_sabaeus
ENSG00000132485	ZRANB2	85	95.956	ENSCHOG00000004408	ZRANB2	80	95.956	Choloepus_hoffmanni
ENSG00000132485	ZRANB2	62	93.939	ENSCPBG00000022504	ZRANB2	58	97.409	Chrysemys_picta_bellii
ENSG00000132485	ZRANB2	66	55.157	ENSCING00000020967	zf(rbz)	82	56.122	Ciona_intestinalis
ENSG00000132485	ZRANB2	100	100.000	ENSCANG00000036472	ZRANB2	100	100.000	Colobus_angolensis_palliatus
ENSG00000132485	ZRANB2	62	95.980	ENSCGRG00001016525	-	70	96.335	Cricetulus_griseus_chok1gshd
ENSG00000132485	ZRANB2	100	96.250	ENSCGRG00001019737	-	97	96.440	Cricetulus_griseus_chok1gshd
ENSG00000132485	ZRANB2	62	96.482	ENSCGRG00000017414	-	61	96.859	Cricetulus_griseus_crigri
ENSG00000132485	ZRANB2	94	95.349	ENSCGRG00000001487	-	58	99.422	Cricetulus_griseus_crigri
ENSG00000132485	ZRANB2	62	79.612	ENSCSEG00000008624	zranb2	63	79.104	Cynoglossus_semilaevis
ENSG00000132485	ZRANB2	71	70.588	ENSDARG00000044332	zranb2	72	71.008	Danio_rerio
ENSG00000132485	ZRANB2	100	99.091	ENSDNOG00000010455	ZRANB2	100	99.091	Dasypus_novemcinctus
ENSG00000132485	ZRANB2	100	98.438	ENSDORG00000016348	Zranb2	100	98.438	Dipodomys_ordii
ENSG00000132485	ZRANB2	60	44.186	FBgn0034750	CG3732	51	51.389	Drosophila_melanogaster
ENSG00000132485	ZRANB2	59	94.709	ENSETEG00000015825	-	57	94.709	Echinops_telfairi
ENSG00000132485	ZRANB2	82	99.618	ENSETEG00000014461	-	83	99.618	Echinops_telfairi
ENSG00000132485	ZRANB2	62	95.939	ENSETEG00000017849	-	57	96.335	Echinops_telfairi
ENSG00000132485	ZRANB2	100	99.394	ENSEASG00005007831	ZRANB2	100	99.394	Equus_asinus_asinus
ENSG00000132485	ZRANB2	100	99.394	ENSECAG00000014173	ZRANB2	100	99.394	Equus_caballus
ENSG00000132485	ZRANB2	60	80.383	ENSELUG00000013041	zranb2	85	96.032	Esox_lucius
ENSG00000132485	ZRANB2	100	99.688	ENSFCAG00000028246	ZRANB2	100	99.688	Felis_catus
ENSG00000132485	ZRANB2	100	97.812	ENSFDAG00000014203	ZRANB2	100	97.812	Fukomys_damarensis
ENSG00000132485	ZRANB2	60	82.843	ENSFHEG00000003774	zranb2	63	82.843	Fundulus_heteroclitus
ENSG00000132485	ZRANB2	59	74.129	ENSGMOG00000015970	zranb2	63	75.622	Gadus_morhua
ENSG00000132485	ZRANB2	62	93.434	ENSGALG00000011340	ZRANB2	58	96.891	Gallus_gallus
ENSG00000132485	ZRANB2	62	75.980	ENSGAFG00000015912	zranb2	63	82.915	Gambusia_affinis
ENSG00000132485	ZRANB2	62	79.426	ENSGACG00000009457	zranb2	83	81.592	Gasterosteus_aculeatus
ENSG00000132485	ZRANB2	62	93.939	ENSGAGG00000001059	ZRANB2	58	97.409	Gopherus_agassizii
ENSG00000132485	ZRANB2	100	100.000	ENSGGOG00000023501	ZRANB2	100	100.000	Gorilla_gorilla
ENSG00000132485	ZRANB2	100	98.438	ENSHGLG00000004819	ZRANB2	100	98.438	Heterocephalus_glaber_female
ENSG00000132485	ZRANB2	100	98.438	ENSHGLG00100011433	ZRANB2	100	98.438	Heterocephalus_glaber_male
ENSG00000132485	ZRANB2	59	76.596	ENSHCOG00000017021	zranb2	65	96.850	Hippocampus_comes
ENSG00000132485	ZRANB2	58	75.401	ENSIPUG00000022583	zranb2	71	94.488	Ictalurus_punctatus
ENSG00000132485	ZRANB2	100	99.697	ENSSTOG00000000890	-	100	99.697	Ictidomys_tridecemlineatus
ENSG00000132485	ZRANB2	60	85.938	ENSSTOG00000024205	-	61	85.938	Ictidomys_tridecemlineatus
ENSG00000132485	ZRANB2	63	86.700	ENSJJAG00000022813	-	52	91.124	Jaculus_jaculus
ENSG00000132485	ZRANB2	100	98.125	ENSJJAG00000023929	-	100	98.125	Jaculus_jaculus
ENSG00000132485	ZRANB2	62	79.227	ENSLBEG00000024043	zranb2	63	80.198	Labrus_bergylta
ENSG00000132485	ZRANB2	61	86.432	ENSLACG00000005241	ZRANB2	59	85.641	Latimeria_chalumnae
ENSG00000132485	ZRANB2	62	78.774	ENSLOCG00000010010	zranb2	60	81.863	Lepisosteus_oculatus
ENSG00000132485	ZRANB2	75	100.000	ENSLAFG00000017760	ZRANB2	71	100.000	Loxodonta_africana
ENSG00000132485	ZRANB2	100	100.000	ENSMFAG00000003326	ZRANB2	100	100.000	Macaca_fascicularis
ENSG00000132485	ZRANB2	62	92.893	ENSMMUG00000043952	-	63	92.708	Macaca_mulatta
ENSG00000132485	ZRANB2	100	100.000	ENSMMUG00000017312	ZRANB2	100	100.000	Macaca_mulatta
ENSG00000132485	ZRANB2	100	100.000	ENSMNEG00000042080	-	100	100.000	Macaca_nemestrina
ENSG00000132485	ZRANB2	94	97.674	ENSMNEG00000005850	-	100	97.674	Macaca_nemestrina
ENSG00000132485	ZRANB2	62	90.863	ENSMLEG00000027997	-	58	90.625	Mandrillus_leucophaeus
ENSG00000132485	ZRANB2	100	100.000	ENSMLEG00000036639	ZRANB2	100	100.000	Mandrillus_leucophaeus
ENSG00000132485	ZRANB2	59	82.474	ENSMAMG00000022361	zranb2	60	86.598	Mastacembelus_armatus
ENSG00000132485	ZRANB2	50	91.975	ENSMGAG00000012116	ZRANB2	53	96.178	Meleagris_gallopavo
ENSG00000132485	ZRANB2	100	96.250	ENSMAUG00000010817	Zranb2	97	96.440	Mesocricetus_auratus
ENSG00000132485	ZRANB2	100	99.062	ENSMICG00000033818	ZRANB2	100	99.062	Microcebus_murinus
ENSG00000132485	ZRANB2	100	96.875	ENSMOCG00000018818	Zranb2	100	96.875	Microtus_ochrogaster
ENSG00000132485	ZRANB2	59	80.612	ENSMMOG00000008870	zranb2	59	79.500	Mola_mola
ENSG00000132485	ZRANB2	87	96.516	ENSMODG00000000504	ZRANB2	100	96.516	Monodelphis_domestica
ENSG00000132485	ZRANB2	62	80.193	ENSMALG00000016470	zranb2	63	82.178	Monopterus_albus
ENSG00000132485	ZRANB2	100	96.875	MGP_CAROLIEiJ_G0025763	Zranb2	100	96.875	Mus_caroli
ENSG00000132485	ZRANB2	100	97.188	ENSMUSG00000028180	Zranb2	100	97.188	Mus_musculus
ENSG00000132485	ZRANB2	100	97.188	MGP_PahariEiJ_G0027213	Zranb2	100	97.188	Mus_pahari
ENSG00000132485	ZRANB2	100	97.188	MGP_SPRETEiJ_G0026715	Zranb2	100	97.188	Mus_spretus
ENSG00000132485	ZRANB2	100	100.000	ENSMPUG00000000917	ZRANB2	100	100.000	Mustela_putorius_furo
ENSG00000132485	ZRANB2	100	99.091	ENSMLUG00000001762	ZRANB2	100	99.091	Myotis_lucifugus
ENSG00000132485	ZRANB2	62	86.869	ENSNGAG00000021339	Zranb2	58	86.528	Nannospalax_galili
ENSG00000132485	ZRANB2	100	100.000	ENSNLEG00000009455	ZRANB2	100	100.000	Nomascus_leucogenys
ENSG00000132485	ZRANB2	55	98.286	ENSMEUG00000010336	ZRANB2	55	98.844	Notamacropus_eugenii
ENSG00000132485	ZRANB2	63	100.000	ENSOPRG00000003839	ZRANB2	60	100.000	Ochotona_princeps
ENSG00000132485	ZRANB2	58	95.676	ENSODEG00000011466	-	65	95.556	Octodon_degus
ENSG00000132485	ZRANB2	100	98.438	ENSODEG00000006491	-	100	98.438	Octodon_degus
ENSG00000132485	ZRANB2	98	94.872	ENSODEG00000008671	-	95	94.872	Octodon_degus
ENSG00000132485	ZRANB2	100	99.094	ENSOCUG00000004640	ZRANB2	100	99.094	Oryctolagus_cuniculus
ENSG00000132485	ZRANB2	62	80.583	ENSORLG00020019736	zranb2	57	80.597	Oryzias_latipes_hni
ENSG00000132485	ZRANB2	62	75.728	ENSOMEG00000019010	zranb2	63	82.178	Oryzias_melastigma
ENSG00000132485	ZRANB2	97	99.353	ENSOGAG00000000485	ZRANB2	94	99.353	Otolemur_garnettii
ENSG00000132485	ZRANB2	100	99.394	ENSOARG00000012093	-	100	99.394	Ovis_aries
ENSG00000132485	ZRANB2	100	98.485	ENSOARG00000009780	-	100	98.485	Ovis_aries
ENSG00000132485	ZRANB2	100	100.000	ENSPPAG00000037049	ZRANB2	100	100.000	Pan_paniscus
ENSG00000132485	ZRANB2	100	99.688	ENSPPRG00000008962	ZRANB2	100	99.688	Panthera_pardus
ENSG00000132485	ZRANB2	100	99.062	ENSPTIG00000017134	ZRANB2	100	99.062	Panthera_tigris_altaica
ENSG00000132485	ZRANB2	100	100.000	ENSPTRG00000000856	ZRANB2	100	100.000	Pan_troglodytes
ENSG00000132485	ZRANB2	100	100.000	ENSPANG00000013398	ZRANB2	100	100.000	Papio_anubis
ENSG00000132485	ZRANB2	60	78.788	ENSPKIG00000021734	zranb2	59	81.818	Paramormyrops_kingsleyae
ENSG00000132485	ZRANB2	62	93.939	ENSPSIG00000012222	ZRANB2	58	97.409	Pelodiscus_sinensis
ENSG00000132485	ZRANB2	57	98.361	ENSPEMG00000010764	Zranb2	56	94.652	Peromyscus_maniculatus_bairdii
ENSG00000132485	ZRANB2	100	96.667	ENSPCIG00000001426	ZRANB2	100	96.667	Phascolarctos_cinereus
ENSG00000132485	ZRANB2	62	82.439	ENSPFOG00000023402	zranb2	63	82.915	Poecilia_formosa
ENSG00000132485	ZRANB2	58	81.818	ENSPMEG00000000958	zranb2	68	97.638	Poecilia_mexicana
ENSG00000132485	ZRANB2	53	88.000	ENSPREG00000013499	zranb2	93	87.861	Poecilia_reticulata
ENSG00000132485	ZRANB2	100	99.688	ENSPPYG00000001240	ZRANB2	100	99.688	Pongo_abelii
ENSG00000132485	ZRANB2	85	95.956	ENSPCAG00000015159	ZRANB2	80	95.956	Procavia_capensis
ENSG00000132485	ZRANB2	60	92.965	ENSPCOG00000019133	ZRANB2	84	93.991	Propithecus_coquereli
ENSG00000132485	ZRANB2	60	85.417	ENSPVAG00000012510	ZRANB2	57	85.417	Pteropus_vampyrus
ENSG00000132485	ZRANB2	61	80.203	ENSPNAG00000012001	zranb2	60	81.915	Pygocentrus_nattereri
ENSG00000132485	ZRANB2	60	100.000	ENSRNOG00000009990	Zranb2	58	100.000	Rattus_norvegicus
ENSG00000132485	ZRANB2	100	99.688	ENSRBIG00000025103	ZRANB2	100	99.688	Rhinopithecus_bieti
ENSG00000132485	ZRANB2	100	98.182	ENSRROG00000025998	-	100	98.182	Rhinopithecus_roxellana
ENSG00000132485	ZRANB2	100	100.000	ENSSBOG00000013268	ZRANB2	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000132485	ZRANB2	95	96.795	ENSSHAG00000008054	ZRANB2	100	96.795	Sarcophilus_harrisii
ENSG00000132485	ZRANB2	60	83.249	ENSSFOG00015014775	zranb2	59	82.234	Scleropages_formosus
ENSG00000132485	ZRANB2	79	66.787	ENSSMAG00000002678	zranb2	63	81.683	Scophthalmus_maximus
ENSG00000132485	ZRANB2	62	80.583	ENSSLDG00000003278	zranb2	63	81.500	Seriola_lalandi_dorsalis
ENSG00000132485	ZRANB2	60	86.458	ENSSARG00000009452	ZRANB2	57	86.458	Sorex_araneus
ENSG00000132485	ZRANB2	100	98.182	ENSSSCG00000003787	ZRANB2	100	98.182	Sus_scrofa
ENSG00000132485	ZRANB2	66	74.194	ENSTRUG00000003300	zranb2	62	81.726	Takifugu_rubripes
ENSG00000132485	ZRANB2	60	80.729	ENSTNIG00000010498	zranb2	72	79.167	Tetraodon_nigroviridis
ENSG00000132485	ZRANB2	60	85.417	ENSTBEG00000002316	ZRANB2	62	85.417	Tupaia_belangeri
ENSG00000132485	ZRANB2	86	95.636	ENSTTRG00000014680	ZRANB2	81	95.636	Tursiops_truncatus
ENSG00000132485	ZRANB2	97	100.000	ENSUAMG00000023128	ZRANB2	99	100.000	Ursus_americanus
ENSG00000132485	ZRANB2	100	99.394	ENSUMAG00000006559	ZRANB2	100	99.394	Ursus_maritimus
ENSG00000132485	ZRANB2	85	94.139	ENSVPAG00000002940	ZRANB2	81	94.139	Vicugna_pacos
ENSG00000132485	ZRANB2	100	99.697	ENSVVUG00000007123	ZRANB2	100	99.697	Vulpes_vulpes
ENSG00000132485	ZRANB2	87	65.287	ENSXETG00000024108	zranb2	88	67.302	Xenopus_tropicalis
ENSG00000132485	ZRANB2	60	81.313	ENSXMAG00000005445	zranb2	63	82.828	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003700	DNA-binding transcription factor activity	9931435.	TAS	Function
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0005515	protein binding	16982639.17620599.23075850.29513927.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0006355	regulation of transcription, DNA-templated	-	IEA	Process
GO:0006397	mRNA processing	-	IEA	Process
GO:0008380	RNA splicing	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function