EuRBPDB

  • Home
  • Cancer
  • Family
  • Species
  • RBPredictor
  • Search
  • Download
  • Submit
  • Help
  • Contact

  • Description
  • RBDs
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • GWAS
  • PPI
  • Orthologs
  • Gene Ontology
Description
Ensembl ID
ENSG00000132591 (Gene tree)
Gene ID
26284
Gene Symbol
ERAL1
Alias
HERA-B
Full Name
Era like 12S mitochondrial rRNA chaperone 1
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Plus strand
Length
6,130 bases
Position
chr17:28,854,938-28,861,067
Accession
3424
RBP type
canonical RBP
Summary
The protein encoded by this gene is a GTPase that localizes to the mitochondrion. The encoded protein binds to the 3' terminal stem loop of 12S mitochondrial rRNA and is required for proper assembly of the 28S small mitochondrial ribosomal subunit. Deletion of this gene has been shown to cause mitochondrial dysfunction, growth retardation, and apoptosis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
RNA binding domains(RBDs)
Protein IDDomain Pfam IDE-value Domain number Total number
ENSP00000464402MMR_HSR1PF01926.233.1e-2011
ENSP00000254928MMR_HSR1PF01926.236.6e-2011
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
22681889The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts4SURIC & HEK2932012 MayBaltz AGDOI: 10.1016/j.molcel.2012.05.021
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARIC & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
22658674Insights into RNA biology from an atlas of mammalian mRNA-binding proteinsRIC & Hela2012 May 31Castello ADOI: 10.1016/j.cell.2012.04.031
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & MCF72018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
11733036Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity.Genes Cells2001 NovAkiyama T-
20430825ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation.Nucleic Acids Res2010 SepUchiumi Tdoi: 10.1093/nar/gkq305
21920408The role of TFAM-associated proteins in mitochondrial RNA metabolism.Biochim Biophys Acta2012 MayUchiumi Tdoi: 10.1016/j.bbagen.2011.08.014
27814609Mitochondrial nucleic acid binding proteins associated with diseases.Front Biosci (Landmark Ed)2017 Jan 1Uchiumi T-
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000254928ERAL1-2011925-ENSP00000254928437 (aa)-O75616
ENST00000580917ERAL1-207850-ENSP00000464402284 (aa)-J3QRV9
ENST00000577942ERAL1-205698--- (aa)--
ENST00000583487ERAL1-208695-ENSP0000046786080 (aa)-K7EQJ8
ENST00000578001ERAL1-206579--- (aa)--
ENST00000461894ERAL1-2031628-ENSP00000464607276 (aa)-J3QSB2
ENST00000412138ERAL1-2021039-ENSP00000396125171 (aa)-J3QT61
ENST00000471992ERAL1-2041508--- (aa)--
Gene Model
Click here to download ENSG00000132591's gene model file
GWAS
ensgIDSNPChromosomePositionSNP-risk TraitPubmedID95% CIOr or BEAT EFO ID
ENSG00000132591rs99149881728856086AHigh light scatter reticulocyte percentage of red cells27863252[0.037-0.054] unit increase0.04576578EFO_0007986
ENSG00000132591rs99149881728856086AGlycated hemoglobin levels28898252[0.0092-0.017] unit increase0.0131EFO_0004541
ENSG00000132591rs68031728860771TImmature fraction of reticulocytes27863252[0.059-0.076] unit increase0.06748314EFO_0007986
ENSG00000132591rs99149881728856086AHigh light scatter reticulocyte count27863252[0.041-0.059] unit increase0.049934EFO_0007986
ENSG00000132591rs68031728860771?Red cell distribution width30595370EFO_0005192
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132591's network

* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl IDGene SymbolCoverageIdentiy OrthologGene SymbolCoverageIdentiy Species
ENSG00000132591ERAL19951.899ENSAPOG00000000093eral18548.168Acanthochromis_polyacanthus
ENSG00000132591ERAL19988.235ENSAMEG00000004602ERAL110081.693Ailuropoda_melanoleuca
ENSG00000132591ERAL19955.696ENSACIG00000011545eral18550.132Amphilophus_citrinellus
ENSG00000132591ERAL19948.101ENSAOCG00000014398eral18446.597Amphiprion_ocellaris
ENSG00000132591ERAL19948.101ENSAPEG00000015466eral18446.335Amphiprion_percula
ENSG00000132591ERAL19955.696ENSATEG00000005857eral18550.262Anabas_testudineus
ENSG00000132591ERAL18867.143ENSAPLG00000014894ERAL19955.676Anas_platyrhynchos
ENSG00000132591ERAL17172.131ENSANAG00000020670-10067.521Aotus_nancymaae
ENSG00000132591ERAL19990.196ENSANAG00000022216-10089.016Aotus_nancymaae
ENSG00000132591ERAL19953.165ENSACLG00000006437eral18450.789Astatotilapia_calliptera
ENSG00000132591ERAL19054.167ENSAMXG00000037957eral18153.699Astyanax_mexicanus
ENSG00000132591ERAL19986.275ENSBTAG00000015639ERAL110081.236Bos_taurus
ENSG00000132591ERAL110089.931ENSCJAG00000045605ERAL110089.931Callithrix_jacchus
ENSG00000132591ERAL19990.196ENSCAFG00000018813ERAL110080.549Canis_familiaris
ENSG00000132591ERAL19990.196ENSCAFG00020011718ERAL110080.549Canis_lupus_dingo
ENSG00000132591ERAL19984.314ENSCHIG00000021850ERAL110081.007Capra_hircus
ENSG00000132591ERAL19994.118ENSTSYG00000007492ERAL110084.211Carlito_syrichta
ENSG00000132591ERAL19986.275ENSCPOG00000009576ERAL110080.549Cavia_porcellus
ENSG00000132591ERAL18078.125ENSCCAG00000031032-7064.706Cebus_capucinus
ENSG00000132591ERAL110090.389ENSCCAG00000036226-10090.389Cebus_capucinus
ENSG00000132591ERAL19998.039ENSCATG00000041378ERAL110094.050Cercocebus_atys
ENSG00000132591ERAL19086.111ENSCLAG00000004778ERAL110085.593Chinchilla_lanigera
ENSG00000132591ERAL19998.039ENSCSAG00000007105ERAL110093.822Chlorocebus_sabaeus
ENSG00000132591ERAL19081.944ENSCHOG00000007676-5889.157Choloepus_hoffmanni
ENSG00000132591ERAL19865.385ENSCPBG00000020222ERAL18356.177Chrysemys_picta_bellii
ENSG00000132591ERAL16734.899ENSCING00000003676-8334.899Ciona_intestinalis
ENSG00000132591ERAL19998.039ENSCANG00000028131ERAL110094.279Colobus_angolensis_palliatus
ENSG00000132591ERAL19988.235ENSCGRG00001016601Eral110080.594Cricetulus_griseus_chok1gshd
ENSG00000132591ERAL19988.235ENSCGRG00000002004Eral110080.594Cricetulus_griseus_crigri
ENSG00000132591ERAL18850.000ENSCSEG00000016147eral18851.181Cynoglossus_semilaevis
ENSG00000132591ERAL18868.627ENSCVAG00000013714eral18449.471Cyprinodon_variegatus
ENSG00000132591ERAL19948.101ENSDARG00000059887eral18751.671Danio_rerio
ENSG00000132591ERAL19988.235ENSDNOG00000044554ERAL110079.176Dasypus_novemcinctus
ENSG00000132591ERAL19984.314ENSDORG00000011319Eral110078.947Dipodomys_ordii
ENSG00000132591ERAL17431.077FBgn0038106CG74888331.077Drosophila_melanogaster
ENSG00000132591ERAL19377.043ENSETEG00000011551ERAL110075.701Echinops_telfairi
ENSG00000132591ERAL19954.430ENSEBUG00000004405eral18146.400Eptatretus_burgeri
ENSG00000132591ERAL19986.275ENSEASG00005009864ERAL110082.151Equus_asinus_asinus
ENSG00000132591ERAL19988.235ENSECAG00000013325ERAL110082.838Equus_caballus
ENSG00000132591ERAL19079.167ENSEEUG00000005568ERAL18478.102Erinaceus_europaeus
ENSG00000132591ERAL19651.948ENSELUG00000021860eral17952.632Esox_lucius
ENSG00000132591ERAL19988.235ENSFCAG00000005232ERAL110081.922Felis_catus
ENSG00000132591ERAL18666.667ENSFALG00000006357ERAL19856.104Ficedula_albicollis
ENSG00000132591ERAL18679.710ENSFDAG00000001767ERAL19986.861Fukomys_damarensis
ENSG00000132591ERAL18868.627ENSFHEG00000012028eral19147.406Fundulus_heteroclitus
ENSG00000132591ERAL19955.696ENSGMOG00000014198eral19949.112Gadus_morhua
ENSG00000132591ERAL18376.471ENSGALG00000003995ERAL19353.953Gallus_gallus
ENSG00000132591ERAL19958.228ENSGAFG00000013837eral18449.738Gambusia_affinis
ENSG00000132591ERAL19950.633ENSGACG00000020251eral19962.319Gasterosteus_aculeatus
ENSG00000132591ERAL19964.557ENSGAGG00000023159ERAL110059.788Gopherus_agassizii
ENSG00000132591ERAL18598.195ENSGGOG00000015953ERAL110098.195Gorilla_gorilla
ENSG00000132591ERAL19953.165ENSHBUG00000022014eral18450.660Haplochromis_burtoni
ENSG00000132591ERAL110081.693ENSHGLG00000009773ERAL110081.693Heterocephalus_glaber_female
ENSG00000132591ERAL110081.693ENSHGLG00100018820ERAL110081.693Heterocephalus_glaber_male
ENSG00000132591ERAL19946.835ENSHCOG00000009314eral18451.381Hippocampus_comes
ENSG00000132591ERAL19955.696ENSIPUG00000013409eral18551.958Ictalurus_punctatus
ENSG00000132591ERAL19888.235ENSSTOG00000003459ERAL19979.405Ictidomys_tridecemlineatus
ENSG00000132591ERAL19083.333ENSJJAG00000014664-9780.345Jaculus_jaculus
ENSG00000132591ERAL19081.944ENSJJAG00000002041-9486.667Jaculus_jaculus
ENSG00000132591ERAL18861.429ENSKMAG00000012520eral18550.262Kryptolebias_marmoratus
ENSG00000132591ERAL19953.165ENSLBEG00000016447eral18451.330Labrus_bergylta
ENSG00000132591ERAL17972.549ENSLACG00000012328ERAL19754.815Latimeria_chalumnae
ENSG00000132591ERAL19062.500ENSLOCG00000003302eral19049.526Lepisosteus_oculatus
ENSG00000132591ERAL19986.792ENSLAFG00000005438ERAL110078.947Loxodonta_africana
ENSG00000132591ERAL19996.078ENSMFAG00000000501ERAL110094.279Macaca_fascicularis
ENSG00000132591ERAL19996.078ENSMMUG00000002776ERAL18594.050Macaca_mulatta
ENSG00000132591ERAL199100.000ENSMNEG00000039112ERAL110094.292Macaca_nemestrina
ENSG00000132591ERAL19998.039ENSMLEG00000040246ERAL110093.822Mandrillus_leucophaeus
ENSG00000132591ERAL19954.430ENSMAMG00000006623eral18450.524Mastacembelus_armatus
ENSG00000132591ERAL19953.165ENSMZEG00005000255eral18450.789Maylandia_zebra
ENSG00000132591ERAL18668.116ENSMGAG00000012769ERAL19954.897Meleagris_gallopavo
ENSG00000132591ERAL19379.457ENSMAUG00000001516Eral110078.947Mesocricetus_auratus
ENSG00000132591ERAL19990.196ENSMICG00000005345ERAL110080.594Microcebus_murinus
ENSG00000132591ERAL19982.353ENSMOCG00000022786Eral110077.803Microtus_ochrogaster
ENSG00000132591ERAL19853.846ENSMMOG00000005143eral19649.373Mola_mola
ENSG00000132591ERAL18088.235ENSMODG00000019305ERAL19069.681Monodelphis_domestica
ENSG00000132591ERAL19958.228ENSMALG00000013394eral19350.552Monopterus_albus
ENSG00000132591ERAL19988.235MGP_CAROLIEiJ_G0016788Eral110078.261Mus_caroli
ENSG00000132591ERAL19888.235ENSMUSG00000020832Eral110078.261Mus_musculus
ENSG00000132591ERAL19888.235MGP_PahariEiJ_G0017925Eral110072.769Mus_pahari
ENSG00000132591ERAL19888.235MGP_SPRETEiJ_G0017631Eral110078.719Mus_spretus
ENSG00000132591ERAL19988.235ENSMPUG00000014146ERAL19981.422Mustela_putorius_furo
ENSG00000132591ERAL19988.235ENSMLUG00000013467ERAL19979.452Myotis_lucifugus
ENSG00000132591ERAL19880.392ENSNGAG00000019318Eral110077.117Nannospalax_galili
ENSG00000132591ERAL19954.430ENSNBRG00000015799eral18450.923Neolamprologus_brichardi
ENSG00000132591ERAL199100.000ENSNLEG00000002994ERAL110095.652Nomascus_leucogenys
ENSG00000132591ERAL17988.235ENSMEUG00000015582ERAL19271.237Notamacropus_eugenii
ENSG00000132591ERAL19988.679ENSOPRG00000014488ERAL110077.626Ochotona_princeps
ENSG00000132591ERAL19086.111ENSODEG00000011337ERAL110082.203Octodon_degus
ENSG00000132591ERAL19954.430ENSONIG00000012792eral19948.068Oreochromis_niloticus
ENSG00000132591ERAL19080.556ENSOANG00000008691-9973.973Ornithorhynchus_anatinus
ENSG00000132591ERAL19986.275ENSOCUG00000005572ERAL19978.490Oryctolagus_cuniculus
ENSG00000132591ERAL19954.430ENSORLG00000011440eral18450.811Oryzias_latipes
ENSG00000132591ERAL19954.430ENSORLG00020018272eral18450.811Oryzias_latipes_hni
ENSG00000132591ERAL19955.696ENSORLG00015001511eral18451.351Oryzias_latipes_hsok
ENSG00000132591ERAL19954.430ENSOMEG00000007662eral18256.548Oryzias_melastigma
ENSG00000132591ERAL19986.275ENSOGAG00000011082ERAL110081.236Otolemur_garnettii
ENSG00000132591ERAL19984.314ENSOARG00000004456ERAL19281.465Ovis_aries
ENSG00000132591ERAL1100100.000ENSPPAG00000034297-100100.000Pan_paniscus
ENSG00000132591ERAL188100.000ENSPPAG00000033864-9199.573Pan_paniscus
ENSG00000132591ERAL19988.235ENSPPRG00000006097ERAL110081.465Panthera_pardus
ENSG00000132591ERAL19988.235ENSPTIG00000013961ERAL110081.693Panthera_tigris_altaica
ENSG00000132591ERAL110099.085ENSPTRG00000008938ERAL110099.085Pan_troglodytes
ENSG00000132591ERAL199100.000ENSPANG00000023400ERAL110094.279Papio_anubis
ENSG00000132591ERAL18762.745ENSPKIG00000016278eral18947.101Paramormyrops_kingsleyae
ENSG00000132591ERAL19965.060ENSPSIG00000007018ERAL19853.286Pelodiscus_sinensis
ENSG00000132591ERAL19268.627ENSPMGG00000007387eral19947.685Periophthalmus_magnuspinnatus
ENSG00000132591ERAL19882.353ENSPEMG00000000668Eral110077.626Peromyscus_maniculatus_bairdii
ENSG00000132591ERAL18453.731ENSPMAG00000008076eral19949.560Petromyzon_marinus
ENSG00000132591ERAL19958.228ENSPFOG00000018592eral19450.785Poecilia_formosa
ENSG00000132591ERAL19272.549ENSPLAG00000022753eral19846.785Poecilia_latipinna
ENSG00000132591ERAL19272.549ENSPMEG00000018207eral19846.532Poecilia_mexicana
ENSG00000132591ERAL19956.962ENSPREG00000006895eral18750.524Poecilia_reticulata
ENSG00000132591ERAL199100.000ENSPPYG00000008113ERAL110097.483Pongo_abelii
ENSG00000132591ERAL19984.314ENSPCAG00000003013ERAL110077.803Procavia_capensis
ENSG00000132591ERAL19992.157ENSPCOG00000023179ERAL110083.105Propithecus_coquereli
ENSG00000132591ERAL19982.692ENSPVAG00000001796ERAL19982.609Pteropus_vampyrus
ENSG00000132591ERAL19953.165ENSPNYG00000017330eral18450.396Pundamilia_nyererei
ENSG00000132591ERAL19951.163ENSPNAG00000009960eral18751.671Pygocentrus_nattereri
ENSG00000132591ERAL110077.346ENSRNOG00000010673Eral110077.346Rattus_norvegicus
ENSG00000132591ERAL199100.000ENSRBIG00000006150ERAL110094.737Rhinopithecus_bieti
ENSG00000132591ERAL199100.000ENSRROG00000026778ERAL110094.737Rhinopithecus_roxellana
ENSG00000132591ERAL19970.886ENSSHAG00000014995ERAL19969.086Sarcophilus_harrisii
ENSG00000132591ERAL19056.944ENSSFOG00015015511eral19053.699Scleropages_formosus
ENSG00000132591ERAL19950.602ENSSMAG00000000305eral18449.476Scophthalmus_maximus
ENSG00000132591ERAL19955.696ENSSDUG00000017121eral18451.047Seriola_dumerili
ENSG00000132591ERAL19955.696ENSSLDG00000019349eral18450.919Seriola_lalandi_dorsalis
ENSG00000132591ERAL19980.392ENSSARG00000010129ERAL110076.888Sorex_araneus
ENSG00000132591ERAL19070.833ENSSPUG00000005676ERAL110070.339Sphenodon_punctatus
ENSG00000132591ERAL19951.899ENSSPAG00000018370eral18448.953Stegastes_partitus
ENSG00000132591ERAL19984.314ENSSSCG00000017776ERAL110078.947Sus_scrofa
ENSG00000132591ERAL17846.036ENSTGUG00000006210ERAL19946.036Taeniopygia_guttata
ENSG00000132591ERAL19953.165ENSTRUG00000000660eral18349.730Takifugu_rubripes
ENSG00000132591ERAL16564.706ENSTNIG00000008531eral19963.636Tetraodon_nigroviridis
ENSG00000132591ERAL19980.392ENSTBEG00000007215ERAL110075.973Tupaia_belangeri
ENSG00000132591ERAL19988.235ENSTTRG00000004107ERAL110081.922Tursiops_truncatus
ENSG00000132591ERAL19986.275ENSUAMG00000015904ERAL110081.922Ursus_americanus
ENSG00000132591ERAL19986.275ENSUMAG00000011679ERAL110082.151Ursus_maritimus
ENSG00000132591ERAL19986.275ENSVPAG00000006626ERAL110073.784Vicugna_pacos
ENSG00000132591ERAL19990.196ENSVVUG00000017651ERAL110081.236Vulpes_vulpes
ENSG00000132591ERAL19968.354ENSXETG00000019633eral110058.793Xenopus_tropicalis
ENSG00000132591ERAL19870.588ENSXCOG00000005705eral19945.140Xiphophorus_couchianus
ENSG00000132591ERAL19268.627ENSXMAG00000005455eral19745.434Xiphophorus_maculatus
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000028ribosomal small subunit assembly21873635.IBAProcess
GO:0000028ribosomal small subunit assembly20604745.28449065.IMPProcess
GO:0003723RNA binding22658674.22681889.HDAFunction
GO:0005515protein binding25416956.IPIFunction
GO:0005525GTP binding-IEAFunction
GO:0005739mitochondrion-IDAComponent
GO:0005743mitochondrial inner membrane-IEAComponent
GO:0005759mitochondrial matrix21873635.IBAComponent
GO:0005759mitochondrial matrix20604745.IDAComponent
GO:0005759mitochondrial matrix-TASComponent
GO:0005829cytosol-IDAComponent
GO:0019843rRNA binding21873635.IBAFunction
GO:0019843rRNA binding20604745.IDAFunction
GO:0043024ribosomal small subunit binding21873635.IBAFunction
GO:0043024ribosomal small subunit binding20604745.IDAFunction
GO:0070125mitochondrial translational elongation-TASProcess
GO:0070126mitochondrial translational termination-TASProcess

Copyright © , Bioinformatics Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, China. All Rights Reserved.

Any comment and suggestion, please contact us