EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132773 (Gene tree)
Gene ID: 114034
Gene Symbol: TOE1
Alias: hCaf1z
Full Name: target of EGR1, exonuclease
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 4,309 bases
Position: chr1:45,339,670-45,343,978
Accession: 15954
RBP type: canonical RBP
Summary: (Target Of EGR1, Exonuclease) is a Protein Coding gene. Diseases associated with TOE1 include Pontocerebellar Hypoplasia, Type 7 and Pontocerebellar Hypoplasia. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is PNLDC1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000361162	zf-CCCH	PF00642.24	2.5e-05	1	1
ENSP00000361162	CAF1	PF04857.20	3e-87	1	2
ENSP00000361162	CAF1	PF04857.20	3e-87	2	2

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000372090	TOE1-201	2389	XM_005270412	ENSP00000361162	510 (aa)	XP_005270469	Q96GM8
ENST00000495703	TOE1-205	2173	-	-	- (aa)	-	-
ENST00000471337	TOE1-203	1074	-	-	- (aa)	-	-
ENST00000460057	TOE1-202	592	-	-	- (aa)	-	-
ENST00000477731	TOE1-204	994	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132773's gene model file

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132773's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132773	TOE1	93	50.484	ENSAPOG00000010450	toe1	97	49.804	Acanthochromis_polyacanthus
ENSG00000132773	TOE1	100	88.258	ENSAMEG00000013576	TOE1	100	88.258	Ailuropoda_melanoleuca
ENSG00000132773	TOE1	93	52.218	ENSACIG00000004175	toe1	97	51.738	Amphilophus_citrinellus
ENSG00000132773	TOE1	93	49.905	ENSAOCG00000022922	toe1	97	49.234	Amphiprion_ocellaris
ENSG00000132773	TOE1	93	50.095	ENSAPEG00000005572	toe1	98	48.893	Amphiprion_percula
ENSG00000132773	TOE1	93	50.579	ENSATEG00000008973	toe1	97	49.806	Anabas_testudineus
ENSG00000132773	TOE1	94	53.407	ENSACAG00000015161	TOE1	95	54.857	Anolis_carolinensis
ENSG00000132773	TOE1	100	85.127	ENSANAG00000032328	-	100	83.757	Aotus_nancymaae
ENSG00000132773	TOE1	100	95.695	ENSANAG00000023815	-	98	97.200	Aotus_nancymaae
ENSG00000132773	TOE1	93	48.485	ENSACLG00000021437	toe1	97	49.326	Astatotilapia_calliptera
ENSG00000132773	TOE1	93	51.000	ENSAMXG00000031029	toe1	94	52.371	Astyanax_mexicanus
ENSG00000132773	TOE1	100	85.496	ENSBTAG00000011243	TOE1	100	85.496	Bos_taurus
ENSG00000132773	TOE1	95	30.920	WBGene00013265	parn-2	89	30.137	Caenorhabditis_elegans
ENSG00000132773	TOE1	100	95.890	ENSCJAG00000004716	TOE1	100	95.890	Callithrix_jacchus
ENSG00000132773	TOE1	98	89.157	ENSCAFG00000004603	TOE1	100	88.627	Canis_familiaris
ENSG00000132773	TOE1	98	89.157	ENSCAFG00020016716	TOE1	100	88.627	Canis_lupus_dingo
ENSG00000132773	TOE1	100	86.471	ENSCHIG00000026678	TOE1	100	86.471	Capra_hircus
ENSG00000132773	TOE1	100	92.157	ENSTSYG00000011320	TOE1	98	96.400	Carlito_syrichta
ENSG00000132773	TOE1	69	84.857	ENSCAPG00000003952	TOE1	100	84.857	Cavia_aperea
ENSG00000132773	TOE1	100	86.667	ENSCPOG00000036595	TOE1	100	85.294	Cavia_porcellus
ENSG00000132773	TOE1	100	95.695	ENSCCAG00000030245	TOE1	98	98.000	Cebus_capucinus
ENSG00000132773	TOE1	100	96.667	ENSCATG00000038458	TOE1	99	98.800	Cercocebus_atys
ENSG00000132773	TOE1	100	87.059	ENSCLAG00000003906	TOE1	100	87.059	Chinchilla_lanigera
ENSG00000132773	TOE1	100	96.667	ENSCSAG00000001213	TOE1	100	96.667	Chlorocebus_sabaeus
ENSG00000132773	TOE1	100	88.627	ENSCHOG00000004270	TOE1	100	88.627	Choloepus_hoffmanni
ENSG00000132773	TOE1	94	52.773	ENSCPBG00000005398	TOE1	97	53.091	Chrysemys_picta_bellii
ENSG00000132773	TOE1	73	42.951	ENSCING00000003872	-	97	35.471	Ciona_intestinalis
ENSG00000132773	TOE1	78	42.763	ENSCSAVG00000004594	-	96	34.747	Ciona_savignyi
ENSG00000132773	TOE1	100	96.667	ENSCANG00000037540	TOE1	100	96.667	Colobus_angolensis_palliatus
ENSG00000132773	TOE1	100	84.344	ENSCGRG00001022323	Toe1	100	84.344	Cricetulus_griseus_chok1gshd
ENSG00000132773	TOE1	100	83.953	ENSCGRG00000004377	Toe1	100	83.953	Cricetulus_griseus_crigri
ENSG00000132773	TOE1	93	47.692	ENSCSEG00000021445	toe1	97	47.758	Cynoglossus_semilaevis
ENSG00000132773	TOE1	94	51.485	ENSCVAG00000006577	toe1	97	51.210	Cyprinodon_variegatus
ENSG00000132773	TOE1	94	54.339	ENSDARG00000077544	toe1	95	53.992	Danio_rerio
ENSG00000132773	TOE1	100	87.476	ENSDNOG00000015596	TOE1	97	87.280	Dasypus_novemcinctus
ENSG00000132773	TOE1	100	84.510	ENSDORG00000007153	Toe1	100	84.510	Dipodomys_ordii
ENSG00000132773	TOE1	96	83.367	ENSETEG00000013367	TOE1	100	83.367	Echinops_telfairi
ENSG00000132773	TOE1	86	37.528	ENSEBUG00000000655	toe1	93	36.404	Eptatretus_burgeri
ENSG00000132773	TOE1	100	80.233	ENSEASG00005004198	TOE1	100	78.035	Equus_asinus_asinus
ENSG00000132773	TOE1	100	88.627	ENSECAG00000023204	TOE1	100	88.627	Equus_caballus
ENSG00000132773	TOE1	100	83.922	ENSEEUG00000015402	TOE1	100	83.922	Erinaceus_europaeus
ENSG00000132773	TOE1	94	52.344	ENSELUG00000012307	toe1	94	52.286	Esox_lucius
ENSG00000132773	TOE1	100	89.804	ENSFCAG00000038191	TOE1	100	89.804	Felis_catus
ENSG00000132773	TOE1	85	54.361	ENSFALG00000005017	TOE1	99	53.955	Ficedula_albicollis
ENSG00000132773	TOE1	100	85.882	ENSFDAG00000019031	TOE1	100	85.882	Fukomys_damarensis
ENSG00000132773	TOE1	93	50.386	ENSFHEG00000021893	toe1	97	50.295	Fundulus_heteroclitus
ENSG00000132773	TOE1	93	52.621	ENSGMOG00000004656	toe1	97	51.915	Gadus_morhua
ENSG00000132773	TOE1	94	54.820	ENSGALG00000010228	TOE1	98	54.127	Gallus_gallus
ENSG00000132773	TOE1	94	52.381	ENSGAFG00000013948	toe1	97	52.323	Gambusia_affinis
ENSG00000132773	TOE1	93	53.002	ENSGACG00000014339	toe1	97	52.521	Gasterosteus_aculeatus
ENSG00000132773	TOE1	94	51.978	ENSGAGG00000023228	TOE1	97	53.199	Gopherus_agassizii
ENSG00000132773	TOE1	100	99.216	ENSGGOG00000003290	TOE1	100	99.216	Gorilla_gorilla
ENSG00000132773	TOE1	93	49.042	ENSHBUG00000012101	toe1	97	49.133	Haplochromis_burtoni
ENSG00000132773	TOE1	100	84.932	ENSHGLG00000003603	TOE1	100	85.714	Heterocephalus_glaber_female
ENSG00000132773	TOE1	100	84.932	ENSHGLG00100015361	TOE1	100	85.714	Heterocephalus_glaber_male
ENSG00000132773	TOE1	91	51.534	ENSHCOG00000016394	toe1	97	51.534	Hippocampus_comes
ENSG00000132773	TOE1	92	55.165	ENSIPUG00000002717	toe1	96	54.886	Ictalurus_punctatus
ENSG00000132773	TOE1	100	87.451	ENSSTOG00000010669	TOE1	100	86.078	Ictidomys_tridecemlineatus
ENSG00000132773	TOE1	61	86.992	ENSJJAG00000021743	Toe1	99	86.992	Jaculus_jaculus
ENSG00000132773	TOE1	93	51.277	ENSKMAG00000020891	toe1	96	50.996	Kryptolebias_marmoratus
ENSG00000132773	TOE1	93	48.846	ENSLBEG00000010456	toe1	97	48.538	Labrus_bergylta
ENSG00000132773	TOE1	94	53.755	ENSLOCG00000002852	toe1	98	54.309	Lepisosteus_oculatus
ENSG00000132773	TOE1	100	87.059	ENSLAFG00000017370	TOE1	100	87.059	Loxodonta_africana
ENSG00000132773	TOE1	100	96.667	ENSMFAG00000042312	TOE1	99	98.400	Macaca_fascicularis
ENSG00000132773	TOE1	100	96.863	ENSMMUG00000020081	TOE1	100	97.198	Macaca_mulatta
ENSG00000132773	TOE1	100	96.863	ENSMNEG00000032131	TOE1	100	96.863	Macaca_nemestrina
ENSG00000132773	TOE1	100	96.471	ENSMLEG00000028729	TOE1	100	96.471	Mandrillus_leucophaeus
ENSG00000132773	TOE1	93	48.859	ENSMAMG00000015291	toe1	97	49.711	Mastacembelus_armatus
ENSG00000132773	TOE1	93	48.485	ENSMZEG00005014305	toe1	97	49.326	Maylandia_zebra
ENSG00000132773	TOE1	85	56.463	ENSMGAG00000010387	TOE1	99	56.463	Meleagris_gallopavo
ENSG00000132773	TOE1	100	83.953	ENSMAUG00000022118	Toe1	100	83.953	Mesocricetus_auratus
ENSG00000132773	TOE1	99	89.587	ENSMICG00000047305	-	100	88.212	Microcebus_murinus
ENSG00000132773	TOE1	69	79.830	ENSMICG00000032375	-	94	79.830	Microcebus_murinus
ENSG00000132773	TOE1	100	83.203	ENSMOCG00000012917	Toe1	100	83.203	Microtus_ochrogaster
ENSG00000132773	TOE1	93	47.699	ENSMMOG00000020894	toe1	96	47.134	Mola_mola
ENSG00000132773	TOE1	94	65.235	ENSMODG00000002430	TOE1	98	66.042	Monodelphis_domestica
ENSG00000132773	TOE1	93	49.071	ENSMALG00000010017	toe1	97	49.240	Monopterus_albus
ENSG00000132773	TOE1	100	81.996	MGP_CAROLIEiJ_G0026342	Toe1	98	94.565	Mus_caroli
ENSG00000132773	TOE1	100	81.605	ENSMUSG00000028688	Toe1	98	95.652	Mus_musculus
ENSG00000132773	TOE1	100	82.583	MGP_PahariEiJ_G0028674	Toe1	98	95.652	Mus_pahari
ENSG00000132773	TOE1	100	82.192	MGP_SPRETEiJ_G0027314	Toe1	98	95.652	Mus_spretus
ENSG00000132773	TOE1	97	88.844	ENSMPUG00000013123	TOE1	100	88.281	Mustela_putorius_furo
ENSG00000132773	TOE1	100	87.843	ENSMLUG00000005649	TOE1	100	87.843	Myotis_lucifugus
ENSG00000132773	TOE1	93	52.236	ENSNBRG00000019107	toe1	96	51.546	Neolamprologus_brichardi
ENSG00000132773	TOE1	100	98.039	ENSNLEG00000014383	TOE1	100	98.276	Nomascus_leucogenys
ENSG00000132773	TOE1	82	58.513	ENSMEUG00000000629	-	100	58.513	Notamacropus_eugenii
ENSG00000132773	TOE1	100	86.667	ENSOPRG00000004057	TOE1	100	86.667	Ochotona_princeps
ENSG00000132773	TOE1	100	85.686	ENSODEG00000008239	TOE1	100	85.686	Octodon_degus
ENSG00000132773	TOE1	93	48.184	ENSONIG00000009053	toe1	97	48.184	Oreochromis_niloticus
ENSG00000132773	TOE1	98	52.549	ENSOANG00000011797	-	94	53.734	Ornithorhynchus_anatinus
ENSG00000132773	TOE1	100	88.235	ENSOCUG00000017503	TOE1	100	88.235	Oryctolagus_cuniculus
ENSG00000132773	TOE1	94	50.685	ENSORLG00000012609	toe1	97	50.397	Oryzias_latipes
ENSG00000132773	TOE1	94	51.186	ENSORLG00020006441	toe1	97	50.902	Oryzias_latipes_hni
ENSG00000132773	TOE1	94	51.186	ENSORLG00015001476	toe1	97	50.902	Oryzias_latipes_hsok
ENSG00000132773	TOE1	94	49.806	ENSOMEG00000014153	toe1	97	49.310	Oryzias_melastigma
ENSG00000132773	TOE1	100	67.568	ENSOGAG00000032761	-	100	66.988	Otolemur_garnettii
ENSG00000132773	TOE1	100	85.687	ENSOARG00000001561	TOE1	100	85.687	Ovis_aries
ENSG00000132773	TOE1	100	99.020	ENSPPAG00000043315	TOE1	100	99.020	Pan_paniscus
ENSG00000132773	TOE1	100	89.804	ENSPPRG00000011880	TOE1	100	89.804	Panthera_pardus
ENSG00000132773	TOE1	100	89.804	ENSPTIG00000008086	TOE1	100	89.804	Panthera_tigris_altaica
ENSG00000132773	TOE1	100	99.216	ENSPTRG00000000672	TOE1	100	99.216	Pan_troglodytes
ENSG00000132773	TOE1	100	96.863	ENSPANG00000012549	TOE1	98	96.863	Papio_anubis
ENSG00000132773	TOE1	95	51.540	ENSPKIG00000010811	toe1	94	51.380	Paramormyrops_kingsleyae
ENSG00000132773	TOE1	54	73.285	ENSPSIG00000010299	TOE1	95	73.234	Pelodiscus_sinensis
ENSG00000132773	TOE1	93	50.905	ENSPMGG00000020389	toe1	97	50.612	Periophthalmus_magnuspinnatus
ENSG00000132773	TOE1	100	83.953	ENSPEMG00000021892	Toe1	100	83.953	Peromyscus_maniculatus_bairdii
ENSG00000132773	TOE1	92	42.424	ENSPMAG00000004794	toe1	96	42.115	Petromyzon_marinus
ENSG00000132773	TOE1	95	65.795	ENSPCIG00000027569	TOE1	96	66.460	Phascolarctos_cinereus
ENSG00000132773	TOE1	94	52.362	ENSPFOG00000019517	toe1	97	51.992	Poecilia_formosa
ENSG00000132773	TOE1	94	52.559	ENSPLAG00000018228	toe1	97	52.191	Poecilia_latipinna
ENSG00000132773	TOE1	94	52.250	ENSPMEG00000019956	toe1	97	52.191	Poecilia_mexicana
ENSG00000132773	TOE1	100	98.824	ENSPPYG00000001414	TOE1	100	98.824	Pongo_abelii
ENSG00000132773	TOE1	100	84.902	ENSPCAG00000013351	TOE1	100	84.902	Procavia_capensis
ENSG00000132773	TOE1	99	92.338	ENSPCOG00000000982	TOE1	100	90.963	Propithecus_coquereli
ENSG00000132773	TOE1	97	80.972	ENSPVAG00000014998	TOE1	99	80.972	Pteropus_vampyrus
ENSG00000132773	TOE1	93	48.485	ENSPNYG00000019914	toe1	97	49.326	Pundamilia_nyererei
ENSG00000132773	TOE1	95	52.096	ENSPNAG00000021933	toe1	96	51.943	Pygocentrus_nattereri
ENSG00000132773	TOE1	100	82.387	ENSRNOG00000017561	Toe1	99	85.567	Rattus_norvegicus
ENSG00000132773	TOE1	100	96.863	ENSRBIG00000031463	TOE1	99	98.400	Rhinopithecus_bieti
ENSG00000132773	TOE1	100	96.667	ENSRROG00000026371	TOE1	99	98.400	Rhinopithecus_roxellana
ENSG00000132773	TOE1	100	86.693	ENSSBOG00000032639	-	98	86.693	Saimiri_boliviensis_boliviensis
ENSG00000132773	TOE1	100	96.282	ENSSBOG00000026044	-	98	98.400	Saimiri_boliviensis_boliviensis
ENSG00000132773	TOE1	92	67.017	ENSSHAG00000010201	TOE1	96	67.782	Sarcophilus_harrisii
ENSG00000132773	TOE1	94	54.209	ENSSFOG00015021182	toe1	95	53.975	Scleropages_formosus
ENSG00000132773	TOE1	77	45.740	ENSSMAG00000015322	toe1	83	45.740	Scophthalmus_maximus
ENSG00000132773	TOE1	93	48.762	ENSSDUG00000013278	toe1	97	49.042	Seriola_dumerili
ENSG00000132773	TOE1	93	49.143	ENSSLDG00000021979	toe1	97	49.808	Seriola_lalandi_dorsalis
ENSG00000132773	TOE1	94	54.917	ENSSPUG00000003464	TOE1	98	54.528	Sphenodon_punctatus
ENSG00000132773	TOE1	93	49.432	ENSSPAG00000009490	toe1	97	48.944	Stegastes_partitus
ENSG00000132773	TOE1	99	84.736	ENSSSCG00000003918	TOE1	99	84.736	Sus_scrofa
ENSG00000132773	TOE1	94	53.441	ENSTGUG00000007927	TOE1	98	52.881	Taeniopygia_guttata
ENSG00000132773	TOE1	93	51.329	ENSTRUG00000025603	toe1	97	51.660	Takifugu_rubripes
ENSG00000132773	TOE1	92	53.263	ENSTNIG00000017614	toe1	97	52.854	Tetraodon_nigroviridis
ENSG00000132773	TOE1	78	93.092	ENSTBEG00000017625	TOE1	78	93.092	Tupaia_belangeri
ENSG00000132773	TOE1	100	89.020	ENSTTRG00000008815	TOE1	100	89.020	Tursiops_truncatus
ENSG00000132773	TOE1	100	89.216	ENSUAMG00000017724	TOE1	100	89.216	Ursus_americanus
ENSG00000132773	TOE1	91	89.009	ENSUMAG00000024253	TOE1	100	89.009	Ursus_maritimus
ENSG00000132773	TOE1	100	88.627	ENSVPAG00000011731	TOE1	100	88.627	Vicugna_pacos
ENSG00000132773	TOE1	98	88.755	ENSVVUG00000007469	TOE1	91	89.047	Vulpes_vulpes
ENSG00000132773	TOE1	94	54.118	ENSXETG00000003534	toe1	97	54.217	Xenopus_tropicalis
ENSG00000132773	TOE1	94	51.606	ENSXCOG00000007796	toe1	97	51.738	Xiphophorus_couchianus
ENSG00000132773	TOE1	94	51.479	ENSXMAG00000011102	toe1	97	51.911	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000175	3'-5'-exoribonuclease activity	21873635.	IBA	Function
GO:0000175	3'-5'-exoribonuclease activity	17178830.	IDA	Function
GO:0004535	poly(A)-specific ribonuclease activity	17178830.	IDA	Function
GO:0005515	protein binding	19508870.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IEA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	17178830.	IDA	Component
GO:0015030	Cajal body	21873635.	IBA	Component
GO:0015030	Cajal body	17178830.	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0016607	nuclear speck	-	IEA	Component
GO:0017069	snRNA binding	21873635.	IBA	Function
GO:0017069	snRNA binding	28092684.	IDA	Function
GO:0034472	snRNA 3'-end processing	21873635.	IBA	Process
GO:0034472	snRNA 3'-end processing	28092684.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic	17178830.	IDA	Process