EuRBPDB

Description

Ensembl ID: ENSG00000132792 (Gene tree)
Gene ID: 56259
Gene Symbol: CTNNBL1
Alias: FLJ21108|P14L|P14|NAP|NYD-SP19|C20orf33
Full Name: catenin beta like 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 178,175 bases
Position: chr20:37,693,955-37,872,129
Accession: 15879
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
21385873	CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.	J Biol Chem	2011 May 13	Ganesh K	doi: 10.1074/jbc.M110.208769

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000361383	CTNNBL1-201	1925	-	ENSP00000355050	563 (aa)	-	Q8WYA6
ENST00000628103	CTNNBL1-210	1958	XM_011528917	ENSP00000487198	536 (aa)	XP_011527219	Q8WYA6
ENST00000447935	CTNNBL1-205	778	-	ENSP00000394464	166 (aa)	-	A2A2P1
ENST00000373469	CTNNBL1-202	1130	-	ENSP00000362568	311 (aa)	-	Q8WYA6
ENST00000473857	CTNNBL1-207	2990	-	-	- (aa)	-	-
ENST00000405275	CTNNBL1-204	2076	-	ENSP00000384355	536 (aa)	-	Q8WYA6
ENST00000481674	CTNNBL1-208	450	-	-	- (aa)	-	-
ENST00000472237	CTNNBL1-206	582	-	-	- (aa)	-	-
ENST00000373473	CTNNBL1-203	1493	-	ENSP00000362572	376 (aa)	-	Q8WYA6
ENST00000621317	CTNNBL1-209	1990	-	ENSP00000478532	568 (aa)	-	A0A087WUB9

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa03040	Spliceosome	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000132792	Angiography	7.97999786095019E-5	17903301
ENSG00000132792	Angiography	8.63701550855023E-5	17903301
ENSG00000132792	Bone Density	1.13159393937551E-6	17903296
ENSG00000132792	Bone Density	1E-6	17903296

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132792	rs4811196	20	37841292	?	Bone mineral density	17903296			EFO_0003923

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132792	CTNNBL1	100	97.106	ENSMUSG00000027649	Ctnnbl1	100	96.092	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0000974	Prp19 complex	15175653.	IDA	Component
GO:0005515	protein binding	18722174.20176811.21385873.22365833.24269683.25416956.	IPI	Function
GO:0005634	nucleus	12659813.18722174.20176811.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005681	spliceosomal complex	21873635.	IBA	Component
GO:0005681	spliceosomal complex	20176811.	IDA	Component
GO:0005737	cytoplasm	-	IEA	Component
GO:0006915	apoptotic process	-	IEA	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016445	somatic diversification of immunoglobulins	18722174.	IMP	Process
GO:0019899	enzyme binding	18722174.	IPI	Function
GO:0043065	positive regulation of apoptotic process	12659813.	IDA	Process