EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000132953 (Gene tree)
Gene ID: 64328
Gene Symbol: XPO4
Alias: FLJ13046|KIAA1721
Full Name: exportin 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 125,720 bases
Position: chr13:20,777,329-20,903,048
Accession: 17796
RBP type: canonical RBP
Summary: XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000255305	CRM1_C	PF08767.11	0.00048	1	1
ENSP00000383444	CRM1_C	PF08767.11	0.00048	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000255305	XPO4-201	9921	XM_005266502	ENSP00000255305	1151 (aa)	XP_005266559	Q9C0E2
ENST00000400602	XPO4-202	9884	XM_005266504	ENSP00000383444	1151 (aa)	XP_005266561	F2Z2X4
ENST00000465018	XPO4-203	367	-	-	- (aa)	-	-
ENST00000490513	XPO4-204	914	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000132953's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000132953	Bipolar Disorder	6.22E-5	19488044
ENSG00000132953	Neuroblastoma	5.81e-007	23222812
ENSG00000132953	Monocytes	7.9200000E-005	-
ENSG00000132953	Monocytes	4.3530000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000132953	rs4294650	13	20782401	T	Educational attainment (MTAG)	30038396	[0.0068-0.0122] unit increase	0.0095	EFO_0004784
ENSG00000132953	rs4294650	13	20782401	T	Highest math class taken (MTAG)	30038396	[0.0095-0.0165] unit increase	0.013	EFO_0004875
ENSG00000132953	rs4294650	13	20782401	T	Cognitive performance (MTAG)	30038396	[0.012-0.022] unit increase	0.0171	EFO_0008354
ENSG00000132953	rs2585897	13	20824840	A	PR interval	30046033	[0.91-1.49] ms increase	1.2	EFO_0004462
ENSG00000132953	rs4294650	13	20782401	T	General cognitive ability	29844566	z-score increase	5.92	EFO_0004337

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000132953's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000132953	XPO4	100	99.566	ENSAMEG00000014679	XPO4	100	99.566	Ailuropoda_melanoleuca
ENSG00000132953	XPO4	98	83.682	ENSACIG00000006476	xpo4	100	83.682	Amphilophus_citrinellus
ENSG00000132953	XPO4	98	85.422	ENSATEG00000001554	xpo4	100	85.422	Anabas_testudineus
ENSG00000132953	XPO4	99	95.534	ENSAPLG00000003203	XPO4	99	95.534	Anas_platyrhynchos
ENSG00000132953	XPO4	99	95.101	ENSACAG00000002526	XPO4	100	94.627	Anolis_carolinensis
ENSG00000132953	XPO4	99	83.433	ENSACLG00000017587	xpo4	100	83.462	Astatotilapia_calliptera
ENSG00000132953	XPO4	98	86.714	ENSAMXG00000005543	xpo4	100	86.714	Astyanax_mexicanus
ENSG00000132953	XPO4	100	96.441	ENSBTAG00000003710	XPO4	100	96.441	Bos_taurus
ENSG00000132953	XPO4	100	99.739	ENSCJAG00000004899	XPO4	100	99.739	Callithrix_jacchus
ENSG00000132953	XPO4	100	99.739	ENSCAFG00000007222	XPO4	100	100.000	Canis_familiaris
ENSG00000132953	XPO4	100	99.826	ENSCCAG00000020123	XPO4	100	99.826	Cebus_capucinus
ENSG00000132953	XPO4	100	99.652	ENSCATG00000036978	XPO4	100	99.652	Cercocebus_atys
ENSG00000132953	XPO4	78	99.778	ENSCSAG00000018125	XPO4	100	99.778	Chlorocebus_sabaeus
ENSG00000132953	XPO4	75	38.408	ENSCING00000002840	-	99	38.639	Ciona_intestinalis
ENSG00000132953	XPO4	99	37.898	ENSCSAVG00000008902	-	99	38.157	Ciona_savignyi
ENSG00000132953	XPO4	100	99.739	ENSCANG00000031628	XPO4	100	99.739	Colobus_angolensis_palliatus
ENSG00000132953	XPO4	100	98.089	ENSCGRG00001004627	Xpo4	100	98.089	Cricetulus_griseus_chok1gshd
ENSG00000132953	XPO4	100	97.325	ENSCGRG00000015666	Xpo4	100	97.325	Cricetulus_griseus_crigri
ENSG00000132953	XPO4	99	84.188	ENSCSEG00000009017	xpo4	100	84.188	Cynoglossus_semilaevis
ENSG00000132953	XPO4	99	87.043	ENSDARG00000010281	xpo4	100	87.043	Danio_rerio
ENSG00000132953	XPO4	98	98.941	ENSDNOG00000008001	XPO4	100	98.941	Dasypus_novemcinctus
ENSG00000132953	XPO4	99	83.795	ENSELUG00000006395	xpo4	100	83.795	Esox_lucius
ENSG00000132953	XPO4	100	99.739	ENSFCAG00000000855	XPO4	100	99.739	Felis_catus
ENSG00000132953	XPO4	100	94.531	ENSFALG00000008733	XPO4	99	94.531	Ficedula_albicollis
ENSG00000132953	XPO4	100	99.479	ENSFDAG00000017460	XPO4	100	99.479	Fukomys_damarensis
ENSG00000132953	XPO4	98	85.802	ENSFHEG00000015300	xpo4	99	85.802	Fundulus_heteroclitus
ENSG00000132953	XPO4	99	95.976	ENSGALG00000017132	XPO4	99	95.822	Gallus_gallus
ENSG00000132953	XPO4	99	83.058	ENSGAFG00000003860	xpo4	99	83.058	Gambusia_affinis
ENSG00000132953	XPO4	99	95.367	ENSGAGG00000025383	XPO4	97	95.367	Gopherus_agassizii
ENSG00000132953	XPO4	100	100.000	ENSGGOG00000000890	XPO4	100	100.000	Gorilla_gorilla
ENSG00000132953	XPO4	99	85.230	ENSHBUG00000003863	xpo4	99	85.230	Haplochromis_burtoni
ENSG00000132953	XPO4	100	99.566	ENSHGLG00000018113	XPO4	100	99.566	Heterocephalus_glaber_female
ENSG00000132953	XPO4	100	99.566	ENSHGLG00100011413	XPO4	100	99.566	Heterocephalus_glaber_male
ENSG00000132953	XPO4	99	86.552	ENSIPUG00000003777	xpo4	100	86.552	Ictalurus_punctatus
ENSG00000132953	XPO4	100	99.479	ENSSTOG00000010695	XPO4	100	99.479	Ictidomys_tridecemlineatus
ENSG00000132953	XPO4	99	84.841	ENSKMAG00000013983	xpo4	100	84.841	Kryptolebias_marmoratus
ENSG00000132953	XPO4	99	84.996	ENSLBEG00000014303	xpo4	99	84.996	Labrus_bergylta
ENSG00000132953	XPO4	100	79.602	ENSLOCG00000010910	xpo4	100	87.141	Lepisosteus_oculatus
ENSG00000132953	XPO4	100	99.305	ENSLAFG00000003781	XPO4	100	99.305	Loxodonta_africana
ENSG00000132953	XPO4	100	99.652	ENSMFAG00000030414	XPO4	100	99.652	Macaca_fascicularis
ENSG00000132953	XPO4	100	99.566	ENSMNEG00000043776	XPO4	100	99.566	Macaca_nemestrina
ENSG00000132953	XPO4	99	86.186	ENSMAMG00000020520	xpo4	99	86.186	Mastacembelus_armatus
ENSG00000132953	XPO4	99	83.433	ENSMZEG00005019337	xpo4	100	83.462	Maylandia_zebra
ENSG00000132953	XPO4	100	98.960	ENSMICG00000004636	XPO4	100	98.960	Microcebus_murinus
ENSG00000132953	XPO4	100	98.523	ENSMOCG00000006678	Xpo4	100	98.523	Microtus_ochrogaster
ENSG00000132953	XPO4	99	84.418	ENSMMOG00000019453	xpo4	99	84.418	Mola_mola
ENSG00000132953	XPO4	100	96.277	ENSMODG00000008262	XPO4	100	96.277	Monodelphis_domestica
ENSG00000132953	XPO4	98	81.826	ENSMALG00000018033	xpo4	98	81.826	Monopterus_albus
ENSG00000132953	XPO4	100	98.262	MGP_CAROLIEiJ_G0019352	Xpo4	100	98.262	Mus_caroli
ENSG00000132953	XPO4	100	98.523	ENSMUSG00000021952	Xpo4	100	98.523	Mus_musculus
ENSG00000132953	XPO4	100	98.436	MGP_PahariEiJ_G0030370	Xpo4	100	98.436	Mus_pahari
ENSG00000132953	XPO4	100	98.523	MGP_SPRETEiJ_G0020246	Xpo4	100	98.523	Mus_spretus
ENSG00000132953	XPO4	92	99.351	ENSMPUG00000000600	XPO4	100	99.351	Mustela_putorius_furo
ENSG00000132953	XPO4	98	97.703	ENSMLUG00000012089	-	99	97.703	Myotis_lucifugus
ENSG00000132953	XPO4	100	99.392	ENSNGAG00000014823	Xpo4	100	99.392	Nannospalax_galili
ENSG00000132953	XPO4	81	81.556	ENSNBRG00000011410	xpo4	94	81.662	Neolamprologus_brichardi
ENSG00000132953	XPO4	100	99.913	ENSNLEG00000001816	XPO4	100	99.913	Nomascus_leucogenys
ENSG00000132953	XPO4	90	99.207	ENSOPRG00000010581	XPO4	90	99.207	Ochotona_princeps
ENSG00000132953	XPO4	99	85.404	ENSONIG00000015714	xpo4	99	85.404	Oreochromis_niloticus
ENSG00000132953	XPO4	100	95.061	ENSOANG00000009030	-	100	95.061	Ornithorhynchus_anatinus
ENSG00000132953	XPO4	99	98.685	ENSOCUG00000008490	XPO4	99	98.685	Oryctolagus_cuniculus
ENSG00000132953	XPO4	98	84.466	ENSORLG00000013136	xpo4	99	84.466	Oryzias_latipes
ENSG00000132953	XPO4	98	84.533	ENSORLG00020009218	xpo4	100	84.533	Oryzias_latipes_hni
ENSG00000132953	XPO4	99	84.201	ENSORLG00015012168	xpo4	99	84.201	Oryzias_latipes_hsok
ENSG00000132953	XPO4	98	82.982	ENSOMEG00000009492	xpo4	100	83.246	Oryzias_melastigma
ENSG00000132953	XPO4	100	97.747	ENSOGAG00000000048	XPO4	100	97.747	Otolemur_garnettii
ENSG00000132953	XPO4	98	96.646	ENSOARG00000013784	XPO4	100	96.646	Ovis_aries
ENSG00000132953	XPO4	100	100.000	ENSPPAG00000031464	XPO4	100	100.000	Pan_paniscus
ENSG00000132953	XPO4	100	99.392	ENSPPRG00000017050	XPO4	100	99.392	Panthera_pardus
ENSG00000132953	XPO4	100	99.826	ENSPANG00000001765	XPO4	100	99.826	Papio_anubis
ENSG00000132953	XPO4	99	88.348	ENSPKIG00000001940	xpo4	100	88.348	Paramormyrops_kingsleyae
ENSG00000132953	XPO4	88	97.917	ENSPSIG00000006908	XPO4	100	95.752	Pelodiscus_sinensis
ENSG00000132953	XPO4	100	98.871	ENSPEMG00000017255	Xpo4	100	98.871	Peromyscus_maniculatus_bairdii
ENSG00000132953	XPO4	100	96.710	ENSPCIG00000000193	XPO4	100	96.710	Phascolarctos_cinereus
ENSG00000132953	XPO4	100	85.455	ENSPFOG00000005062	xpo4	100	85.455	Poecilia_formosa
ENSG00000132953	XPO4	100	80.746	ENSPLAG00000001184	xpo4	100	80.746	Poecilia_latipinna
ENSG00000132953	XPO4	100	80.642	ENSPMEG00000016525	xpo4	100	80.642	Poecilia_mexicana
ENSG00000132953	XPO4	100	85.294	ENSPREG00000000899	xpo4	100	85.294	Poecilia_reticulata
ENSG00000132953	XPO4	100	99.913	ENSPPYG00000005196	XPO4	100	99.913	Pongo_abelii
ENSG00000132953	XPO4	100	89.922	ENSPCAG00000004580	XPO4	100	89.922	Procavia_capensis
ENSG00000132953	XPO4	91	94.689	ENSPCOG00000013299	-	97	94.689	Propithecus_coquereli
ENSG00000132953	XPO4	99	83.433	ENSPNYG00000006605	xpo4	100	83.462	Pundamilia_nyererei
ENSG00000132953	XPO4	99	87.130	ENSPNAG00000005781	xpo4	100	87.130	Pygocentrus_nattereri
ENSG00000132953	XPO4	100	98.089	ENSRNOG00000010137	Xpo4	100	98.089	Rattus_norvegicus
ENSG00000132953	XPO4	100	99.739	ENSRROG00000034581	XPO4	100	99.739	Rhinopithecus_roxellana
ENSG00000132953	XPO4	100	99.739	ENSSBOG00000020841	XPO4	100	99.739	Saimiri_boliviensis_boliviensis
ENSG00000132953	XPO4	91	97.042	ENSSHAG00000006069	XPO4	100	97.042	Sarcophilus_harrisii
ENSG00000132953	XPO4	98	88.523	ENSSFOG00015001025	xpo4	100	88.523	Scleropages_formosus
ENSG00000132953	XPO4	99	84.856	ENSSMAG00000007828	xpo4	99	84.856	Scophthalmus_maximus
ENSG00000132953	XPO4	91	82.521	ENSSDUG00000013955	xpo4	93	82.521	Seriola_dumerili
ENSG00000132953	XPO4	99	83.753	ENSSLDG00000013233	xpo4	99	83.753	Seriola_lalandi_dorsalis
ENSG00000132953	XPO4	98	95.217	ENSSPUG00000014529	XPO4	99	95.217	Sphenodon_punctatus
ENSG00000132953	XPO4	89	97.368	ENSSSCG00000009276	XPO4	100	98.718	Sus_scrofa
ENSG00000132953	XPO4	98	95.664	ENSTGUG00000011343	XPO4	100	95.664	Taeniopygia_guttata
ENSG00000132953	XPO4	99	81.929	ENSTRUG00000015851	xpo4	100	81.929	Takifugu_rubripes
ENSG00000132953	XPO4	99	83.795	ENSTNIG00000015669	xpo4	99	83.795	Tetraodon_nigroviridis
ENSG00000132953	XPO4	100	96.788	ENSTTRG00000015597	XPO4	100	96.788	Tursiops_truncatus
ENSG00000132953	XPO4	92	89.610	ENSXCOG00000018340	xpo4	100	75.410	Xiphophorus_couchianus
ENSG00000132953	XPO4	100	83.291	ENSXMAG00000014884	xpo4	100	83.291	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005049	nuclear export signal receptor activity	21873635.	IBA	Function
GO:0005515	protein binding	10944119.15282309.	IPI	Function
GO:0005643	nuclear pore	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006611	protein export from nucleus	21873635.	IBA	Process
GO:0046827	positive regulation of protein export from nucleus	16449645.	IMP	Process