EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000133026 (Gene tree)
Gene ID: 4628
Gene Symbol: MYH10
Alias: NMMHCB
Full Name: myosin heavy chain 10
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 156,808 bases
Position: chr17:8,474,205-8,631,012
Accession: 7568
RBP type: non-canonical RBP
Summary: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000411957	MYH10-204	732	-	ENSP00000408220	187 (aa)	-	E7ERA5
ENST00000379980	MYH10-203	7694	XM_011523878	ENSP00000369315	1985 (aa)	XP_011522180	P35580
ENST00000465458	MYH10-206	799	-	-	- (aa)	-	-
ENST00000488329	MYH10-210	538	-	-	- (aa)	-	-
ENST00000584124	MYH10-211	317	-	-	- (aa)	-	-
ENST00000469865	MYH10-207	504	-	-	- (aa)	-	-
ENST00000459986	MYH10-205	711	-	-	- (aa)	-	-
ENST00000476737	MYH10-209	592	-	-	- (aa)	-	-
ENST00000472728	MYH10-208	383	-	-	- (aa)	-	-
ENST00000360416	MYH10-202	7762	XM_011523875	ENSP00000353590	2007 (aa)	XP_011522177	P35580
ENST00000269243	MYH10-201	7662	XM_011523880	ENSP00000269243	1976 (aa)	XP_011522182	P35580

Gene Model

Click here to download ENSG00000133026's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04530	Tight junction	KEGG
hsa04810	Regulation of actin cytoskeleton	KEGG
hsa05132	Salmonella infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000133026	Leptin	9.1510000E-005	-
ENSG00000133026	Leptin	9.4010000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133026's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000133026	MYH10	100	100.000	ENSMUSG00000020900	Myh10	100	99.089	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000146	microfilament motor activity	15845534.	IDA	Function
GO:0000281	mitotic cytokinesis	15774463.	IDA	Process
GO:0001701	in utero embryonic development	-	IEA	Process
GO:0001725	stress fiber	7699007.15774463.	IDA	Component
GO:0001764	neuron migration	-	IEA	Process
GO:0001778	plasma membrane repair	-	IEA	Process
GO:0003279	cardiac septum development	-	IEA	Process
GO:0003779	actin binding	7782316.	NAS	Function
GO:0005515	protein binding	7542763.20603131.	IPI	Function
GO:0005516	calmodulin binding	-	IEA	Function
GO:0005524	ATP binding	15845534.	IDA	Function
GO:0005524	ATP binding	7782316.	NAS	Function
GO:0005634	nucleus	21630459.	HDA	Component
GO:0005737	cytoplasm	7699007.	IDA	Component
GO:0005819	spindle	-	IEA	Component
GO:0005829	cytosol	20603131.	IMP	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005844	polysome	20603131.	IMP	Component
GO:0005903	brush border	-	IEA	Component
GO:0005938	cell cortex	7699007.	IDA	Component
GO:0006887	exocytosis	-	IEA	Process
GO:0006930	substrate-dependent cell migration, cell extension	-	IEA	Process
GO:0007097	nuclear migration	-	IEA	Process
GO:0007155	cell adhesion	-	IEA	Process
GO:0007411	axon guidance	-	IEA	Process
GO:0007512	adult heart development	-	IEA	Process
GO:0008283	cell proliferation	-	IEA	Process
GO:0008360	regulation of cell shape	-	IEA	Process
GO:0016459	myosin complex	7499478.	NAS	Component
GO:0016460	myosin II complex	24072716.	IDA	Component
GO:0016887	ATPase activity	24072716.	IMP	Function
GO:0021592	fourth ventricle development	-	IEA	Process
GO:0021670	lateral ventricle development	-	IEA	Process
GO:0021678	third ventricle development	-	IEA	Process
GO:0021680	cerebellar Purkinje cell layer development	-	IEA	Process
GO:0030027	lamellipodium	-	IEA	Component
GO:0030048	actin filament-based movement	15845534.	IDA	Process
GO:0030426	growth cone	-	IEA	Component
GO:0030496	midbody	11029059.	IDA	Component
GO:0030898	actin-dependent ATPase activity	15845534.	IDA	Function
GO:0030898	actin-dependent ATPase activity	24072716.	IMP	Function
GO:0031032	actomyosin structure organization	24072716.	IMP	Process
GO:0031594	neuromuscular junction	-	IEA	Component
GO:0032154	cleavage furrow	7699007.11029059.	IDA	Component
GO:0035613	RNA stem-loop binding	20603131.	IDA	Function
GO:0035904	aorta development	-	IEA	Process
GO:0042641	actomyosin	24072716.	IDA	Component
GO:0043025	neuronal cell body	-	IEA	Component
GO:0043197	dendritic spine	-	IEA	Component
GO:0043531	ADP binding	15845534.	IDA	Function
GO:0048027	mRNA 5'-UTR binding	20603131.	IDA	Function
GO:0050714	positive regulation of protein secretion	20603131.	IMP	Process
GO:0050885	neuromuscular process controlling balance	-	IEA	Process
GO:0051015	actin filament binding	15845534.	IDA	Function
GO:0051015	actin filament binding	24072716.	IMP	Function
GO:0055003	cardiac myofibril assembly	-	IEA	Process
GO:0055015	ventricular cardiac muscle cell development	-	IEA	Process
GO:0060041	retina development in camera-type eye	-	IEA	Process
GO:0060976	coronary vasculature development	-	IEA	Process
GO:0070062	extracellular exosome	23533145.	HDA	Component
GO:0097513	myosin II filament	24072716.	IDA	Component
GO:0098885	modification of postsynaptic actin cytoskeleton	-	IEA	Process
GO:0098974	postsynaptic actin cytoskeleton organization	-	IEA	Process
GO:0098978	glutamatergic synapse	-	IEA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
15619008	Myosin regulation in the migration of tumor cells and leukocytes within a three-dimensional collagen matrix.	Cell Mol Life Sci	2005 Jan	Bastian P	-
24858044	miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo.	Oncogene	2015 Apr 2	Senol O	doi: 10.1038/onc.2014.120

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr17	8521227	Silent	NA	S641S	0.47
BLCA	chr17	8492970	Nonsense_Mutation	novel	E1391*	0.13
BLCA	chr17	8480268	Silent	novel	K1782K	0.35
BLCA	chr17	8546655	Silent	NA	Q379Q	0.26
BLCA	chr17	8513882	Silent	NA	K808K	0.57
BLCA	chr17	8481374	Missense_Mutation	rs199665530	E1707K	0.26
BLCA	chr17	8546595	Silent	novel	P399P	0.66
BLCA	chr17	8477025	Missense_Mutation	novel	M1879I	0.11
BLCA	chr17	8623184	Missense_Mutation	novel	I21M	0.13
BLCA	chr17	8545459	Missense_Mutation	novel	E464Q	0.39
BLCA	chr17	8518779	Nonsense_Mutation	novel	E755*	0.34
BLCA	chr17	8500927	Missense_Mutation	NA	E1184K	0.22
BLCA	chr17	8475809	Missense_Mutation	NA	E1976Q	0.71
BLCA	chr17	8548771	Frame_Shift_Ins	novel	*G303Tfs7**	0.08
BLCA	chr17	8499377	Missense_Mutation	novel	E1251Q	0.34
BLCA	chr17	8506490	Splice_Site	novel	X1041_splice	0.31
BLCA	chr17	8535898	Missense_Mutation	novel	E537K	0.48
BLCA	chr17	8492791	Silent	NA	Q1450Q	0.2
BLCA	chr17	8623093	Missense_Mutation	novel	E52Q	0.43
BLCA	chr17	8484180	Silent	novel	K1680K	0.19
BLCA	chr17	8477029	Missense_Mutation	novel	R1878P	0.24
BLCA	chr17	8500858	Missense_Mutation	novel	E1207Q	0.41
BLCA	chr17	8520880	Missense_Mutation	NA	Q726H	0.1
BLCA	chr17	8604941	Missense_Mutation	NA	K129N	0.19
BLCA	chr17	8518747	Missense_Mutation	NA	Q765H	0.5
BLCA	chr17	8512583	Missense_Mutation	novel	M909I	0.32
BLCA	chr17	8500851	Missense_Mutation	novel	S1209L	0.4
BLCA	chr17	8623111	Missense_Mutation	novel	E46Q	0.53
BLCA	chr17	8520891	Nonsense_Mutation	novel	E723*	0.17
BRCA	chr17	8577245	Silent	NA	H208H	0.42
BRCA	chr17	8506460	Missense_Mutation	novel	Q1051K	0.15
BRCA	chr17	8474678	3'UTR	novel		0.26
BRCA	chr17	8480316	Splice_Region	novel	V1766V	0.26
BRCA	chr17	8535787	Missense_Mutation	NA	D574Y	0.77
BRCA	chr17	8481383	Silent	novel	R1704R	0.17
BRCA	chr17	8493814	Missense_Mutation	NA	K1345N	0.32
BRCA	chr17	8481328	Missense_Mutation	NA	S1722F	0.19
BRCA	chr17	8521244	Missense_Mutation	rs778892637	E636K	0.34
BRCA	chr17	8481359	Missense_Mutation	NA	E1712Q	0.59
BRCA	chr17	8577236	Splice_Region	novel	P211P	0.07
BRCA	chr17	8512570	Missense_Mutation	NA	A914P	0.26
BRCA	chr17	8475772	3'UTR	novel		0.18
BRCA	chr17	8577254	Missense_Mutation	novel	R205S	0.07
BRCA	chr17	8577255	Missense_Mutation	NA	R205K	0.07
BRCA	chr17	8518712	Missense_Mutation	NA	H777R	0.33
BRCA	chr17	8513818	Missense_Mutation	NA	R830W	0.7
BRCA	chr17	8475686	3'UTR	novel		0.59
BRCA	chr17	8492423	Silent	novel	K1484K	0.09
BRCA	chr17	8492484	Missense_Mutation	NA	S1464C	0.16
BRCA	chr17	8495186	Missense_Mutation	NA	K1305T	0.32
BRCA	chr17	8521167	Silent	NA	L661L	0.34
BRCA	chr17	8487552	Missense_Mutation	rs776217752	R1612W	0.32
BRCA	chr17	8492941	Silent	NA	D1400D	0.44
BRCA	chr17	8492838	Missense_Mutation	NA	D1435N	0.67
BRCA	chr17	8492484	Missense_Mutation	NA	S1464C	0.12
CESC	chr17	8500913	Missense_Mutation	novel	K1188N	0.05
CESC	chr17	8535787	Missense_Mutation	novel	D574N	0.09
CESC	chr17	8478398	Silent	NA	L1851L	0.24
CESC	chr17	8478370	Missense_Mutation	rs748972290	E1861K	0.38
CESC	chr17	8542241	Missense_Mutation	NA	E481Q	0.39
CESC	chr17	8490444	Missense_Mutation	novel	L1563F	0.38
CESC	chr17	8542181	Missense_Mutation	novel	R501C	0.29
CESC	chr17	8504836	Missense_Mutation	NA	E1122K	0.13
CESC	chr17	8508626	Missense_Mutation	novel	E1017K	0.21
CESC	chr17	8492431	Missense_Mutation	NA	E1482Q	0.21
CESC	chr17	8474319	3'UTR	novel		0.41
CESC	chr17	8481395	Missense_Mutation	novel	E1700K	0.27
CESC	chr17	8604922	Missense_Mutation	novel	E136Q	0.17
CESC	chr17	8492979	Missense_Mutation	NA	E1388K	0.57
CESC	chr17	8546601	Silent	NA	L397L	0.32
CESC	chr17	8493847	Silent	NA	L1334L	0.58
CESC	chr17	8475854	Missense_Mutation	novel	E1961K	0.49
CESC	chr17	8487564	Missense_Mutation	NA	E1608K	0.36
CESC	chr17	8521227	Silent	NA	S641S	0.41
COAD	chr17	8552088	Missense_Mutation	novel	I283L	0.28
COAD	chr17	8475916	Missense_Mutation	rs370970711	R1940Q	0.39
COAD	chr17	8548740	Missense_Mutation	NA	G313C	0.35
COAD	chr17	8481378	Silent	rs200645746	H1705H	0.45
COAD	chr17	8509887	Silent	novel	V974V	0.28
COAD	chr17	8480163	Silent	novel	S1817S	0.26
COAD	chr17	8535844	Missense_Mutation	novel	Q555K	0.19
COAD	chr17	8521227	Silent	NA	S641S	0.79
COAD	chr17	8513831	Silent	novel	A825A	0.22
COAD	chr17	8477034	Silent	rs145331684	N1876N	0.34
COAD	chr17	8521226	Missense_Mutation	novel	A642T	0.06
COAD	chr17	8535843	Missense_Mutation	novel	Q555R	0.1
COAD	chr17	8513800	Nonsense_Mutation	novel	R836*	0.09
COAD	chr17	8521144	Missense_Mutation	rs773722498	R669Q	0.2
COAD	chr17	8521279	Missense_Mutation	NA	R624H	0.26
COAD	chr17	8548719	Missense_Mutation	novel	Q320K	0.18
COAD	chr17	8548721	Missense_Mutation	novel	G319E	0.16
COAD	chr17	8506384	Missense_Mutation	rs150206681	A1076V	0.3
COAD	chr17	8623123	Missense_Mutation	NA	R42C	0.17
COAD	chr17	8492303	Silent	NA	G1524G	0.84
COAD	chr17	8478356	Silent	rs766085338	A1865A	0.39
COAD	chr17	8499417	Silent	rs772713569	A1237A	0.14
COAD	chr17	8492941	Silent	NA	D1400D	0.31
COAD	chr17	8535763	Missense_Mutation	NA	G582R	0.44
COAD	chr17	8490512	Missense_Mutation	novel	Q1540R	0.26
COAD	chr17	8500833	Missense_Mutation	NA	A1215V	0.24
COAD	chr17	8475867	Silent	rs751540483	S1956S	0.4
COAD	chr17	8546562	Frame_Shift_Del	novel	*A411Pfs11**	0.15
COAD	chr17	8480483	Silent	novel	I1738I	0.2
COAD	chr17	8477040	Missense_Mutation	novel	K1874N	0.38
COAD	chr17	8545549	Missense_Mutation	novel	R434C	0.24
DLBC	chr17	8552074	Silent	novel	L287L	0.09
ESCA	chr17	8518683	Missense_Mutation	novel	T787P	0.11
ESCA	chr17	8474683	3'UTR	rs112236556		0.32
ESCA	chr17	8490499	Missense_Mutation	novel	M1544I	0.28
ESCA	chr17	8506396	Missense_Mutation	novel	A1072E	0.08
GBM	chr17	8535391	Frame_Shift_Del	novel	F614*	0.28
GBM	chr17	8512488	Missense_Mutation	novel	L941H	0.12
GBM	chr17	8481382	Missense_Mutation	rs150261129	R1704Q	0.21
GBM	chr17	8506431	Silent	rs185230215	L1060L	0.46
GBM	chr17	8509847	Missense_Mutation	novel	L988M	0.43
GBM	chr17	8499311	Missense_Mutation	novel	R1273G	0.42
GBM	chr17	8475761	3'UTR	novel		0.15
GBM	chr17	8552070	Missense_Mutation	novel	S289A	0.46
GBM	chr17	8506355	Missense_Mutation	novel	A1086T	0.41
GBM	chr17	8475733	3'UTR	novel		0.06
GBM	chr17	8506328	Missense_Mutation	rs753724964	A1095T	0.38
HNSC	chr17	8480271	Missense_Mutation	novel	Q1781H	0.32
HNSC	chr17	8484212	Missense_Mutation	novel	E1670K	0.15
HNSC	chr17	8499383	Missense_Mutation	novel	E1249Q	0.39
HNSC	chr17	8623002	Missense_Mutation	novel	P82R	0.29
HNSC	chr17	8535442	Silent	novel	V603V	0.19
HNSC	chr17	8480487	Missense_Mutation	rs765309529	R1737Q	0.48
HNSC	chr17	8495211	Missense_Mutation	novel	E1297K	0.35
HNSC	chr17	8622982	Missense_Mutation	novel	D89N	0.21
HNSC	chr17	8480135	Missense_Mutation	novel	E1827Q	0.05
HNSC	chr17	8495222	Missense_Mutation	rs775866479	S1293F	0.35
HNSC	chr17	8475854	Missense_Mutation	NA	E1961Q	0.59
HNSC	chr17	8490499	Missense_Mutation	novel	M1544I	0.51
HNSC	chr17	8508597	Silent	novel	A1026A	0.35
HNSC	chr17	8548387	Missense_Mutation	novel	S352L	0.49
HNSC	chr17	8623242	Missense_Mutation	novel	A2G	0.07
HNSC	chr17	8508628	Missense_Mutation	novel	A1016D	0.4
HNSC	chr17	8509863	Missense_Mutation	novel	K982N	0.23
HNSC	chr17	8546631	Missense_Mutation	novel	M387I	0.27
HNSC	chr17	8553958	Missense_Mutation	novel	T263A	0.52
HNSC	chr17	8480190	Silent	novel	V1808V	0.16
HNSC	chr17	8622930	Missense_Mutation	novel	K106R	0.45
HNSC	chr17	8492940	Missense_Mutation	rs201117056	A1401T	0.61
HNSC	chr17	8509949	Missense_Mutation	novel	D954N	0.12
KIRC	chr17	8506433	Missense_Mutation	NA	L1060V	0.37
KIRC	chr17	8518674	Missense_Mutation	NA	I790L	0.34
KIRC	chr17	8589084	Missense_Mutation	novel	C176Y	0.09
KIRC	chr17	8535865	Frame_Shift_Ins	novel	*T548Cfs26**	0.05
KIRP	chr17	8548708	Frame_Shift_Del	novel	*D324Ifs12**	0.1
KIRP	chr17	8535430	Silent	novel	L607L	0.56
KIRP	chr17	8500830	Missense_Mutation	novel	K1216T	0.37
KIRP	chr17	8545462	Missense_Mutation	novel	F463L	0.38
KIRP	chr17	8484261	Silent	novel	Q1653Q	0.53
KIRP	chr17	8500865	Silent	novel	A1204A	0.36
LAML	chr17	8577332	Missense_Mutation	novel	E179D	0.07
LAML	chr17	8492458	Missense_Mutation	novel	R1473W	0.08
LGG	chr17	8521257	Silent	NA	V631V	0.35
LGG	chr17	8623202	Frame_Shift_Del	novel	*F15Cfs14**	0.23
LGG	chr17	8490357	Missense_Mutation	novel	R1592W	0.07
LGG	chr17	8512551	Missense_Mutation	novel	L920S	0.4
LGG	chr17	8604832	Missense_Mutation	novel	L166I	0.22
LIHC	chr17	8520980	Missense_Mutation	novel	H693L	0.2
LIHC	chr17	8487559	Silent	NA	R1609R	0.72
LIHC	chr17	8475685	3'UTR	novel		0.88
LIHC	chr17	8480159	Silent	novel	L1819L	0.09
LUAD	chr17	8506467	Silent	novel	K1048K	0.07
LUAD	chr17	8504714	Silent	rs575524243	T1162T	0.06
LUAD	chr17	8481378	Silent	rs200645746	H1705H	0.16
LUAD	chr17	8552090	Missense_Mutation	NA	H282R	0.19
LUAD	chr17	8490369	Missense_Mutation	novel	E1588K	0.16
LUAD	chr17	8545464	Missense_Mutation	NA	G462E	0.23
LUAD	chr17	8552145	Splice_Site	novel	X264_splice	0.14
LUAD	chr17	8480174	Missense_Mutation	novel	A1814T	0.1
LUAD	chr17	8623259	5'UTR	rs373167874		0.1
LUAD	chr17	8512646	Missense_Mutation	NA	E888D	0.13
LUAD	chr17	8577339	Splice_Site	novel	X177_splice	0.56
LUAD	chr17	8490424	Missense_Mutation	novel	M1569I	0.46
LUAD	chr17	8623143	Missense_Mutation	novel	L35P	0.09
LUAD	chr17	8542141	Missense_Mutation	NA	D514G	0.06
LUSC	chr17	8499357	Silent	rs780658326	L1257L	0.23
LUSC	chr17	8623142	Silent	novel	L35L	0.04
LUSC	chr17	8513641	Missense_Mutation	novel	Q850L	0.19
LUSC	chr17	8480494	Missense_Mutation	novel	E1735K	0.28
LUSC	chr17	8569798	Frame_Shift_Del	novel	*Q217Sfs18**	0.07
LUSC	chr17	8506438	Missense_Mutation	novel	R1058T	0.55
LUSC	chr17	8493835	Silent	novel	I1338I	0.18
LUSC	chr17	8492413	Missense_Mutation	rs762499918	L1488V	0.23
LUSC	chr17	8622921	Missense_Mutation	NA	Y109C	0.32
LUSC	chr17	8569808	Frame_Shift_Ins	NA	*E213Gfs3**	0.25
OV	chr17	8622909	Missense_Mutation	novel	L113R	0.2
OV	chr17	8475746	3'UTR	novel		0.29
OV	chr17	8492978	Missense_Mutation	NA	E1388G	0.68
OV	chr17	8475764	3'UTR	novel		0.09
OV	chr17	8492297	Splice_Region	rs374580626	N1526N	0.43
OV	chr17	8480296	Missense_Mutation	novel	L1773P	0.05
OV	chr17	8518656	Missense_Mutation	rs755114317	V796I	0.88
PAAD	chr17	8476984	Missense_Mutation	rs778680463	A1893V	0.2
PAAD	chr17	8478362	Silent	NA	R1863R	0.04
PAAD	chr17	8487487	Silent	rs375050384	I1633I	0.2
PAAD	chr17	8542169	Missense_Mutation	NA	E505K	0.19
PAAD	chr17	8545533	Missense_Mutation	rs768634600	R439H	0.19
PAAD	chr17	8495193	Missense_Mutation	novel	G1303C	0.05
PRAD	chr17	8577255	Missense_Mutation	NA	R205K	0.53
PRAD	chr17	8506427	Missense_Mutation	NA	G1062R	0.27
PRAD	chr17	8476984	Missense_Mutation	rs778680463	A1893V	0.28
PRAD	chr17	8622903	Missense_Mutation	NA	Y115S	0.34
PRAD	chr17	8545549	Missense_Mutation	novel	R434C	0.31
PRAD	chr17	8475620	3'UTR	novel		0.27
PRAD	chr17	8545507	Missense_Mutation	novel	K448E	0.39
READ	chr17	8604915	Missense_Mutation	NA	I138S	0.13
READ	chr17	8487478	Silent	NA	A1636A	0.35
READ	chr17	8506419	Silent	novel	T1064T	0.3
READ	chr17	8508617	Nonsense_Mutation	novel	E1020*	0.42
READ	chr17	8552086	Silent	NA	I283I	0.29
READ	chr17	8623259	5'UTR	rs373167874		0.43
READ	chr17	8545454	Missense_Mutation	NA	I465M	0.73
READ	chr17	8548328	Missense_Mutation	novel	M372V	0.23
READ	chr17	8622993	Missense_Mutation	NA	S85F	0.7
SARC	chr17	8476960	Missense_Mutation	NA	R1901H	0.21
SARC	chr17	8480470	Missense_Mutation	novel	E1743K	0.5
SARC	chr17	8546659	Missense_Mutation	rs757539505	A378V	0.09
SARC	chr17	8487438	Missense_Mutation	novel	L1650I	0.11
SARC	chr17	8518907	Missense_Mutation	novel	D742Y	0.34
SKCM	chr17	8622969	Missense_Mutation	novel	L93S	0.46
SKCM	chr17	8546582	Missense_Mutation	novel	G404C	0.09
SKCM	chr17	8513891	Silent	rs185750723	A805A	0.29
SKCM	chr17	8518789	Splice_Region	NA	I751I	0.47
SKCM	chr17	8521286	Splice_Site	NA	X622_splice	0.28
SKCM	chr17	8492805	Silent	NA	L1446L	0.25
SKCM	chr17	8604883	Missense_Mutation	NA	E149K	0.42
SKCM	chr17	8521199	Missense_Mutation	novel	R651C	0.46
SKCM	chr17	8492375	Silent	NA	E1500E	0.19
SKCM	chr17	8513636	Missense_Mutation	NA	E852K	0.1
SKCM	chr17	8490522	Silent	rs377742356	L1537L	0.44
SKCM	chr17	8569725	Missense_Mutation	novel	R241C	0.75
SKCM	chr17	8504770	Missense_Mutation	NA	L1144V	0.51
SKCM	chr17	8476927	Missense_Mutation	novel	E1912G	0.16
SKCM	chr17	8548731	Missense_Mutation	rs769801603	P316S	0.11
SKCM	chr17	8548374	Missense_Mutation	NA	F356L	0.23
SKCM	chr17	8493763	Silent	NA	L1362L	0.83
SKCM	chr17	8512486	Nonsense_Mutation	NA	Q942*	0.27
SKCM	chr17	8623262	5'UTR	novel		0.32
SKCM	chr17	8604949	Missense_Mutation	NA	P127S	0.49
SKCM	chr17	8506431	Silent	rs185230215	L1060L	0.24
SKCM	chr17	8546639	Missense_Mutation	NA	L385F	0.48
SKCM	chr17	8569766	Missense_Mutation	NA	S227L	0.16
SKCM	chr17	8504790	Missense_Mutation	NA	A1137V	0.18
SKCM	chr17	8548745	Missense_Mutation	NA	S311F	0.15
SKCM	chr17	8546583	Silent	rs760755512	V403V	0.35
SKCM	chr17	8577286	Missense_Mutation	novel	L195F	0.35
STAD	chr17	8492843	Missense_Mutation	rs539038765	T1433M	0.22
STAD	chr17	8622980	Silent	novel	D89D	0.12
STAD	chr17	8504860	Nonsense_Mutation	NA	R1114*	0.08
STAD	chr17	8512468	Frame_Shift_Del	novel	*M948Cfs12**	0.39
STAD	chr17	8513799	Missense_Mutation	NA	R836Q	0.22
STAD	chr17	8480311	Missense_Mutation	novel	T1768I	0.2
STAD	chr17	8548380	Silent	NA	L354L	0.24
STAD	chr17	8492954	Missense_Mutation	NA	K1396R	0.2
STAD	chr17	8500868	Silent	NA	T1203T	0.19
STAD	chr17	8506428	Silent	rs138732743	D1061D	0.21
STAD	chr17	8477033	Missense_Mutation	rs371705630	A1877T	0.08
STAD	chr17	8487486	Missense_Mutation	rs184124261	E1634K	0.39
STAD	chr17	8506384	Missense_Mutation	rs150206681	A1076V	0.33
STAD	chr17	8548771	Silent	NA	E302E	0.18
STAD	chr17	8490462	Missense_Mutation	NA	A1557T	0.27
STAD	chr17	8506384	Missense_Mutation	rs150206681	A1076V	0.33
STAD	chr17	8542231	Missense_Mutation	NA	Q484L	0.24
STAD	chr17	8478385	Missense_Mutation	novel	M1856V	0.36
STAD	chr17	8487443	Missense_Mutation	novel	R1648H	0.05
STAD	chr17	8623146	Frame_Shift_Del	novel	*K34Sfs2**	0.22
STAD	chr17	8506420	Missense_Mutation	rs201075759	T1064M	0.28
STAD	chr17	8542145	Silent	NA	L513L	0.47
STAD	chr17	8508655	Missense_Mutation	NA	R1007H	0.4
STAD	chr17	8495147	In_Frame_Ins	novel	L1317dup	0.33
STAD	chr17	8506328	Missense_Mutation	rs753724964	A1095T	0.25
STAD	chr17	8622999	Missense_Mutation	NA	K83T	0.38
STAD	chr17	8512464	Missense_Mutation	NA	Q949P	0.09
STAD	chr17	8518741	Silent	NA	K767K	0.19
STAD	chr17	8478414	Missense_Mutation	NA	R1846H	0.26
STAD	chr17	8487591	Missense_Mutation	rs760846004	R1599W	0.14
STAD	chr17	8546642	Missense_Mutation	NA	L384F	0.19
STAD	chr17	8552107	Frame_Shift_Del	novel	*D277Mfs19**	0.2
STAD	chr17	8521187	Missense_Mutation	NA	Q655K	0.13
STAD	chr17	8492938	Silent	rs35712248	A1401A	0.28
STAD	chr17	8480152	Missense_Mutation	NA	A1821V	0.18
STAD	chr17	8475823	Missense_Mutation	NA	Q1971R	0.07
STAD	chr17	8622997	Missense_Mutation	NA	F84V	0.16
STAD	chr17	8480500	Missense_Mutation	rs371077973	R1733C	0.37
STAD	chr17	8481377	Missense_Mutation	rs772298747	A1706T	0.19
STAD	chr17	8476928	Missense_Mutation	rs778816874	E1912K	0.41
STAD	chr17	8480499	Missense_Mutation	rs371976533	R1733H	0.8
STAD	chr17	8622967	Missense_Mutation	NA	T94A	0.31
TGCT	chr17	8535883	Missense_Mutation	novel	P542S	0.14
TGCT	chr17	8478359	Missense_Mutation	novel	H1864Q	0.05
THCA	chr17	8478394	Nonsense_Mutation	novel	E1853*	0.1
UCEC	chr17	8535808	Nonsense_Mutation	NA	R567*	0.31
UCEC	chr17	8499475	Missense_Mutation	NA	F1218S	0.23
UCEC	chr17	8492347	Nonsense_Mutation	NA	R1510*	0.3
UCEC	chr17	8475867	Silent	rs751540483	S1956S	0.37
UCEC	chr17	8493020	Missense_Mutation	novel	A1374D	0.4
UCEC	chr17	8535405	Missense_Mutation	novel	A616T	0.31
UCEC	chr17	8576665	Intron	novel		0.36
UCEC	chr17	8548376	Missense_Mutation	novel	F356I	0.38
UCEC	chr17	8508601	Missense_Mutation	novel	L1025S	0.09
UCEC	chr17	8495214	Missense_Mutation	novel	L1296M	0.04
UCEC	chr17	8622947	Silent	rs775686660	S100S	0.43
UCEC	chr17	8518788	Missense_Mutation	novel	R752W	0.28
UCEC	chr17	8623241	Silent	rs375726376	A2A	0.38
UCEC	chr17	8487553	Missense_Mutation	novel	Q1611H	0.34
UCEC	chr17	8490472	Silent	rs143979126	D1553D	0.28
UCEC	chr17	8506431	Silent	rs185230215	L1060L	0.39
UCEC	chr17	8474402	3'UTR	novel		0.35
UCEC	chr17	8474703	3'UTR	novel		0.33
UCEC	chr17	8552086	Silent	NA	I283I	0.09
UCEC	chr17	8604975	Missense_Mutation	novel	S118Y	0.2
UCEC	chr17	8475913	Missense_Mutation	novel	S1941Y	0.07
UCEC	chr17	8493757	Silent	NA	K1364K	0.15
UCEC	chr17	8520880	Missense_Mutation	NA	Q726H	0.26
UCEC	chr17	8546560	Missense_Mutation	novel	A411V	0.06
UCEC	chr17	8476980	Silent	rs183489368	T1894T	0.55
UCEC	chr17	8474944	3'UTR	novel		0.65
UCEC	chr17	8604915	Missense_Mutation	NA	I138S	0.13
UCEC	chr17	8487479	Missense_Mutation	rs778316906	A1636V	0.21
UCEC	chr17	8509929	Silent	rs139264814	D960D	0.21
UCEC	chr17	8623245	Translation_Start_Site	novel	M1?	0.21
UCEC	chr17	8521279	Missense_Mutation	NA	R624H	0.13
UCEC	chr17	8546580	Silent	novel	G404G	0.17
UCEC	chr17	8509910	Nonsense_Mutation	NA	Q967*	0.52
UCEC	chr17	8513540	Nonsense_Mutation	novel	Q884*	0.06
UCEC	chr17	8535486	Missense_Mutation	NA	D589H	0.24
UCEC	chr17	8490403	Silent	novel	F1576F	0.39
UCEC	chr17	8520994	Silent	novel	G688G	0.36
UCEC	chr17	8535808	Nonsense_Mutation	NA	R567*	0.57
UCEC	chr17	8552086	Silent	NA	I283I	0.1
UCEC	chr17	8623046	Missense_Mutation	novel	K67N	0.28
UCEC	chr17	8521144	Missense_Mutation	rs773722498	R669Q	0.28
UCEC	chr17	8487548	Missense_Mutation	rs746613898	A1613V	0.36
UCEC	chr17	8604972	Missense_Mutation	novel	G119E	0.29
UCEC	chr17	8487499	Silent	rs147066424	L1629L	0.45
UCEC	chr17	8490357	Missense_Mutation	novel	R1592W	0.31
UCEC	chr17	8504698	Silent	rs772149998	L1168L	0.38
UCEC	chr17	8518684	Silent	novel	I786I	0.37
UCEC	chr17	8535930	Missense_Mutation	rs752480302	A526V	0.4
UCEC	chr17	8546659	Missense_Mutation	rs757539505	A378V	0.29
UCEC	chr17	8569754	Missense_Mutation	novel	A231V	0.5
UCEC	chr17	8474618	3'UTR	novel		0.3
UCEC	chr17	8478415	Missense_Mutation	rs763285249	R1846C	0.58
UCEC	chr17	8506431	Silent	rs185230215	L1060L	0.25
UCEC	chr17	8545548	Missense_Mutation	novel	R434H	0.31
UCEC	chr17	8478418	Missense_Mutation	NA	R1845C	0.34
UCEC	chr17	8492823	Missense_Mutation	rs767545696	R1440C	0.34
UCEC	chr17	8475870	Silent	novel	L1955L	0.52
UCEC	chr17	8478418	Missense_Mutation	NA	R1845C	0.4
UCEC	chr17	8622925	Missense_Mutation	novel	R108C	0.42
UCEC	chr17	8623016	Missense_Mutation	novel	Q77H	0.52
UCEC	chr17	8492308	Missense_Mutation	NA	V1523M	0.41
UCEC	chr17	8589105	Missense_Mutation	NA	R169H	0.33
UCEC	chr17	8476984	Missense_Mutation	rs778680463	A1893V	0.36
UCEC	chr17	8478364	Nonsense_Mutation	NA	R1863*	0.35
UCEC	chr17	8513633	Nonsense_Mutation	NA	E853*	0.18
UCEC	chr17	8509839	Silent	rs374591741	L990L	0.44
UCEC	chr17	8545541	Silent	rs756368132	L436L	0.31
UCEC	chr17	8548776	Missense_Mutation	novel	L301F	0.33
UCEC	chr17	8474256	3'UTR	novel		0.39
UCEC	chr17	8492787	Missense_Mutation	novel	K1452E	0.4
UCEC	chr17	8506392	Silent	novel	E1073E	0.27
UCEC	chr17	8545575	Missense_Mutation	novel	A425V	0.27
UCEC	chr17	8548323	Silent	novel	P373P	0.25
UCEC	chr17	8508649	Missense_Mutation	rs780518542	A1009V	0.39
UCEC	chr17	8474309	3'UTR	novel		0.22
UCEC	chr17	8474713	3'UTR	novel		0.34
UCEC	chr17	8490441	Missense_Mutation	NA	R1564C	0.23
UCEC	chr17	8499315	Silent	rs553844407	G1271G	0.14
UCEC	chr17	8506328	Missense_Mutation	rs753724964	A1095T	0.19
UCEC	chr17	8513662	Missense_Mutation	rs762239237	P843L	0.15
UCEC	chr17	8530661	Intron	novel		0.29
UCEC	chr17	8542154	Missense_Mutation	novel	D510N	0.15
UCEC	chr17	8548363	Missense_Mutation	novel	S360Y	0.24
UCEC	chr17	8553977	Silent	NA	I256I	0.29
UCEC	chr17	8508604	Missense_Mutation	novel	N1024S	0.07
UCEC	chr17	8535873	Missense_Mutation	novel	T545I	0.44
UCEC	chr17	8545532	Silent	novel	R439R	0.31
UCEC	chr17	8480185	Missense_Mutation	novel	S1810F	0.36
UCEC	chr17	8535863	Silent	novel	T548T	0.09
UCEC	chr17	8622947	Silent	rs775686660	S100S	0.23
UCEC	chr17	8513815	Missense_Mutation	novel	H831Y	0.15
UCEC	chr17	8506428	Silent	rs138732743	D1061D	0.21
UCEC	chr17	8577297	Missense_Mutation	novel	V191A	0.26
UCEC	chr17	8508609	Silent	novel	A1022A	0.31
UCEC	chr17	8476984	Missense_Mutation	rs778680463	A1893V	0.43
UCEC	chr17	8512468	Frame_Shift_Del	novel	*M948Cfs12**	0.46
UCEC	chr17	8545495	Missense_Mutation	novel	A452T	0.43
UCEC	chr17	8490357	Missense_Mutation	novel	R1592W	0.39
UCEC	chr17	8508654	Silent	novel	R1007R	0.29
UCEC	chr17	8546593	Missense_Mutation	novel	R400Q	0.33
UCEC	chr17	8554006	Missense_Mutation	novel	R247W	0.07
UCEC	chr17	8492463	Missense_Mutation	rs755969165	R1471Q	0.31
UCEC	chr17	8506329	Silent	rs757031791	G1094G	0.24
UCEC	chr17	8548725	Missense_Mutation	novel	P318S	0.33
UCEC	chr17	8604884	Silent	novel	H148H	0.38
UCEC	chr17	8478367	Missense_Mutation	rs780650576	R1862C	0.12
UCEC	chr17	8506358	Silent	novel	L1085L	0.34
UCEC	chr17	8480482	Missense_Mutation	rs767265670	A1739T	0.48
UCEC	chr17	8545510	Missense_Mutation	NA	T447A	0.36
UCEC	chr17	8475899	Silent	novel	L1946L	0.5
UCEC	chr17	8478380	Missense_Mutation	novel	Q1857H	0.27
UCEC	chr17	8509950	Splice_Site	novel	X954_splice	0.33
UCEC	chr17	8478389	Silent	NA	I1854I	0.43
UCEC	chr17	8487478	Silent	NA	A1636A	0.54
UCEC	chr17	8552100	Missense_Mutation	NA	R279C	0.05
UCEC	chr17	8553977	Silent	NA	I256I	0.43
UCEC	chr17	8622937	Missense_Mutation	NA	N104D	0.46
UCEC	chr17	8480488	Missense_Mutation	rs371758579	R1737W	0.32
UCEC	chr17	8589088	Missense_Mutation	NA	L175I	0.31
UCEC	chr17	8499352	Missense_Mutation	rs765363104	A1259V	0.05
UCEC	chr17	8604937	Missense_Mutation	novel	L131I	0.17
UCEC	chr17	8476929	Silent	rs199937589	T1911T	0.31
UCEC	chr17	8480240	Missense_Mutation	rs373530537	R1792W	0.39
UCEC	chr17	8499354	Silent	rs373423150	D1258D	0.2
UCEC	chr17	8506427	Missense_Mutation	NA	G1062R	0.17
UCEC	chr17	8518893	Silent	novel	A746A	0.21
UCEC	chr17	8535486	Missense_Mutation	novel	D589Y	0.17
UCEC	chr17	8535890	Silent	novel	C539C	0.43
UCEC	chr17	8623087	Missense_Mutation	rs377262737	R54W	0.47
UCEC	chr17	8475643	3'UTR	novel		0.48
UCEC	chr17	8476905	Silent	rs201668761	R1919R	0.5
UCEC	chr17	8474379	3'UTR	novel		0.25
UCEC	chr17	8474841	3'UTR	novel		0.31
UCEC	chr17	8548342	Missense_Mutation	novel	T367I	0.25
UCEC	chr17	8475821	Missense_Mutation	NA	P1972S	0.28
UCEC	chr17	8476984	Missense_Mutation	rs778680463	A1893V	0.28
UCEC	chr17	8513820	Missense_Mutation	NA	L829S	0.31
UCEC	chr17	8518652	Missense_Mutation	NA	C797Y	0.31
UCEC	chr17	8623123	Missense_Mutation	NA	R42C	0.3
UCEC	chr17	8604929	Missense_Mutation	NA	I133M	0.37
UCEC	chr17	8520896	Frame_Shift_Del	novel	*F721Sfs11**	0.38
UCEC	chr17	8509879	Missense_Mutation	NA	E977A	0.34
UCEC	chr17	8476883	Missense_Mutation	rs763121137	R1927W	0.47
UCEC	chr17	8490410	Missense_Mutation	rs745726185	A1574V	0.47
UCEC	chr17	8499444	Silent	novel	G1228G	0.44
UCEC	chr17	8513818	Missense_Mutation	NA	R830W	0.25
UCEC	chr17	8475867	Silent	rs751540483	S1956S	0.36
UCEC	chr17	8480197	Missense_Mutation	novel	G1806D	0.27
UCEC	chr17	8492991	Missense_Mutation	novel	L1384M	0.32
UCEC	chr17	8518942	Missense_Mutation	novel	I730T	0.37
UCS	chr17	8545582	Missense_Mutation	novel	A423T	0.4
UCS	chr17	8604968	Silent	rs375038020	L120L	0.29

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	DEL	0.2083	0.18166
LIHC	DEL	0.5784	3.9592e-10
READ	DEL	0.6727	0.077076
THCA	DEL	0.016	0.221

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0001	Kaplan-Meier Survival Analysis
STAD	0.041	Kaplan-Meier Survival Analysis
SARC	0.021	Kaplan-Meier Survival Analysis
MESO	0.00021	Kaplan-Meier Survival Analysis
ACC	0.0022	Kaplan-Meier Survival Analysis
HNSC	0.026	Kaplan-Meier Survival Analysis
SKCM	0.02	Kaplan-Meier Survival Analysis
PRAD	0.025	Kaplan-Meier Survival Analysis
LUSC	0.014	Kaplan-Meier Survival Analysis
ESCA	0.023	Kaplan-Meier Survival Analysis
PAAD	0.024	Kaplan-Meier Survival Analysis
BLCA	0.0001	Kaplan-Meier Survival Analysis
KICH	0.047	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742