EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000133226 (Gene tree)
Gene ID: 10250
Gene Symbol: SRRM1
Alias: SRM160|POP101|MGC39488
Full Name: serine and arginine repetitive matrix 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 41,566 bases
Position: chr1:24,631,716-24,673,281
Accession: 16638
RBP type: canonical RBP
Summary: (Serine And Arginine Repetitive Matrix 1) is a Protein Coding gene. Among its related pathways are Transport of Mature Transcript to Cytoplasm and RNA Polymerase II Transcription Termination.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000469151	PWI	PF01480.17	4.7e-31	1	1
ENSP00000471084	PWI	PF01480.17	1.9e-29	1	1
ENSP00000391430	PWI	PF01480.17	2.2e-29	1	1
ENSP00000326261	PWI	PF01480.17	2.3e-29	1	1
ENSP00000363510	PWI	PF01480.17	2.4e-29	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
12600940	Structure and function of the PWI motif: a novel nucleic acid-binding domain that facilitates pre-mRNA processing.	Genes Dev	2003 Feb 15	Szymczyna BR	-
29750417	HITS-CLIP reveals sex-differential RNA binding and alterative splicing regulation of SRm160 in Drosophila.	J Mol Cell Biol	2019 Feb 1	Qiu C	doi: 10.1093/jmcb/mjy029.
18411249	Binding of ATP to UAP56 is necessary for mRNA export.	J Cell Sci	2008 May 1	Kota KP	doi: 10.1242/jcs.021055
17560998	Identification and characterization of RED120: a conserved PWI domain protein with links to splicing and 3'-end formation.	FEBS Lett	2007 Jun 26	Fortes P	-

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496882	SRRM1-220	834	-	-	- (aa)	-	-
ENST00000596378	SRRM1-222	2314	-	ENSP00000471084	681 (aa)	-	M0R088
ENST00000479034	SRRM1-212	2671	-	-	- (aa)	-	-
ENST00000461768	SRRM1-204	496	-	-	- (aa)	-	-
ENST00000490543	SRRM1-217	673	-	-	- (aa)	-	-
ENST00000474843	SRRM1-210	817	-	-	- (aa)	-	-
ENST00000470243	SRRM1-208	721	-	-	- (aa)	-	-
ENST00000600523	SRRM1-223	575	-	ENSP00000471819	79 (aa)	-	M0R1E7
ENST00000495561	SRRM1-219	563	-	-	- (aa)	-	-
ENST00000374389	SRRM1-202	3110	XM_005245717	ENSP00000363510	913 (aa)	XP_005245774	A9Z1X7
ENST00000323848	SRRM1-201	4011	XM_005245721	ENSP00000326261	904 (aa)	XP_005245778	Q8IYB3
ENST00000489130	SRRM1-216	513	-	-	- (aa)	-	-
ENST00000478890	SRRM1-211	480	-	-	- (aa)	-	-
ENST00000494934	SRRM1-218	802	-	-	- (aa)	-	-
ENST00000485441	SRRM1-213	561	-	-	- (aa)	-	-
ENST00000447431	SRRM1-203	3691	-	ENSP00000391430	820 (aa)	-	E9PCT1
ENST00000462710	SRRM1-205	2624	-	-	- (aa)	-	-
ENST00000466910	SRRM1-206	799	-	-	- (aa)	-	-
ENST00000593639	SRRM1-221	563	-	ENSP00000469151	101 (aa)	-	M0QXG5
ENST00000485541	SRRM1-214	679	-	-	- (aa)	-	-
ENST00000471693	SRRM1-209	377	-	-	- (aa)	-	-
ENST00000468822	SRRM1-207	768	-	-	- (aa)	-	-
ENST00000488317	SRRM1-215	333	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000133226's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa03015	mRNA surveillance pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000133226	Heart Rate	6.756e-005	-
ENSG00000133226	Body Height	2E-12	20881960

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000133226	rs143916866	1	24641046	T	Male-pattern baldness	28196072	NR unit decrease	0.15486	Orphanet_79364

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133226's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000133226	SRRM1	100	100.000	ENSAMEG00000010075	SRRM1	100	98.357	Ailuropoda_melanoleuca
ENSG00000133226	SRRM1	99	94.872	ENSACIG00000023398	-	68	88.344	Amphilophus_citrinellus
ENSG00000133226	SRRM1	100	99.010	ENSAPLG00000002066	SRRM1	59	76.335	Anas_platyrhynchos
ENSG00000133226	SRRM1	100	100.000	ENSANAG00000035606	SRRM1	100	99.004	Aotus_nancymaae
ENSG00000133226	SRRM1	99	94.872	ENSACLG00000019786	-	68	88.272	Astatotilapia_calliptera
ENSG00000133226	SRRM1	100	94.059	ENSAMXG00000040320	-	99	71.084	Astyanax_mexicanus
ENSG00000133226	SRRM1	100	100.000	ENSBTAG00000013772	SRRM1	100	97.677	Bos_taurus
ENSG00000133226	SRRM1	100	100.000	ENSCJAG00000020822	SRRM1	100	98.576	Callithrix_jacchus
ENSG00000133226	SRRM1	100	98.020	ENSCAFG00020000003	-	98	89.573	Canis_lupus_dingo
ENSG00000133226	SRRM1	100	100.000	ENSCAFG00020020948	SRRM1	100	98.230	Canis_lupus_dingo
ENSG00000133226	SRRM1	96	98.684	ENSCHIG00000021159	-	54	98.684	Capra_hircus
ENSG00000133226	SRRM1	100	100.000	ENSCHIG00000014656	SRRM1	100	96.507	Capra_hircus
ENSG00000133226	SRRM1	100	100.000	ENSTSYG00000006782	SRRM1	100	98.357	Carlito_syrichta
ENSG00000133226	SRRM1	100	94.436	ENSCAPG00000011473	SRRM1	100	94.649	Cavia_aperea
ENSG00000133226	SRRM1	99	100.000	ENSCPOG00000015594	SRRM1	100	95.575	Cavia_porcellus
ENSG00000133226	SRRM1	100	100.000	ENSCCAG00000029474	SRRM1	100	98.795	Cebus_capucinus
ENSG00000133226	SRRM1	100	100.000	ENSCATG00000031303	SRRM1	100	99.558	Cercocebus_atys
ENSG00000133226	SRRM1	100	100.000	ENSCLAG00000014592	SRRM1	100	96.571	Chinchilla_lanigera
ENSG00000133226	SRRM1	79	97.486	ENSCHOG00000000027	SRRM1	73	98.873	Choloepus_hoffmanni
ENSG00000133226	SRRM1	96	72.368	ENSCING00000022242	-	94	66.443	Ciona_intestinalis
ENSG00000133226	SRRM1	96	77.632	ENSCSAVG00000003919	-	77	68.098	Ciona_savignyi
ENSG00000133226	SRRM1	100	100.000	ENSCANG00000028271	SRRM1	100	99.562	Colobus_angolensis_palliatus
ENSG00000133226	SRRM1	100	100.000	ENSCGRG00001014174	Srrm1	77	95.779	Cricetulus_griseus_chok1gshd
ENSG00000133226	SRRM1	100	100.000	ENSCGRG00000017603	Srrm1	75	95.779	Cricetulus_griseus_crigri
ENSG00000133226	SRRM1	99	93.590	ENSCVAG00000000504	-	67	93.590	Cyprinodon_variegatus
ENSG00000133226	SRRM1	100	100.000	ENSDNOG00000049141	SRRM1	98	93.100	Dasypus_novemcinctus
ENSG00000133226	SRRM1	99	100.000	ENSDORG00000028601	-	100	82.456	Dipodomys_ordii
ENSG00000133226	SRRM1	99	100.000	ENSETEG00000006817	SRRM1	59	95.733	Echinops_telfairi
ENSG00000133226	SRRM1	100	80.198	ENSEBUG00000002653	-	81	72.727	Eptatretus_burgeri
ENSG00000133226	SRRM1	100	100.000	ENSEASG00005004270	SRRM1	100	96.623	Equus_asinus_asinus
ENSG00000133226	SRRM1	100	100.000	ENSECAG00000026981	SRRM1	100	97.345	Equus_caballus
ENSG00000133226	SRRM1	99	100.000	ENSEEUG00000013830	SRRM1	63	90.385	Erinaceus_europaeus
ENSG00000133226	SRRM1	100	100.000	ENSFCAG00000000678	-	100	98.451	Felis_catus
ENSG00000133226	SRRM1	99	83.333	ENSFCAG00000044640	-	73	83.750	Felis_catus
ENSG00000133226	SRRM1	100	99.010	ENSFCAG00000034671	-	85	89.069	Felis_catus
ENSG00000133226	SRRM1	100	99.010	ENSFALG00000000476	SRRM1	100	100.000	Ficedula_albicollis
ENSG00000133226	SRRM1	100	100.000	ENSFDAG00000009903	SRRM1	100	97.345	Fukomys_damarensis
ENSG00000133226	SRRM1	99	93.590	ENSFHEG00000007359	-	83	91.358	Fundulus_heteroclitus
ENSG00000133226	SRRM1	100	100.000	ENSGALG00000001283	SRRM1	100	100.000	Gallus_gallus
ENSG00000133226	SRRM1	99	94.872	ENSGAFG00000019431	-	98	62.406	Gambusia_affinis
ENSG00000133226	SRRM1	100	100.000	ENSGGOG00000005209	SRRM1	100	99.890	Gorilla_gorilla
ENSG00000133226	SRRM1	100	94.937	ENSHBUG00000020354	-	100	94.937	Haplochromis_burtoni
ENSG00000133226	SRRM1	100	100.000	ENSHGLG00000017105	SRRM1	100	97.345	Heterocephalus_glaber_female
ENSG00000133226	SRRM1	100	100.000	ENSHGLG00100016772	SRRM1	99	96.889	Heterocephalus_glaber_male
ENSG00000133226	SRRM1	99	79.487	ENSHGLG00100010430	-	99	78.750	Heterocephalus_glaber_male
ENSG00000133226	SRRM1	94	97.895	ENSHGLG00100017918	-	100	90.299	Heterocephalus_glaber_male
ENSG00000133226	SRRM1	100	100.000	ENSSTOG00000014640	SRRM1	100	98.562	Ictidomys_tridecemlineatus
ENSG00000133226	SRRM1	100	100.000	ENSJJAG00000018643	Srrm1	74	93.558	Jaculus_jaculus
ENSG00000133226	SRRM1	100	93.671	ENSKMAG00000013810	-	88	93.671	Kryptolebias_marmoratus
ENSG00000133226	SRRM1	100	100.000	ENSLAFG00000013830	SRRM1	100	94.486	Loxodonta_africana
ENSG00000133226	SRRM1	99	72.000	ENSMFAG00000038841	-	61	80.885	Macaca_fascicularis
ENSG00000133226	SRRM1	100	100.000	ENSMFAG00000025726	SRRM1	100	99.668	Macaca_fascicularis
ENSG00000133226	SRRM1	100	100.000	ENSMMUG00000006645	SRRM1	100	99.558	Macaca_mulatta
ENSG00000133226	SRRM1	100	100.000	ENSMNEG00000039415	SRRM1	100	99.668	Macaca_nemestrina
ENSG00000133226	SRRM1	61	91.935	ENSMLEG00000032221	-	61	73.764	Mandrillus_leucophaeus
ENSG00000133226	SRRM1	100	100.000	ENSMLEG00000038030	-	100	93.428	Mandrillus_leucophaeus
ENSG00000133226	SRRM1	99	94.872	ENSMZEG00005006344	-	68	88.272	Maylandia_zebra
ENSG00000133226	SRRM1	100	100.000	ENSMICG00000006553	SRRM1	100	98.451	Microcebus_murinus
ENSG00000133226	SRRM1	99	94.872	ENSMMOG00000002390	-	77	94.872	Mola_mola
ENSG00000133226	SRRM1	100	92.079	ENSMALG00000010813	-	67	76.687	Monopterus_albus
ENSG00000133226	SRRM1	100	100.000	MGP_CAROLIEiJ_G0026636	Srrm1	100	85.965	Mus_caroli
ENSG00000133226	SRRM1	100	100.000	ENSMUSG00000028809	Srrm1	100	85.965	Mus_musculus
ENSG00000133226	SRRM1	100	100.000	MGP_PahariEiJ_G0028969	Srrm1	100	85.965	Mus_pahari
ENSG00000133226	SRRM1	100	100.000	MGP_SPRETEiJ_G0027616	Srrm1	100	85.965	Mus_spretus
ENSG00000133226	SRRM1	100	98.020	ENSMPUG00000000018	-	83	98.780	Mustela_putorius_furo
ENSG00000133226	SRRM1	100	100.000	ENSMPUG00000015831	-	99	87.552	Mustela_putorius_furo
ENSG00000133226	SRRM1	100	100.000	ENSNGAG00000014562	Srrm1	75	95.362	Nannospalax_galili
ENSG00000133226	SRRM1	99	94.872	ENSNBRG00000010911	-	67	87.730	Neolamprologus_brichardi
ENSG00000133226	SRRM1	100	100.000	ENSNLEG00000008966	SRRM1	100	100.000	Nomascus_leucogenys
ENSG00000133226	SRRM1	71	80.000	ENSMEUG00000014704	SRRM1	57	83.598	Notamacropus_eugenii
ENSG00000133226	SRRM1	99	89.744	ENSODEG00000002361	-	100	89.744	Octodon_degus
ENSG00000133226	SRRM1	96	93.421	ENSODEG00000007221	-	99	93.421	Octodon_degus
ENSG00000133226	SRRM1	99	96.154	ENSODEG00000019473	-	100	96.154	Octodon_degus
ENSG00000133226	SRRM1	100	100.000	ENSOCUG00000008438	SRRM1	100	97.162	Oryctolagus_cuniculus
ENSG00000133226	SRRM1	99	94.872	ENSORLG00000017510	-	68	87.117	Oryzias_latipes
ENSG00000133226	SRRM1	100	94.937	ENSORLG00020018419	-	100	94.937	Oryzias_latipes_hni
ENSG00000133226	SRRM1	100	100.000	ENSOGAG00000010210	SRRM1	100	96.950	Otolemur_garnettii
ENSG00000133226	SRRM1	100	100.000	ENSOARG00000006453	SRRM1	99	97.406	Ovis_aries
ENSG00000133226	SRRM1	100	100.000	ENSPPAG00000043918	SRRM1	100	99.890	Pan_paniscus
ENSG00000133226	SRRM1	100	100.000	ENSPPRG00000002509	SRRM1	100	98.451	Panthera_pardus
ENSG00000133226	SRRM1	100	87.129	ENSPTIG00000022093	-	74	87.261	Panthera_tigris_altaica
ENSG00000133226	SRRM1	100	100.000	ENSPTIG00000008778	-	100	92.896	Panthera_tigris_altaica
ENSG00000133226	SRRM1	100	100.000	ENSPTRG00000000349	SRRM1	100	100.000	Pan_troglodytes
ENSG00000133226	SRRM1	99	72.000	ENSPANG00000035568	-	59	78.629	Papio_anubis
ENSG00000133226	SRRM1	100	100.000	ENSPANG00000010194	SRRM1	100	98.901	Papio_anubis
ENSG00000133226	SRRM1	100	91.139	ENSPMGG00000009036	-	73	92.308	Periophthalmus_magnuspinnatus
ENSG00000133226	SRRM1	100	100.000	ENSPEMG00000006254	Srrm1	74	95.501	Peromyscus_maniculatus_bairdii
ENSG00000133226	SRRM1	100	94.937	ENSPMEG00000002615	-	100	94.937	Poecilia_mexicana
ENSG00000133226	SRRM1	100	94.937	ENSPMEG00000011776	-	100	94.937	Poecilia_mexicana
ENSG00000133226	SRRM1	100	100.000	ENSPPYG00000001716	SRRM1	100	99.672	Pongo_abelii
ENSG00000133226	SRRM1	66	100.000	ENSPCAG00000015138	SRRM1	52	100.000	Procavia_capensis
ENSG00000133226	SRRM1	100	100.000	ENSPCOG00000021311	SRRM1	100	98.468	Propithecus_coquereli
ENSG00000133226	SRRM1	100	100.000	ENSPVAG00000005836	SRRM1	100	98.138	Pteropus_vampyrus
ENSG00000133226	SRRM1	99	94.872	ENSPNYG00000005058	-	68	88.272	Pundamilia_nyererei
ENSG00000133226	SRRM1	99	93.590	ENSPNAG00000005888	-	75	93.590	Pygocentrus_nattereri
ENSG00000133226	SRRM1	100	100.000	ENSRNOG00000018194	Srrm1	75	95.646	Rattus_norvegicus
ENSG00000133226	SRRM1	100	100.000	ENSRBIG00000035461	SRRM1	99	92.982	Rhinopithecus_bieti
ENSG00000133226	SRRM1	100	72.277	ENSRROG00000041543	-	52	71.255	Rhinopithecus_roxellana
ENSG00000133226	SRRM1	100	100.000	ENSRROG00000035151	SRRM1	100	99.671	Rhinopithecus_roxellana
ENSG00000133226	SRRM1	100	100.000	ENSSBOG00000019884	SRRM1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000133226	SRRM1	99	93.590	ENSSMAG00000009318	-	58	92.647	Scophthalmus_maximus
ENSG00000133226	SRRM1	99	83.513	ENSSARG00000013718	SRRM1	91	83.513	Sorex_araneus
ENSG00000133226	SRRM1	100	100.000	ENSSPUG00000015890	SRRM1	57	83.026	Sphenodon_punctatus
ENSG00000133226	SRRM1	100	100.000	ENSSSCG00000032947	SRRM1	100	97.929	Sus_scrofa
ENSG00000133226	SRRM1	91	98.611	ENSTGUG00000016669	-	99	100.000	Taeniopygia_guttata
ENSG00000133226	SRRM1	100	100.000	ENSTBEG00000000100	SRRM1	100	97.700	Tupaia_belangeri
ENSG00000133226	SRRM1	100	100.000	ENSTTRG00000009365	SRRM1	100	97.572	Tursiops_truncatus
ENSG00000133226	SRRM1	100	98.734	ENSUAMG00000011740	-	87	100.000	Ursus_americanus
ENSG00000133226	SRRM1	100	100.000	ENSUMAG00000013121	SRRM1	95	98.997	Ursus_maritimus
ENSG00000133226	SRRM1	100	100.000	ENSVPAG00000007698	SRRM1	100	93.764	Vicugna_pacos
ENSG00000133226	SRRM1	100	99.010	ENSVVUG00000026966	SRRM1	97	95.642	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000375	RNA splicing, via transesterification reactions	9531537.	TAS	Process
GO:0000398	mRNA splicing, via spliceosome	11991638.	IC	Process
GO:0000398	mRNA splicing, via spliceosome	-	TAS	Process
GO:0003677	DNA binding	-	IEA	Function
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005515	protein binding	25416956.26871637.	IPI	Function
GO:0005634	nucleus	9531537.	TAS	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006405	RNA export from nucleus	-	TAS	Process
GO:0006406	mRNA export from nucleus	-	TAS	Process
GO:0008380	RNA splicing	9531537.	TAS	Process
GO:0016363	nuclear matrix	-	IEA	Component
GO:0016607	nuclear speck	-	IDA	Component
GO:0031124	mRNA 3'-end processing	-	TAS	Process
GO:0071013	catalytic step 2 spliceosome	11991638.	IDA	Component