EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000133704 (Gene tree)
Gene ID: 10526
Gene Symbol: IPO8
Alias: IMP8|RANBP8
Full Name: importin 8
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 67,015 bases
Position: chr12:30,628,981-30,695,995
Accession: 9853
RBP type: canonical RBP
Summary: The importin-alpha/beta complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. The protein encoded by this gene is a member of a class of approximately 20 potential Ran targets that share a sequence motif related to the Ran-binding site of importin-beta. This protein binds to the nuclear pore complex and, along with RanGTP and RANBP1, inhibits the GAP stimulation of the Ran GTPase. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000256079	IBN_N	PF03810.19	3.1e-20	1	1
ENSP00000439413	IBN_N	PF03810.19	4.8e-09	1	1
ENSP00000446254	IBN_N	PF03810.19	4.1e-07	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000538338	IPO8-205	536	-	-	- (aa)	-	-
ENST00000256079	IPO8-201	5325	XM_017018691	ENSP00000256079	1037 (aa)	XP_016874180	O15397
ENST00000544829	IPO8-209	3212	-	ENSP00000444520	832 (aa)	-	O15397
ENST00000611458	IPO8-211	426	-	ENSP00000481026	142 (aa)	-	A0A087WXH2
ENST00000535598	IPO8-203	758	-	ENSP00000446232	167 (aa)	-	H0YH64
ENST00000542464	IPO8-207	535	-	ENSP00000439556	167 (aa)	-	F5H244
ENST00000358724	IPO8-202	526	-	ENSP00000444050	33 (aa)	-	F5H009
ENST00000535989	IPO8-204	537	-	ENSP00000440979	151 (aa)	-	F5GXT5
ENST00000540979	IPO8-206	792	-	ENSP00000443789	35 (aa)	-	F5H815
ENST00000543446	IPO8-208	544	-	ENSP00000439413	84 (aa)	-	F5H292
ENST00000545077	IPO8-210	239	-	ENSP00000446254	46 (aa)	-	F5H2I3

Gene Model

Click here to download ENSG00000133704's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000133704	Cholesterol, HDL	9.9130000E-005	-
ENSG00000133704	Iron	6.9520000E-005	-
ENSG00000133704	Bronchial Provocation Tests	6E-8	25514360
ENSG00000133704	Pulmonary Disease, Chronic Obstructive	6E-8	25514360

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000133704	rs142754383	12	30661250	?	Initial pursuit acceleration in psychotic disorders	29064472			EFO_0000692\|EFO_0008434\|EFO_0000289\|EFO_0005411
ENSG00000133704	rs142754383	12	30661250	?	Initial pursuit acceleration in psychotic disorders	29064472			EFO_0000692\|EFO_0008434\|EFO_0000289\|EFO_0005411

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133704's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000133704	IPO8	100	65.563	ENSG00000205339	IPO7	99	64.666

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000133704	IPO8	100	96.970	ENSAMEG00000009154	IPO8	100	96.923	Ailuropoda_melanoleuca
ENSG00000133704	IPO8	97	81.250	ENSACIG00000005543	ipo8	99	76.874	Amphilophus_citrinellus
ENSG00000133704	IPO8	100	78.788	ENSAOCG00000018199	ipo8	99	73.346	Amphiprion_ocellaris
ENSG00000133704	IPO8	100	78.788	ENSAPEG00000002396	ipo8	99	77.033	Amphiprion_percula
ENSG00000133704	IPO8	100	84.848	ENSATEG00000023469	ipo8	98	66.897	Anabas_testudineus
ENSG00000133704	IPO8	100	96.970	ENSAPLG00000009843	IPO8	100	86.633	Anas_platyrhynchos
ENSG00000133704	IPO8	100	96.970	ENSACAG00000012959	IPO8	100	83.605	Anolis_carolinensis
ENSG00000133704	IPO8	100	100.000	ENSANAG00000032923	IPO8	100	97.107	Aotus_nancymaae
ENSG00000133704	IPO8	97	81.250	ENSACLG00000015219	ipo8	97	76.555	Astatotilapia_calliptera
ENSG00000133704	IPO8	100	75.758	ENSAMXG00000036026	ipo8	99	73.327	Astyanax_mexicanus
ENSG00000133704	IPO8	100	100.000	ENSBTAG00000014106	IPO8	100	97.011	Bos_taurus
ENSG00000133704	IPO8	100	96.970	ENSCJAG00000001057	IPO8	100	96.914	Callithrix_jacchus
ENSG00000133704	IPO8	100	97.396	ENSCAFG00000010768	IPO8	100	97.396	Canis_familiaris
ENSG00000133704	IPO8	100	97.498	ENSCAFG00020013795	IPO8	100	97.498	Canis_lupus_dingo
ENSG00000133704	IPO8	100	100.000	ENSCHIG00000022393	IPO8	99	97.214	Capra_hircus
ENSG00000133704	IPO8	100	100.000	ENSTSYG00000004436	IPO8	100	97.878	Carlito_syrichta
ENSG00000133704	IPO8	100	96.970	ENSCAPG00000013099	IPO8	100	85.744	Cavia_aperea
ENSG00000133704	IPO8	100	96.970	ENSCPOG00000010365	IPO8	97	95.108	Cavia_porcellus
ENSG00000133704	IPO8	100	100.000	ENSCCAG00000027484	IPO8	100	97.396	Cebus_capucinus
ENSG00000133704	IPO8	100	100.000	ENSCATG00000038860	IPO8	100	99.711	Cercocebus_atys
ENSG00000133704	IPO8	100	96.970	ENSCLAG00000002557	IPO8	100	95.757	Chinchilla_lanigera
ENSG00000133704	IPO8	100	100.000	ENSCSAG00000007458	IPO8	100	99.711	Chlorocebus_sabaeus
ENSG00000133704	IPO8	100	96.970	ENSCPBG00000027234	IPO8	100	86.398	Chrysemys_picta_bellii
ENSG00000133704	IPO8	100	100.000	ENSCANG00000022452	IPO8	100	97.107	Colobus_angolensis_palliatus
ENSG00000133704	IPO8	100	96.970	ENSCGRG00001014551	Ipo8	100	92.095	Cricetulus_griseus_chok1gshd
ENSG00000133704	IPO8	100	96.970	ENSCGRG00000002481	Ipo8	100	91.565	Cricetulus_griseus_crigri
ENSG00000133704	IPO8	100	81.818	ENSCSEG00000003320	ipo8	99	71.372	Cynoglossus_semilaevis
ENSG00000133704	IPO8	100	78.808	ENSCVAG00000013038	ipo8	96	74.964	Cyprinodon_variegatus
ENSG00000133704	IPO8	100	75.758	ENSDARG00000058159	ipo8	99	72.107	Danio_rerio
ENSG00000133704	IPO8	100	96.970	ENSDORG00000005959	Ipo8	99	93.004	Dipodomys_ordii
ENSG00000133704	IPO8	100	100.000	ENSEASG00005006112	IPO8	100	97.448	Equus_asinus_asinus
ENSG00000133704	IPO8	100	100.000	ENSECAG00000012848	IPO8	100	97.300	Equus_caballus
ENSG00000133704	IPO8	76	100.000	ENSEEUG00000007618	-	87	90.426	Erinaceus_europaeus
ENSG00000133704	IPO8	100	78.788	ENSELUG00000001212	ipo8	99	73.183	Esox_lucius
ENSG00000133704	IPO8	100	97.107	ENSFCAG00000007002	IPO8	100	97.107	Felis_catus
ENSG00000133704	IPO8	100	96.970	ENSFDAG00000003130	IPO8	100	84.392	Fukomys_damarensis
ENSG00000133704	IPO8	100	78.788	ENSFHEG00000004531	ipo8	99	70.977	Fundulus_heteroclitus
ENSG00000133704	IPO8	100	75.758	ENSGMOG00000008722	ipo8	79	71.639	Gadus_morhua
ENSG00000133704	IPO8	100	96.970	ENSGALG00000012953	IPO8	100	86.507	Gallus_gallus
ENSG00000133704	IPO8	100	78.788	ENSGAFG00000005851	ipo8	99	70.866	Gambusia_affinis
ENSG00000133704	IPO8	100	78.788	ENSGACG00000019236	IPO8	100	63.350	Gasterosteus_aculeatus
ENSG00000133704	IPO8	100	96.970	ENSGAGG00000015070	IPO8	100	85.660	Gopherus_agassizii
ENSG00000133704	IPO8	100	100.000	ENSGGOG00000023152	IPO8	100	99.807	Gorilla_gorilla
ENSG00000133704	IPO8	97	81.250	ENSHBUG00000012196	ipo8	99	72.682	Haplochromis_burtoni
ENSG00000133704	IPO8	100	96.970	ENSHGLG00000011526	IPO8	99	95.333	Heterocephalus_glaber_female
ENSG00000133704	IPO8	100	96.970	ENSHGLG00100010369	IPO8	99	93.942	Heterocephalus_glaber_male
ENSG00000133704	IPO8	100	71.523	ENSHCOG00000013067	ipo8	99	69.010	Hippocampus_comes
ENSG00000133704	IPO8	100	75.758	ENSIPUG00000020709	ipo8	99	75.758	Ictalurus_punctatus
ENSG00000133704	IPO8	100	100.000	ENSSTOG00000015509	-	100	86.207	Ictidomys_tridecemlineatus
ENSG00000133704	IPO8	100	96.970	ENSJJAG00000021253	Ipo8	100	89.219	Jaculus_jaculus
ENSG00000133704	IPO8	100	81.818	ENSLBEG00000028213	ipo8	99	76.592	Labrus_bergylta
ENSG00000133704	IPO8	100	87.879	ENSLACG00000004177	IPO8	99	77.679	Latimeria_chalumnae
ENSG00000133704	IPO8	100	84.848	ENSLOCG00000015102	ipo8	100	70.196	Lepisosteus_oculatus
ENSG00000133704	IPO8	100	96.970	ENSLAFG00000012885	IPO8	100	93.247	Loxodonta_africana
ENSG00000133704	IPO8	100	100.000	ENSMFAG00000012472	IPO8	100	99.711	Macaca_fascicularis
ENSG00000133704	IPO8	100	100.000	ENSMMUG00000001361	IPO8	100	99.711	Macaca_mulatta
ENSG00000133704	IPO8	100	100.000	ENSMNEG00000039910	IPO8	100	99.711	Macaca_nemestrina
ENSG00000133704	IPO8	100	100.000	ENSMLEG00000031593	IPO8	100	99.614	Mandrillus_leucophaeus
ENSG00000133704	IPO8	100	78.788	ENSMAMG00000023301	ipo8	99	74.082	Mastacembelus_armatus
ENSG00000133704	IPO8	97	81.250	ENSMZEG00005008224	ipo8	97	76.555	Maylandia_zebra
ENSG00000133704	IPO8	100	96.970	ENSMAUG00000011526	Ipo8	100	93.379	Mesocricetus_auratus
ENSG00000133704	IPO8	100	96.970	ENSMICG00000010635	IPO8	100	95.665	Microcebus_murinus
ENSG00000133704	IPO8	100	100.000	ENSMOCG00000010554	-	100	84.483	Microtus_ochrogaster
ENSG00000133704	IPO8	100	78.788	ENSMMOG00000007268	ipo8	99	66.963	Mola_mola
ENSG00000133704	IPO8	100	81.818	ENSMALG00000021008	ipo8	99	72.332	Monopterus_albus
ENSG00000133704	IPO8	100	96.970	MGP_CAROLIEiJ_G0029072	Ipo8	100	92.292	Mus_caroli
ENSG00000133704	IPO8	100	96.970	ENSMUSG00000040029	Ipo8	100	92.095	Mus_musculus
ENSG00000133704	IPO8	100	96.970	MGP_PahariEiJ_G0022833	Ipo8	100	91.798	Mus_pahari
ENSG00000133704	IPO8	100	96.970	MGP_SPRETEiJ_G0030127	Ipo8	100	92.194	Mus_spretus
ENSG00000133704	IPO8	100	97.300	ENSMPUG00000011001	IPO8	100	97.300	Mustela_putorius_furo
ENSG00000133704	IPO8	100	100.000	ENSMLUG00000007721	IPO8	100	95.356	Myotis_lucifugus
ENSG00000133704	IPO8	100	96.970	ENSNGAG00000001055	Ipo8	99	90.999	Nannospalax_galili
ENSG00000133704	IPO8	97	81.250	ENSNBRG00000006642	-	95	79.343	Neolamprologus_brichardi
ENSG00000133704	IPO8	100	100.000	ENSNLEG00000005683	IPO8	100	99.614	Nomascus_leucogenys
ENSG00000133704	IPO8	100	96.970	ENSODEG00000004763	-	100	85.222	Octodon_degus
ENSG00000133704	IPO8	97	81.250	ENSONIG00000012030	ipo8	99	72.799	Oreochromis_niloticus
ENSG00000133704	IPO8	100	100.000	ENSOANG00000003774	-	72	88.889	Ornithorhynchus_anatinus
ENSG00000133704	IPO8	80	92.857	ENSOANG00000029411	-	65	87.931	Ornithorhynchus_anatinus
ENSG00000133704	IPO8	100	90.909	ENSOCUG00000029016	IPO8	97	94.427	Oryctolagus_cuniculus
ENSG00000133704	IPO8	100	78.788	ENSORLG00000012548	ipo8	99	72.887	Oryzias_latipes
ENSG00000133704	IPO8	100	78.788	ENSORLG00020020896	ipo8	93	69.231	Oryzias_latipes_hni
ENSG00000133704	IPO8	100	78.788	ENSORLG00015019508	ipo8	99	72.727	Oryzias_latipes_hsok
ENSG00000133704	IPO8	100	78.788	ENSOMEG00000021459	ipo8	99	72.611	Oryzias_melastigma
ENSG00000133704	IPO8	100	96.970	ENSOGAG00000010059	IPO8	99	96.922	Otolemur_garnettii
ENSG00000133704	IPO8	100	100.000	ENSOARG00000019534	IPO8	100	96.920	Ovis_aries
ENSG00000133704	IPO8	100	100.000	ENSPPAG00000042123	IPO8	100	99.904	Pan_paniscus
ENSG00000133704	IPO8	100	97.203	ENSPPRG00000015678	IPO8	100	97.203	Panthera_pardus
ENSG00000133704	IPO8	100	96.970	ENSPTIG00000014323	IPO8	100	95.950	Panthera_tigris_altaica
ENSG00000133704	IPO8	100	100.000	ENSPTRG00000004801	IPO8	100	99.807	Pan_troglodytes
ENSG00000133704	IPO8	100	100.000	ENSPANG00000013653	IPO8	100	99.711	Papio_anubis
ENSG00000133704	IPO8	100	84.848	ENSPKIG00000011380	ipo8	99	73.689	Paramormyrops_kingsleyae
ENSG00000133704	IPO8	100	96.970	ENSPSIG00000017127	IPO8	99	91.063	Pelodiscus_sinensis
ENSG00000133704	IPO8	80	85.714	ENSPMGG00000008318	-	92	80.000	Periophthalmus_magnuspinnatus
ENSG00000133704	IPO8	100	100.000	ENSPEMG00000011306	-	100	85.468	Peromyscus_maniculatus_bairdii
ENSG00000133704	IPO8	100	100.000	ENSPCIG00000015209	IPO8	100	91.880	Phascolarctos_cinereus
ENSG00000133704	IPO8	100	78.788	ENSPFOG00000000833	IPO8	99	71.063	Poecilia_formosa
ENSG00000133704	IPO8	80	89.286	ENSPLAG00000002754	-	69	87.273	Poecilia_latipinna
ENSG00000133704	IPO8	100	78.788	ENSPMEG00000023545	IPO8	99	70.149	Poecilia_mexicana
ENSG00000133704	IPO8	100	78.788	ENSPREG00000012667	-	99	70.936	Poecilia_reticulata
ENSG00000133704	IPO8	100	100.000	ENSPCAG00000015590	IPO8	82	98.182	Procavia_capensis
ENSG00000133704	IPO8	100	97.107	ENSPCOG00000018051	IPO8	100	97.107	Propithecus_coquereli
ENSG00000133704	IPO8	100	100.000	ENSPVAG00000006079	IPO8	100	85.373	Pteropus_vampyrus
ENSG00000133704	IPO8	97	81.250	ENSPNYG00000020683	ipo8	97	76.555	Pundamilia_nyererei
ENSG00000133704	IPO8	100	75.758	ENSPNAG00000001408	ipo8	99	76.715	Pygocentrus_nattereri
ENSG00000133704	IPO8	100	96.970	ENSRNOG00000056041	AABR07062570.1	100	76.495	Rattus_norvegicus
ENSG00000133704	IPO8	100	100.000	ENSRBIG00000027706	IPO8	100	99.421	Rhinopithecus_bieti
ENSG00000133704	IPO8	100	100.000	ENSRROG00000035930	IPO8	100	99.421	Rhinopithecus_roxellana
ENSG00000133704	IPO8	100	100.000	ENSSBOG00000031275	IPO8	100	97.396	Saimiri_boliviensis_boliviensis
ENSG00000133704	IPO8	100	81.818	ENSSFOG00015022699	ipo8	99	75.668	Scleropages_formosus
ENSG00000133704	IPO8	100	78.788	ENSSDUG00000019961	ipo8	99	72.925	Seriola_dumerili
ENSG00000133704	IPO8	100	100.000	ENSSPUG00000013387	IPO8	100	91.228	Sphenodon_punctatus
ENSG00000133704	IPO8	100	78.788	ENSSPAG00000018051	ipo8	99	73.399	Stegastes_partitus
ENSG00000133704	IPO8	100	100.000	ENSSSCG00000000534	IPO8	100	97.767	Sus_scrofa
ENSG00000133704	IPO8	100	96.970	ENSTGUG00000011446	IPO8	100	89.920	Taeniopygia_guttata
ENSG00000133704	IPO8	100	81.818	ENSTRUG00000012975	ipo8	100	75.279	Takifugu_rubripes
ENSG00000133704	IPO8	100	78.788	ENSTNIG00000007224	-	100	70.887	Tetraodon_nigroviridis
ENSG00000133704	IPO8	100	100.000	ENSTTRG00000008462	IPO8	93	96.135	Tursiops_truncatus
ENSG00000133704	IPO8	100	96.970	ENSUAMG00000012054	IPO8	96	95.856	Ursus_americanus
ENSG00000133704	IPO8	100	96.970	ENSUMAG00000001976	IPO8	100	95.082	Ursus_maritimus
ENSG00000133704	IPO8	100	100.000	ENSVPAG00000007234	IPO8	100	85.728	Vicugna_pacos
ENSG00000133704	IPO8	100	97.686	ENSVVUG00000007129	IPO8	100	97.686	Vulpes_vulpes
ENSG00000133704	IPO8	100	81.818	ENSXETG00000007514	ipo8	100	76.732	Xenopus_tropicalis
ENSG00000133704	IPO8	80	89.286	ENSXCOG00000000730	-	75	85.714	Xiphophorus_couchianus
ENSG00000133704	IPO8	100	78.788	ENSXMAG00000008581	ipo8	99	70.149	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	17932509.19167051.26168401.	IPI	Function
GO:0005635	nuclear envelope	21873635.	IBA	Component
GO:0005654	nucleoplasm	-	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006606	protein import into nucleus	21873635.	IBA	Process
GO:0007165	signal transduction	9214382.	TAS	Process
GO:0008536	Ran GTPase binding	-	IEA	Function
GO:0008565	protein transporter activity	21873635.	IBA	Function
GO:0060964	regulation of gene silencing by miRNA	-	TAS	Process