Description
Ensembl ID
ENSG00000133706 (Gene tree)
Gene ID
51520
Gene Symbol
LARS
Alias
HSPC192|FLJ10595|FLJ21788|LARS1|LEUS|RNTLS
Full Name
leucyl-tRNA synthetase
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
69,762 bases
Position
chr5:146,113,026-146,182,787
Accession
6512
RBP type
canonical RBP
Summary
This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. A mutation in this gene was found in affected individuals with infantile liver failure syndrome 1. Alternatively spliced transcript variants of this gene have been observed. [provided by RefSeq, Dec 2015]
RNA binding domains(RBDs)
Protein ID
Domain
Pfam ID
E-value
Domain number
Total number
ENSP00000377954tRNA-synt_1gPF09334.114.4e-1712
ENSP00000377954tRNA-synt_1gPF09334.114.4e-1722
ENSP00000426005tRNA-synt_1gPF09334.114.5e-1311
ENSP00000274562tRNA-synt_1gPF09334.115e-0711
ENSP00000481381tRNA-synt_1gPF09334.111.9e-0611
ENSP00000274562Anticodon_1PF08264.131.4e-1711
ENSP00000426005Anticodon_1PF08264.133.1e-1711
ENSP00000377954Anticodon_1PF08264.133.4e-1711
ENSP00000377954tRNA-synt_1PF00133.226.1e-4012
ENSP00000377954tRNA-synt_1PF00133.226.1e-4022
ENSP00000426005tRNA-synt_1PF00133.229e-3311
ENSP00000481381tRNA-synt_1PF00133.221.1e-1111
ENSP00000426005tRNA-synt_1ePF01406.198.6e-0611
ENSP00000377954tRNA-synt_1ePF01406.199e-0611
ENSP00000274562tRNA-synt_1ePF01406.195e-0511
RNA binding proteome (RBPome)
PID
Title
Method
Time
Author
Doi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & Hela2018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & MCF10A2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & U2OS2019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity
Expression
Adipose_TissueAdrenal_GlandBladderBloodBlood_VesselBrainBreastCervix_UteriColonEsophagusFallopian_TubeHeartKidneyLiverLungMuscleNerveOvaryPancreasPituitaryProstateSalivary_GlandSkinSmall_IntestineSpleenStomachTestisThyroidUterusVagina050100150200
Adipose_TissueAdrenal_GlandBladderBloodBlood_VesselBrainBreastCervix_UteriColonEsophagusFallopian_TubeHeartKidneyLiverLungMuscleNerveOvaryPancreasPituitaryProstateSalivary_GlandSkinSmall_IntestineSpleenStomachTestisThyroidUterusVaginaTPM
Transcripts
Transcript ID
Name
Length
RefSeq ID
Protein ID
Length
RefSeq ID
UniportKB ID
ENST00000508667LARS-210707--- (aa)--
ENST00000514104LARS-215509--- (aa)--
ENST00000504323LARS-204608--- (aa)--
ENST00000394434LARS-2024766-ENSP000003779541176 (aa)-Q9P2J5
ENST00000503654LARS-203534--- (aa)--
ENST00000511505LARS-2131089--- (aa)--
ENST00000505223LARS-206582--- (aa)--
ENST00000510191LARS-2123737XM_011537656ENSP000004260051122 (aa)XP_011535958Q9P2J5
ENST00000506436LARS-208539--- (aa)--
ENST00000508709LARS-211633--- (aa)--
ENST00000274562LARS-2012213-ENSP00000274562485 (aa)-Q9P2J5
ENST00000506231LARS-2073707--- (aa)--
ENST00000512412LARS-214575--- (aa)--
ENST00000504611LARS-205576--- (aa)--
ENST00000618084LARS-216720-ENSP00000481381160 (aa)-A0A087WXY1
ENST00000507095LARS-209384--- (aa)--
Pathways
Pathway ID
Pathway Name
Source
hsa00970Aminoacyl-tRNA biosynthesisKEGG
Phenotypes
ensgID
Trait
pValue
Pubmed ID
ENSG00000133706Alzheimer Disease4E-826830138
ENSG00000133706Age of Onset4E-826830138
GWAS
ensgID
SNP
Chromosome
Position
SNP-risk
Trait
PubmedID
95% CI
Or or BEAT
EFO ID
ENSG00000133706rs29625085146158952TAlzheimer disease and age of onset26830138unit increase5.499EFO_0000249|EFO_0004847
Protein-Protein Interaction (PPI)


CanvasJS.com
* RBP PPI network refers to all genes directly bind to RBP
Orthologs
Ensembl ID
Gene Symbol
Coverage
Identiy
Ortholog
Gene Symbol
Coverage
Identiy
Species
ENSG00000133706LARS10079.399ENSAPOG00000010585larsb10079.554Acanthochromis_polyacanthus
ENSG00000133706LARS10095.018ENSAMEG00000017584LARS10094.813Ailuropoda_melanoleuca
ENSG00000133706LARS10078.242ENSACIG00000014026larsb10077.124Amphilophus_citrinellus
ENSG00000133706LARS10079.539ENSAOCG00000016931larsb10078.716Amphiprion_ocellaris
ENSG00000133706LARS10079.628ENSAPEG00000017720larsb10078.801Amphiprion_percula
ENSG00000133706LARS10076.779ENSATEG00000010441larsb9976.081Anabas_testudineus
ENSG00000133706LARS10086.821ENSAPLG00000008145LARS10086.972Anas_platyrhynchos
ENSG00000133706LARS10085.116ENSACAG00000013916LARS10085.119Anolis_carolinensis
ENSG00000133706LARS10097.113ENSANAG00000014375LARS10084.779Aotus_nancymaae
ENSG00000133706LARS10079.274ENSACLG00000010881larsb10078.547Astatotilapia_calliptera
ENSG00000133706LARS10080.944ENSAMXG00000019979larsb10080.136Astyanax_mexicanus
ENSG00000133706LARS10092.424ENSBTAG00000006765LARS10092.262Bos_taurus
ENSG00000133706LARS9956.890WBGene00003073lars-19956.334Caenorhabditis_elegans
ENSG00000133706LARS10096.791ENSCJAG00000021314LARS10096.791Callithrix_jacchus
ENSG00000133706LARS10095.187ENSCAFG00000006431LARS10094.983Canis_familiaris
ENSG00000133706LARS10095.187ENSCAFG00020025009LARS9994.974Canis_lupus_dingo
ENSG00000133706LARS10092.781ENSCHIG00000014949LARS10092.687Capra_hircus
ENSG00000133706LARS10094.218ENSTSYG00000001253LARS10094.218Carlito_syrichta
ENSG00000133706LARS9978.750ENSCAPG00000015676LARS9774.515Cavia_aperea
ENSG00000133706LARS10093.048ENSCPOG00000012329LARS10092.772Cavia_porcellus
ENSG00000133706LARS10097.237ENSCCAG00000020789LARS10097.109Cebus_capucinus
ENSG00000133706LARS10098.763ENSCATG00000033463LARS10098.574Cercocebus_atys
ENSG00000133706LARS10093.316ENSCLAG00000011193LARS10093.197Chinchilla_lanigera
ENSG00000133706LARS9998.625ENSCSAG00000012280LARS9798.625Chlorocebus_sabaeus
ENSG00000133706LARS9090.503ENSCHOG00000009309LARS9090.503Choloepus_hoffmanni
ENSG00000133706LARS10086.554ENSCPBG00000008415LARS9987.353Chrysemys_picta_bellii
ENSG00000133706LARS10065.214ENSCING00000008535-9964.407Ciona_intestinalis
ENSG00000133706LARS10064.894ENSCSAVG00000009040-10068.577Ciona_savignyi
ENSG00000133706LARS10098.763ENSCANG00000031137LARS10098.724Colobus_angolensis_palliatus
ENSG00000133706LARS10090.103ENSCGRG00001004647Lars9986.172Cricetulus_griseus_chok1gshd
ENSG00000133706LARS10088.681ENSCGRG00000007284Lars10088.540Cricetulus_griseus_crigri
ENSG00000133706LARS10078.603ENSCSEG00000014984larsb10077.656Cynoglossus_semilaevis
ENSG00000133706LARS10079.717ENSCVAG00000014685larsb10078.867Cyprinodon_variegatus
ENSG00000133706LARS9965.060ENSDARG00000090988larsa9979.775Danio_rerio
ENSG00000133706LARS9976.860ENSDARG00000019280larsb10079.725Danio_rerio
ENSG00000133706LARS10091.918ENSDNOG00000017963LARS10092.186Dasypus_novemcinctus
ENSG00000133706LARS10090.928ENSDORG00000014913Lars10088.625Dipodomys_ordii
ENSG00000133706LARS9959.063FBgn0284253LeuRS9958.833Drosophila_melanogaster
ENSG00000133706LARS9475.226ENSETEG00000003145LARS10075.226Echinops_telfairi
ENSG00000133706LARS9461.935ENSEBUG00000014985larsb9760.548Eptatretus_burgeri
ENSG00000133706LARS10094.563ENSEASG00005020569LARS10094.455Equus_asinus_asinus
ENSG00000133706LARS10094.742ENSECAG00000008963LARS10094.742Equus_caballus
ENSG00000133706LARS8592.647ENSEEUG00000014854LARS9277.262Erinaceus_europaeus
ENSG00000133706LARS10077.362ENSELUG00000023311larsb10076.720Esox_lucius
ENSG00000133706LARS10094.474ENSFCAG00000008715LARS10095.099Felis_catus
ENSG00000133706LARS10086.465ENSFALG00000003209LARS9386.151Ficedula_albicollis
ENSG00000133706LARS10093.939ENSFDAG00000020764LARS10093.622Fukomys_damarensis
ENSG00000133706LARS9080.896ENSFHEG00000010437larsb10079.558Fundulus_heteroclitus
ENSG00000133706LARS10076.492ENSGMOG00000013645larsb9976.105Gadus_morhua
ENSG00000133706LARS10087.533ENSGALG00000007494LARS10087.001Gallus_gallus
ENSG00000133706LARS10078.831ENSGAFG00000005029larsb10078.125Gambusia_affinis
ENSG00000133706LARS9977.451ENSGACG00000020720larsb9976.681Gasterosteus_aculeatus
ENSG00000133706LARS10085.931ENSGAGG00000002353LARS9985.787Gopherus_agassizii
ENSG00000133706LARS10099.575ENSGGOG00000004103LARS10099.575Gorilla_gorilla
ENSG00000133706LARS10078.203ENSHBUG00000003051larsb10079.492Haplochromis_burtoni
ENSG00000133706LARS10093.939ENSHGLG00000006937LARS10093.707Heterocephalus_glaber_female
ENSG00000133706LARS10093.939ENSHGLG00100002801LARS10093.707Heterocephalus_glaber_male
ENSG00000133706LARS9977.837ENSHCOG00000003651larsb10077.008Hippocampus_comes
ENSG00000133706LARS9980.660ENSIPUG00000010756lars10080.294Ictalurus_punctatus
ENSG00000133706LARS10094.652ENSSTOG00000002356LARS10094.473Ictidomys_tridecemlineatus
ENSG00000133706LARS10092.513ENSJJAG00000015265Lars10092.262Jaculus_jaculus
ENSG00000133706LARS10079.027ENSKMAG00000009903larsb10078.228Kryptolebias_marmoratus
ENSG00000133706LARS10079.292ENSLBEG00000025237larsb10078.565Labrus_bergylta
ENSG00000133706LARS10081.495ENSLACG00000009321LARS10081.409Latimeria_chalumnae
ENSG00000133706LARS9980.196ENSLOCG00000010442larsb10079.167Lepisosteus_oculatus
ENSG00000133706LARS10093.672ENSLAFG00000000318LARS10093.447Loxodonta_africana
ENSG00000133706LARS10099.175ENSMFAG00000038685LARS10098.724Macaca_fascicularis
ENSG00000133706LARS10098.969ENSMMUG00000029787LARS10098.554Macaca_mulatta
ENSG00000133706LARS10096.435ENSMNEG00000044014LARS9996.593Macaca_nemestrina
ENSG00000133706LARS10098.969ENSMLEG00000037563LARS9998.722Mandrillus_leucophaeus
ENSG00000133706LARS10079.097ENSMAMG00000021385larsb10078.547Mastacembelus_armatus
ENSG00000133706LARS10079.185ENSMZEG00005002662larsb10078.463Maylandia_zebra
ENSG00000133706LARS10087.444ENSMGAG00000009388LARS10087.588Meleagris_gallopavo
ENSG00000133706LARS10089.072ENSMAUG00000003063Lars9688.971Mesocricetus_auratus
ENSG00000133706LARS10095.238ENSMICG00000035589-10095.238Microcebus_murinus
ENSG00000133706LARS10084.375ENSMICG00000035435-10088.406Microcebus_murinus
ENSG00000133706LARS10090.463ENSMOCG00000002092Lars10090.323Microtus_ochrogaster
ENSG00000133706LARS10076.423ENSMMOG00000013802larsb10075.912Mola_mola
ENSG00000133706LARS10089.072ENSMODG00000010231LARS9983.503Monodelphis_domestica
ENSG00000133706LARS10077.414ENSMALG00000018444larsb9976.904Monopterus_albus
ENSG00000133706LARS10090.553MGP_CAROLIEiJ_G0022225Lars10090.323Mus_caroli
ENSG00000133706LARS10090.553ENSMUSG00000024493Lars10090.068Mus_musculus
ENSG00000133706LARS10090.374MGP_PahariEiJ_G0018958Lars10090.238Mus_pahari
ENSG00000133706LARS10090.731MGP_SPRETEiJ_G0023135Lars10090.492Mus_spretus
ENSG00000133706LARS10094.742ENSMPUG00000007844LARS10094.728Mustela_putorius_furo
ENSG00000133706LARS10092.965ENSMLUG00000001125LARS10093.106Myotis_lucifugus
ENSG00000133706LARS10092.335ENSNGAG00000011596Lars10092.347Nannospalax_galili
ENSG00000133706LARS10079.539ENSNBRG00000005764larsb10078.801Neolamprologus_brichardi
ENSG00000133706LARS10098.663ENSNLEG00000009816LARS9998.467Nomascus_leucogenys
ENSG00000133706LARS8482.836ENSMEUG00000002332-6089.552Notamacropus_eugenii
ENSG00000133706LARS8395.135ENSOPRG00000003076LARS8394.086Ochotona_princeps
ENSG00000133706LARS10090.722ENSODEG00000004882LARS10090.375Octodon_degus
ENSG00000133706LARS10079.628ENSONIG00000008493larsb10078.885Oreochromis_niloticus
ENSG00000133706LARS10084.978ENSOANG00000005755LARS10084.531Ornithorhynchus_anatinus
ENSG00000133706LARS10095.009ENSOCUG00000015684LARS10094.813Oryctolagus_cuniculus
ENSG00000133706LARS10078.299ENSORLG00000001622larsb10077.365Oryzias_latipes
ENSG00000133706LARS10078.699ENSORLG00020019950larsb10077.449Oryzias_latipes_hni
ENSG00000133706LARS10078.477ENSORLG00015003895larsb10077.534Oryzias_latipes_hsok
ENSG00000133706LARS10078.565ENSOMEG00000005677larsb10077.787Oryzias_melastigma
ENSG00000133706LARS10091.753ENSOGAG00000008750LARS10090.289Otolemur_garnettii
ENSG00000133706LARS10092.513ENSOARG00000015911-9992.432Ovis_aries
ENSG00000133706LARS10092.520ENSOARG00000002454-10092.426Ovis_aries
ENSG00000133706LARS10099.643ENSPPAG00000027964LARS9999.659Pan_paniscus
ENSG00000133706LARS10095.009ENSPPRG00000023492LARS10094.983Panthera_pardus
ENSG00000133706LARS10094.831ENSPTIG00000013110LARS10094.813Panthera_tigris_altaica
ENSG00000133706LARS10099.575ENSPTRG00000017372LARS10099.575Pan_troglodytes
ENSG00000133706LARS10098.969ENSPANG00000002663LARS10098.724Papio_anubis
ENSG00000133706LARS10078.191ENSPKIG00000006650larsb9977.373Paramormyrops_kingsleyae
ENSG00000133706LARS10086.020ENSPSIG00000015641LARS10085.957Pelodiscus_sinensis
ENSG00000133706LARS8669.565ENSPMGG00000019552-9069.565Periophthalmus_magnuspinnatus
ENSG00000133706LARS10077.320ENSPMGG00000019556LARS10079.000Periophthalmus_magnuspinnatus
ENSG00000133706LARS10086.809ENSPEMG00000010933Lars10086.672Peromyscus_maniculatus_bairdii
ENSG00000133706LARS9960.612ENSPMAG00000005301larsb9963.350Petromyzon_marinus
ENSG00000133706LARS10089.572ENSPCIG00000030572LARS10089.116Phascolarctos_cinereus
ENSG00000133706LARS10079.185ENSPFOG00000002361larsb10078.547Poecilia_formosa
ENSG00000133706LARS10079.362ENSPLAG00000016550larsb10078.716Poecilia_latipinna
ENSG00000133706LARS10079.097ENSPMEG00000018422larsb10078.463Poecilia_mexicana
ENSG00000133706LARS10078.919ENSPREG00000005668larsb10078.125Poecilia_reticulata
ENSG00000133706LARS9997.530ENSPPYG00000015908LARS9797.530Pongo_abelii
ENSG00000133706LARS8987.500ENSPCAG00000005621LARS10087.500Procavia_capensis
ENSG00000133706LARS10095.625ENSPCOG00000019325LARS10095.625Propithecus_coquereli
ENSG00000133706LARS10082.546ENSPVAG00000011237LARS10083.187Pteropus_vampyrus
ENSG00000133706LARS10079.008ENSPNYG00000015254larsb10078.294Pundamilia_nyererei
ENSG00000133706LARS10079.947ENSPNAG00000027191larsb10079.184Pygocentrus_nattereri
ENSG00000133706LARS10090.285ENSRNOG00000018304Lars10089.983Rattus_norvegicus
ENSG00000133706LARS9298.650ENSRBIG00000043198LARS9996.564Rhinopithecus_bieti
ENSG00000133706LARS9996.203ENSRROG00000041701-9996.203Rhinopithecus_roxellana
ENSG00000133706LARS9098.630ENSRROG00000019939-10098.630Rhinopithecus_roxellana
ENSG00000133706LARS9045.577YPL160WCDC609943.841Saccharomyces_cerevisiae
ENSG00000133706LARS10096.907ENSSBOG00000026661LARS10096.833Saimiri_boliviensis_boliviensis
ENSG00000133706LARS10090.917ENSSHAG00000006084LARS10090.399Sarcophilus_harrisii
ENSG00000133706LARS9681.574ENSSFOG00015018117larsb9080.776Scleropages_formosus
ENSG00000133706LARS8879.962ENSSMAG00000004078larsb9779.962Scophthalmus_maximus
ENSG00000133706LARS10079.362ENSSDUG00000021142larsb10078.632Seriola_dumerili
ENSG00000133706LARS10079.539ENSSLDG00000007054larsb10078.801Seriola_lalandi_dorsalis
ENSG00000133706LARS8792.086ENSSARG00000013481LARS8591.912Sorex_araneus
ENSG00000133706LARS10086.121ENSSPUG00000013805LARS10085.993Sphenodon_punctatus
ENSG00000133706LARS10079.451ENSSPAG00000012124larsb10078.632Stegastes_partitus
ENSG00000133706LARS10088.946ENSSSCG00000014411LARS10088.946Sus_scrofa
ENSG00000133706LARS10086.999ENSTGUG00000000092-9986.468Taeniopygia_guttata
ENSG00000133706LARS10079.097ENSTRUG00000005358larsb10078.378Takifugu_rubripes
ENSG00000133706LARS9976.896ENSTNIG00000018214larsb10075.254Tetraodon_nigroviridis
ENSG00000133706LARS9491.880ENSTBEG00000003757LARS9491.870Tupaia_belangeri
ENSG00000133706LARS10089.572ENSTTRG00000016712LARS9689.594Tursiops_truncatus
ENSG00000133706LARS9495.256ENSUAMG00000019907LARS9995.036Ursus_americanus
ENSG00000133706LARS10095.009ENSUMAG00000010585LARS10094.728Ursus_maritimus
ENSG00000133706LARS10091.134ENSVPAG00000000557LARS9291.275Vicugna_pacos
ENSG00000133706LARS10095.009ENSVVUG00000021124LARS10094.813Vulpes_vulpes
ENSG00000133706LARS9983.882ENSXETG00000002320lars10083.531Xenopus_tropicalis
ENSG00000133706LARS10078.742ENSXMAG00000001454larsb10078.041Xiphophorus_maculatus
Gene Ontology
Go ID
Go_term
PubmedID
Evidence
Category
GO:0002161aminoacyl-tRNA editing activity-IEAFunction
GO:0004819glutamine-tRNA ligase activity26869582.IDAFunction
GO:0004823leucine-tRNA ligase activity21873635.IBAFunction
GO:0004823leucine-tRNA ligase activity-TASFunction
GO:0005096GTPase activator activity22424946.IMPFunction
GO:0005515protein binding16055448.22424946.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005737cytoplasm22424946.IDAComponent
GO:0005764lysosome22424946.IMPComponent
GO:0005783endoplasmic reticulum22424946.IDAComponent
GO:0005829cytosol19289464.IDAComponent
GO:0005829cytosol-TASComponent
GO:0006418tRNA aminoacylation for protein translation-TASProcess
GO:0006425glutaminyl-tRNA aminoacylation26869582.IDAProcess
GO:0006429leucyl-tRNA aminoacylation21873635.IBAProcess
GO:0006622protein targeting to lysosome22424946.IMPProcess
GO:0008361regulation of cell size22424946.IMPProcess
GO:0010507negative regulation of autophagy22424946.IMPProcess
GO:0012505endomembrane system22424946.IDAComponent
GO:0016604nuclear body-IDAComponent
GO:0017101aminoacyl-tRNA synthetase multienzyme complex19131329.IDAComponent
GO:0034198cellular response to amino acid starvation22424946.IMPProcess
GO:0043547positive regulation of GTPase activity22424946.IMPProcess
GO:0071230cellular response to amino acid stimulus22424946.IMPProcess
GO:0071233cellular response to leucine22424946.IMPProcess
GO:0106074aminoacyl-tRNA metabolism involved in translational fidelity-IEAProcess
GO:1904263positive regulation of TORC1 signaling22424946.IMPProcess
GO:1990253cellular response to leucine starvation22424946.IMPProcess
Mpgyi