EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000133773 (Gene tree)
Gene ID: 29080
Gene Symbol: CCDC59
Alias: HSPC128|TAP26|BR22
Full Name: coiled-coil domain containing 59
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 135,125 bases
Position: chr12:82,223,681-82,358,805
Accession: 25005
RBP type: canonical RBP
Summary: (Coiled-Coil Domain Containing 59) is a Protein Coding gene. Among its related pathways are Surfactant metabolism and Diseases of metabolism.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000256151	rRNA_processing	PF08524.11	1.9e-09	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000552377	CCDC59-205	563	-	ENSP00000450183	181 (aa)	-	F8VNY5
ENST00000550589	CCDC59-204	2101	-	-	- (aa)	-	-
ENST00000256151	CCDC59-201	1983	-	ENSP00000256151	241 (aa)	-	Q9P031
ENST00000552412	CCDC59-206	287	-	-	- (aa)	-	-
ENST00000547758	CCDC59-202	553	-	-	- (aa)	-	-
ENST00000548126	CCDC59-203	984	NR_033192	-	- (aa)	-	-
ENST00000552606	CCDC59-207	600	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000133773's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000133773	Sodium	7.6760000E-005	-
ENSG00000133773	Hypospadias	6E-8	25108383

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000133773	rs143136847	12	82354560	G	Hypospadias	25108383	[NR]	2.6	EFO_0004209

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000133773's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000133773	CCDC59	86	42.035	ENSAPOG00000013793	-	86	42.035	Acanthochromis_polyacanthus
ENSG00000133773	CCDC59	93	74.779	ENSAMEG00000016875	CCDC59	99	74.779	Ailuropoda_melanoleuca
ENSG00000133773	CCDC59	99	39.560	ENSACIG00000004060	ccdc59	98	41.241	Amphilophus_citrinellus
ENSG00000133773	CCDC59	85	40.969	ENSAOCG00000001895	ccdc59	86	40.969	Amphiprion_ocellaris
ENSG00000133773	CCDC59	85	40.969	ENSAPEG00000006365	ccdc59	86	40.969	Amphiprion_percula
ENSG00000133773	CCDC59	84	40.506	ENSATEG00000017992	ccdc59	85	41.228	Anabas_testudineus
ENSG00000133773	CCDC59	79	58.333	ENSAPLG00000007839	CCDC59	99	58.333	Anas_platyrhynchos
ENSG00000133773	CCDC59	78	47.917	ENSACAG00000014707	CCDC59	99	47.917	Anolis_carolinensis
ENSG00000133773	CCDC59	100	89.256	ENSANAG00000033505	CCDC59	100	89.256	Aotus_nancymaae
ENSG00000133773	CCDC59	80	44.498	ENSACLG00000023759	ccdc59	82	44.498	Astatotilapia_calliptera
ENSG00000133773	CCDC59	86	40.909	ENSAMXG00000036253	ccdc59	87	43.891	Astyanax_mexicanus
ENSG00000133773	CCDC59	90	79.452	ENSBTAG00000036282	CCDC59	99	76.667	Bos_taurus
ENSG00000133773	CCDC59	100	85.892	ENSCJAG00000019396	CCDC59	100	85.892	Callithrix_jacchus
ENSG00000133773	CCDC59	99	72.083	ENSCAFG00000023758	CCDC59	99	72.083	Canis_familiaris
ENSG00000133773	CCDC59	91	79.091	ENSCHIG00000004977	-	99	76.763	Capra_hircus
ENSG00000133773	CCDC59	91	79.545	ENSCHIG00000025817	-	99	77.178	Capra_hircus
ENSG00000133773	CCDC59	99	78.333	ENSTSYG00000007979	CCDC59	99	78.333	Carlito_syrichta
ENSG00000133773	CCDC59	100	74.793	ENSCPOG00000036718	CCDC59	100	74.793	Cavia_porcellus
ENSG00000133773	CCDC59	100	87.552	ENSCCAG00000021997	CCDC59	100	87.552	Cebus_capucinus
ENSG00000133773	CCDC59	99	90.833	ENSCATG00000044760	CCDC59	99	90.833	Cercocebus_atys
ENSG00000133773	CCDC59	100	72.727	ENSCLAG00000015050	CCDC59	100	72.727	Chinchilla_lanigera
ENSG00000133773	CCDC59	99	90.833	ENSCSAG00000003867	CCDC59	99	90.833	Chlorocebus_sabaeus
ENSG00000133773	CCDC59	99	73.859	ENSCHOG00000007788	CCDC59	99	73.859	Choloepus_hoffmanni
ENSG00000133773	CCDC59	86	53.846	ENSCPBG00000000075	CCDC59	88	53.846	Chrysemys_picta_bellii
ENSG00000133773	CCDC59	99	89.167	ENSCANG00000032140	CCDC59	99	89.167	Colobus_angolensis_palliatus
ENSG00000133773	CCDC59	99	71.250	ENSCGRG00001015959	Ccdc59	99	71.250	Cricetulus_griseus_chok1gshd
ENSG00000133773	CCDC59	99	71.250	ENSCGRG00000014122	Ccdc59	99	71.250	Cricetulus_griseus_crigri
ENSG00000133773	CCDC59	85	41.126	ENSCSEG00000008298	ccdc59	87	41.558	Cynoglossus_semilaevis
ENSG00000133773	CCDC59	84	45.283	ENSCVAG00000009807	ccdc59	98	42.000	Cyprinodon_variegatus
ENSG00000133773	CCDC59	99	38.168	ENSDARG00000045755	ccdc59	98	38.462	Danio_rerio
ENSG00000133773	CCDC59	99	72.803	ENSETEG00000000256	CCDC59	99	72.803	Echinops_telfairi
ENSG00000133773	CCDC59	99	77.510	ENSEASG00005021237	CCDC59	99	77.510	Equus_asinus_asinus
ENSG00000133773	CCDC59	99	77.600	ENSECAG00000010450	CCDC59	99	77.600	Equus_caballus
ENSG00000133773	CCDC59	56	80.000	ENSEEUG00000004885	-	56	80.000	Erinaceus_europaeus
ENSG00000133773	CCDC59	87	39.827	ENSELUG00000001779	ccdc59	86	39.827	Esox_lucius
ENSG00000133773	CCDC59	99	75.934	ENSFCAG00000028462	CCDC59	99	75.934	Felis_catus
ENSG00000133773	CCDC59	94	48.918	ENSFALG00000010525	CCDC59	94	48.918	Ficedula_albicollis
ENSG00000133773	CCDC59	100	75.620	ENSFDAG00000018726	CCDC59	100	75.620	Fukomys_damarensis
ENSG00000133773	CCDC59	84	45.161	ENSFHEG00000021511	ccdc59	98	41.860	Fundulus_heteroclitus
ENSG00000133773	CCDC59	81	41.026	ENSGMOG00000018721	ccdc59	94	41.026	Gadus_morhua
ENSG00000133773	CCDC59	100	47.718	ENSGALG00000028648	CCDC59	100	47.718	Gallus_gallus
ENSG00000133773	CCDC59	85	44.344	ENSGAFG00000008786	ccdc59	86	44.344	Gambusia_affinis
ENSG00000133773	CCDC59	98	37.405	ENSGACG00000019765	ccdc59	98	37.405	Gasterosteus_aculeatus
ENSG00000133773	CCDC59	86	53.365	ENSGAGG00000017055	CCDC59	88	53.365	Gopherus_agassizii
ENSG00000133773	CCDC59	100	96.680	ENSGGOG00000025296	CCDC59	100	96.680	Gorilla_gorilla
ENSG00000133773	CCDC59	80	44.749	ENSHBUG00000018713	ccdc59	83	44.395	Haplochromis_burtoni
ENSG00000133773	CCDC59	100	76.033	ENSHGLG00000001711	CCDC59	100	76.033	Heterocephalus_glaber_female
ENSG00000133773	CCDC59	100	76.446	ENSHGLG00100000248	CCDC59	100	76.446	Heterocephalus_glaber_male
ENSG00000133773	CCDC59	99	43.411	ENSHCOG00000004915	ccdc59	96	43.798	Hippocampus_comes
ENSG00000133773	CCDC59	86	42.152	ENSIPUG00000017904	ccdc59	86	42.152	Ictalurus_punctatus
ENSG00000133773	CCDC59	100	77.273	ENSSTOG00000009858	CCDC59	100	77.273	Ictidomys_tridecemlineatus
ENSG00000133773	CCDC59	99	67.220	ENSJJAG00000015263	Ccdc59	99	67.220	Jaculus_jaculus
ENSG00000133773	CCDC59	85	40.611	ENSLBEG00000018654	ccdc59	80	40.611	Labrus_bergylta
ENSG00000133773	CCDC59	93	45.228	ENSLACG00000016632	CCDC59	89	45.228	Latimeria_chalumnae
ENSG00000133773	CCDC59	91	50.893	ENSLOCG00000016324	ccdc59	90	50.893	Lepisosteus_oculatus
ENSG00000133773	CCDC59	99	74.689	ENSLAFG00000015368	CCDC59	99	74.689	Loxodonta_africana
ENSG00000133773	CCDC59	99	91.250	ENSMFAG00000034303	CCDC59	99	91.250	Macaca_fascicularis
ENSG00000133773	CCDC59	99	91.250	ENSMNEG00000037462	CCDC59	99	91.250	Macaca_nemestrina
ENSG00000133773	CCDC59	99	90.833	ENSMLEG00000039811	CCDC59	99	90.833	Mandrillus_leucophaeus
ENSG00000133773	CCDC59	85	41.485	ENSMAMG00000011380	ccdc59	85	42.609	Mastacembelus_armatus
ENSG00000133773	CCDC59	80	44.292	ENSMZEG00005005994	ccdc59	83	43.119	Maylandia_zebra
ENSG00000133773	CCDC59	84	52.404	ENSMGAG00000011116	CCDC59	100	55.155	Meleagris_gallopavo
ENSG00000133773	CCDC59	99	68.750	ENSMAUG00000017516	Ccdc59	99	68.750	Mesocricetus_auratus
ENSG00000133773	CCDC59	99	78.008	ENSMICG00000041747	CCDC59	99	78.008	Microcebus_murinus
ENSG00000133773	CCDC59	100	66.122	ENSMOCG00000006690	Ccdc59	100	66.122	Microtus_ochrogaster
ENSG00000133773	CCDC59	71	42.938	ENSMMOG00000001931	ccdc59	70	42.938	Mola_mola
ENSG00000133773	CCDC59	85	40.625	ENSMALG00000013053	ccdc59	84	40.625	Monopterus_albus
ENSG00000133773	CCDC59	100	70.248	MGP_CAROLIEiJ_G0015781	Ccdc59	100	70.248	Mus_caroli
ENSG00000133773	CCDC59	100	69.835	ENSMUSG00000019897	Ccdc59	100	69.835	Mus_musculus
ENSG00000133773	CCDC59	100	70.661	MGP_PahariEiJ_G0031306	Ccdc59	99	71.250	Mus_pahari
ENSG00000133773	CCDC59	100	69.835	MGP_SPRETEiJ_G0016603	Ccdc59	100	69.835	Mus_spretus
ENSG00000133773	CCDC59	99	65.714	ENSMPUG00000011361	CCDC59	99	65.714	Mustela_putorius_furo
ENSG00000133773	CCDC59	99	74.689	ENSMLUG00000008071	CCDC59	99	74.689	Myotis_lucifugus
ENSG00000133773	CCDC59	100	70.248	ENSNGAG00000023637	Ccdc59	100	70.248	Nannospalax_galili
ENSG00000133773	CCDC59	100	95.436	ENSNLEG00000033968	CCDC59	100	95.436	Nomascus_leucogenys
ENSG00000133773	CCDC59	99	46.058	ENSMEUG00000000635	-	99	44.398	Notamacropus_eugenii
ENSG00000133773	CCDC59	85	44.156	ENSONIG00000011545	ccdc59	87	43.830	Oreochromis_niloticus
ENSG00000133773	CCDC59	99	76.349	ENSOCUG00000017824	CCDC59	99	76.349	Oryctolagus_cuniculus
ENSG00000133773	CCDC59	99	43.775	ENSORLG00000027963	ccdc59	98	43.775	Oryzias_latipes
ENSG00000133773	CCDC59	99	43.922	ENSORLG00020014686	ccdc59	98	43.922	Oryzias_latipes_hni
ENSG00000133773	CCDC59	99	44.177	ENSORLG00015013061	ccdc59	98	44.177	Oryzias_latipes_hsok
ENSG00000133773	CCDC59	99	41.699	ENSOMEG00000007247	ccdc59	99	41.699	Oryzias_melastigma
ENSG00000133773	CCDC59	99	74.380	ENSOGAG00000004383	CCDC59	100	74.380	Otolemur_garnettii
ENSG00000133773	CCDC59	99	75.000	ENSOARG00000015247	CCDC59	99	76.639	Ovis_aries
ENSG00000133773	CCDC59	99	84.167	ENSPPAG00000039810	-	99	84.167	Pan_paniscus
ENSG00000133773	CCDC59	100	96.680	ENSPPAG00000030113	CCDC59	100	96.680	Pan_paniscus
ENSG00000133773	CCDC59	99	76.349	ENSPPRG00000022500	CCDC59	99	76.349	Panthera_pardus
ENSG00000133773	CCDC59	99	76.349	ENSPTIG00000020934	CCDC59	99	76.349	Panthera_tigris_altaica
ENSG00000133773	CCDC59	100	97.510	ENSPTRG00000005266	CCDC59	100	97.510	Pan_troglodytes
ENSG00000133773	CCDC59	99	84.583	ENSPTRG00000048467	-	99	84.583	Pan_troglodytes
ENSG00000133773	CCDC59	99	90.833	ENSPANG00000023011	CCDC59	99	90.833	Papio_anubis
ENSG00000133773	CCDC59	99	42.248	ENSPKIG00000019649	ccdc59	98	42.248	Paramormyrops_kingsleyae
ENSG00000133773	CCDC59	93	40.637	ENSPMGG00000009816	ccdc59	96	40.637	Periophthalmus_magnuspinnatus
ENSG00000133773	CCDC59	100	59.091	ENSPCIG00000007808	CCDC59	100	59.091	Phascolarctos_cinereus
ENSG00000133773	CCDC59	99	42.578	ENSPFOG00000005611	ccdc59	98	42.578	Poecilia_formosa
ENSG00000133773	CCDC59	99	41.445	ENSPLAG00000003832	ccdc59	98	41.445	Poecilia_latipinna
ENSG00000133773	CCDC59	99	41.065	ENSPMEG00000007149	ccdc59	98	41.065	Poecilia_mexicana
ENSG00000133773	CCDC59	99	42.578	ENSPREG00000002686	ccdc59	98	42.578	Poecilia_reticulata
ENSG00000133773	CCDC59	100	95.436	ENSPPYG00000004804	CCDC59	100	95.436	Pongo_abelii
ENSG00000133773	CCDC59	78	80.000	ENSPCAG00000000679	CCDC59	100	80.000	Procavia_capensis
ENSG00000133773	CCDC59	99	78.838	ENSPCOG00000013658	CCDC59	99	78.838	Propithecus_coquereli
ENSG00000133773	CCDC59	80	43.721	ENSPNYG00000000586	ccdc59	82	43.721	Pundamilia_nyererei
ENSG00000133773	CCDC59	85	39.910	ENSPNAG00000029087	ccdc59	87	39.910	Pygocentrus_nattereri
ENSG00000133773	CCDC59	100	70.661	ENSRNOG00000004183	Ccdc59	100	70.661	Rattus_norvegicus
ENSG00000133773	CCDC59	99	82.500	ENSRBIG00000037638	CCDC59	99	82.500	Rhinopithecus_bieti
ENSG00000133773	CCDC59	99	90.000	ENSRROG00000041324	CCDC59	99	90.000	Rhinopithecus_roxellana
ENSG00000133773	CCDC59	99	88.797	ENSSBOG00000029711	CCDC59	99	88.797	Saimiri_boliviensis_boliviensis
ENSG00000133773	CCDC59	100	57.490	ENSSHAG00000007040	CCDC59	100	57.490	Sarcophilus_harrisii
ENSG00000133773	CCDC59	99	43.028	ENSSFOG00015008683	ccdc59	99	43.028	Scleropages_formosus
ENSG00000133773	CCDC59	85	40.000	ENSSMAG00000001292	ccdc59	77	40.171	Scophthalmus_maximus
ENSG00000133773	CCDC59	85	40.611	ENSSDUG00000003120	ccdc59	87	40.611	Seriola_dumerili
ENSG00000133773	CCDC59	85	40.708	ENSSLDG00000023499	ccdc59	86	40.611	Seriola_lalandi_dorsalis
ENSG00000133773	CCDC59	79	50.262	ENSSPUG00000011405	CCDC59	87	50.262	Sphenodon_punctatus
ENSG00000133773	CCDC59	85	43.612	ENSSPAG00000022368	ccdc59	86	43.612	Stegastes_partitus
ENSG00000133773	CCDC59	99	75.100	ENSSSCG00000038987	CCDC59	99	75.100	Sus_scrofa
ENSG00000133773	CCDC59	80	50.259	ENSTGUG00000007835	CCDC59	99	52.083	Taeniopygia_guttata
ENSG00000133773	CCDC59	85	42.797	ENSTRUG00000015207	ccdc59	87	42.797	Takifugu_rubripes
ENSG00000133773	CCDC59	93	39.300	ENSTNIG00000011028	ccdc59	94	39.526	Tetraodon_nigroviridis
ENSG00000133773	CCDC59	99	77.083	ENSTBEG00000008887	CCDC59	99	77.083	Tupaia_belangeri
ENSG00000133773	CCDC59	99	78.750	ENSTTRG00000000199	CCDC59	99	78.750	Tursiops_truncatus
ENSG00000133773	CCDC59	99	74.274	ENSUAMG00000009205	CCDC59	99	74.274	Ursus_americanus
ENSG00000133773	CCDC59	99	78.333	ENSVPAG00000001931	CCDC59	99	78.333	Vicugna_pacos
ENSG00000133773	CCDC59	99	69.167	ENSVVUG00000010954	CCDC59	99	69.167	Vulpes_vulpes
ENSG00000133773	CCDC59	95	43.154	ENSXETG00000014539	ccdc59	91	45.643	Xenopus_tropicalis
ENSG00000133773	CCDC59	85	44.700	ENSXCOG00000013601	ccdc59	86	44.700	Xiphophorus_couchianus
ENSG00000133773	CCDC59	85	44.292	ENSXMAG00000011199	ccdc59	86	44.292	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.	HDA	Function
GO:0005515	protein binding	11152647.	IPI	Function
GO:0005654	nucleoplasm	-	TAS	Component
GO:0044267	cellular protein metabolic process	-	TAS	Process