EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134001 (Gene tree)
Gene ID: 1965
Gene Symbol: EIF2S1
Alias: EIF-2alpha|EIF2A|EIF2
Full Name: eukaryotic translation initiation factor 2 subunit alpha
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 26,520 bases
Position: chr14:67,359,997-67,386,516
Accession: 3265
RBP type: canonical RBP
Summary: The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000452034	EIF_2_alpha	PF07541.12	2.5e-36	1	1
ENSP00000451975	EIF_2_alpha	PF07541.12	3.4e-36	1	1
ENSP00000256383	EIF_2_alpha	PF07541.12	4.2e-36	1	1
ENSP00000425299	EIF_2_alpha	PF07541.12	4.2e-36	1	1
ENSP00000451975	S1	PF00575.23	6.6e-15	1	1
ENSP00000256383	S1	PF00575.23	7e-15	1	1
ENSP00000425299	S1	PF00575.23	7e-15	1	1
ENSP00000452034	S1	PF00575.23	7.5e-06	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
10613902	RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules.	J Cell Biol	1999 Dec 27	Kedersha NL	-
1373554	Mechanism of interferon action: identification of a RNA binding domain within the N-terminal region of the human RNA-dependent P1/eIF-2 alpha protein kinase.	Virology	1992 May	McCormack SJ	-
1383091	Translational initiation factors IF-1 and eIF-2 alpha share an RNA-binding motif with prokaryotic ribosomal protein S1 and polynucleotide phosphorylase.	Gene	1992 Sep 21	Gribskov M	-
23766293	Two RNA-binding motifs in eIF3 direct HCV IRES-dependent translation.	Nucleic Acids Res	2013 Aug	Sun C	doi: 10.1093/nar/gkt510
6088993	Inhibition of mRNA binding to ribosomes by localized activation of dsRNA-dependent protein kinase.	Nature	1984 Sep 6-11	De Benedetti A	-
10074192	A herpesvirus ribosome-associated, RNA-binding protein confers a growth advantage upon mutants deficient in a GADD34-related function.	J Virol	1999 Apr	Mulvey M	-
1465480	Role of the RNA-dependent protein kinase in the regulated expression of genes in transfected cells.	Pharmacol Ther	1992	Samuel CE	-
8626809	Phosphorylation of plant eukaryotic initiation factor-2 by the plant-encoded double-stranded RNA-dependent protein kinase, pPKR, and inhibition of protein synthesis in vitro.	J Biol Chem	1996 Feb 23	Langland JO	-
7799945	Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae.	Mol Cell Biol	1995 Jan	Romano PR	-
7622470	Calcium depletion from the endoplasmic reticulum activates the double-stranded RNA-dependent protein kinase (PKR) to inhibit protein synthesis.	J Biol Chem	1995 Jul 14	Srivastava SP	-
12380690	Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation.	Cell Stress Chaperones	2002 Apr	Anderson P	-
16466763	Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.	Virology	2006 May 25	Li S	-
12140254	Stressful initiations.	J Cell Sci	2002 Aug 15	Anderson P	-
11070019	Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein.	J Virol	2000 Dec	Poppers J	-
26802109	The Nrf2 Activator Vinylsulfone Reduces High Glucose-Induced Neural Tube Defects by Suppressing Cellular Stress and Apoptosis.	Reprod Sci	2016 Aug	Dong D	doi: 10.1177/1933719115625846
16179258	Higher-order substrate recognition of eIF2alpha by the RNA-dependent protein kinase PKR.	Cell	2005 Sep 23	Dar AC	-
15659335	Translational control in virus-infected cells: models for cellular stress responses.	Semin Cell Dev Biol	2005 Feb	Clemens MJ	-
21285413	Quantitative profiling of in vivo-assembled RNA-protein complexes using a novel integrated proteomic approach.	Mol Cell Proteomics	2011 Apr	Tsai BP	doi: 10.1074/mcp.M110.007385
27470367	The protective effect of the earthworm active ingredients on hepatocellular injury induced by endoplasmic reticulum stress.	Biomed Pharmacother	2016 Aug	Wang Q	doi: 10.1016/j.biopha.2016.05.001
1647211	The 5' untranslated region of encephalomyocarditis virus contains a sequence for very efficient binding of eukaryotic initiation factor eIF-2/2B.	Biochim Biophys Acta	1991 Jun 13	Scheper GC	-
249315	mRNA-induced dissociation of initiation factor 2.	J Biol Chem	1978 Sep 25	Barrieux A	-
16580685	Uncoupling of RNA binding and PKR kinase activation by viral inhibitor RNAs.	J Mol Biol	2006 May 19	McKenna SA	-
11836380	The herpes simplex virus type 1 U(S)11 protein interacts with protein kinase R in infected cells and requires a 30-amino-acid sequence adjacent to a kinase substrate domain.	J Virol	2002 Mar	Cassady KA	-
16246087	Alternative mechanisms of initiating translation of mammalian mRNAs.	Biochem Soc Trans	2005 Dec	Jackson RJ	-
18784653	Eukaryotic initiation factor 6 is rate-limiting in translation, growth and transformation.	Nature	2008 Oct 2	Gandin V	doi: 10.1038/nature07267

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000557310	EIF2S1-206	999	-	ENSP00000451975	273 (aa)	-	G3V4T5
ENST00000556724	EIF2S1-205	527	-	-	- (aa)	-	-
ENST00000466499	EIF2S1-202	2390	-	ENSP00000425299	315 (aa)	-	P05198
ENST00000555876	EIF2S1-204	783	-	ENSP00000452034	252 (aa)	-	H0YJS4
ENST00000554332	EIF2S1-203	534	-	-	- (aa)	-	-
ENST00000256383	EIF2S1-201	4485	-	ENSP00000256383	315 (aa)	-	P05198

Gene Model

Click here to download ENSG00000134001's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa03013	RNA transport	KEGG
hsa04140	Autophagy - animal	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG
hsa04210	Apoptosis	KEGG
hsa04932	Non-alcoholic fatty liver disease (NAFLD)	KEGG
hsa05160	Hepatitis C	KEGG
hsa05162	Measles	KEGG
hsa05164	Influenza A	KEGG
hsa05168	Herpes simplex virus 1 infection	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134001's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134001	EIF2S1	100	93.968	ENSAPOG00000016619	eif2s1b	100	93.968	Acanthochromis_polyacanthus
ENSG00000134001	EIF2S1	96	97.318	ENSAMEG00000008210	EIF2S1	96	91.447	Ailuropoda_melanoleuca
ENSG00000134001	EIF2S1	100	94.286	ENSACIG00000014215	eif2s1b	100	94.286	Amphilophus_citrinellus
ENSG00000134001	EIF2S1	100	93.968	ENSAOCG00000019340	eif2s1b	100	93.968	Amphiprion_ocellaris
ENSG00000134001	EIF2S1	100	93.968	ENSAPEG00000009626	eif2s1b	100	93.968	Amphiprion_percula
ENSG00000134001	EIF2S1	100	93.968	ENSATEG00000017366	eif2s1b	100	93.968	Anabas_testudineus
ENSG00000134001	EIF2S1	100	97.802	ENSACAG00000005994	EIF2S1	100	97.460	Anolis_carolinensis
ENSG00000134001	EIF2S1	100	99.683	ENSANAG00000024611	EIF2S1	100	99.683	Aotus_nancymaae
ENSG00000134001	EIF2S1	100	94.286	ENSACLG00000024532	eif2s1b	100	94.286	Astatotilapia_calliptera
ENSG00000134001	EIF2S1	100	94.921	ENSAMXG00000034687	eif2s1b	100	94.921	Astyanax_mexicanus
ENSG00000134001	EIF2S1	100	99.267	ENSBTAG00000016311	EIF2S1	100	99.048	Bos_taurus
ENSG00000134001	EIF2S1	99	59.108	WBGene00021351	eif-2alpha	86	56.026	Caenorhabditis_elegans
ENSG00000134001	EIF2S1	100	99.683	ENSCJAG00000015368	EIF2S1	100	99.683	Callithrix_jacchus
ENSG00000134001	EIF2S1	100	99.267	ENSCAFG00000016386	EIF2S1	100	99.048	Canis_familiaris
ENSG00000134001	EIF2S1	100	99.267	ENSCAFG00020006539	EIF2S1	100	99.048	Canis_lupus_dingo
ENSG00000134001	EIF2S1	100	99.267	ENSCHIG00000011066	EIF2S1	100	99.048	Capra_hircus
ENSG00000134001	EIF2S1	100	99.267	ENSTSYG00000014171	EIF2S1	100	98.730	Carlito_syrichta
ENSG00000134001	EIF2S1	100	68.571	ENSCAPG00000015698	EIF2S1	100	68.571	Cavia_aperea
ENSG00000134001	EIF2S1	100	99.267	ENSCPOG00000038969	EIF2S1	100	99.048	Cavia_porcellus
ENSG00000134001	EIF2S1	100	99.683	ENSCCAG00000028622	-	100	99.683	Cebus_capucinus
ENSG00000134001	EIF2S1	98	95.896	ENSCCAG00000021038	-	97	95.896	Cebus_capucinus
ENSG00000134001	EIF2S1	100	100.000	ENSCATG00000044130	EIF2S1	100	100.000	Cercocebus_atys
ENSG00000134001	EIF2S1	100	99.267	ENSCLAG00000003254	EIF2S1	100	99.048	Chinchilla_lanigera
ENSG00000134001	EIF2S1	100	100.000	ENSCSAG00000013324	EIF2S1	100	100.000	Chlorocebus_sabaeus
ENSG00000134001	EIF2S1	100	97.460	ENSCHOG00000004230	-	100	97.460	Choloepus_hoffmanni
ENSG00000134001	EIF2S1	100	96.190	ENSCHOG00000009030	-	100	96.190	Choloepus_hoffmanni
ENSG00000134001	EIF2S1	68	97.468	ENSCHOG00000003744	-	71	97.196	Choloepus_hoffmanni
ENSG00000134001	EIF2S1	100	97.802	ENSCPBG00000006364	EIF2S1	100	97.778	Chrysemys_picta_bellii
ENSG00000134001	EIF2S1	100	100.000	ENSCANG00000026840	EIF2S1	100	100.000	Colobus_angolensis_palliatus
ENSG00000134001	EIF2S1	100	98.535	ENSCGRG00001015826	Eif2s1	100	98.095	Cricetulus_griseus_chok1gshd
ENSG00000134001	EIF2S1	100	98.535	ENSCGRG00000013519	Eif2s1	100	98.095	Cricetulus_griseus_crigri
ENSG00000134001	EIF2S1	100	93.773	ENSCSEG00000003717	eif2s1b	80	92.810	Cynoglossus_semilaevis
ENSG00000134001	EIF2S1	100	93.968	ENSCVAG00000003446	eif2s1b	100	93.968	Cyprinodon_variegatus
ENSG00000134001	EIF2S1	100	93.651	ENSDARG00000005827	eif2s1a	100	93.651	Danio_rerio
ENSG00000134001	EIF2S1	100	94.505	ENSDARG00000052178	eif2s1b	100	94.286	Danio_rerio
ENSG00000134001	EIF2S1	100	89.623	ENSDNOG00000024635	EIF2S1	100	89.623	Dasypus_novemcinctus
ENSG00000134001	EIF2S1	99	62.362	FBgn0261609	eIF2alpha	89	62.092	Drosophila_melanogaster
ENSG00000134001	EIF2S1	100	97.070	ENSETEG00000019003	EIF2S1	100	97.080	Echinops_telfairi
ENSG00000134001	EIF2S1	100	78.022	ENSEBUG00000013302	-	99	78.457	Eptatretus_burgeri
ENSG00000134001	EIF2S1	100	99.267	ENSEASG00005008720	EIF2S1	100	98.730	Equus_asinus_asinus
ENSG00000134001	EIF2S1	100	99.267	ENSECAG00000018424	EIF2S1	100	98.730	Equus_caballus
ENSG00000134001	EIF2S1	100	99.267	ENSEEUG00000010225	EIF2S1	100	99.048	Erinaceus_europaeus
ENSG00000134001	EIF2S1	100	93.040	ENSELUG00000007752	eif2s1b	100	92.381	Esox_lucius
ENSG00000134001	EIF2S1	100	93.773	ENSELUG00000023906	EIF2S1	100	93.016	Esox_lucius
ENSG00000134001	EIF2S1	100	98.901	ENSFCAG00000031891	EIF2S1	100	98.730	Felis_catus
ENSG00000134001	EIF2S1	100	97.091	ENSFALG00000005244	EIF2S1	100	96.845	Ficedula_albicollis
ENSG00000134001	EIF2S1	100	99.267	ENSFDAG00000001587	EIF2S1	100	98.730	Fukomys_damarensis
ENSG00000134001	EIF2S1	100	94.603	ENSFHEG00000003522	eif2s1b	100	94.603	Fundulus_heteroclitus
ENSG00000134001	EIF2S1	100	93.968	ENSGMOG00000003302	eif2s1b	100	93.968	Gadus_morhua
ENSG00000134001	EIF2S1	100	97.436	ENSGALG00000009565	EIF2S1	100	97.143	Gallus_gallus
ENSG00000134001	EIF2S1	100	94.286	ENSGAFG00000001145	eif2s1b	84	94.286	Gambusia_affinis
ENSG00000134001	EIF2S1	100	91.746	ENSGACG00000008569	eif2s1b	100	91.746	Gasterosteus_aculeatus
ENSG00000134001	EIF2S1	100	97.143	ENSGAGG00000010227	EIF2S1	100	97.143	Gopherus_agassizii
ENSG00000134001	EIF2S1	100	100.000	ENSGGOG00000001603	EIF2S1	100	100.000	Gorilla_gorilla
ENSG00000134001	EIF2S1	100	93.968	ENSHBUG00000018417	eif2s1b	100	93.968	Haplochromis_burtoni
ENSG00000134001	EIF2S1	100	99.267	ENSHGLG00000015570	EIF2S1	100	98.730	Heterocephalus_glaber_female
ENSG00000134001	EIF2S1	100	99.267	ENSHGLG00100014128	EIF2S1	100	98.730	Heterocephalus_glaber_male
ENSG00000134001	EIF2S1	100	93.651	ENSHCOG00000005159	eif2s1b	100	93.651	Hippocampus_comes
ENSG00000134001	EIF2S1	100	94.286	ENSIPUG00000021013	eif2s1	100	94.286	Ictalurus_punctatus
ENSG00000134001	EIF2S1	100	99.267	ENSSTOG00000001565	EIF2S1	100	99.048	Ictidomys_tridecemlineatus
ENSG00000134001	EIF2S1	100	98.535	ENSJJAG00000020369	Eif2s1	100	98.413	Jaculus_jaculus
ENSG00000134001	EIF2S1	100	93.968	ENSKMAG00000018887	eif2s1b	100	93.968	Kryptolebias_marmoratus
ENSG00000134001	EIF2S1	100	87.342	ENSLBEG00000010808	eif2s1b	100	87.342	Labrus_bergylta
ENSG00000134001	EIF2S1	100	93.407	ENSLBEG00000028961	-	95	93.431	Labrus_bergylta
ENSG00000134001	EIF2S1	100	93.651	ENSLACG00000009219	EIF2S1	100	93.651	Latimeria_chalumnae
ENSG00000134001	EIF2S1	100	95.255	ENSLOCG00000014165	eif2s1a	100	94.937	Lepisosteus_oculatus
ENSG00000134001	EIF2S1	100	97.460	ENSLAFG00000013423	EIF2S1	100	97.460	Loxodonta_africana
ENSG00000134001	EIF2S1	100	100.000	ENSMFAG00000037691	EIF2S1	100	100.000	Macaca_fascicularis
ENSG00000134001	EIF2S1	100	100.000	ENSMMUG00000021419	EIF2S1	100	100.000	Macaca_mulatta
ENSG00000134001	EIF2S1	100	100.000	ENSMNEG00000033037	EIF2S1	100	100.000	Macaca_nemestrina
ENSG00000134001	EIF2S1	100	100.000	ENSMLEG00000041672	EIF2S1	100	100.000	Mandrillus_leucophaeus
ENSG00000134001	EIF2S1	100	94.286	ENSMAMG00000004658	eif2s1b	96	94.286	Mastacembelus_armatus
ENSG00000134001	EIF2S1	100	94.286	ENSMZEG00005001483	eif2s1b	100	94.286	Maylandia_zebra
ENSG00000134001	EIF2S1	100	97.436	ENSMGAG00000011974	EIF2S1	100	97.143	Meleagris_gallopavo
ENSG00000134001	EIF2S1	100	98.535	ENSMAUG00000014812	-	100	98.095	Mesocricetus_auratus
ENSG00000134001	EIF2S1	100	73.626	ENSMAUG00000000538	-	100	69.257	Mesocricetus_auratus
ENSG00000134001	EIF2S1	100	98.901	ENSMICG00000041438	EIF2S1	100	98.730	Microcebus_murinus
ENSG00000134001	EIF2S1	100	76.508	ENSMOCG00000013818	-	100	76.508	Microtus_ochrogaster
ENSG00000134001	EIF2S1	100	97.802	ENSMOCG00000003380	-	100	97.460	Microtus_ochrogaster
ENSG00000134001	EIF2S1	100	92.722	ENSMMOG00000015548	eif2s1b	100	92.722	Mola_mola
ENSG00000134001	EIF2S1	100	98.168	ENSMODG00000009911	EIF2S1	100	98.095	Monodelphis_domestica
ENSG00000134001	EIF2S1	100	93.407	ENSMALG00000020456	eif2s1b	100	93.831	Monopterus_albus
ENSG00000134001	EIF2S1	100	99.267	MGP_CAROLIEiJ_G0017881	Eif2s1	100	99.048	Mus_caroli
ENSG00000134001	EIF2S1	100	99.267	ENSMUSG00000021116	Eif2s1	100	99.048	Mus_musculus
ENSG00000134001	EIF2S1	100	98.901	MGP_PahariEiJ_G0029637	Eif2s1	100	98.730	Mus_pahari
ENSG00000134001	EIF2S1	100	98.765	MGP_SPRETEiJ_G0018727	-	96	98.765	Mus_spretus
ENSG00000134001	EIF2S1	100	98.901	ENSMPUG00000007065	EIF2S1	100	98.730	Mustela_putorius_furo
ENSG00000134001	EIF2S1	99	94.304	ENSMLUG00000004440	EIF2S1	100	94.304	Myotis_lucifugus
ENSG00000134001	EIF2S1	100	67.085	ENSNGAG00000013850	-	100	67.085	Nannospalax_galili
ENSG00000134001	EIF2S1	100	99.267	ENSNGAG00000008053	-	100	99.048	Nannospalax_galili
ENSG00000134001	EIF2S1	100	94.286	ENSNBRG00000022223	eif2s1b	100	94.286	Neolamprologus_brichardi
ENSG00000134001	EIF2S1	100	100.000	ENSNLEG00000000647	EIF2S1	100	100.000	Nomascus_leucogenys
ENSG00000134001	EIF2S1	100	81.270	ENSMEUG00000011775	EIF2S1	100	81.270	Notamacropus_eugenii
ENSG00000134001	EIF2S1	100	96.190	ENSOPRG00000004520	EIF2S1	100	96.190	Ochotona_princeps
ENSG00000134001	EIF2S1	100	98.901	ENSODEG00000013168	EIF2S1	100	98.730	Octodon_degus
ENSG00000134001	EIF2S1	100	94.603	ENSONIG00000005931	eif2s1b	100	94.603	Oreochromis_niloticus
ENSG00000134001	EIF2S1	100	97.802	ENSOANG00000005409	EIF2S1	100	97.778	Ornithorhynchus_anatinus
ENSG00000134001	EIF2S1	100	99.267	ENSOCUG00000012023	EIF2S1	100	99.048	Oryctolagus_cuniculus
ENSG00000134001	EIF2S1	100	94.286	ENSORLG00015011304	eif2s1	100	94.286	Oryzias_latipes_hsok
ENSG00000134001	EIF2S1	100	94.139	ENSOMEG00000023124	eif2s1b	84	94.161	Oryzias_melastigma
ENSG00000134001	EIF2S1	100	99.267	ENSOGAG00000030230	EIF2S1	100	99.048	Otolemur_garnettii
ENSG00000134001	EIF2S1	100	99.267	ENSOARG00000021166	EIF2S1	100	98.730	Ovis_aries
ENSG00000134001	EIF2S1	100	100.000	ENSPPAG00000041464	EIF2S1	100	100.000	Pan_paniscus
ENSG00000134001	EIF2S1	100	98.901	ENSPPRG00000000944	EIF2S1	100	98.730	Panthera_pardus
ENSG00000134001	EIF2S1	100	98.901	ENSPTIG00000019576	EIF2S1	100	98.730	Panthera_tigris_altaica
ENSG00000134001	EIF2S1	100	100.000	ENSPTRG00000006462	EIF2S1	100	100.000	Pan_troglodytes
ENSG00000134001	EIF2S1	100	100.000	ENSPANG00000017559	EIF2S1	100	100.000	Papio_anubis
ENSG00000134001	EIF2S1	100	93.968	ENSPKIG00000007541	eif2s1a	100	93.968	Paramormyrops_kingsleyae
ENSG00000134001	EIF2S1	100	97.802	ENSPSIG00000014235	EIF2S1	100	97.460	Pelodiscus_sinensis
ENSG00000134001	EIF2S1	100	94.139	ENSPMGG00000015736	eif2s1a	77	94.161	Periophthalmus_magnuspinnatus
ENSG00000134001	EIF2S1	100	98.535	ENSPEMG00000008092	Eif2s1	100	98.095	Peromyscus_maniculatus_bairdii
ENSG00000134001	EIF2S1	100	90.476	ENSPMAG00000006991	-	99	90.032	Petromyzon_marinus
ENSG00000134001	EIF2S1	100	97.802	ENSPCIG00000005216	EIF2S1	100	97.778	Phascolarctos_cinereus
ENSG00000134001	EIF2S1	100	94.286	ENSPFOG00000018787	eif2s1b	100	94.286	Poecilia_formosa
ENSG00000134001	EIF2S1	100	94.286	ENSPLAG00000005484	eif2s1b	100	94.286	Poecilia_latipinna
ENSG00000134001	EIF2S1	100	94.286	ENSPMEG00000012501	eif2s1b	100	94.286	Poecilia_mexicana
ENSG00000134001	EIF2S1	100	94.139	ENSPREG00000008596	eif2s1b	88	94.161	Poecilia_reticulata
ENSG00000134001	EIF2S1	100	100.000	ENSPPYG00000005921	EIF2S1	100	100.000	Pongo_abelii
ENSG00000134001	EIF2S1	100	82.540	ENSPCAG00000002613	EIF2S1	100	82.540	Procavia_capensis
ENSG00000134001	EIF2S1	100	91.111	ENSPCOG00000020641	-	100	91.111	Propithecus_coquereli
ENSG00000134001	EIF2S1	100	73.651	ENSPCOG00000018237	-	75	98.969	Propithecus_coquereli
ENSG00000134001	EIF2S1	100	76.190	ENSPCOG00000019568	-	100	76.190	Propithecus_coquereli
ENSG00000134001	EIF2S1	100	94.603	ENSPVAG00000003040	EIF2S1	100	94.603	Pteropus_vampyrus
ENSG00000134001	EIF2S1	100	93.968	ENSPNYG00000023310	eif2s1b	100	93.968	Pundamilia_nyererei
ENSG00000134001	EIF2S1	100	93.968	ENSPNAG00000012003	eif2s1b	100	93.968	Pygocentrus_nattereri
ENSG00000134001	EIF2S1	100	94.603	ENSPNAG00000013676	eif2s1a	100	94.603	Pygocentrus_nattereri
ENSG00000134001	EIF2S1	100	99.267	ENSRNOG00000009432	Eif2s1	100	99.048	Rattus_norvegicus
ENSG00000134001	EIF2S1	100	100.000	ENSRBIG00000043190	EIF2S1	100	100.000	Rhinopithecus_bieti
ENSG00000134001	EIF2S1	100	100.000	ENSRROG00000030203	EIF2S1	93	100.000	Rhinopithecus_roxellana
ENSG00000134001	EIF2S1	100	55.109	YJR007W	-	99	53.074	Saccharomyces_cerevisiae
ENSG00000134001	EIF2S1	100	99.683	ENSSBOG00000036115	EIF2S1	100	99.683	Saimiri_boliviensis_boliviensis
ENSG00000134001	EIF2S1	100	98.168	ENSSHAG00000009815	EIF2S1	100	98.095	Sarcophilus_harrisii
ENSG00000134001	EIF2S1	100	94.139	ENSSFOG00015002443	EIF2S1	88	93.968	Scleropages_formosus
ENSG00000134001	EIF2S1	100	93.407	ENSSFOG00015020235	eif2s1a	100	93.016	Scleropages_formosus
ENSG00000134001	EIF2S1	100	94.603	ENSSMAG00000002566	eif2s1b	100	94.603	Scophthalmus_maximus
ENSG00000134001	EIF2S1	100	93.968	ENSSDUG00000003859	eif2s1b	100	93.968	Seriola_dumerili
ENSG00000134001	EIF2S1	100	93.968	ENSSLDG00000024556	eif2s1b	100	93.968	Seriola_lalandi_dorsalis
ENSG00000134001	EIF2S1	100	98.901	ENSSARG00000011682	EIF2S1	100	98.730	Sorex_araneus
ENSG00000134001	EIF2S1	100	96.337	ENSSPUG00000013723	EIF2S1	100	96.190	Sphenodon_punctatus
ENSG00000134001	EIF2S1	100	93.333	ENSSPAG00000016141	eif2s1b	100	93.333	Stegastes_partitus
ENSG00000134001	EIF2S1	100	99.267	ENSSSCG00000033295	EIF2S1	100	99.048	Sus_scrofa
ENSG00000134001	EIF2S1	100	97.802	ENSTGUG00000011542	EIF2S1	100	97.460	Taeniopygia_guttata
ENSG00000134001	EIF2S1	100	92.381	ENSTRUG00000017958	eif2s1b	100	92.381	Takifugu_rubripes
ENSG00000134001	EIF2S1	100	93.333	ENSTNIG00000012223	eif2s1b	100	93.333	Tetraodon_nigroviridis
ENSG00000134001	EIF2S1	100	71.795	ENSTBEG00000010682	EIF2S1	100	71.898	Tupaia_belangeri
ENSG00000134001	EIF2S1	100	88.254	ENSTTRG00000015806	EIF2S1	100	88.254	Tursiops_truncatus
ENSG00000134001	EIF2S1	100	98.901	ENSUAMG00000008939	EIF2S1	100	98.730	Ursus_americanus
ENSG00000134001	EIF2S1	100	98.901	ENSUMAG00000010637	EIF2S1	100	98.730	Ursus_maritimus
ENSG00000134001	EIF2S1	100	86.984	ENSVPAG00000005698	EIF2S1	100	86.984	Vicugna_pacos
ENSG00000134001	EIF2S1	100	99.267	ENSVVUG00000000639	EIF2S1	100	99.048	Vulpes_vulpes
ENSG00000134001	EIF2S1	100	87.912	ENSXETG00000011221	eif2s1	100	87.107	Xenopus_tropicalis
ENSG00000134001	EIF2S1	100	94.286	ENSXCOG00000002210	eif2s1b	100	94.286	Xiphophorus_couchianus
ENSG00000134001	EIF2S1	100	94.286	ENSXMAG00000017281	eif2s1b	100	94.286	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003743	translation initiation factor activity	21873635.	IBA	Function
GO:0003743	translation initiation factor activity	16289705.	IDA	Function
GO:0005515	protein binding	9431994.11500362.16288713.16932749.17894550.18596238.18971339.22323517.25393282.	IPI	Function
GO:0005634	nucleus	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005844	polysome	2948954.	TAS	Component
GO:0005850	eukaryotic translation initiation factor 2 complex	21873635.	IBA	Component
GO:0005850	eukaryotic translation initiation factor 2 complex	23063529.	IDA	Component
GO:0005851	eukaryotic translation initiation factor 2B complex	21873635.	IBA	Component
GO:0005851	eukaryotic translation initiation factor 2B complex	11323413.	IDA	Component
GO:0006413	translational initiation	-	TAS	Process
GO:0007568	aging	-	IEA	Process
GO:0010494	cytoplasmic stress granule	-	ISS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0032057	negative regulation of translational initiation in response to stress	-	ISS	Process
GO:0033290	eukaryotic 48S preinitiation complex	21873635.	IBA	Component
GO:0034063	stress granule assembly	-	ISS	Process
GO:0034198	cellular response to amino acid starvation	-	ISS	Process
GO:0034599	cellular response to oxidative stress	-	ISS	Process
GO:0034605	cellular response to heat	-	IEA	Process
GO:0034644	cellular response to UV	-	ISS	Process
GO:0034976	response to endoplasmic reticulum stress	18508033.	IMP	Process
GO:0034976	response to endoplasmic reticulum stress	-	ISS	Process
GO:0036499	PERK-mediated unfolded protein response	22934019.	NAS	Process
GO:0043022	ribosome binding	21873635.	IBA	Function
GO:0043022	ribosome binding	17894550.	IDA	Function
GO:0043614	multi-eIF complex	21873635.	IBA	Component
GO:0044207	translation initiation ternary complex	-	IEA	Component
GO:0045202	synapse	-	IEA	Component
GO:0046777	protein autophosphorylation	-	IEA	Process
GO:0055085	transmembrane transport	-	TAS	Process
GO:0070062	extracellular exosome	20458337.	HDA	Component
GO:0097451	glial limiting end-foot	-	IEA	Component
GO:1901216	positive regulation of neuron death	18508033.	IMP	Process
GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity	-	IEA	Process
GO:1990737	response to manganese-induced endoplasmic reticulum stress	-	IEA	Process
GO:2000676	positive regulation of type B pancreatic cell apoptotic process	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
27272779	Activation of the PERK-eIF2α Pathway Is Associated with Tumor-infiltrating Lymphocytes in HER2-Positive Breast Cancer.	Anticancer Res	2016 Jun	Kim JY	-
17113348	Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera.	Clin Immunol	2007 Mar	Xiong Z	-
24609900	Translational regulator eIF2α in tumor.	Tumour Biol	2014 Jul	Zheng Q	doi: 10.1007/s13277-014-1789-0
27211800	The Role of the PERK/eIF2α/ATF4/CHOP Signaling Pathway in Tumor Progression During Endoplasmic Reticulum Stress.	Curr Mol Med	2016	Rozpedek W	-
25576733	Hepsin inhibits CDK11p58 IRES activity by suppressing unr expression and eIF-2α phosphorylation in prostate cancer.	Cell Signal	2015 Apr	Zhang C	doi: 10.1016/j.cellsig.2014.12.020
24204783	Eukaryotic initiation factor 2α--a downstream effector of mammalian target of rapamycin--modulates DNA repair and cancer response to treatment.	PLoS One	2013 Oct 25	Tuval-Kochen L	doi: 10.1371/journal.pone.0077260
22102852	The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer.	PLoS One	2011	He Y	doi: 10.1371/journal.pone.0024855
12186496	Expression of eukaryotic translation initiation factors 4E and 2alpha correlates with the progression of thyroid carcinoma.	Thyroid	2001 Dec	Wang S	-
26283179	OLA1 regulates protein synthesis and integrated stress response by inhibiting eIF2 ternary complex formation.	Sci Rep	2015 Aug 18	Chen H	doi: 10.1038/srep13241.
26898246	A microRNA-mediated decrease in eukaryotic initiation factor 2α promotes cell survival during PS-341 treatment.	Sci Rep	2016 Feb 22	Jiang L	doi: 10.1038/srep21565.
21090173	Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells.	Mol Biol (Mosk)	2010 Sep-Oct	Yerlikaya A	-
28294178	Phosphorylated eIF2α predicts disease-free survival in triple-negative breast cancer patients.	Sci Rep	2017 Mar 15	Guo L	doi: 10.1038/srep44674.

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
BLCA	chr14	67382555	Missense_Mutation	novel	E263Q	0.16
BLCA	chr14	67380667	Missense_Mutation	novel	S161F	0.49
BLCA	chr14	67376532	Missense_Mutation	novel	D139N	0.24
BLCA	chr14	67381643	Missense_Mutation	novel	A211P	0.42
BLCA	chr14	67382479	Missense_Mutation	novel	M237I	0.32
BRCA	chr14	67374519	Missense_Mutation	novel	C98S	0.11
BRCA	chr14	67380760	Missense_Mutation	NA	R192Q	0.29
BRCA	chr14	67364810	Missense_Mutation	NA	E15K	0.3	EIF_2_alpha
CESC	chr14	67383402	Missense_Mutation	NA	D304H	0.23
CESC	chr14	67380737	Missense_Mutation	NA	L184F	0.38
CESC	chr14	67364946	Missense_Mutation	novel	N60S	0.08
CESC	chr14	67376496	Silent	novel	L127L	0.42
CESC	chr14	67383339	Missense_Mutation	NA	E283K	0.23
COAD	chr14	67381606	Silent	NA	A198A	0.26
COAD	chr14	67383483	3'UTR	novel		0.34
COAD	chr14	67383546	3'UTR	novel		0.56
COAD	chr14	67374479	Missense_Mutation	NA	L85V	0.36
ESCA	chr14	67382590	In_Frame_Ins	novel	P275_K276dup	0.07
ESCA	chr14	67382591	Splice_Site	novel	X274_splice	0.07
ESCA	chr14	67376585	Silent	novel	A156A	0.26
HNSC	chr14	67383353	Silent	rs55950335	A287A	0.1
HNSC	chr14	67376585	Silent	novel	A156A	0.19
HNSC	chr14	67364902	Missense_Mutation	novel	M45I	0.15	EIF_2_alpha
LUSC	chr14	67364860	Silent	NA	G31G	0.19
LUSC	chr14	67382565	Missense_Mutation	novel	R266M	0.09
OV	chr14	67364770	Translation_Start_Site	NA	M1?	0.32
PRAD	chr14	67383370	Missense_Mutation	novel	L293P	0.37
READ	chr14	67382479	Missense_Mutation	NA	M237I	0.17
SKCM	chr14	67380672	Frame_Shift_Del	novel	*L163Ffs5**	0.37
SKCM	chr14	67382466	Missense_Mutation	novel	P233L	0.5
SKCM	chr14	67381646	Missense_Mutation	novel	L212I	0.06
STAD	chr14	67376442	Missense_Mutation	NA	Y109H	0.39
STAD	chr14	67365002	Missense_Mutation	NA	E79Q	0.2
STAD	chr14	67380751	Missense_Mutation	novel	V189D	0.07
STAD	chr14	67364897	Missense_Mutation	novel	G44C	0.16	EIF_2_alpha
THCA	chr14	67383504	3'UTR	novel		0.13
THCA	chr14	67383557	3'UTR	novel		0.29
THCA	chr14	67383558	3'UTR	novel		0.29
UCEC	chr14	67380759	Nonsense_Mutation	NA	R192*	0.36
UCEC	chr14	67383547	3'UTR	novel		0.27
UCEC	chr14	67381606	Silent	novel	A198A	0.41
UCEC	chr14	67383783	3'UTR	novel		0.26
UCEC	chr14	67382484	Missense_Mutation	novel	T239M	0.4
UCEC	chr14	67380687	Missense_Mutation	novel	L168V	0.08
UCEC	chr14	67383920	3'UTR	novel		0.32
UCEC	chr14	67383910	3'UTR	novel		0.38
UCEC	chr14	67376525	Missense_Mutation	novel	W136C	0.32
UCEC	chr14	67383352	Missense_Mutation	novel	A287V	0.43
UCEC	chr14	67383571	3'UTR	novel		0.47
UCEC	chr14	67386309	3'UTR	novel		0.33
UCEC	chr14	67376454	Missense_Mutation	novel	R113C	0.5
UCEC	chr14	67383976	3'UTR	novel		0.16
UCEC	chr14	67382484	Missense_Mutation	novel	T239M	0.44
UCEC	chr14	67383920	3'UTR	novel		0.35
UCEC	chr14	67380759	Nonsense_Mutation	NA	R192*	0.43
UCEC	chr14	67383932	3'UTR	novel		0.23
UCEC	chr14	67386167	3'UTR	novel		0.36
UCEC	chr14	67382573	Missense_Mutation	novel	F269V	0.12
UCEC	chr14	67383875	3'UTR	novel		0.36
UCEC	chr14	67376590	Missense_Mutation	novel	S158L	0.54
UCEC	chr14	67381602	Missense_Mutation	novel	V197A	0.16
UCEC	chr14	67382546	Missense_Mutation	novel	E260K	0.25
UCEC	chr14	67364771	Missense_Mutation	NA	P2S	0.19	EIF_2_alpha
UCEC	chr14	67376454	Missense_Mutation	novel	R113C	0.2
UCEC	chr14	67382463	Missense_Mutation	novel	P232L	0.57
UCEC	chr14	67383552	3'UTR	novel		0.44
UCEC	chr14	67383881	3'UTR	novel		0.27
UCS	chr14	67383527	3'UTR	novel		0.8
UCS	chr14	67380759	Nonsense_Mutation	NA	R192*	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
ACC	DEL	0.1333	0.19769
BRCA	DEL	0.2667	6.1292e-10
CHOL	DEL	0.5556	0.00040262
COAD	DEL	0.2882	0.050084
GBM	DEL	0.2756	5.7274e-07
KIRC	DEL	0.3807	0.0074281
KIRP	DEL	0.1667	0.085174
LGG	DEL	0.2086	1.1681e-13
MESO	DEL	0.4138	0.088547
OV	DEL	0.4732	6.0694e-08
PAAD	DEL	0.0598	0.11332
READ	DEL	0.3576	0.189
SARC	DEL	0.2918	0.0013077

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.00015	Kaplan-Meier Survival Analysis
MESO	0.0053	Kaplan-Meier Survival Analysis
ACC	0.00013	Kaplan-Meier Survival Analysis
HNSC	0.00066	Kaplan-Meier Survival Analysis
KIRP	0.0051	Kaplan-Meier Survival Analysis
PAAD	0.00029	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
BLCA	0.0034	Kaplan-Meier Survival Analysis
CESC	0.0085	Kaplan-Meier Survival Analysis
LAML	0.0056	Kaplan-Meier Survival Analysis
KICH	0.017	Kaplan-Meier Survival Analysis
GBM	0.03	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
THCA	0.027	Kaplan-Meier Survival Analysis
LUAD	0.00012	Kaplan-Meier Survival Analysis
UVM	0.0021	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742