EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000134247 (Gene tree)
Gene ID: 5738
Gene Symbol: PTGFRN
Alias: FPRP|EWI-F|CD9P-1|FLJ11001|KIAA1436|SMAP-6|CD315
Full Name: prostaglandin F2 receptor inhibitor
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 80,436 bases
Position: chr1:116,909,923-116,990,358
Accession: 9601
RBP type: non-canonical RBP
Summary: (Prostaglandin F2 Receptor Inhibitor) is a Protein Coding gene. An important paralog of this gene is IGSF3.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496699	PTGFRN-202	553	-	-	- (aa)	-	-
ENST00000393203	PTGFRN-201	6178	XM_017001874	ENSP00000376899	879 (aa)	XP_016857363	Q9P2B2
ENST00000497385	PTGFRN-203	457	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000134247's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134247	Albumins	5.4690000E-005	-
ENSG00000134247	Erectile Dysfunction	6E-7	20932654
ENSG00000134247	Prostatic Neoplasms	6E-7	20932654
ENSG00000134247	Electromagnetic Radiation	6E-7	20932654

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134247	rs77786465	1	116969182	C	Blood protein levels	29875488	[0.45-0.61] unit decrease	0.53	EFO_0007937
ENSG00000134247	rs4233450	1	116947639	T	Blood protein levels	29875488	[0.94-1.06] unit increase	1	EFO_0007937
ENSG00000134247	rs4546904	1	116945089	A	Blood protein levels	29875488	[1.18-1.34] unit increase	1.26	EFO_0007937
ENSG00000134247	rs2806864	1	116927159	?	Erectile dysfunction and prostate cancer treatment	20932654	[NR]	6.42	GO_0009314\|EFO_0001663\|EFO_0004234
ENSG00000134247	rs1127655	1	116987885	C	Type 2 diabetes	30054458	[0.028-0.059] unit increase	0.0438	EFO_0001360
ENSG00000134247	rs4233450	1	116947639	T	Blood protein levels	30072576	[0.42-0.54] unit increase	0.478	EFO_0007937

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134247's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	11278880.	IPI	Function
GO:0005789	endoplasmic reticulum membrane	-	IEA	Component
GO:0005794	Golgi apparatus	-	IEA	Component
GO:0009986	cell surface	19581412.	HDA	Component
GO:0014905	myoblast fusion involved in skeletal muscle regeneration	-	ISS	Process
GO:0016021	integral component of membrane	21873635.	IBA	Component
GO:0034389	lipid droplet organization	-	IEA	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
21206492	CD9P-1 expression correlates with the metastatic status of lung cancer, and a truncated form of CD9P-1, GS-168AT2, inhibits in vivo tumour growth.	Br J Cancer	2011 Feb 1	Guilmain W	doi: 10.1038/sj.bjc.6606033

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
BLCA	chr1	116967214	Nonsense_Mutation	novel	S648*	0.25
BLCA	chr1	116961511	Frame_Shift_Ins	novel	*T495Nfs46**	0.19
BLCA	chr1	116961554	Missense_Mutation	NA	D509H	0.06
BLCA	chr1	116967058	Missense_Mutation	novel	L596R	0.42
BLCA	chr1	116986877	Silent	rs748854692	I850I	0.39
BLCA	chr1	116987032	3'UTR	novel		0.1
BLCA	chr1	116986991	3'UTR	novel		0.3
BLCA	chr1	116949243	Missense_Mutation	novel	L295Q	0.25
BLCA	chr1	116961323	Missense_Mutation	novel	V432L	0.25
BRCA	chr1	116949387	Missense_Mutation	rs201175251	S343L	0.13
BRCA	chr1	116967015	Missense_Mutation	NA	R582C	0.24
BRCA	chr1	116984682	Missense_Mutation	NA	D724H	0.12
BRCA	chr1	116984929	Nonsense_Mutation	novel	W806*	0.09
BRCA	chr1	116961412	Silent	rs147606477	S461S	0.27
BRCA	chr1	116941952	Missense_Mutation	NA	R96Q	0.18
BRCA	chr1	116984842	Missense_Mutation	novel	L777W	0.1
BRCA	chr1	116966945	Missense_Mutation	novel	K558N	0.34
CESC	chr1	116987023	3'UTR	novel		0.23
CESC	chr1	116949293	Missense_Mutation	rs773910797	E312K	0.12
CESC	chr1	116967296	Silent	NA	L675L	0.42
CESC	chr1	116987104	3'UTR	novel		0.21
CESC	chr1	116967029	Silent	NA	L586L	0.27
CESC	chr1	116944725	Silent	rs745433963	P155P	0.44
CESC	chr1	116986926	Missense_Mutation	rs140355100	R867W	0.33
CESC	chr1	116967296	Silent	NA	L675L	0.35
CESC	chr1	116990133	3'UTR	novel		0.11
CESC	chr1	116984694	Missense_Mutation	NA	D728N	0.24
CESC	chr1	116988419	3'UTR	novel		0.1
CESC	chr1	116967106	Missense_Mutation	NA	S612F	0.35
CESC	chr1	116967328	Nonsense_Mutation	NA	S686*	0.38
CESC	chr1	116944958	Missense_Mutation	novel	S233L	0.55
CESC	chr1	116941791	Silent	novel	P42P	0.14
CHOL	chr1	116988643	3'UTR	novel		0.17
COAD	chr1	116961371	Missense_Mutation	novel	Y448H	0.37
COAD	chr1	116944705	Missense_Mutation	novel	P149S	0.35
COAD	chr1	116966932	Missense_Mutation	NA	A554V	0.32
COAD	chr1	116986809	Missense_Mutation	NA	A828T	0.35
COAD	chr1	116941818	Silent	NA	P51P	0.32
COAD	chr1	116961408	Missense_Mutation	NA	T460I	0.27
COAD	chr1	116961330	Missense_Mutation	rs372487027	T434M	0.46
COAD	chr1	116961444	Missense_Mutation	rs371176280	T472M	0.42
COAD	chr1	116944926	Silent	rs768573793	L222L	0.37
COAD	chr1	116966953	Missense_Mutation	novel	F561Y	0.1
COAD	chr1	116974223	Missense_Mutation	NA	I689M	0.17
COAD	chr1	116941729	Missense_Mutation	NA	R22C	0.38
COAD	chr1	116949253	Silent	NA	T298T	0.28
COAD	chr1	116984899	Missense_Mutation	NA	T796I	0.45
COAD	chr1	116944951	Missense_Mutation	novel	R231C	0.15
COAD	chr1	116942027	Frame_Shift_Del	novel	*S123Afs35**	0.15
COAD	chr1	116949388	Silent	novel	S343S	0.06
COAD	chr1	116941989	Silent	rs757606870	N108N	0.13
COAD	chr1	116944901	Missense_Mutation	NA	R214H	0.28
COAD	chr1	116941962	Silent	NA	N99N	0.29
COAD	chr1	116941752	Silent	rs375720205	A29A	0.16
COAD	chr1	116961524	Missense_Mutation	NA	N499H	0.23
COAD	chr1	116944981	Missense_Mutation	NA	D241N	0.24
COAD	chr1	116949490	Silent	novel	L377L	0.27
DLBC	chr1	116949517	Nonsense_Mutation	novel	W386*	0.1
DLBC	chr1	116949287	Missense_Mutation	rs560392261	R310W	0.33
GBM	chr1	116967196	Missense_Mutation	novel	M642K	0.07
GBM	chr1	116967197	Missense_Mutation	NA	M642I	0.06
GBM	chr1	116942021	Missense_Mutation	NA	C119F	0.3
GBM	chr1	116961362	Missense_Mutation	novel	V445I	0.18
GBM	chr1	116984947	Missense_Mutation	novel	I812T	0.07
GBM	chr1	116949464	Missense_Mutation	novel	G369S	0.61
GBM	chr1	116966911	Missense_Mutation	novel	D547G	0.2
GBM	chr1	116967253	Frame_Shift_Del	novel	*S661Ffs21**	0.11
GBM	chr1	116941953	Silent	novel	R96R	0.36
HNSC	chr1	116967207	Missense_Mutation	rs140095202	Q646E	0.06
HNSC	chr1	116984810	Silent	novel	L766L	0.38
HNSC	chr1	116961612	Missense_Mutation	novel	W528L	0.4
HNSC	chr1	116961274	Silent	novel	S415S	0.27
HNSC	chr1	116945041	Missense_Mutation	novel	E261K	0.16
HNSC	chr1	116944845	Silent	novel	S195S	0.27
HNSC	chr1	116961344	Missense_Mutation	novel	A439S	0.21
HNSC	chr1	116949388	Silent	novel	S343S	0.1
HNSC	chr1	116941762	Nonsense_Mutation	rs537971311	R33*	0.13
HNSC	chr1	116941962	Silent	NA	N99N	0.15
KIRC	chr1	116949236	Missense_Mutation	NA	K293E	0.56
KIRC	chr1	116974256	Silent	novel	S700S	0.37
KIRP	chr1	116961575	Missense_Mutation	novel	V516I	0.39
LGG	chr1	116945040	Silent	NA	Q260Q	0.45
LGG	chr1	116961573	Missense_Mutation	rs753357980	C515S	0.34
LGG	chr1	116967187	Missense_Mutation	rs771569415	R639H	0.43
LGG	chr1	116967326	Silent	novel	T685T	0.11
LGG	chr1	116987023	3'UTR	novel		0.07
LUAD	chr1	116984700	Missense_Mutation	novel	S730P	0.13
LUAD	chr1	116967118	Missense_Mutation	NA	L616P	0.17
LUAD	chr1	116961415	Missense_Mutation	NA	E462D	0.25
LUAD	chr1	116961514	Silent	NA	T495T	0.21
LUAD	chr1	116967226	Missense_Mutation	novel	L652R	0.51
LUAD	chr1	116967182	Missense_Mutation	novel	E637D	0.4
LUAD	chr1	116949357	Missense_Mutation	NA	R333L	0.23
LUAD	chr1	116949355	Silent	rs745764390	A332A	0.18
LUAD	chr1	116949441	Missense_Mutation	NA	R361L	0.24
LUSC	chr1	116984742	Missense_Mutation	NA	V744L	0.33
LUSC	chr1	116967216	Missense_Mutation	novel	D649Y	0.53
LUSC	chr1	116949356	Missense_Mutation	rs141382228	R333W	0.2
LUSC	chr1	116967108	Missense_Mutation	novel	V613L	0.32
OV	chr1	116967056	Missense_Mutation	novel	D595E	0.06
OV	chr1	116974217	Splice_Region	novel	G687G	0.06
OV	chr1	116945074	Missense_Mutation	novel	V272M	0.29
OV	chr1	116941730	Missense_Mutation	novel	R22L	0.06
OV	chr1	116966991	Missense_Mutation	novel	S574T	0.26
PRAD	chr1	116986926	Missense_Mutation	rs140355100	R867W	0.33
PRAD	chr1	116974234	Missense_Mutation	NA	S693Y	0.36
PRAD	chr1	116941965	Silent	rs772638079	D100D	0.19
READ	chr1	116966943	Missense_Mutation	novel	K558Q	0.44
READ	chr1	116967193	Missense_Mutation	NA	R641Q	0.18
SARC	chr1	116987669	3'UTR	novel		0.07
SARC	chr1	116941843	Missense_Mutation	novel	F60L	0.37
SARC	chr1	116967182	Silent	novel	E637E	0.47
SARC	chr1	116990262	3'UTR	novel		0.16
SKCM	chr1	116944691	Missense_Mutation	NA	S144F	0.3
SKCM	chr1	116941776	Silent	novel	T37T	0.15
SKCM	chr1	116986891	Missense_Mutation	NA	S855F	0.26
SKCM	chr1	116961412	Silent	rs147606477	S461S	0.28
SKCM	chr1	116944924	Missense_Mutation	novel	L222F	0.63
SKCM	chr1	116961366	Missense_Mutation	rs749956453	S446L	0.68
SKCM	chr1	116974267	Missense_Mutation	novel	G704A	0.32
SKCM	chr1	116961530	Missense_Mutation	NA	R501W	0.28
SKCM	chr1	116966995	Missense_Mutation	NA	S575F	0.19
SKCM	chr1	116945057	Missense_Mutation	rs137888350	A266V	0.23
SKCM	chr1	116961366	Missense_Mutation	rs749956453	S446L	0.23
SKCM	chr1	116961346	Silent	rs375627235	A439A	0.23
SKCM	chr1	116961645	Missense_Mutation	novel	V539A	0.38
SKCM	chr1	116949292	Silent	rs140719535	P311P	0.27
SKCM	chr1	116944781	Missense_Mutation	NA	A174V	0.6
SKCM	chr1	116966915	Silent	rs779183691	S548S	0.3
SKCM	chr1	116967066	Missense_Mutation	NA	P599S	0.33
SKCM	chr1	116961665	Missense_Mutation	novel	E546K	0.24
SKCM	chr1	116984901	Missense_Mutation	rs532216050	P797S	0.17
SKCM	chr1	116967270	Missense_Mutation	NA	L667F	0.23
SKCM	chr1	116949291	Missense_Mutation	NA	P311L	0.13
SKCM	chr1	116949365	Missense_Mutation	rs749073852	R336C	0.58
SKCM	chr1	116941744	Missense_Mutation	NA	P27S	0.26
STAD	chr1	116986968	3'UTR	novel		0.31
STAD	chr1	116949354	Missense_Mutation	rs781003149	A332V	0.13
STAD	chr1	116941936	Missense_Mutation	rs769663692	E91K	0.28
STAD	chr1	116944852	Missense_Mutation	rs761726439	A198T	0.29
STAD	chr1	116942016	Silent	novel	Y117Y	0.46
STAD	chr1	116942027	Frame_Shift_Del	novel	*S123Afs35**	0.22
STAD	chr1	116961656	Nonsense_Mutation	novel	W543*	0.08
STAD	chr1	116945092	Missense_Mutation	NA	V278F	0.07
STAD	chr1	116949292	Silent	rs140719535	P311P	0.12
STAD	chr1	116941835	Missense_Mutation	novel	D57G	0.4
STAD	chr1	116949297	Missense_Mutation	novel	V313A	0.35
STAD	chr1	116961294	Missense_Mutation	novel	D422V	0.05
STAD	chr1	116967043	Missense_Mutation	NA	K591R	0.26
STAD	chr1	116967152	Silent	rs779715817	G627G	0.08
STAD	chr1	116961473	Missense_Mutation	rs767876294	R482W	0.18
STAD	chr1	116987013	3'UTR	novel		0.21
STAD	chr1	116949500	Missense_Mutation	rs150341125	G381R	0.1
STAD	chr1	116949309	Missense_Mutation	novel	F317Y	0.45
STAD	chr1	116974272	Silent	novel	L706L	0.17
STAD	chr1	116949523	Missense_Mutation	NA	K388N	0.32
UCEC	chr1	116967092	Silent	novel	S607S	0.21
UCEC	chr1	116987603	3'UTR	novel		0.18
UCEC	chr1	116989918	3'UTR	novel		0.4
UCEC	chr1	116967091	Missense_Mutation	NA	S607F	0.37
UCEC	chr1	116974263	Missense_Mutation	rs199657269	R703W	0.32
UCEC	chr1	116987152	3'UTR	novel		0.33
UCEC	chr1	116987032	3'UTR	novel		0.41
UCEC	chr1	116989658	3'UTR	novel		0.37
UCEC	chr1	116966960	Silent	rs746791474	A563A	0.5
UCEC	chr1	116945057	Missense_Mutation	rs137888350	A266V	0.39
UCEC	chr1	116989600	3'UTR	novel		0.17
UCEC	chr1	116974263	Missense_Mutation	rs199657269	R703W	0.05
UCEC	chr1	116961353	Nonsense_Mutation	rs763937461	R442*	0.35
UCEC	chr1	116945027	Missense_Mutation	novel	Q256L	0.15
UCEC	chr1	116949481	Silent	rs771592911	H374H	0.19
UCEC	chr1	116949273	Missense_Mutation	NA	R305Q	0.47
UCEC	chr1	116961473	Missense_Mutation	rs767876294	R482W	0.51
UCEC	chr1	116984974	Missense_Mutation	NA	V821A	0.43
UCEC	chr1	116986832	Silent	rs765377157	I835I	0.44
UCEC	chr1	116967276	Nonsense_Mutation	NA	R669*	0.66
UCEC	chr1	116961389	Missense_Mutation	NA	R454C	0.42
UCEC	chr1	116988558	3'UTR	rs35107839		0.38
UCEC	chr1	116949328	Silent	novel	S323S	0.25
UCEC	chr1	116988385	3'UTR	novel		0.19
UCEC	chr1	116988720	3'UTR	novel		0.14
UCEC	chr1	116941754	Missense_Mutation	novel	T30I	0.27
UCEC	chr1	116941969	Missense_Mutation	rs765722452	V102M	0.42
UCEC	chr1	116949354	Missense_Mutation	rs781003149	A332V	0.36
UCEC	chr1	116949461	Missense_Mutation	novel	S368P	0.28
UCEC	chr1	116986925	Silent	novel	T866T	0.22
UCEC	chr1	116987480	3'UTR	novel		0.41
UCEC	chr1	116988815	3'UTR	novel		0.46
UCEC	chr1	116988817	3'UTR	novel		0.46
UCEC	chr1	116989468	3'UTR	rs543755669		0.14
UCEC	chr1	116974219	Missense_Mutation	novel	P688L	0.29
UCEC	chr1	116988622	3'UTR	novel		0.07
UCEC	chr1	116989572	3'UTR	novel		0.65
UCEC	chr1	116989664	3'UTR	novel		0.44
UCEC	chr1	116949214	Missense_Mutation	novel	K285N	0.18
UCEC	chr1	116989828	3'UTR	novel		0.56
UCEC	chr1	116989778	3'UTR	novel		0.34
UCEC	chr1	116987197	3'UTR	novel		0.38
UCEC	chr1	116989901	3'UTR	novel		0.16
UCEC	chr1	116944931	Missense_Mutation	novel	T224I	0.42
UCEC	chr1	116989711	3'UTR	rs570221680		0.4
UCEC	chr1	116989594	3'UTR	novel		0.37
UCEC	chr1	116987496	3'UTR	novel		0.38
UCEC	chr1	116961308	Silent	novel	L427L	0.62
UCEC	chr1	116987130	3'UTR	novel		0.45
UCEC	chr1	116961524	Missense_Mutation	rs145469544	N499D	0.37
UCEC	chr1	116944714	Missense_Mutation	novel	R152W	0.32
UCEC	chr1	116987554	3'UTR	novel		0.67
UCEC	chr1	116987789	3'UTR	novel		0.4
UCEC	chr1	116986931	Silent	rs763120740	R868R	0.46
UCEC	chr1	116961437	Missense_Mutation	novel	D470Y	0.07
UCEC	chr1	116974263	Missense_Mutation	rs199657269	R703W	0.19
UCEC	chr1	116987043	3'UTR	novel		0.15
UCEC	chr1	116987298	3'UTR	novel		0.21
UCEC	chr1	116990321	3'UTR	novel		0.19
UCEC	chr1	116941805	Missense_Mutation	novel	D47G	0.24
UCEC	chr1	116941892	Missense_Mutation	novel	V76A	0.24
UCEC	chr1	116984874	Nonsense_Mutation	novel	F788*	0.08
UCEC	chr1	116984875	Missense_Mutation	novel	F788C	0.03
UCEC	chr1	116941989	Silent	rs757606870	N108N	0.4
UCEC	chr1	116942042	Missense_Mutation	NA	A126V	0.2
UCEC	chr1	116987238	3'UTR	novel		0.55
UCEC	chr1	116961511	Frame_Shift_Ins	novel	*T495Gfs4**	0.07
UCEC	chr1	116984710	Missense_Mutation	rs775510089	A733V	0.21
UCEC	chr1	116989710	3'UTR	novel		0.46
UCEC	chr1	116988558	3'UTR	rs35107839		0.44
UCEC	chr1	116990044	3'UTR	novel		0.28
UCEC	chr1	116949387	Missense_Mutation	rs201175251	S343L	0.07
UCEC	chr1	116967306	Missense_Mutation	NA	I679V	0.09
UCEC	chr1	116990044	3'UTR	novel		0.44
UCEC	chr1	116944918	Missense_Mutation	novel	V220M	0.38
UCEC	chr1	116967076	Missense_Mutation	rs745646518	T602M	0.54
UCEC	chr1	116986975	3'UTR	rs373026059		0.36
UCEC	chr1	116944840	Missense_Mutation	novel	R194W	0.29
UCS	chr1	116941729	Missense_Mutation	NA	R22C	0.46
UCS	chr1	116949358	Silent	novel	R333R	0.44

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CESC	DEL	0.0983	0.01281
COAD	DEL	0.2084	0.00038973
DLBC	DEL	0.1875	0.0017831
HNSC	DEL	0.205	7.836e-19
LUAD	DEL	0.2306	2.5961e-13
LUSC	DEL	0.3832	1.8628e-17
READ	DEL	0.2606	0.013822
SKCM	DEL	0.1689	9.7877e-07
STAD	DEL	0.1655	0.0040659
TGCT	AMP	0.22	0.088103
UVM	DEL	0.2375	0.061261

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0057	Kaplan-Meier Survival Analysis
SARC	0.034	Kaplan-Meier Survival Analysis
ACC	0.0013	Kaplan-Meier Survival Analysis
SKCM	0.0073	Kaplan-Meier Survival Analysis
ESCA	0.021	Kaplan-Meier Survival Analysis
CESC	0.011	Kaplan-Meier Survival Analysis
KICH	0.0047	Kaplan-Meier Survival Analysis
LIHC	0.00044	Kaplan-Meier Survival Analysis
LUAD	0.0016	Kaplan-Meier Survival Analysis
UVM	0.017	Kaplan-Meier Survival Analysis