EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000134255 (Gene tree)
Gene ID: 10390
Gene Symbol: CEPT1
Alias: HCEPT1
Full Name: Choline/Ethanolamine Phosphotransferase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 45,478 bases
Position: chr1:111,139,627-111,185,104
Accession: 24289
RBP type: non-canonical RBP
Summary: This gene codes for a choline/ethanolaminephosphotransferase, which functions in the synthesis of choline- or ethanolamine- containing phospholipids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000498239	CEPT1-209	1957	-	-	- (aa)	-	-
ENST00000473474	CEPT1-204	764	-	-	- (aa)	-	-
ENST00000476865	CEPT1-205	783	-	-	- (aa)	-	-
ENST00000460443	CEPT1-202	851	-	-	- (aa)	-	-
ENST00000467362	CEPT1-203	5300	-	-	- (aa)	-	-
ENST00000545121	CEPT1-210	2251	XM_024450080	ENSP00000441980	416 (aa)	XP_024305848	Q9Y6K0
ENST00000483427	CEPT1-208	511	-	-	- (aa)	-	-
ENST00000480324	CEPT1-207	2110	-	-	- (aa)	-	-
ENST00000615636	CEPT1-211	1966	-	ENSP00000477632	280 (aa)	-	A0A0C4DGS9
ENST00000357172	CEPT1-201	2198	XM_011540496	ENSP00000349696	416 (aa)	XP_011538798	Q9Y6K0
ENST00000478042	CEPT1-206	2175	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000134255's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00440	Phosphonate and phosphinate metabolism	KEGG
hsa00564	Glycerophospholipid metabolism	KEGG
hsa00565	Ether lipid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134255	Platelet Function Tests	1.0013700E-005	-
ENSG00000134255	Interleukin-1beta	3.7960000E-005	-
ENSG00000134255	gamma-Glutamyltransferase	7E-9	22001757

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134255's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004142	diacylglycerol cholinephosphotransferase activity	21873635.	IBA	Function
GO:0004307	ethanolaminephosphotransferase activity	21873635.	IBA	Function
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0005794	Golgi apparatus	21873635.	IBA	Component
GO:0006629	lipid metabolic process	10191259.	TAS	Process
GO:0006646	phosphatidylethanolamine biosynthetic process	21873635.	IBA	Process
GO:0006646	phosphatidylethanolamine biosynthetic process	-	IEA	Process
GO:0006646	phosphatidylethanolamine biosynthetic process	-	TAS	Process
GO:0006656	phosphatidylcholine biosynthetic process	-	TAS	Process
GO:0006657	CDP-choline pathway	-	IEA	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016780	phosphotransferase activity, for other substituted phosphate groups	21873635.	IBA	Function
GO:0031965	nuclear membrane	-	IEA	Component
GO:0046872	metal ion binding	-	IEA	Function

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
28844958	Growth arrest and DNA damage-inducible 45α protects against nonalcoholic steatohepatitis induced by methionine- and choline-deficient diet.	Biochim Biophys Acta Mol Basis Dis	2017 Dec	Tanaka N	doi: 10.1016/j.bbadis.2017.08.017

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr1	111182861	Silent	novel	I303I	0.5
BLCA	chr1	111184202	Missense_Mutation	novel	F381L	0.15
BLCA	chr1	111147871	Nonsense_Mutation	novel	E53*	0.27
BLCA	chr1	111159536	Intron	novel		0.55
BRCA	chr1	111159404	Missense_Mutation	novel	C122S	0.07
BRCA	chr1	111182208	Missense_Mutation	NA	M246L	0.26
CESC	chr1	111184736	3'UTR	rs546551835		0.48
CESC	chr1	111161239	Missense_Mutation	novel	F191C	0.04
CESC	chr1	111184336	3'UTR	novel		0.13
CESC	chr1	111147862	Missense_Mutation	novel	R50W	0.26
CESC	chr1	111147863	Missense_Mutation	rs749655031	R50Q	0.17
COAD	chr1	111159639	Intron	novel		0.57
COAD	chr1	111184246	Missense_Mutation	NA	A396V	0.39
COAD	chr1	111161214	Frame_Shift_Del	NA	*C185Vfs26**	0.36
COAD	chr1	111161213	Frame_Shift_Ins	NA	*C185Lfs28**	0.43
COAD	chr1	111161188	Missense_Mutation	novel	Q174P	0.05
COAD	chr1	111148000	Missense_Mutation	NA	N96H	0.1
COAD	chr1	111159534	Splice_Region	novel		0.07
DLBC	chr1	111182242	Missense_Mutation	novel	G257E	0.26
GBM	chr1	111159630	Intron	novel		0.49
HNSC	chr1	111159442	Silent	novel	A134A	0.17
HNSC	chr1	111159465	Missense_Mutation	novel	R142I	0.26
HNSC	chr1	111183580	Frame_Shift_Del	novel	*I375Sfs8**	0.25
LAML	chr1	111182815	Frame_Shift_Del	novel	*S288Ffs9**	0.11
LGG	chr1	111183479	Silent	novel	K341K	0.21
LGG	chr1	111184246	Missense_Mutation	NA	A396V	0.05
LIHC	chr1	111161214	Frame_Shift_Del	NA	*C185Vfs26**	0.45
LIHC	chr1	111159658	Intron	novel		0.13
LIHC	chr1	111159396	Missense_Mutation	novel	Y119C	0.08
LUAD	chr1	111183569	Missense_Mutation	NA	I371M	0.09
LUSC	chr1	111147977	Missense_Mutation	novel	I88T	0.25
OV	chr1	111161207	Silent	rs567601468	D180D	0.43
OV	chr1	111184246	Missense_Mutation	NA	A396V	0.04
PAAD	chr1	111159491	Nonsense_Mutation	NA	E151*	0.28
PAAD	chr1	111147895	Missense_Mutation	novel	R61W	0.21
READ	chr1	111147698	5'UTR	rs560770564		0.57
READ	chr1	111161214	Frame_Shift_Del	NA	*C185Vfs26**	0.26
SKCM	chr1	111182245	Missense_Mutation	NA	T258I	0.29
SKCM	chr1	111147755	Missense_Mutation	novel	S14F	0.32
SKCM	chr1	111182817	Missense_Mutation	NA	P289S	0.21
SKCM	chr1	111184369	3'UTR	novel		0.15
SKCM	chr1	111147687	5'UTR	novel		0.31
SKCM	chr1	111147767	Missense_Mutation	novel	S18F	0.58
SKCM	chr1	111182193	Missense_Mutation	novel	V241M	0.42
STAD	chr1	111161213	Frame_Shift_Ins	NA	*C185Lfs28**	0.13
STAD	chr1	111161214	Frame_Shift_Del	NA	*C185Vfs26**	0.22
STAD	chr1	111183471	Missense_Mutation	rs757785358	M339V	0.33
STAD	chr1	111147698	5'UTR	rs560770564		0.45
STAD	chr1	111147862	Missense_Mutation	novel	R50W	0.41
STAD	chr1	111147698	5'UTR	rs560770564		0.48
STAD	chr1	111147797	Missense_Mutation	NA	T28I	0.06
STAD	chr1	111147940	Missense_Mutation	rs752416064	V76I	0.47
STAD	chr1	111182270	Silent	novel	F266F	0.56
STAD	chr1	111160954	Intron	novel		0.78
STAD	chr1	111161213	Frame_Shift_Ins	NA	*C185Lfs28**	0.09
THYM	chr1	111161214	Frame_Shift_Del	NA	*C185Vfs26**	0.31
UCEC	chr1	111184426	3'UTR	novel		0.24
UCEC	chr1	111161238	Missense_Mutation	novel	F191L	0.18
UCEC	chr1	111184336	3'UTR	novel		0.12
UCEC	chr1	111161214	Frame_Shift_Del	NA	*C185Vfs26**	0.13
UCEC	chr1	111147890	Missense_Mutation	rs773409190	A59V	0.53
UCEC	chr1	111182920	Missense_Mutation	novel	F323C	0.19
UCEC	chr1	111182802	Missense_Mutation	NA	T284A	0.09
UCEC	chr1	111160954	Intron	novel		0.64
UCEC	chr1	111147714	5'UTR	novel		0.15
UCEC	chr1	111161286	Nonsense_Mutation	novel	R207*	0.3
UCEC	chr1	111182186	Splice_Site	novel	X239_splice	0.35
UCEC	chr1	111147881	Missense_Mutation	novel	Y56C	0.4
UCEC	chr1	111185073	3'UTR	novel		0.41
UCEC	chr1	111184997	3'UTR	novel		0.06
UCEC	chr1	111182815	Missense_Mutation	novel	S288Y	0.13
UCEC	chr1	111184361	3'UTR	rs755761590		0.4
UCEC	chr1	111185063	3'UTR	novel		0.27
UCEC	chr1	111183517	Missense_Mutation	rs374219627	P354L	0.28
UCEC	chr1	111182271	Missense_Mutation	rs143162153	R267C	0.41
UCEC	chr1	111147727	Nonsense_Mutation	novel	R5*	0.5
UCEC	chr1	111182802	Missense_Mutation	NA	T284A	0.48
UCEC	chr1	111161157	Missense_Mutation	novel	F164V	0.11
UCEC	chr1	111182271	Missense_Mutation	rs143162153	R267C	0.47
UCEC	chr1	111184216	Missense_Mutation	rs778057254	R386H	0.06
UCEC	chr1	111161213	Frame_Shift_Ins	NA	*C185Lfs28**	0.28
UCEC	chr1	111147878	Missense_Mutation	novel	R55I	0.11
UCEC	chr1	111182271	Missense_Mutation	rs143162153	R267C	0.29
UCEC	chr1	111184246	Missense_Mutation	NA	A396V	0.25
UCEC	chr1	111147862	Missense_Mutation	novel	R50W	0.24
UCEC	chr1	111161254	Missense_Mutation	NA	A196V	0.3
UCEC	chr1	111159540	Intron	novel		0.2
UCEC	chr1	111159441	Missense_Mutation	NA	A134V	0.32
UCEC	chr1	111183475	Missense_Mutation	novel	T340M	0.4
UCEC	chr1	111174897	Silent	novel	V216V	0.48

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BRCA	DEL	0.2463	5.7821e-10
CESC	DEL	0.0881	0.01281
COAD	DEL	0.2195	0.00038973
DLBC	DEL	0.1042	0.0017831
LUAD	DEL	0.2364	2.5961e-13
MESO	DEL	0.3678	5.9874e-12
READ	DEL	0.2727	0.013822
SKCM	DEL	0.1717	9.7877e-07
STAD	DEL	0.1655	0.0040659
TGCT	AMP	0.1933	0.088103

Survival Analysis

Cancer	P-value	Q-value
KIRC	0.0015	Kaplan-Meier Survival Analysis
STAD	0.032	Kaplan-Meier Survival Analysis
MESO	0.031	Kaplan-Meier Survival Analysis
ACC	0.029	Kaplan-Meier Survival Analysis
SKCM	0.011	Kaplan-Meier Survival Analysis
PRAD	0.041	Kaplan-Meier Survival Analysis
KIRP	0.037	Kaplan-Meier Survival Analysis
PAAD	0.014	Kaplan-Meier Survival Analysis
READ	0.00026	Kaplan-Meier Survival Analysis
GBM	0.023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

PPI

Gene Ontology

Select Dataset :

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Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742