EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134308 (Gene tree)
Gene ID: 10971
Gene Symbol: YWHAQ
Alias: HS1|14-3-3
Full Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 47,089 bases
Position: chr2:9,583,967-9,631,055
Accession: 12854
RBP type: non-canonical RBP
Summary: This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
17018010	The proline-rich domain and the microtubule binding domain of protein tau acting as RNA binding domains.	Protein Pept Lett	2006	Wang X	-
16053712	Identification of p54(nrb) and the 14-3-3 Protein HS1 as TNF-alpha-inducible genes related to cell cycle control and apoptosis in human arterial endothelial cells.	J Biochem Mol Biol	2005 Jul 31	Stier S	-
31260737	Biomolecular condensation of the microtubule-associated protein tau.	Semin Cell Dev Biol	2019 Jul 4	Ukmar-Godec T	doi: 10.1016/j.semcdb.2019.06.007
21248138	Drosophila tao controls mushroom body development and ethanol-stimulated behavior through par-1.	J Neurosci	2011 Jan 19	King I	doi: 10.1523/JNEUROSCI.4416-10.2011.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000460093	YWHAQ-204	345	-	-	- (aa)	-	-
ENST00000446619	YWHAQ-203	665	-	ENSP00000398990	149 (aa)	-	E9PG15
ENST00000474715	YWHAQ-205	709	-	-	- (aa)	-	-
ENST00000381844	YWHAQ-202	2216	-	ENSP00000371267	245 (aa)	-	P27348
ENST00000238081	YWHAQ-201	2208	-	ENSP00000238081	245 (aa)	-	P27348

Gene Model

Click here to download ENSG00000134308's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa04151	PI3K-Akt signaling pathway	KEGG
hsa04390	Hippo signaling pathway	KEGG
hsa05130	Pathogenic Escherichia coli infection	KEGG
hsa05160	Hepatitis C	KEGG
hsa05161	Hepatitis B	KEGG
hsa05203	Viral carcinogenesis	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134308	Cholesterol, LDL	4.34076935891055E-8	17903299
ENSG00000134308	Heart Rate	6.8050755579474E-5	17903306
ENSG00000134308	Platelet Function Tests	1.2486500E-005	-
ENSG00000134308	Platelet Function Tests	1.2400000E-006	-
ENSG00000134308	Platelet Function Tests	6.0141074E-006	-
ENSG00000134308	3-hydroxy-1-methylpropylmercapturic acid	2E-7	26053186
ENSG00000134308	Smoking	2E-7	26053186
ENSG00000134308	Depressive Disorder	7E-7	27622933
ENSG00000134308	Serotonin Uptake Inhibitors	7E-7	27622933
ENSG00000134308	Mood Disorders	7E-7	27622933
ENSG00000134308	Cleft Lip	6E-9	28232668
ENSG00000134308	Cleft Palate	6E-9	28232668
ENSG00000134308	Diagnostic Self Evaluation	4E-6	20707712

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134308	rs55883249	2	9601406	?	3-hydroxy-1-methylpropylmercapturic acid levels in smokers	26053186	[NR] unit decrease	0.6204	EFO_0004318\|EFO_0007015

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134308's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134308	YWHAQ	98	77.406	WBGene00001502	ftt-2	96	77.406	Caenorhabditis_elegans
ENSG00000134308	YWHAQ	100	77.143	FBgn0004907	14-3-3zeta	99	77.143	Drosophila_melanogaster
ENSG00000134308	YWHAQ	99	81.818	ENSG00000166913	YWHAB	95	87.143	Homo_sapiens
ENSG00000134308	YWHAQ	100	79.592	ENSG00000164924	YWHAZ	100	90.196	Homo_sapiens
ENSG00000134308	YWHAQ	100	99.592	ENSMUSG00000076432	Ywhaq	100	99.592	Mus_musculus
ENSG00000134308	YWHAQ	100	80.000	ENSMUSG00000022285	Ywhaz	100	88.636	Mus_musculus
ENSG00000134308	YWHAQ	99	80.992	ENSMUSG00000018326	Ywhab	98	80.992	Mus_musculus
ENSG00000134308	YWHAQ	95	72.650	ENSMUSG00000047281	Sfn	98	72.314	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0005515	protein binding	7760835.8663231.9092538.10954706.11697890.15094368.15196694.15657067.15660133.16775625.16868027.17085597.17620599.18458160.19172738.19289404.19371722.19559006.19640509.19860830.20029029.20600589.20642453.20936779.21988832.23075850.23572552.23622247.24189400.24255178.24351927.24658140.24947832.25416956.25588844.25852190.28330616.28436939.	IPI	Function
GO:0005737	cytoplasm	15163635.	IDA	Component
GO:0005739	mitochondrion	-	IEA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0005925	focal adhesion	21423176.	HDA	Component
GO:0008022	protein C-terminus binding	-	IEA	Function
GO:0016020	membrane	19946888.	HDA	Component
GO:0019904	protein domain specific binding	-	IEA	Function
GO:0021762	substantia nigra development	22926577.	HEP	Process
GO:0032991	protein-containing complex	22797923.	IDA	Component
GO:0034766	negative regulation of ion transmembrane transport	-	IEA	Process
GO:0042802	identical protein binding	17085597.	IPI	Function
GO:0044325	ion channel binding	-	IEA	Function
GO:0045202	synapse	-	IEA	Component
GO:0045892	negative regulation of transcription, DNA-templated	15163635.	IDA	Process
GO:0047485	protein N-terminus binding	11984006.	IPI	Function
GO:0061024	membrane organization	-	TAS	Process
GO:0070062	extracellular exosome	19056867.19199708.20458337.	HDA	Component
GO:0071889	14-3-3 protein binding	-	IEA	Function
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway	-	TAS	Process

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
25041782	Epigenetic changes of TIMP-3, GSTP-1 and 14-3-3 sigma genes as indication of status of chronic inflammation and cancer.	Int J Biol Markers	2014 Sep 30	Wang YJ	doi: 10.5301/jbm.5000104.
26033570	Quantitative proteomic analysis of mitochondria from human ovarian cancer cells and their paclitaxel-resistant sublines.	Cancer Sci	2015 Aug	Chen M	doi: 10.1111/cas.12710
18089831	Identification of 14-3-3 theta as an antigen that induces a humoral response in lung cancer.	Cancer Res	2007 Dec 15	Pereira-Faca SR	-
22115752	Proteomic identification of predictive biomarkers of resistance to neoadjuvant chemotherapy in luminal breast cancer: a possible role for 14-3-3 theta/tau and tBID?	J Proteomics	2012 Feb 2	Hodgkinson VC	doi: 10.1016/j.jprot.2011.11.005
21946067	The role of 14-3-3β in transcriptional activation of estrogen receptor α and its involvement in proliferation of breast cancer cells.	Biochem Biophys Res Commun	2011 Oct 14	Kim Y	doi: 10.1016/j.bbrc.2011.09.056
20086099	14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer.	Mol Cell Biol	2010 Mar	Wang B	doi: 10.1128/MCB.01335-09
18794547	Occurrence of autoantibodies to annexin I, 14-3-3 theta and LAMR1 in prediagnostic lung cancer sera.	J Clin Oncol	2008 Nov 1	Qiu J	doi: 10.1200/JCO.2008.16.2388
29363506	Chk1 and 14-3-3 proteins inhibit atypical E2Fs to prevent a permanent cell cycle arrest.	EMBO J	2018 Mar 1	Yuan R	doi: 10.15252/embj.201797877

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr2	9591398	Missense_Mutation	novel	R138G	0.24
BLCA	chr2	9585174	3'UTR	novel		0.7
BLCA	chr2	9585188	3'UTR	novel		0.28
BLCA	chr2	9588173	Missense_Mutation	NA	A192T	0.59
BLCA	chr2	9630183	Silent	novel	L90L	0.27
BLCA	chr2	9588328	In_Frame_Ins	novel	K139_Q140insLACGDDRK	0.11
BLCA	chr2	9591413	Missense_Mutation	novel	A133T	0.08
BLCA	chr2	9630174	Missense_Mutation	novel	I93M	0.09
BRCA	chr2	9585051	3'UTR	novel		0.11
BRCA	chr2	9630241	Missense_Mutation	novel	T71I	0.18
BRCA	chr2	9585073	3'UTR	novel		0.35
CESC	chr2	9588276	Missense_Mutation	NA	K157N	0.5
COAD	chr2	9591491	Missense_Mutation	NA	A107S	0.33
COAD	chr2	9585252	3'UTR	novel		0.33
COAD	chr2	9630370	Missense_Mutation	NA	A28V	0.45
COAD	chr2	9591436	Missense_Mutation	novel	Y125C	0.09
ESCA	chr2	9630350	Missense_Mutation	novel	E35K	0.24
ESCA	chr2	9585199	3'UTR	novel		0.35
GBM	chr2	9591394	Missense_Mutation	novel	K139I	0.15
HNSC	chr2	9588249	Missense_Mutation	novel	I166M	0.55
HNSC	chr2	9630363	Silent	NA	T30T	0.44
HNSC	chr2	9585317	Missense_Mutation	novel	E236V	0.07
HNSC	chr2	9585318	Nonsense_Mutation	novel	E236*	0.06
LGG	chr2	9630286	Missense_Mutation	novel	R56M	0.14
LUAD	chr2	9630283	Missense_Mutation	NA	S57F	0.1
LUAD	chr2	9591398	Missense_Mutation	novel	R138G	0.19
LUAD	chr2	9585293	Missense_Mutation	novel	E244G	0.17
LUAD	chr2	9630232	Missense_Mutation	rs756400871	K74R	0.19
LUSC	chr2	9588328	In_Frame_Ins	novel	K139_Q140insLACGDDRK	0.17
LUSC	chr2	9630258	Missense_Mutation	NA	I65M	0.21
MESO	chr2	9630397	Missense_Mutation	novel	Y19C	0.58
PCPG	chr2	9588251	Missense_Mutation	rs200884745	I166V	0.06
PRAD	chr2	9591392	Frame_Shift_Ins	novel	*Q140Nfs4**	0.28
PRAD	chr2	9591391	Splice_Site	novel	X140_splice	0.29
SKCM	chr2	9588307	Missense_Mutation	NA	G147E	0.27
SKCM	chr2	9587465	Silent	NA	D209D	0.2
SKCM	chr2	9588164	Splice_Site	NA	X194_splice	0.7
SKCM	chr2	9587495	Silent	NA	A199A	0.32
SKCM	chr2	9591398	Nonsense_Mutation	novel	R138*	0.38
SKCM	chr2	9587442	Missense_Mutation	NA	I217S	0.29
STAD	chr2	9591488	Missense_Mutation	novel	N108D	0.33
STAD	chr2	9588248	Missense_Mutation	NA	R167C	0.32
STAD	chr2	9587421	Missense_Mutation	NA	N224S	0.21
TGCT	chr2	9587495	Silent	NA	A199A	0.12
UCEC	chr2	9588247	Missense_Mutation	rs367832498	R167H	0.07
UCEC	chr2	9584126	3'UTR	novel		0.42
UCEC	chr2	9630474	5'UTR	novel		0.16
UCEC	chr2	9585198	3'UTR	novel		0.31
UCEC	chr2	9630201	Missense_Mutation	NA	E84D	0.13
UCEC	chr2	9591411	Silent	rs773284973	A133A	0.17
UCEC	chr2	9584582	3'UTR	novel		0.13
UCEC	chr2	9584342	3'UTR	novel		0.41
UCEC	chr2	9588207	Silent	novel	E180E	0.36
UCEC	chr2	9585231	3'UTR	novel		0.31
UCEC	chr2	9584276	3'UTR	novel		0.4
UCEC	chr2	9584860	3'UTR	novel		0.33
UCEC	chr2	9591397	Missense_Mutation	novel	R138Q	0.16
UCEC	chr2	9585257	3'UTR	novel		0.41
UCEC	chr2	9588247	Missense_Mutation	rs367832498	R167H	0.36
UCEC	chr2	9588164	Splice_Site	NA	X194_splice	0.39
UCEC	chr2	9591411	Silent	rs773284973	A133A	0.53
UCEC	chr2	9588281	Missense_Mutation	novel	S156R	0.27
UCEC	chr2	9591414	Silent	novel	V132V	0.24
UCEC	chr2	9591473	Nonsense_Mutation	novel	E113*	0.18
UCEC	chr2	9630205	Missense_Mutation	novel	R83Q	0.15
UCEC	chr2	9630221	Silent	NA	L78L	0.34

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
BLCA	AMP	0.3064	0.033813
CESC	AMP	0.2373	0.099937
KIRP	DEL	0.0313	0.08832
LUSC	DEL	0.0659	0.20634
OV	DEL	0.1468	0.087942
PAAD	DEL	0.0924	0.2014
TGCT	AMP	0.28	0.0050216
UCEC	DEL	0.0371	0.18809

Survival Analysis

Cancer	P-value	Q-value
THYM	0.025	Kaplan-Meier Survival Analysis
SARC	0.00071	Kaplan-Meier Survival Analysis
MESO	0.00014	Kaplan-Meier Survival Analysis
ACC	0.00026	Kaplan-Meier Survival Analysis
HNSC	0.0074	Kaplan-Meier Survival Analysis
SKCM	0.036	Kaplan-Meier Survival Analysis
BRCA	0.027	Kaplan-Meier Survival Analysis
BLCA	0.015	Kaplan-Meier Survival Analysis
CESC	0.027	Kaplan-Meier Survival Analysis
KICH	0.018	Kaplan-Meier Survival Analysis
UCEC	0.0023	Kaplan-Meier Survival Analysis
LIHC	0.0001	Kaplan-Meier Survival Analysis
LUAD	0.0054	Kaplan-Meier Survival Analysis
UVM	0.029	Kaplan-Meier Survival Analysis
OV	0.043	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

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Cell lines and drugs in GSE70138 or GSE92742