EuRBPDB

Basic Information
Cancer Related Information

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134398 (Gene tree)
Gene ID: 10595
Gene Symbol: ERN2
Alias: IRE1b
Full Name: endoplasmic reticulum to nucleus signaling 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Minus strand
Length: 23,197 bases
Position: chr16:23,690,304-23,713,500
Accession: 16942
RBP type: canonical RBP
Summary: (Endoplasmic Reticulum To Nucleus Signaling 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is ERN1.

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000413812	Ribonuc_2-5A	PF06479.12	3.8e-39	1	1
ENSP00000256797	Ribonuc_2-5A	PF06479.12	4.1e-39	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000566565	ERN2-206	313	-	-	- (aa)	-	-
ENST00000457008	ERN2-202	3169	-	ENSP00000413812	874 (aa)	-	E7ETG2
ENST00000561478	ERN2-203	412	-	-	- (aa)	-	-
ENST00000256797	ERN2-201	3549	XM_011545708	ENSP00000256797	926 (aa)	XP_011544010	Q76MJ5
ENST00000562458	ERN2-204	759	-	ENSP00000456866	23 (aa)	-	H3BSU1
ENST00000569903	ERN2-207	980	-	ENSP00000457796	80 (aa)	-	H3BUU2
ENST00000562562	ERN2-205	2263	XM_011545712	ENSP00000457361	129 (aa)	XP_011544014	H3BTW8

Gene Model

Click here to download ENSG00000134398's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134398	S-(3-hydroxypropyl)cysteine N-acetate	1E-7	26053186
ENSG00000134398	Smoking	1E-7	26053186

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134398's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000134398	ERN2	94	65.517	ENSG00000178607	ERN1	87	63.387

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134398	ERN2	97	87.653	ENSAMEG00000014205	ERN2	100	86.222	Ailuropoda_melanoleuca
ENSG00000134398	ERN2	92	64.944	ENSAPLG00000010981	ERN2	96	55.449	Anas_platyrhynchos
ENSG00000134398	ERN2	96	56.503	ENSACAG00000012164	ERN2	97	56.813	Anolis_carolinensis
ENSG00000134398	ERN2	100	95.680	ENSANAG00000016991	ERN2	100	95.680	Aotus_nancymaae
ENSG00000134398	ERN2	99	84.096	ENSBTAG00000014456	ERN2	99	84.211	Bos_taurus
ENSG00000134398	ERN2	100	94.060	ENSCJAG00000020632	ERN2	100	94.060	Callithrix_jacchus
ENSG00000134398	ERN2	97	85.033	ENSCAFG00000017643	ERN2	99	84.416	Canis_familiaris
ENSG00000134398	ERN2	97	82.262	ENSCAFG00020021342	ERN2	99	81.710	Canis_lupus_dingo
ENSG00000134398	ERN2	99	85.005	ENSCHIG00000022191	ERN2	99	85.545	Capra_hircus
ENSG00000134398	ERN2	99	89.480	ENSTSYG00000001334	ERN2	99	89.942	Carlito_syrichta
ENSG00000134398	ERN2	91	74.125	ENSCAPG00000005936	ERN2	94	84.112	Cavia_aperea
ENSG00000134398	ERN2	99	83.134	ENSCPOG00000005916	ERN2	99	83.134	Cavia_porcellus
ENSG00000134398	ERN2	100	94.737	ENSCCAG00000035789	ERN2	100	94.924	Cebus_capucinus
ENSG00000134398	ERN2	100	96.652	ENSCATG00000040324	ERN2	100	96.652	Cercocebus_atys
ENSG00000134398	ERN2	96	82.735	ENSCLAG00000014120	ERN2	100	82.735	Chinchilla_lanigera
ENSG00000134398	ERN2	100	95.910	ENSCSAG00000006703	ERN2	100	95.910	Chlorocebus_sabaeus
ENSG00000134398	ERN2	52	77.404	ENSCHOG00000010014	-	81	77.404	Choloepus_hoffmanni
ENSG00000134398	ERN2	89	71.679	ENSCPBG00000002165	ERN2	94	58.849	Chrysemys_picta_bellii
ENSG00000134398	ERN2	100	96.436	ENSCANG00000015296	ERN2	100	96.436	Colobus_angolensis_palliatus
ENSG00000134398	ERN2	96	84.086	ENSCGRG00001019098	Ern2	100	84.086	Cricetulus_griseus_chok1gshd
ENSG00000134398	ERN2	97	80.894	ENSDNOG00000017619	ERN2	97	80.894	Dasypus_novemcinctus
ENSG00000134398	ERN2	99	82.890	ENSDORG00000001246	Ern2	97	84.099	Dipodomys_ordii
ENSG00000134398	ERN2	92	85.277	ENSETEG00000019530	ERN2	98	85.277	Echinops_telfairi
ENSG00000134398	ERN2	50	58.581	ENSEBUG00000003994	-	90	54.183	Eptatretus_burgeri
ENSG00000134398	ERN2	99	85.022	ENSEASG00005017645	ERN2	99	84.682	Equus_asinus_asinus
ENSG00000134398	ERN2	99	87.055	ENSECAG00000017742	ERN2	99	86.717	Equus_caballus
ENSG00000134398	ERN2	89	76.387	ENSEEUG00000005382	ERN2	86	76.387	Erinaceus_europaeus
ENSG00000134398	ERN2	99	84.800	ENSFCAG00000012945	ERN2	99	85.371	Felis_catus
ENSG00000134398	ERN2	91	71.223	ENSFALG00000003790	ERN2	84	71.223	Ficedula_albicollis
ENSG00000134398	ERN2	98	80.592	ENSFDAG00000006000	ERN2	98	82.426	Fukomys_damarensis
ENSG00000134398	ERN2	89	71.178	ENSGAGG00000002490	ERN2	89	63.025	Gopherus_agassizii
ENSG00000134398	ERN2	100	98.812	ENSGGOG00000012853	ERN2	100	98.812	Gorilla_gorilla
ENSG00000134398	ERN2	99	84.855	ENSHGLG00000012125	ERN2	97	85.318	Heterocephalus_glaber_female
ENSG00000134398	ERN2	96	85.442	ENSHGLG00100009410	ERN2	96	85.442	Heterocephalus_glaber_male
ENSG00000134398	ERN2	97	86.272	ENSSTOG00000012411	ERN2	99	85.854	Ictidomys_tridecemlineatus
ENSG00000134398	ERN2	96	84.400	ENSJJAG00000015169	Ern2	96	84.400	Jaculus_jaculus
ENSG00000134398	ERN2	97	87.584	ENSLAFG00000005429	ERN2	99	86.457	Loxodonta_africana
ENSG00000134398	ERN2	83	83.377	ENSMFAG00000038350	ERN2	92	83.377	Macaca_fascicularis
ENSG00000134398	ERN2	100	96.544	ENSMMUG00000013806	ERN2	100	96.453	Macaca_mulatta
ENSG00000134398	ERN2	100	96.652	ENSMNEG00000034382	ERN2	100	96.652	Macaca_nemestrina
ENSG00000134398	ERN2	89	96.590	ENSMLEG00000040622	ERN2	100	96.590	Mandrillus_leucophaeus
ENSG00000134398	ERN2	98	67.603	ENSMGAG00000006523	ERN2	99	59.201	Meleagris_gallopavo
ENSG00000134398	ERN2	87	83.704	ENSMAUG00000013187	Ern2	91	81.420	Mesocricetus_auratus
ENSG00000134398	ERN2	99	86.270	ENSMICG00000007841	ERN2	99	86.054	Microcebus_murinus
ENSG00000134398	ERN2	99	82.826	ENSMOCG00000000736	Ern2	98	82.826	Microtus_ochrogaster
ENSG00000134398	ERN2	96	66.882	ENSMODG00000006717	ERN2	97	66.882	Monodelphis_domestica
ENSG00000134398	ERN2	99	81.828	MGP_CAROLIEiJ_G0030420	Ern2	99	82.995	Mus_caroli
ENSG00000134398	ERN2	99	81.610	ENSMUSG00000030866	Ern2	99	81.610	Mus_musculus
ENSG00000134398	ERN2	99	81.937	MGP_PahariEiJ_G0013630	Ern2	99	83.333	Mus_pahari
ENSG00000134398	ERN2	99	81.828	MGP_SPRETEiJ_G0031534	Ern2	99	82.995	Mus_spretus
ENSG00000134398	ERN2	99	85.097	ENSMPUG00000012189	ERN2	99	85.653	Mustela_putorius_furo
ENSG00000134398	ERN2	89	76.428	ENSMLUG00000012167	ERN2	99	76.521	Myotis_lucifugus
ENSG00000134398	ERN2	98	83.942	ENSNGAG00000021537	Ern2	97	84.129	Nannospalax_galili
ENSG00000134398	ERN2	100	94.384	ENSNLEG00000011950	ERN2	100	94.384	Nomascus_leucogenys
ENSG00000134398	ERN2	95	63.949	ENSOANG00000007667	-	99	63.949	Ornithorhynchus_anatinus
ENSG00000134398	ERN2	99	81.885	ENSOCUG00000008483	ERN2	99	82.408	Oryctolagus_cuniculus
ENSG00000134398	ERN2	99	86.659	ENSOGAG00000005577	ERN2	97	87.946	Otolemur_garnettii
ENSG00000134398	ERN2	97	84.633	ENSOARG00000017432	ERN2	99	84.633	Ovis_aries
ENSG00000134398	ERN2	100	99.136	ENSPPAG00000037128	ERN2	100	99.136	Pan_paniscus
ENSG00000134398	ERN2	99	84.898	ENSPPRG00000001852	ERN2	99	85.437	Panthera_pardus
ENSG00000134398	ERN2	97	83.501	ENSPTIG00000016188	ERN2	99	82.435	Panthera_tigris_altaica
ENSG00000134398	ERN2	100	99.244	ENSPTRG00000007893	ERN2	100	99.244	Pan_troglodytes
ENSG00000134398	ERN2	100	96.436	ENSPANG00000023632	ERN2	100	96.436	Papio_anubis
ENSG00000134398	ERN2	96	83.708	ENSPEMG00000012773	Ern2	97	83.557	Peromyscus_maniculatus_bairdii
ENSG00000134398	ERN2	94	67.841	ENSPCIG00000026605	ERN2	95	67.841	Phascolarctos_cinereus
ENSG00000134398	ERN2	100	97.732	ENSPPYG00000007196	ERN2	95	97.732	Pongo_abelii
ENSG00000134398	ERN2	99	82.792	ENSPCAG00000016200	ERN2	93	83.667	Procavia_capensis
ENSG00000134398	ERN2	97	87.678	ENSPCOG00000017614	ERN2	98	87.618	Propithecus_coquereli
ENSG00000134398	ERN2	99	78.162	ENSPVAG00000008445	ERN2	95	78.595	Pteropus_vampyrus
ENSG00000134398	ERN2	99	80.978	ENSRNOG00000018974	Ern2	98	80.978	Rattus_norvegicus
ENSG00000134398	ERN2	100	96.682	ENSRBIG00000034872	ERN2	100	96.682	Rhinopithecus_bieti
ENSG00000134398	ERN2	100	96.652	ENSRROG00000008752	ERN2	100	96.652	Rhinopithecus_roxellana
ENSG00000134398	ERN2	85	88.732	ENSSBOG00000027251	ERN2	96	88.732	Saimiri_boliviensis_boliviensis
ENSG00000134398	ERN2	94	68.274	ENSSHAG00000005538	ERN2	98	68.274	Sarcophilus_harrisii
ENSG00000134398	ERN2	78	73.984	ENSSPUG00000010312	ERN2	91	60.938	Sphenodon_punctatus
ENSG00000134398	ERN2	99	85.297	ENSSSCG00000040637	ERN2	93	85.405	Sus_scrofa
ENSG00000134398	ERN2	86	72.682	ENSTGUG00000006039	ERN2	99	57.811	Taeniopygia_guttata
ENSG00000134398	ERN2	97	87.025	ENSTBEG00000000414	ERN2	99	87.472	Tupaia_belangeri
ENSG00000134398	ERN2	92	81.935	ENSTTRG00000005264	ERN2	95	81.702	Tursiops_truncatus
ENSG00000134398	ERN2	97	84.316	ENSUAMG00000021038	ERN2	100	82.992	Ursus_americanus
ENSG00000134398	ERN2	97	81.646	ENSUMAG00000008840	ERN2	97	81.646	Ursus_maritimus
ENSG00000134398	ERN2	99	83.459	ENSVVUG00000005617	ERN2	99	84.017	Vulpes_vulpes

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000287	magnesium ion binding	11175748.	IDA	Function
GO:0004519	endonuclease activity	11175748.	IDA	Function
GO:0004521	endoribonuclease activity	21873635.	IBA	Function
GO:0004672	protein kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	11175748.	IDA	Function
GO:0005524	ATP binding	11175748.	IDA	Function
GO:0005789	endoplasmic reticulum membrane	21873635.	IBA	Component
GO:0006397	mRNA processing	-	IEA	Process
GO:0006468	protein phosphorylation	11175748.	IDA	Process
GO:0007050	cell cycle arrest	-	IEA	Process
GO:0007257	activation of JUN kinase activity	-	IEA	Process
GO:0016021	integral component of membrane	-	IEA	Component
GO:0016075	rRNA catabolic process	11175748.	IDA	Process
GO:0030263	apoptotic chromosome condensation	11175748.	IMP	Process
GO:0030968	endoplasmic reticulum unfolded protein response	21873635.	IBA	Process
GO:0034976	response to endoplasmic reticulum stress	22013210.	TAS	Process
GO:0036498	IRE1-mediated unfolded protein response	21873635.	IBA	Process
GO:0045892	negative regulation of transcription, DNA-templated	11175748.	IMP	Process
GO:0051082	unfolded protein binding	21873635.	IBA	Function
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	21873635.	IBA	Process
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic	-	IEA	Process
GO:1990604	IRE1-TRAF2-ASK1 complex	21873635.	IBA	Component
GO:1990604	IRE1-TRAF2-ASK1 complex	-	ISS	Component

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq	RBD
ACC	chr16	23695071	Silent	novel	V664V	0.46
ACC	chr16	23694886	Missense_Mutation	novel	P696S	0.5
ACC	chr16	23704969	Silent	novel	L304L	0.44
BLCA	chr16	23695325	Missense_Mutation	novel	R607W	0.31
BLCA	chr16	23702233	Silent	novel	L422L	0.14
BLCA	chr16	23707040	Missense_Mutation	NA	P164T	0.33
BLCA	chr16	23691393	Silent	novel	E851E	0.29
BLCA	chr16	23702536	Missense_Mutation	novel	P360R	0.09
BLCA	chr16	23700869	Intron	novel		0.44
BLCA	chr16	23694883	Missense_Mutation	NA	D697H	0.22
BLCA	chr16	23702437	Missense_Mutation	NA	R393T	0.3
BLCA	chr16	23692220	Missense_Mutation	novel	A786T	0.14
BLCA	chr16	23695976	Missense_Mutation	rs768661196	E558K	0.34
BLCA	chr16	23692016	Missense_Mutation	novel	V823L	0.32
BLCA	chr16	23692279	Missense_Mutation	NA	S766C	0.25
BLCA	chr16	23705107	Silent	novel	L258L	0.19
BLCA	chr16	23713332	5'UTR	novel		0.56
BLCA	chr16	23695056	Silent	novel	L669L	0.33
BLCA	chr16	23713182	Silent	NA	A50A	0.64
BLCA	chr16	23710922	Silent	novel	L112L	0.31
BLCA	chr16	23713154	Missense_Mutation	novel	P60T	0.67
BLCA	chr16	23707037	Missense_Mutation	novel	C165R	0.16
BLCA	chr16	23713272	Silent	novel	A20A	0.78
BRCA	chr16	23700573	Silent	novel	P545P	0.18
BRCA	chr16	23701094	Silent	NA	E456E	0.07
BRCA	chr16	23710991	Silent	NA	L89L	0.3
BRCA	chr16	23702637	Missense_Mutation	NA	G355E	0.3
BRCA	chr16	23710992	Silent	NA	L88L	0.18
BRCA	chr16	23691368	Missense_Mutation	NA	E860K	0.33
BRCA	chr16	23700864	Intron	novel		0.26
BRCA	chr16	23700846	Intron	novel		0.13
BRCA	chr16	23694760	Missense_Mutation	NA	E738K	0.21
BRCA	chr16	23700614	Missense_Mutation	NA	S532T	0.16
BRCA	chr16	23700711	Splice_Region	novel		0.38
BRCA	chr16	23694923	Missense_Mutation	NA	H683Q	0.29
BRCA	chr16	23700798	Intron	novel		0.6
BRCA	chr16	23690905	Missense_Mutation	rs751236768	E951Q	0.21
BRCA	chr16	23702266	Missense_Mutation	novel	H411Q	0.16
CESC	chr16	23710531	Missense_Mutation	novel	P121L	0.23
CESC	chr16	23706837	Frame_Shift_Del	novel	*V183Gfs11**	0.09
CESC	chr16	23694921	Missense_Mutation	novel	R684Q	0.38
CESC	chr16	23700942	Intron	novel		0.29
COAD	chr16	23692211	Missense_Mutation	novel	L789V	0.21
COAD	chr16	23705015	Missense_Mutation	rs140769667	R289H	0.16
COAD	chr16	23691330	Silent	rs775420918	H872H	0.14
COAD	chr16	23695950	Missense_Mutation	novel	I566M	0.31
COAD	chr16	23707066	Missense_Mutation	rs141088910	T155I	0.09
COAD	chr16	23694921	Missense_Mutation	novel	R684Q	0.17
COAD	chr16	23695965	Silent	rs61730173	T561T	0.23
COAD	chr16	23706371	Missense_Mutation	novel	R231H	0.24
COAD	chr16	23705058	Missense_Mutation	rs752855204	V275M	0.12
COAD	chr16	23710964	Missense_Mutation	novel	L98F	0.08
COAD	chr16	23705067	Missense_Mutation	NA	D272N	0.06
COAD	chr16	23692019	Frame_Shift_Del	novel	*Q822Rfs35**	0.26
COAD	chr16	23710940	Frame_Shift_Del	NA	*D107Pfs8**	0.46
COAD	chr16	23706358	Silent	rs765244062	A235A	0.38
COAD	chr16	23700665	Frame_Shift_Del	rs763540496	*L515Wfs48**	0.41
COAD	chr16	23706399	Missense_Mutation	novel	P222T	0.38
COAD	chr16	23692007	Missense_Mutation	NA	H826Y	0.2	Ribonuc_2-5A
COAD	chr16	23705085	Missense_Mutation	NA	T266A	0.4
COAD	chr16	23695325	Missense_Mutation	novel	R607W	0.34
COAD	chr16	23695911	Silent	rs375355404	G579G	0.16
COAD	chr16	23694753	In_Frame_Del	novel	L740del	0.25
COAD	chr16	23704946	Missense_Mutation	rs771277199	R312Q	0.15
COAD	chr16	23701089	Missense_Mutation	novel	L458R	0.19
COAD	chr16	23707063	Missense_Mutation	NA	I156T	0.23
COAD	chr16	23694864	Missense_Mutation	novel	R703K	0.16
COAD	chr16	23691002	Silent	NA	A918A	0.32
COAD	chr16	23706775	Frame_Shift_Del	rs763805636	*R204Afs43**	0.28
COAD	chr16	23691330	Silent	rs775420918	H872H	0.2
ESCA	chr16	23695019	Missense_Mutation	novel	V682M	0.27
ESCA	chr16	23702674	Missense_Mutation	novel	T343P	0.38
ESCA	chr16	23695919	Missense_Mutation	novel	G577R	0.26
ESCA	chr16	23701079	Silent	novel	S461S	0.06
ESCA	chr16	23692041	Silent	rs145229386	P814P	0.38
GBM	chr16	23692209	Silent	novel	L789L	0.92
GBM	chr16	23701048	Missense_Mutation	NA	S472P	0.25
GBM	chr16	23704997	Missense_Mutation	rs374022289	T295M	0.31
GBM	chr16	23706774	Missense_Mutation	NA	R204H	0.29
GBM	chr16	23706779	Silent	novel	T202T	0.47
GBM	chr16	23706859	Missense_Mutation	rs148177655	R176W	0.44
GBM	chr16	23706759	Missense_Mutation	rs768486434	R209Q	0.18
GBM	chr16	23691193	Missense_Mutation	novel	L883Q	0.2
GBM	chr16	23700903	Intron	novel		0.11
GBM	chr16	23704985	Missense_Mutation	novel	D299V	0.67
GBM	chr16	23692244	Missense_Mutation	novel	R778S	0.31
GBM	chr16	23695325	Missense_Mutation	novel	R607W	0.21
GBM	chr16	23702217	Missense_Mutation	novel	L428M	0.16
GBM	chr16	23710222	Missense_Mutation	novel	A134T	0.44
GBM	chr16	23710515	Splice_Site	novel	X126_splice	0.25
GBM	chr16	23707053	Silent	rs369299952	L159L	0.15
HNSC	chr16	23695385	Missense_Mutation	novel	Q587E	0.72
HNSC	chr16	23694839	Silent	NA	L711L	0.26
HNSC	chr16	23695922	Missense_Mutation	novel	R576S	0.08
HNSC	chr16	23690933	Silent	novel	T941T	0.29
HNSC	chr16	23702213	Missense_Mutation	novel	G429E	0.36
HNSC	chr16	23695361	Missense_Mutation	novel	V595I	0.2
HNSC	chr16	23695343	Missense_Mutation	novel	E601Q	0.33
HNSC	chr16	23702212	Silent	novel	G429G	0.35
HNSC	chr16	23702213	Missense_Mutation	novel	G429E	0.34
HNSC	chr16	23700923	Intron	novel		0.08
KIRC	chr16	23690849	Silent	novel	P969P	0.23
KIRP	chr16	23700670	Missense_Mutation	novel	T513I	0.45
LGG	chr16	23705125	Silent	rs774207313	C252C	0.2
LGG	chr16	23692244	Missense_Mutation	rs373315072	R778C	0.42
LGG	chr16	23691182	Missense_Mutation	rs377714643	R887W	0.1
LGG	chr16	23700866	Intron	novel		0.52
LIHC	chr16	23694873	Missense_Mutation	novel	G700A	0.12
LIHC	chr16	23695928	Silent	NA	L574L	0.29
LIHC	chr16	23713129	Missense_Mutation	novel	F68S	0.35
LIHC	chr16	23700541	Missense_Mutation	novel	E556V	0.59
LIHC	chr16	23692288	Missense_Mutation	novel	Y763C	0.4
LIHC	chr16	23702463	Silent	novel	R384R	0.15
LIHC	chr16	23702449	Missense_Mutation	novel	S389T	0.39
LUAD	chr16	23707038	Silent	NA	P164P	0.15
LUAD	chr16	23707030	Missense_Mutation	NA	S167I	0.44
LUAD	chr16	23702420	Missense_Mutation	novel	V399L	0.31
LUAD	chr16	23700991	Silent	NA	L491L	0.11
LUAD	chr16	23702212	Silent	NA	G429G	0.24
LUAD	chr16	23695254	Silent	novel	R630R	0.15
LUAD	chr16	23691354	Silent	rs755569749	C864C	0.26
LUAD	chr16	23702172	Missense_Mutation	novel	A443S	0.36
LUAD	chr16	23705044	Silent	novel	G279G	0.39
LUAD	chr16	23706782	Silent	NA	S201S	0.51
LUAD	chr16	23702677	Missense_Mutation	NA	E342K	0.09
LUAD	chr16	23700600	Silent	novel	R536R	0.28
LUAD	chr16	23710198	Missense_Mutation	novel	G142R	0.28
LUAD	chr16	23702200	Silent	NA	A433A	0.18
LUAD	chr16	23702662	Missense_Mutation	NA	V347I	0.31
LUAD	chr16	23700665	Frame_Shift_Del	rs763540496	*L515Wfs48**	0.18
LUAD	chr16	23700797	Intron	novel		0.22
LUAD	chr16	23692216	Missense_Mutation	novel	P787H	0.46
LUAD	chr16	23692217	Missense_Mutation	NA	P787T	0.47
LUAD	chr16	23690999	Silent	novel	L919L	0.21
LUAD	chr16	23706819	Missense_Mutation	NA	G189E	0.18
LUAD	chr16	23707053	Silent	rs369299952	L159L	0.1
LUAD	chr16	23694760	Missense_Mutation	NA	E738K	0.39
LUAD	chr16	23710547	Missense_Mutation	NA	P116T	0.47
LUAD	chr16	23706775	Missense_Mutation	NA	R204S	0.2
LUAD	chr16	23710215	Frame_Shift_Del	novel	*G136Afs14**	0.18
LUAD	chr16	23702451	Silent	NA	P388P	0.47
LUAD	chr16	23694758	Silent	NA	E738E	0.2
LUAD	chr16	23700985	Missense_Mutation	novel	G493W	0.32
LUAD	chr16	23704890	Missense_Mutation	novel	Q331K	0.12
LUAD	chr16	23711001	Silent	novel	P85P	0.43
LUSC	chr16	23700780	Intron	novel		0.19
LUSC	chr16	23704993	Silent	NA	L296L	0.34
LUSC	chr16	23700692	Missense_Mutation	novel	V506M	0.27
LUSC	chr16	23700693	Silent	novel	Q505Q	0.26
LUSC	chr16	23700697	Missense_Mutation	novel	P504Q	0.33
LUSC	chr16	23690921	Missense_Mutation	rs752294858	M945I	0.18
LUSC	chr16	23705135	Splice_Site	novel	X245_splice	0.19
LUSC	chr16	23695331	Silent	novel	L605L	0.3
LUSC	chr16	23710977	Silent	novel	T93T	0.29
LUSC	chr16	23710978	Missense_Mutation	novel	T93I	0.29
LUSC	chr16	23692063	Missense_Mutation	NA	G807A	0.28
LUSC	chr16	23690918	Missense_Mutation	NA	R946S	0.18
LUSC	chr16	23700781	Intron	novel		0.28
LUSC	chr16	23710921	Missense_Mutation	NA	L112Q	0.3
LUSC	chr16	23701022	Missense_Mutation	NA	D480E	0.38
LUSC	chr16	23710989	Silent	novel	L89L	0.24
LUSC	chr16	23710990	Missense_Mutation	novel	L89P	0.24
LUSC	chr16	23702528	Missense_Mutation	novel	L363M	0.3
LUSC	chr16	23702268	Missense_Mutation	novel	H411D	0.19
LUSC	chr16	23695919	Missense_Mutation	novel	G577W	0.3
LUSC	chr16	23691040	Missense_Mutation	novel	H906N	0.08
LUSC	chr16	23702155	Missense_Mutation	NA	L448F	0.24
LUSC	chr16	23702514	Silent	rs201669721	P367P	0.19
LUSC	chr16	23700935	Intron	novel		0.15
OV	chr16	23692247	Missense_Mutation	novel	Y777H	0.11
OV	chr16	23692269	Missense_Mutation	novel	S769R	0.51
OV	chr16	23695948	Missense_Mutation	novel	S567F	0.08
OV	chr16	23702518	Missense_Mutation	rs754261303	A366D	0.37
OV	chr16	23695259	Nonsense_Mutation	NA	E629*	0.61
OV	chr16	23692040	In_Frame_Del	novel	P814del	0.13
OV	chr16	23710178	Silent	novel	G148G	0.29
OV	chr16	23705059	Silent	rs756412528	G274G	0.77
OV	chr16	23690977	Missense_Mutation	rs375401457	V927I	0.37
OV	chr16	23692206	Silent	novel	A790A	0.19
OV	chr16	23700611	Missense_Mutation	NA	G533R	0.36
OV	chr16	23700884	Intron	novel		0.15
OV	chr16	23700966	Missense_Mutation	NA	M499T	0.36
OV	chr16	23702199	Nonsense_Mutation	novel	E434*	0.32
OV	chr16	23702201	Missense_Mutation	novel	A433V	0.13
OV	chr16	23692289	Missense_Mutation	novel	Y763H	0.12
PAAD	chr16	23690885	Nonsense_Mutation	novel	Y957*	0.15
PAAD	chr16	23690958	Missense_Mutation	novel	R933H	0.08
PAAD	chr16	23694874	Missense_Mutation	novel	G700C	0.18
PAAD	chr16	23702176	Silent	novel	T441T	0.17
PRAD	chr16	23701079	Silent	rs572180599	S461S	0.18
PRAD	chr16	23695920	Silent	rs571051287	R576R	0.26
PRAD	chr16	23705134	Silent	NA	L249L	0.08
PRAD	chr16	23691343	Missense_Mutation	novel	R868L	0.64	Ribonuc_2-5A
PRAD	chr16	23695929	Silent	rs763180083	V573V	0.26
READ	chr16	23695313	Frame_Shift_Ins	NA	*Q611Sfs7**	0.56
READ	chr16	23710998	Missense_Mutation	NA	E86D	0.24
READ	chr16	23705005	Silent	rs144880499	P292P	0.38
SARC	chr16	23710982	Missense_Mutation	novel	S92P	0.6
SARC	chr16	23710179	Missense_Mutation	NA	G148E	0.23
SKCM	chr16	23707039	Missense_Mutation	NA	P164L	0.41
SKCM	chr16	23695253	Missense_Mutation	novel	G631R	0.6
SKCM	chr16	23700880	Intron	novel		0.5
SKCM	chr16	23695958	Missense_Mutation	NA	G564R	0.17
SKCM	chr16	23705093	Missense_Mutation	rs768360632	G263E	0.1
SKCM	chr16	23706759	Missense_Mutation	rs768486434	R209Q	0.23
SKCM	chr16	23700803	Intron	novel		0.32
SKCM	chr16	23705034	Missense_Mutation	novel	W283R	0.15
SKCM	chr16	23700746	Intron	novel		0.29
SKCM	chr16	23702703	Splice_Site	novel	X333_splice	0.28
SKCM	chr16	23707040	Missense_Mutation	novel	P164S	0.31
SKCM	chr16	23710917	Silent	NA	R113R	0.37
SKCM	chr16	23695388	Missense_Mutation	novel	G586R	0.38
SKCM	chr16	23700774	Intron	novel		0.18
SKCM	chr16	23702437	Missense_Mutation	NA	R393K	0.27
SKCM	chr16	23702198	Missense_Mutation	novel	E434A	0.22
SKCM	chr16	23710534	Missense_Mutation	novel	G120E	0.54
SKCM	chr16	23711015	Missense_Mutation	novel	H81Y	0.23
SKCM	chr16	23707058	Missense_Mutation	NA	E158K	0.76
SKCM	chr16	23690844	Missense_Mutation	rs750985679	A971V	0.11
SKCM	chr16	23705046	Missense_Mutation	NA	G279S	0.07
SKCM	chr16	23704972	Silent	NA	F303F	0.37
SKCM	chr16	23700636	Silent	novel	S524S	0.2
SKCM	chr16	23704988	Missense_Mutation	rs149889613	R298Q	0.13
SKCM	chr16	23691135	Silent	NA	R902R	0.41
SKCM	chr16	23695203	Silent	NA	Q647Q	0.42
SKCM	chr16	23700880	Intron	novel		0.54
SKCM	chr16	23702182	Silent	NA	E439E	0.36
SKCM	chr16	23713151	Missense_Mutation	novel	R61W	0.6
SKCM	chr16	23695948	Missense_Mutation	novel	S567F	0.18
SKCM	chr16	23702449	Missense_Mutation	NA	S389N	0.05
SKCM	chr16	23700924	Intron	novel		0.31
SKCM	chr16	23702208	Missense_Mutation	NA	G431R	0.62
SKCM	chr16	23710546	Missense_Mutation	NA	P116L	0.2
SKCM	chr16	23691168	Silent	NA	G891G	0.27
SKCM	chr16	23700983	Silent	NA	G493G	0.36
SKCM	chr16	23707049	Missense_Mutation	NA	H161Y	0.45
SKCM	chr16	23700666	Silent	novel	P514P	0.42
SKCM	chr16	23711009	Missense_Mutation	rs139816512	L83F	0.14
SKCM	chr16	23705082	Missense_Mutation	novel	V267M	0.38
SKCM	chr16	23702516	Missense_Mutation	NA	P367S	0.3
SKCM	chr16	23704947	Nonsense_Mutation	rs540505898	R312*	0.3
SKCM	chr16	23710538	Missense_Mutation	rs758739777	E119K	0.22
SKCM	chr16	23704972	Silent	NA	F303F	0.12
SKCM	chr16	23705067	Missense_Mutation	NA	D272N	0.3
SKCM	chr16	23701080	Missense_Mutation	novel	S461F	0.37
SKCM	chr16	23692187	Missense_Mutation	NA	H797Y	0.48
SKCM	chr16	23691993	Nonsense_Mutation	NA	W830*	0.42
SKCM	chr16	23701094	Silent	NA	E456E	0.29
SKCM	chr16	23692002	Silent	novel	P827P	0.5
SKCM	chr16	23692003	Missense_Mutation	rs139320105	P827L	0.5
SKCM	chr16	23705082	Missense_Mutation	novel	V267M	0.27
SKCM	chr16	23710917	Silent	NA	R113R	0.24
SKCM	chr16	23702677	Missense_Mutation	NA	E342K	0.48
SKCM	chr16	23706859	Missense_Mutation	rs148177655	R176W	0.5
SKCM	chr16	23702644	Missense_Mutation	NA	H353Y	0.39
SKCM	chr16	23700819	Intron	novel		0.44
SKCM	chr16	23702187	Missense_Mutation	NA	P438S	0.4
STAD	chr16	23694918	Missense_Mutation	NA	D685G	0.27
STAD	chr16	23702217	Silent	NA	L428L	0.33
STAD	chr16	23705006	Missense_Mutation	rs371169798	P292L	0.39
STAD	chr16	23692019	Frame_Shift_Del	novel	*Q822Rfs35**	0.39
STAD	chr16	23706774	Frame_Shift_Ins	rs760310462	*R204Pfs15**	0.33
STAD	chr16	23706775	Frame_Shift_Del	rs763805636	*R204Afs43**	0.27
STAD	chr16	23700901	Intron	novel		0.4
STAD	chr16	23702533	Missense_Mutation	NA	R361H	0.15
STAD	chr16	23692324	Missense_Mutation	NA	A751V	0.11
STAD	chr16	23692299	Silent	rs201663878	C759C	0.37
STAD	chr16	23695259	Missense_Mutation	rs374029883	E629K	0.2
STAD	chr16	23692220	Missense_Mutation	novel	A786T	0.31
STAD	chr16	23705046	Missense_Mutation	NA	G279S	0.31
STAD	chr16	23695263	Missense_Mutation	novel	C627W	0.5
STAD	chr16	23700747	Intron	novel		0.38
STAD	chr16	23702465	Nonsense_Mutation	rs144370049	R384*	0.12
STAD	chr16	23691192	Splice_Site	novel	X882_splice	0.1
STAD	chr16	23700982	Missense_Mutation	rs765119605	W494R	0.2
THYM	chr16	23700665	Frame_Shift_Del	rs763540496	*L515Wfs48**	0.23
UCEC	chr16	23704906	Missense_Mutation	NA	F325L	0.29
UCEC	chr16	23706364	Nonsense_Mutation	NA	Y233*	0.4
UCEC	chr16	23690959	Missense_Mutation	rs771312988	R933C	0.06
UCEC	chr16	23702669	Silent	NA	G344G	0.25
UCEC	chr16	23702454	Silent	novel	S387S	0.19
UCEC	chr16	23701090	Missense_Mutation	rs55687638	L458F	0.12
UCEC	chr16	23691147	Silent	NA	L898L	0.39
UCEC	chr16	23691309	Silent	novel	L879L	0.44
UCEC	chr16	23700784	Intron	novel		0.5
UCEC	chr16	23690871	Nonsense_Mutation	novel	S962*	0.46
UCEC	chr16	23702196	Missense_Mutation	novel	T435A	0.26
UCEC	chr16	23702660	Silent	novel	V347V	0.15
UCEC	chr16	23694822	Missense_Mutation	NA	A717V	0.16
UCEC	chr16	23692287	Silent	rs374661363	Y763Y	0.3
UCEC	chr16	23692018	Frame_Shift_Ins	novel	*Q822Pfs23**	0.45
UCEC	chr16	23706862	Splice_Site	novel	X175_splice	0.15
UCEC	chr16	23707080	Splice_Site	NA	X151_splice	0.17
UCEC	chr16	23701047	Missense_Mutation	novel	S472F	0.15
UCEC	chr16	23695910	Missense_Mutation	NA	G580R	0.31
UCEC	chr16	23691999	Missense_Mutation	novel	F828L	0.12
UCEC	chr16	23691402	In_Frame_Del	novel	K848del	0.42
UCEC	chr16	23695312	Missense_Mutation	novel	Q611R	0.35
UCEC	chr16	23700636	Silent	novel	S524S	0.18
UCEC	chr16	23694928	Splice_Site	novel	X682_splice	0.42
UCEC	chr16	23700588	Missense_Mutation	NA	K540N	0.21
UCEC	chr16	23690839	Missense_Mutation	NA	G973W	0.32
UCEC	chr16	23695256	Missense_Mutation	novel	R630W	0.29
UCEC	chr16	23691169	Missense_Mutation	NA	G891E	0.42
UCEC	chr16	23706834	Missense_Mutation	novel	V184A	0.31
UCEC	chr16	23700819	Intron	novel		0.38
UCEC	chr16	23701094	Missense_Mutation	novel	E456D	0.34
UCEC	chr16	23707044	Silent	novel	A162A	0.21
UCEC	chr16	23701041	Frame_Shift_Del	NA	*Y473Wfs25**	0.24
UCEC	chr16	23702187	Missense_Mutation	NA	P438S	0.13
UCEC	chr16	23691358	Missense_Mutation	rs767739439	G863D	0.25
UCEC	chr16	23702223	Missense_Mutation	novel	P426S	0.43
UCEC	chr16	23694822	Missense_Mutation	NA	A717V	0.52
UCEC	chr16	23691154	Missense_Mutation	novel	D896G	0.45
UCEC	chr16	23695020	Missense_Mutation	novel	I681M	0.36
UCEC	chr16	23700884	Intron	novel		0.35
UCEC	chr16	23695343	Missense_Mutation	novel	E601K	0.52
UCEC	chr16	23710215	Missense_Mutation	novel	G136D	0.16
UCEC	chr16	23702696	Silent	rs151223543	T335T	0.46
UCEC	chr16	23704968	Missense_Mutation	rs753715296	A305T	0.4
UCEC	chr16	23692286	Missense_Mutation	rs368927601	V764M	0.3
UCEC	chr16	23695273	Missense_Mutation	NA	R624H	0.47
UCEC	chr16	23706352	Frame_Shift_Del	novel	*M238Wfs9**	0.22
UCEC	chr16	23704910	Missense_Mutation	novel	L324H	0.11
UCEC	chr16	23706359	Missense_Mutation	rs750508633	A235V	0.27
UCEC	chr16	23700547	Missense_Mutation	NA	D554G	0.48
UCEC	chr16	23700607	Missense_Mutation	NA	A534G	0.39
UCEC	chr16	23706800	Silent	novel	L195L	0.33
UCEC	chr16	23702265	Missense_Mutation	rs377609896	E412K	0.47
UCEC	chr16	23692315	Missense_Mutation	novel	I754T	0.19
UCS	chr16	23700665	Frame_Shift_Del	rs763540496	*L515Wfs48**	0.41

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
CHOL	DEL	0.0833	0.23475
GBM	DEL	0.1092	0.0057085

Survival Analysis

Cancer	P-value	Q-value
HNSC	0.046	Kaplan-Meier Survival Analysis
SKCM	0.0015	Kaplan-Meier Survival Analysis
PAAD	0.013	Kaplan-Meier Survival Analysis
BLCA	0.0009	Kaplan-Meier Survival Analysis
CESC	0.038	Kaplan-Meier Survival Analysis
LAML	0.037	Kaplan-Meier Survival Analysis
LIHC	0.00078	Kaplan-Meier Survival Analysis
DLBC	0.022	Kaplan-Meier Survival Analysis
LGG	0.0001	Kaplan-Meier Survival Analysis
UVM	0.0001	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

PPI

Paralogs

Orthologs

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742