EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134452 (Gene tree)
Gene ID: 84893
Gene Symbol: FBH1
Alias: FLJ14590|Fbx18|FBXO18
Full Name: F-box DNA helicase 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 48,024 bases
Position: chr10:5,889,572-5,937,595
Accession: 13620
RBP type: canonical RBP
Summary: This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000380439	UvrD-helicase	PF00580.21	4.5e-11	1	1
ENSP00000355415	UvrD-helicase	PF00580.21	5.2e-11	1	1
ENSP00000369335	UvrD-helicase	PF00580.21	5.8e-11	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000496013	FBH1-216	336	-	-	- (aa)	-	-
ENST00000462507	FBH1-206	906	-	-	- (aa)	-	-
ENST00000494526	FBH1-215	578	-	-	- (aa)	-	-
ENST00000470089	FBH1-208	979	-	-	- (aa)	-	-
ENST00000489042	FBH1-214	478	-	-	- (aa)	-	-
ENST00000461504	FBH1-205	835	-	-	- (aa)	-	-
ENST00000479433	FBH1-211	527	-	-	- (aa)	-	-
ENST00000481029	FBH1-212	404	-	-	- (aa)	-	-
ENST00000469009	FBH1-207	886	-	-	- (aa)	-	-
ENST00000362091	FBH1-201	3560	XM_017016844	ENSP00000355415	1043 (aa)	XP_016872333	Q8NFZ0
ENST00000475867	FBH1-210	912	-	-	- (aa)	-	-
ENST00000397269	FBH1-203	3640	XM_017016846	ENSP00000380439	986 (aa)	XP_016872335	F6UZG9
ENST00000379999	FBH1-202	3702	XM_011519748	ENSP00000369335	1094 (aa)	XP_011518050	Q8NFZ0
ENST00000470353	FBH1-209	681	-	-	- (aa)	-	-
ENST00000485290	FBH1-213	534	-	-	- (aa)	-	-
ENST00000460453	FBH1-204	634	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000134452's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134452	Language Tests	1.8925000E-005	-
ENSG00000134452	Child Development Disorders, Pervasive	8.6648000E-006	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134452	rs3891620	10	5914871	?	Adolescent idiopathic scoliosis	30019117			EFO_0005423

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134452's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134452	FBH1	97	42.387	ENSAPOG00000007042	fbxo18	97	42.387	Acanthochromis_polyacanthus
ENSG00000134452	FBH1	100	91.388	ENSAMEG00000002043	FBH1	100	91.126	Ailuropoda_melanoleuca
ENSG00000134452	FBH1	88	44.743	ENSACIG00000006171	fbxo18	90	44.469	Amphilophus_citrinellus
ENSG00000134452	FBH1	99	41.057	ENSAOCG00000014826	fbxo18	99	40.967	Amphiprion_ocellaris
ENSG00000134452	FBH1	99	40.593	ENSAPEG00000022846	fbxo18	99	40.893	Amphiprion_percula
ENSG00000134452	FBH1	88	45.958	ENSATEG00000004547	fbxo18	99	42.857	Anabas_testudineus
ENSG00000134452	FBH1	97	49.140	ENSAPLG00000009754	FBH1	99	49.140	Anas_platyrhynchos
ENSG00000134452	FBH1	89	53.027	ENSACAG00000002729	FBH1	83	54.057	Anolis_carolinensis
ENSG00000134452	FBH1	100	97.033	ENSANAG00000032436	FBH1	100	97.033	Aotus_nancymaae
ENSG00000134452	FBH1	99	41.765	ENSACLG00000004266	fbxo18	97	44.802	Astatotilapia_calliptera
ENSG00000134452	FBH1	78	50.567	ENSAMXG00000020772	fbxo18	99	45.927	Astyanax_mexicanus
ENSG00000134452	FBH1	100	88.815	ENSBTAG00000004147	FBH1	100	88.815	Bos_taurus
ENSG00000134452	FBH1	100	97.129	ENSCJAG00000020531	FBH1	100	97.129	Callithrix_jacchus
ENSG00000134452	FBH1	100	90.900	ENSCAFG00000005218	FBH1	100	92.490	Canis_familiaris
ENSG00000134452	FBH1	100	90.900	ENSCAFG00020005396	FBH1	100	92.490	Canis_lupus_dingo
ENSG00000134452	FBH1	100	88.145	ENSCHIG00000016303	FBH1	100	88.145	Capra_hircus
ENSG00000134452	FBH1	100	86.111	ENSCPOG00000010580	FBH1	100	86.111	Cavia_porcellus
ENSG00000134452	FBH1	100	97.225	ENSCCAG00000023218	FBH1	100	97.225	Cebus_capucinus
ENSG00000134452	FBH1	89	97.655	ENSCATG00000035430	FBH1	100	97.655	Cercocebus_atys
ENSG00000134452	FBH1	100	92.536	ENSCLAG00000008089	FBH1	100	92.536	Chinchilla_lanigera
ENSG00000134452	FBH1	100	96.356	ENSCSAG00000013644	FBH1	100	98.043	Chlorocebus_sabaeus
ENSG00000134452	FBH1	73	93.000	ENSCHOG00000007603	FBH1	73	93.000	Choloepus_hoffmanni
ENSG00000134452	FBH1	100	54.588	ENSCPBG00000019260	FBH1	100	53.854	Chrysemys_picta_bellii
ENSG00000134452	FBH1	100	97.874	ENSCANG00000023461	FBH1	100	97.989	Colobus_angolensis_palliatus
ENSG00000134452	FBH1	100	90.249	ENSCGRG00001018795	Fbh1	100	90.249	Cricetulus_griseus_chok1gshd
ENSG00000134452	FBH1	100	90.249	ENSCGRG00000008471	Fbh1	100	90.249	Cricetulus_griseus_crigri
ENSG00000134452	FBH1	88	41.509	ENSCSEG00000018212	fbxo18	98	40.583	Cynoglossus_semilaevis
ENSG00000134452	FBH1	83	40.265	ENSCVAG00000006828	fbxo18	99	40.265	Cyprinodon_variegatus
ENSG00000134452	FBH1	99	45.956	ENSDARG00000062983	fbxo18	99	46.154	Danio_rerio
ENSG00000134452	FBH1	100	88.528	ENSETEG00000019856	FBH1	99	88.528	Echinops_telfairi
ENSG00000134452	FBH1	100	92.065	ENSEASG00005019192	FBH1	100	92.065	Equus_asinus_asinus
ENSG00000134452	FBH1	100	92.161	ENSECAG00000006839	FBH1	100	92.161	Equus_caballus
ENSG00000134452	FBH1	91	83.750	ENSEEUG00000000461	FBH1	91	85.775	Erinaceus_europaeus
ENSG00000134452	FBH1	88	50.619	ENSELUG00000006556	fbxo18	99	52.174	Esox_lucius
ENSG00000134452	FBH1	100	91.874	ENSFCAG00000009004	FBH1	99	90.943	Felis_catus
ENSG00000134452	FBH1	100	91.196	ENSFDAG00000009830	FBH1	100	91.196	Fukomys_damarensis
ENSG00000134452	FBH1	88	44.062	ENSFHEG00000007533	fbxo18	99	41.370	Fundulus_heteroclitus
ENSG00000134452	FBH1	81	46.448	ENSGMOG00000010594	-	93	42.857	Gadus_morhua
ENSG00000134452	FBH1	98	51.052	ENSGALG00000008162	FBH1	99	51.052	Gallus_gallus
ENSG00000134452	FBH1	99	40.754	ENSGAFG00000004166	fbxo18	99	40.897	Gambusia_affinis
ENSG00000134452	FBH1	97	42.857	ENSGACG00000019171	fbxo18	97	43.147	Gasterosteus_aculeatus
ENSG00000134452	FBH1	94	62.406	ENSGAGG00000021773	FBH1	99	57.531	Gopherus_agassizii
ENSG00000134452	FBH1	100	98.988	ENSGGOG00000013326	FBXO18	100	98.988	Gorilla_gorilla
ENSG00000134452	FBH1	99	42.077	ENSHBUG00000016673	fbxo18	99	42.350	Haplochromis_burtoni
ENSG00000134452	FBH1	100	92.727	ENSHGLG00000015581	FBXO18	100	92.727	Heterocephalus_glaber_female
ENSG00000134452	FBH1	100	92.727	ENSHGLG00100009896	FBXO18	100	92.727	Heterocephalus_glaber_male
ENSG00000134452	FBH1	57	43.719	ENSHCOG00000010937	-	78	45.932	Hippocampus_comes
ENSG00000134452	FBH1	90	45.842	ENSIPUG00000019144	fbxo18	96	45.842	Ictalurus_punctatus
ENSG00000134452	FBH1	100	92.153	ENSSTOG00000006496	FBH1	100	92.153	Ictidomys_tridecemlineatus
ENSG00000134452	FBH1	99	41.843	ENSKMAG00000021437	fbxo18	94	41.935	Kryptolebias_marmoratus
ENSG00000134452	FBH1	99	40.926	ENSLBEG00000023717	fbxo18	99	41.289	Labrus_bergylta
ENSG00000134452	FBH1	77	42.735	ENSLACG00000013504	FBH1	99	42.667	Latimeria_chalumnae
ENSG00000134452	FBH1	99	49.906	ENSLOCG00000015655	fbxo18	99	50.000	Lepisosteus_oculatus
ENSG00000134452	FBH1	100	90.822	ENSLAFG00000013105	FBH1	100	90.727	Loxodonta_africana
ENSG00000134452	FBH1	100	97.799	ENSMMUG00000015143	FBH1	100	97.773	Macaca_mulatta
ENSG00000134452	FBH1	100	97.990	ENSMNEG00000043475	FBH1	100	97.990	Macaca_nemestrina
ENSG00000134452	FBH1	100	98.180	ENSMLEG00000035307	FBH1	100	98.276	Mandrillus_leucophaeus
ENSG00000134452	FBH1	99	41.525	ENSMAMG00000000527	fbxo18	99	41.525	Mastacembelus_armatus
ENSG00000134452	FBH1	99	41.765	ENSMZEG00005015202	fbxo18	99	42.287	Maylandia_zebra
ENSG00000134452	FBH1	90	51.817	ENSMGAG00000003231	FBH1	100	51.763	Meleagris_gallopavo
ENSG00000134452	FBH1	100	92.366	ENSMICG00000009646	FBH1	100	100.000	Microcebus_murinus
ENSG00000134452	FBH1	99	40.170	ENSMMOG00000010268	fbxo18	99	40.265	Mola_mola
ENSG00000134452	FBH1	100	68.554	ENSMODG00000018516	FBH1	100	69.753	Monodelphis_domestica
ENSG00000134452	FBH1	97	43.279	ENSMALG00000010440	fbxo18	97	43.279	Monopterus_albus
ENSG00000134452	FBH1	100	90.535	MGP_CAROLIEiJ_G0023178	Fbh1	100	90.535	Mus_caroli
ENSG00000134452	FBH1	100	89.866	ENSMUSG00000058594	Fbh1	100	89.866	Mus_musculus
ENSG00000134452	FBH1	100	90.440	MGP_PahariEiJ_G0019237	Fbh1	100	90.440	Mus_pahari
ENSG00000134452	FBH1	100	89.771	MGP_SPRETEiJ_G0024095	Fbh1	100	89.771	Mus_spretus
ENSG00000134452	FBH1	100	90.144	ENSMPUG00000016343	FBH1	100	90.144	Mustela_putorius_furo
ENSG00000134452	FBH1	100	85.210	ENSMLUG00000000133	FBH1	100	85.210	Myotis_lucifugus
ENSG00000134452	FBH1	96	47.945	ENSNBRG00000018212	fbxo18	99	41.457	Neolamprologus_brichardi
ENSG00000134452	FBH1	100	98.178	ENSNLEG00000011537	FBH1	100	98.178	Nomascus_leucogenys
ENSG00000134452	FBH1	79	67.677	ENSMEUG00000000256	-	79	67.677	Notamacropus_eugenii
ENSG00000134452	FBH1	100	85.564	ENSOPRG00000002898	FBH1	100	83.963	Ochotona_princeps
ENSG00000134452	FBH1	100	90.144	ENSODEG00000004201	FBH1	100	90.144	Octodon_degus
ENSG00000134452	FBH1	95	41.682	ENSONIG00000011830	fbxo18	100	46.485	Oreochromis_niloticus
ENSG00000134452	FBH1	100	63.118	ENSOANG00000015459	FBH1	100	63.118	Ornithorhynchus_anatinus
ENSG00000134452	FBH1	100	90.649	ENSOCUG00000006237	FBH1	100	90.649	Oryctolagus_cuniculus
ENSG00000134452	FBH1	97	41.055	ENSORLG00000026493	fbxo18	97	41.160	Oryzias_latipes
ENSG00000134452	FBH1	97	41.143	ENSORLG00020004678	fbxo18	97	41.088	Oryzias_latipes_hni
ENSG00000134452	FBH1	97	41.149	ENSORLG00015001917	fbxo18	97	40.913	Oryzias_latipes_hsok
ENSG00000134452	FBH1	93	41.231	ENSOMEG00000011975	fbxo18	97	41.541	Oryzias_melastigma
ENSG00000134452	FBH1	100	91.475	ENSOGAG00000015682	FBH1	100	91.475	Otolemur_garnettii
ENSG00000134452	FBH1	100	87.954	ENSOARG00000012605	FBH1	100	87.954	Ovis_aries
ENSG00000134452	FBH1	100	99.190	ENSPPAG00000043946	FBH1	100	99.190	Pan_paniscus
ENSG00000134452	FBH1	100	91.587	ENSPPRG00000009687	FBH1	97	91.587	Panthera_pardus
ENSG00000134452	FBH1	100	91.396	ENSPTIG00000020396	FBH1	100	92.078	Panthera_tigris_altaica
ENSG00000134452	FBH1	100	99.190	ENSPTRG00000002261	FBH1	100	99.190	Pan_troglodytes
ENSG00000134452	FBH1	100	98.086	ENSPANG00000023427	FBH1	100	98.146	Papio_anubis
ENSG00000134452	FBH1	99	45.191	ENSPKIG00000025529	fbxo18	99	45.218	Paramormyrops_kingsleyae
ENSG00000134452	FBH1	99	55.921	ENSPSIG00000013802	FBH1	99	55.921	Pelodiscus_sinensis
ENSG00000134452	FBH1	100	89.675	ENSPEMG00000023309	Fbh1	100	89.675	Peromyscus_maniculatus_bairdii
ENSG00000134452	FBH1	100	69.161	ENSPCIG00000023460	FBH1	100	68.541	Phascolarctos_cinereus
ENSG00000134452	FBH1	99	41.155	ENSPFOG00000005889	fbxo18	99	40.967	Poecilia_formosa
ENSG00000134452	FBH1	99	40.976	ENSPLAG00000014934	fbxo18	99	40.771	Poecilia_latipinna
ENSG00000134452	FBH1	99	41.338	ENSPMEG00000021117	fbxo18	99	41.133	Poecilia_mexicana
ENSG00000134452	FBH1	65	49.020	ENSPREG00000017674	fbxo18	77	49.600	Poecilia_reticulata
ENSG00000134452	FBH1	95	97.776	ENSPPYG00000002064	FBH1	98	97.776	Pongo_abelii
ENSG00000134452	FBH1	100	85.851	ENSPCAG00000013584	FBH1	99	83.623	Procavia_capensis
ENSG00000134452	FBH1	100	88.900	ENSPCOG00000011617	FBH1	99	85.936	Propithecus_coquereli
ENSG00000134452	FBH1	100	89.101	ENSPVAG00000007082	FBH1	99	86.734	Pteropus_vampyrus
ENSG00000134452	FBH1	86	48.387	ENSPNYG00000015327	fbxo18	92	44.693	Pundamilia_nyererei
ENSG00000134452	FBH1	88	50.503	ENSPNAG00000008968	fbxo18	99	45.996	Pygocentrus_nattereri
ENSG00000134452	FBH1	84	36.374	ENSPNAG00000001339	-	92	37.379	Pygocentrus_nattereri
ENSG00000134452	FBH1	100	89.675	ENSRNOG00000018549	Fbh1	100	89.675	Rattus_norvegicus
ENSG00000134452	FBH1	100	97.990	ENSRBIG00000038238	FBH1	100	97.990	Rhinopithecus_bieti
ENSG00000134452	FBH1	100	98.086	ENSRROG00000029282	FBH1	100	98.146	Rhinopithecus_roxellana
ENSG00000134452	FBH1	100	96.842	ENSSBOG00000026129	FBH1	100	96.839	Saimiri_boliviensis_boliviensis
ENSG00000134452	FBH1	100	68.352	ENSSHAG00000009789	FBH1	100	67.874	Sarcophilus_harrisii
ENSG00000134452	FBH1	99	46.452	ENSSFOG00015023855	fbxo18	98	46.267	Scleropages_formosus
ENSG00000134452	FBH1	85	45.924	ENSSMAG00000012330	fbxo18	97	42.673	Scophthalmus_maximus
ENSG00000134452	FBH1	88	45.373	ENSSDUG00000014911	fbxo18	85	46.023	Seriola_dumerili
ENSG00000134452	FBH1	95	41.841	ENSSLDG00000014394	fbxo18	99	42.386	Seriola_lalandi_dorsalis
ENSG00000134452	FBH1	100	48.956	ENSSPUG00000001370	FBH1	98	50.204	Sphenodon_punctatus
ENSG00000134452	FBH1	97	42.724	ENSSPAG00000002282	fbxo18	97	42.631	Stegastes_partitus
ENSG00000134452	FBH1	100	88.084	ENSSSCG00000030030	FBH1	100	88.073	Sus_scrofa
ENSG00000134452	FBH1	86	44.879	ENSTNIG00000006893	fbxo18	100	45.775	Tetraodon_nigroviridis
ENSG00000134452	FBH1	93	98.214	ENSTBEG00000003595	FBH1	93	98.214	Tupaia_belangeri
ENSG00000134452	FBH1	100	87.488	ENSTTRG00000001338	FBH1	97	87.488	Tursiops_truncatus
ENSG00000134452	FBH1	100	91.969	ENSUAMG00000007277	FBH1	100	91.969	Ursus_americanus
ENSG00000134452	FBH1	100	90.900	ENSUMAG00000012189	FBH1	100	92.490	Ursus_maritimus
ENSG00000134452	FBH1	99	92.426	ENSVVUG00000006823	FBH1	100	92.695	Vulpes_vulpes
ENSG00000134452	FBH1	92	58.372	ENSXETG00000018125	fbh1	99	52.672	Xenopus_tropicalis
ENSG00000134452	FBH1	99	40.917	ENSXMAG00000019200	fbxo18	99	41.101	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000724	double-strand break repair via homologous recombination	21873635.	IBA	Process
GO:0000724	double-strand break repair via homologous recombination	-	ISS	Process
GO:0000725	recombinational repair	21873635.	IBA	Process
GO:0000737	DNA catabolic process, endonucleolytic	23361013.	IMP	Process
GO:0000785	chromatin	23319600.	IDA	Component
GO:0001934	positive regulation of protein phosphorylation	23361013.	IMP	Process
GO:0003678	DNA helicase activity	19736316.	IDA	Function
GO:0003678	DNA helicase activity	23361013.	IMP	Function
GO:0003690	double-stranded DNA binding	23393192.	IDA	Function
GO:0003697	single-stranded DNA binding	19736316.23393192.	IDA	Function
GO:0005515	protein binding	23393192.23954233.25585578.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	19736316.	IDA	Component
GO:0006281	DNA repair	21873635.	IBA	Process
GO:0006974	cellular response to DNA damage stimulus	19736316.23319600.23361013.25585578.	IDA	Process
GO:0008219	cell death	23319600.	IDA	Process
GO:0008219	cell death	23361013.	IMP	Process
GO:0015616	DNA translocase activity	24108124.	IDA	Function
GO:0016567	protein ubiquitination	25585578.	IDA	Process
GO:0016567	protein ubiquitination	-	IEA	Process
GO:0019005	SCF ubiquitin ligase complex	11956208.19736316.25585578.	IDA	Component
GO:0031297	replication fork processing	21873635.	IBA	Process
GO:0031297	replication fork processing	25585578.	IDA	Process
GO:0032508	DNA duplex unwinding	-	IEA	Process
GO:0035562	negative regulation of chromatin binding	-	IEA	Process
GO:0043138	3'-5' DNA helicase activity	11956208.23393192.	IDA	Function
GO:0043140	ATP-dependent 3'-5' DNA helicase activity	21873635.	IBA	Function
GO:0048478	replication fork protection	-	ISS	Process
GO:0072429	response to intra-S DNA damage checkpoint signaling	23361013.	IMP	Process
GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	23361013.	IMP	Process
GO:2000042	negative regulation of double-strand break repair via homologous recombination	19736316.	IDA	Process