EuRBPDB

Description

RBDs

RBPome

PRI

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134644 (Gene tree)
Gene ID: 9698
Gene Symbol: PUM1
Alias: PUMH1|KIAA0099
Full Name: pumilio RNA binding family member 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 134,486 bases
Position: chr1:30,931,506-31,065,991
Accession: 14957
RBP type: canonical RBP
Summary: This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000400141	PUF	PF00806.19	8.7e-71	1	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	2	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	3	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	4	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	5	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	6	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	7	8
ENSP00000400141	PUF	PF00806.19	8.7e-71	8	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	1	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	2	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	3	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	4	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	5	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	6	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	7	8
ENSP00000433850	PUF	PF00806.19	1.6e-70	8	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	1	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	2	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	3	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	4	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	5	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	6	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	7	8
ENSP00000435825	PUF	PF00806.19	4.1e-70	8	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	1	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	2	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	3	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	4	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	5	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	6	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	7	8
ENSP00000362847	PUF	PF00806.19	4.2e-70	8	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	1	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	2	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	3	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	4	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	5	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	6	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	7	8
ENSP00000257075	PUF	PF00806.19	6.6e-70	8	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	1	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	2	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	3	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	4	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	5	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	6	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	7	8
ENSP00000401777	PUF	PF00806.19	1.3e-69	8	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	1	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	2	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	3	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	4	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	5	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	6	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	7	8
ENSP00000391723	PUF	PF00806.19	1.6e-69	8	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	1	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	2	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	3	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	4	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	5	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	6	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	7	8
ENSP00000362852	PUF	PF00806.19	1.6e-69	8	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	1	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	2	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	3	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	4	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	5	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	6	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	7	8
ENSP00000362846	PUF	PF00806.19	2.1e-69	8	8
ENSP00000433373	PUF	PF00806.19	1.2e-54	1	6
ENSP00000433373	PUF	PF00806.19	1.2e-54	2	6
ENSP00000433373	PUF	PF00806.19	1.2e-54	3	6
ENSP00000433373	PUF	PF00806.19	1.2e-54	4	6
ENSP00000433373	PUF	PF00806.19	1.2e-54	5	6
ENSP00000433373	PUF	PF00806.19	1.2e-54	6	6
ENSP00000431213	PUF	PF00806.19	1.8e-52	1	6
ENSP00000431213	PUF	PF00806.19	1.8e-52	2	6
ENSP00000431213	PUF	PF00806.19	1.8e-52	3	6
ENSP00000431213	PUF	PF00806.19	1.8e-52	4	6
ENSP00000431213	PUF	PF00806.19	1.8e-52	5	6
ENSP00000431213	PUF	PF00806.19	1.8e-52	6	6

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	PolyT-RICK & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & MCF10A	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
27453046	Comprehensive Identification of RNA-Binding Domains in Human Cells	RIC & Hela	2016 Aug 18	Castello A	DOI: 10.1016/j.molcel.2016.06.029
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Protein-RNA interaction（RNA-Binding Site）

Click here to download all RNA binding sites

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28518098	Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells.	J Vis Exp	2017 Apr 26	Wei HH	doi: 10.3791/54967.
17401370	Imaging dynamics of endogenous mitochondrial RNA in single living cells.	Nat Methods	2007 May	Ozawa T	-
29428722	PUM1 promotes ovarian cancer proliferation, migration and invasion.	Biochem Biophys Res Commun	2018 Feb 26	Guan X	doi: 10.1016/j.bbrc.2018.02.078
31010819	Breast Cancer Subtype Classification Using 4-Plex Droplet Digital PCR.	Clin Chem	2019 Apr 22	Chen W	doi: 10.1373/clinchem.2019.302315
31128486	Triptolide enhances TRAIL sensitivity of pancreatic cancer cells by activating autophagy via downregulation of PUM1.	Phytomedicine	2019 May 9	Dai H	doi: 10.1016/j.phymed.2019.152953
21397187	Alternate modes of cognate RNA recognition by human PUMILIO proteins.	Structure	2011 Mar 9	Lu G	doi: 10.1016/j.str.2010.12.019.
12202039	Modular recognition of RNA by a human pumilio-homology domain.	Cell	2002 Aug 23	Wang X	-
18411299	Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets.	Mol Cell Biol	2008 Jun	Morris AR	doi: 10.1128/MCB.00155-08
21431741	Genetically-encoded fluorescent probes for imaging endogenous mRNA in living cells.	Methods Mol Biol	2011	Ozawa T	doi: 10.1007/978-1-61779-005-8_11.
12667987	Mouse Pum1 and Pum2 genes, members of the Pumilio family of RNA-binding proteins, show differential expression in fetal and adult hematopoietic stem cells and progenitors.	Blood Cells Mol Dis	2003 Jan-Feb	Spassov DS	-
12459267	Cloning and comparative sequence analysis of PUM1 and PUM2 genes, human members of the Pumilio family of RNA-binding proteins.	Gene	2002 Oct 16	Spassov DS	-
19801992	Engineering splicing factors with designed specificities.	Nat Methods	2009 Nov	Wang Y	doi: 10.1038/nmeth.1379
22955276	Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.	J Biol Chem	2012 Oct 19	Van Etten J	doi: 10.1074/jbc.M112.373522
17768378	The RNA-binding protein Musashi-1 is produced in the developing and adult mouse eye.	Mol Vis	2007 Aug 10	Raji B	-
17474090	Identification and gene expression profiling of the Pum1 and Pum2 members of the Pumilio family in the chicken.	Mol Reprod Dev	2008 Jan	Lee JY	-
16954190	Engineering RNA sequence specificity of Pumilio repeats.	Proc Natl Acad Sci U S A	2006 Sep 12	Cheong CG	-
22387832	Fluorescent probes for imaging endogenous β-actin mRNA in living cells using fluorescent protein-tagged pumilio.	ACS Chem Biol	2012 Jun 15	Yoshimura H	doi: 10.1021/cb200474a
21634804	Visualization of nonengineered single mRNAs in living cells using genetically encoded fluorescent probes.	Anal Chem	2011 Jul 15	Yamada T	doi: 10.1021/ac2009405
20818387	A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility.	Nat Cell Biol	2010 Oct	Kedde M	doi: 10.1038/ncb2105
25151966	miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer.	Oncogene	2015 Jun	Fernandez S	doi: 10.1038/onc.2014.267
24062337	Cyclin B1 mRNA translation is temporally controlled through formation and disassembly of RNA granules.	J Cell Biol	2013 Sep 30	Kotani T	doi: 10.1083/jcb.201302139
24412312	Genetic exploration of the exit from self-renewal using haploid embryonic stem cells.	Cell Stem Cell	2014 Mar 6	Leeb M	doi: 10.1016/j.stem.2013.12.008
27157388	NORAD: Defender of the Genome.	Trends Genet	2016 Jul	Ventura A	doi: 10.1016/j.tig.2016.04.002
25768905	Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels.	Cell	2015 Mar 12	Gennarino VA	doi: 10.1016/j.cell.2015.02.012.
28760986	PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.	Proc Natl Acad Sci U S A	2017 Aug 15	Liu Y	doi: 10.1073/pnas.1708713114
29165587	Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.	Nucleic Acids Res	2018 Jan 9	Bohn JA	doi: 10.1093/nar/gkx1120.
29297114	Variation analysis of PUM1 gene in Chinese women with primary ovarian insufficiency.	J Assist Reprod Genet	2018 Apr	Luo W	doi: 10.1007/s10815-017-1110-4
29474920	A Mild PUM1 Mutation Is Associated with Adult-Onset Ataxia, whereas Haploinsufficiency Causes Developmental Delay and Seizures.	Cell	2018 Feb 22	Gennarino VA	doi: 10.1016/j.cell.2018.02.006.
30256721	Essential requirement of mammalian Pumilio family in embryonic development.	Mol Biol Cell	2018 Nov 26	Lin K	doi: 10.1091/mbc.E18-06-0369
30316580	Post-transcriptional Regulatory Functions of Mammalian Pumilio Proteins.	Trends Genet	2018 Dec	Goldstrohm AC	doi: 10.1016/j.tig.2018.09.006
30364263	A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis.	Cell Biosci	2018 Oct 19	Mak W	doi: 10.1186/s13578-018-0251-1
30811992	Mammalian Pum1 and Pum2 Control Body Size via Translational Regulation of the Cell Cycle Inhibitor Cdkn1b.	Cell Rep	2019 Feb 26	Lin K	doi: 10.1016/j.celrep.2019.01.111.
30955425	PUMILIO1 Links Epilepsy to Spinocerebellar Ataxia.	Epilepsy Curr	2019 Mar-Apr	Lyman KA	doi: 10.1177/1535759719835354.
31078383	A Quantitative and Predictive Model for RNA Binding by Human Pumilio Proteins.	Mol Cell	2019 Jun 6	Jarmoskaite I	doi: 10.1016/j.molcel.2019.04.012
29722104	Long noncoding RNA NORAD regulates transforming growth factor-β signaling and epithelial-to-mesenchymal transition-like phenotype.	Cancer Sci	2018 Jul	Kawasaki N	doi: 10.1111/cas.13626

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000532678	PUM1-223	793	-	ENSP00000435589	265 (aa)	-	H0YED4
ENST00000480602	PUM1-209	906	-	ENSP00000437269	124 (aa)	-	E9PMX1
ENST00000527498	PUM1-219	652	-	ENSP00000431779	90 (aa)	-	H0YCK1
ENST00000498627	PUM1-212	422	-	-	- (aa)	-	-
ENST00000530669	PUM1-221	582	-	ENSP00000434096	76 (aa)	-	H0YDQ6
ENST00000525997	PUM1-216	650	-	ENSP00000433373	217 (aa)	-	H0YDC5
ENST00000490546	PUM1-210	707	-	-	- (aa)	-	-
ENST00000426105	PUM1-206	4043	-	ENSP00000391723	1188 (aa)	-	Q14671
ENST00000373742	PUM1-203	3515	-	ENSP00000362847	1127 (aa)	-	Q14671
ENST00000373741	PUM1-202	4242	-	ENSP00000362846	1224 (aa)	-	Q5T1Z8
ENST00000373747	PUM1-204	5375	-	ENSP00000362852	1189 (aa)	-	Q5T1Z4
ENST00000525843	PUM1-214	4528	-	ENSP00000435825	1125 (aa)	-	H0YEH2
ENST00000529846	PUM1-220	683	-	ENSP00000431213	227 (aa)	-	H0YC97
ENST00000526128	PUM1-217	579	-	-	- (aa)	-	-
ENST00000424085	PUM1-205	4631	-	ENSP00000400141	944 (aa)	-	E9PR38
ENST00000440538	PUM1-207	3936	-	ENSP00000401777	1162 (aa)	-	Q14671
ENST00000524516	PUM1-213	561	-	-	- (aa)	-	-
ENST00000471894	PUM1-208	812	-	-	- (aa)	-	-
ENST00000498419	PUM1-211	3068	-	ENSP00000433850	900 (aa)	-	H0YDK8
ENST00000257075	PUM1-201	5360	-	ENSP00000257075	1186 (aa)	-	Q14671
ENST00000526215	PUM1-218	586	-	ENSP00000436921	94 (aa)	-	E9PM68
ENST00000531867	PUM1-222	549	-	ENSP00000431470	96 (aa)	-	E9PL65
ENST00000525948	PUM1-215	1103	-	ENSP00000433099	94 (aa)	-	E9PM68

Gene Model

Click here to download ENSG00000134644's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134644	Lupus Erythematosus, Systemic	1.86E-5	18204446
ENSG00000134644	Lupus Erythematosus, Systemic	2.29E-5	18204446
ENSG00000134644	Lupus Erythematosus, Systemic	2.2E-5	18204446
ENSG00000134644	Lupus Erythematosus, Systemic	2.16E-5	18204446

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134644	rs4949330	1	30976919	?	Colorectal cancer	29228715	[NR]	1.802	EFO_0005842

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134644's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000134644	PUM1	95	87.354	ENSG00000055917	PUM2	100	89.320

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134644	PUM1	99	91.566	ENSAPOG00000021632	pum1	100	91.525	Acanthochromis_polyacanthus
ENSG00000134644	PUM1	100	100.000	ENSAMEG00000017656	PUM1	100	98.940	Ailuropoda_melanoleuca
ENSG00000134644	PUM1	100	81.312	ENSACIG00000021013	pum1	93	90.602	Amphilophus_citrinellus
ENSG00000134644	PUM1	99	91.566	ENSAOCG00000003944	pum1	94	91.084	Amphiprion_ocellaris
ENSG00000134644	PUM1	99	91.566	ENSAPEG00000014550	pum1	94	91.084	Amphiprion_percula
ENSG00000134644	PUM1	99	91.566	ENSATEG00000016004	pum1	100	91.525	Anabas_testudineus
ENSG00000134644	PUM1	100	98.010	ENSAPLG00000009351	PUM1	100	97.729	Anas_platyrhynchos
ENSG00000134644	PUM1	99	98.309	ENSACAG00000000682	PUM1	98	95.875	Anolis_carolinensis
ENSG00000134644	PUM1	100	100.000	ENSANAG00000027865	PUM1	100	100.000	Aotus_nancymaae
ENSG00000134644	PUM1	100	78.439	ENSACLG00000019354	pum1	100	79.001	Astatotilapia_calliptera
ENSG00000134644	PUM1	99	92.754	ENSAMXG00000020607	pum1	92	92.754	Astyanax_mexicanus
ENSG00000134644	PUM1	100	100.000	ENSBTAG00000018979	PUM1	100	100.000	Bos_taurus
ENSG00000134644	PUM1	100	100.000	ENSCJAG00000006035	PUM1	100	100.000	Callithrix_jacchus
ENSG00000134644	PUM1	100	100.000	ENSCAFG00000011205	PUM1	100	99.484	Canis_familiaris
ENSG00000134644	PUM1	99	99.444	ENSCAFG00020024616	PUM1	99	98.767	Canis_lupus_dingo
ENSG00000134644	PUM1	100	100.000	ENSCHIG00000012952	PUM1	100	99.757	Capra_hircus
ENSG00000134644	PUM1	100	100.000	ENSTSYG00000008868	PUM1	100	99.682	Carlito_syrichta
ENSG00000134644	PUM1	100	99.327	ENSCPOG00000031613	PUM1	100	99.327	Cavia_porcellus
ENSG00000134644	PUM1	100	100.000	ENSCATG00000017991	PUM1	100	100.000	Cercocebus_atys
ENSG00000134644	PUM1	100	99.411	ENSCLAG00000007662	PUM1	100	99.515	Chinchilla_lanigera
ENSG00000134644	PUM1	100	100.000	ENSCSAG00000001028	PUM1	100	99.083	Chlorocebus_sabaeus
ENSG00000134644	PUM1	100	100.000	ENSCHOG00000010245	PUM1	93	96.547	Choloepus_hoffmanni
ENSG00000134644	PUM1	100	97.881	ENSCPBG00000009288	PUM1	100	98.544	Chrysemys_picta_bellii
ENSG00000134644	PUM1	100	100.000	ENSCANG00000042606	PUM1	100	100.000	Colobus_angolensis_palliatus
ENSG00000134644	PUM1	100	100.000	ENSCGRG00001024949	Pum1	100	99.306	Cricetulus_griseus_chok1gshd
ENSG00000134644	PUM1	100	100.000	ENSCGRG00000014197	Pum1	100	99.306	Cricetulus_griseus_crigri
ENSG00000134644	PUM1	100	78.067	ENSCSEG00000015981	pum1	100	77.850	Cynoglossus_semilaevis
ENSG00000134644	PUM1	100	80.817	ENSCVAG00000007043	pum1	100	75.785	Cyprinodon_variegatus
ENSG00000134644	PUM1	98	92.995	ENSDARG00000099256	pum1	95	93.750	Danio_rerio
ENSG00000134644	PUM1	100	100.000	ENSDNOG00000010939	PUM1	100	99.243	Dasypus_novemcinctus
ENSG00000134644	PUM1	94	99.034	ENSDORG00000001875	Pum1	100	99.515	Dipodomys_ordii
ENSG00000134644	PUM1	97	92.407	ENSETEG00000004355	PUM1	87	93.945	Echinops_telfairi
ENSG00000134644	PUM1	100	100.000	ENSEASG00005010813	PUM1	100	99.242	Equus_asinus_asinus
ENSG00000134644	PUM1	100	100.000	ENSECAG00000021369	PUM1	100	99.159	Equus_caballus
ENSG00000134644	PUM1	100	100.000	ENSEEUG00000003871	PUM1	77	100.000	Erinaceus_europaeus
ENSG00000134644	PUM1	100	83.354	ENSELUG00000002409	pum1	95	93.237	Esox_lucius
ENSG00000134644	PUM1	100	100.000	ENSFCAG00000010374	PUM1	100	100.000	Felis_catus
ENSG00000134644	PUM1	99	98.309	ENSFALG00000001214	PUM1	97	96.231	Ficedula_albicollis
ENSG00000134644	PUM1	100	99.327	ENSFDAG00000011319	PUM1	100	99.327	Fukomys_damarensis
ENSG00000134644	PUM1	90	91.084	ENSGMOG00000010491	pum1	94	90.602	Gadus_morhua
ENSG00000134644	PUM1	100	99.119	ENSGALG00000042598	PUM1	100	98.785	Gallus_gallus
ENSG00000134644	PUM1	95	87.816	ENSGAFG00000015617	pum1	100	82.030	Gambusia_affinis
ENSG00000134644	PUM1	100	81.034	ENSGACG00000005717	pum1	94	90.843	Gasterosteus_aculeatus
ENSG00000134644	PUM1	100	97.637	ENSGAGG00000001290	PUM1	100	98.583	Gopherus_agassizii
ENSG00000134644	PUM1	100	100.000	ENSGGOG00000011983	PUM1	100	100.000	Gorilla_gorilla
ENSG00000134644	PUM1	100	81.064	ENSHBUG00000018718	pum1	100	76.364	Haplochromis_burtoni
ENSG00000134644	PUM1	100	99.159	ENSHGLG00000013819	Pum1	100	99.159	Heterocephalus_glaber_female
ENSG00000134644	PUM1	100	99.159	ENSHGLG00100008621	Pum1	100	99.159	Heterocephalus_glaber_male
ENSG00000134644	PUM1	100	78.439	ENSHCOG00000005149	pum1	100	75.301	Hippocampus_comes
ENSG00000134644	PUM1	98	92.029	ENSIPUG00000020421	pum1	93	92.029	Ictalurus_punctatus
ENSG00000134644	PUM1	100	100.000	ENSSTOG00000010757	PUM1	100	100.000	Ictidomys_tridecemlineatus
ENSG00000134644	PUM1	100	100.000	ENSJJAG00000000530	Pum1	100	100.000	Jaculus_jaculus
ENSG00000134644	PUM1	98	90.843	ENSKMAG00000003481	pum1	94	90.361	Kryptolebias_marmoratus
ENSG00000134644	PUM1	98	91.566	ENSLBEG00000002527	pum1	94	91.084	Labrus_bergylta
ENSG00000134644	PUM1	100	88.724	ENSLACG00000017188	PUM1	99	86.761	Latimeria_chalumnae
ENSG00000134644	PUM1	99	96.377	ENSLOCG00000005210	pum1	95	96.377	Lepisosteus_oculatus
ENSG00000134644	PUM1	100	98.991	ENSLAFG00000003178	PUM1	100	98.991	Loxodonta_africana
ENSG00000134644	PUM1	100	100.000	ENSMFAG00000010291	PUM1	100	100.000	Macaca_fascicularis
ENSG00000134644	PUM1	100	100.000	ENSMMUG00000013520	PUM1	100	100.000	Macaca_mulatta
ENSG00000134644	PUM1	100	100.000	ENSMNEG00000034639	PUM1	100	100.000	Macaca_nemestrina
ENSG00000134644	PUM1	100	100.000	ENSMLEG00000038743	PUM1	100	100.000	Mandrillus_leucophaeus
ENSG00000134644	PUM1	98	91.325	ENSMAMG00000011606	pum1	94	90.843	Mastacembelus_armatus
ENSG00000134644	PUM1	100	81.064	ENSMZEG00005005834	pum1	100	76.364	Maylandia_zebra
ENSG00000134644	PUM1	100	97.761	ENSMGAG00000000724	PUM1	100	97.645	Meleagris_gallopavo
ENSG00000134644	PUM1	100	100.000	ENSMAUG00000022090	Pum1	100	99.306	Mesocricetus_auratus
ENSG00000134644	PUM1	100	99.664	ENSMICG00000007713	-	100	99.757	Microcebus_murinus
ENSG00000134644	PUM1	100	97.917	ENSMICG00000012213	-	100	97.088	Microcebus_murinus
ENSG00000134644	PUM1	100	98.991	ENSMOCG00000015463	Pum1	100	98.991	Microtus_ochrogaster
ENSG00000134644	PUM1	99	88.276	ENSMMOG00000019817	pum1	100	91.283	Mola_mola
ENSG00000134644	PUM1	100	97.899	ENSMODG00000017067	PUM1	100	97.899	Monodelphis_domestica
ENSG00000134644	PUM1	99	88.506	ENSMALG00000016399	pum1	100	91.525	Monopterus_albus
ENSG00000134644	PUM1	100	100.000	MGP_CAROLIEiJ_G0026549	Pum1	100	98.738	Mus_caroli
ENSG00000134644	PUM1	100	100.000	ENSMUSG00000028580	Pum1	100	99.306	Mus_musculus
ENSG00000134644	PUM1	100	100.000	MGP_PahariEiJ_G0028881	Pum1	100	99.306	Mus_pahari
ENSG00000134644	PUM1	100	100.000	MGP_SPRETEiJ_G0027529	Pum1	100	99.306	Mus_spretus
ENSG00000134644	PUM1	100	100.000	ENSMPUG00000015454	PUM1	100	99.327	Mustela_putorius_furo
ENSG00000134644	PUM1	100	100.000	ENSMLUG00000006490	PUM1	100	99.326	Myotis_lucifugus
ENSG00000134644	PUM1	100	99.364	ENSNGAG00000002378	Pum1	100	99.376	Nannospalax_galili
ENSG00000134644	PUM1	100	78.452	ENSNBRG00000010689	pum1	100	83.663	Neolamprologus_brichardi
ENSG00000134644	PUM1	100	99.306	ENSNLEG00000001151	PUM1	100	99.306	Nomascus_leucogenys
ENSG00000134644	PUM1	98	94.262	ENSMEUG00000000976	-	82	96.959	Notamacropus_eugenii
ENSG00000134644	PUM1	100	100.000	ENSOPRG00000001776	PUM1	73	100.000	Ochotona_princeps
ENSG00000134644	PUM1	100	99.242	ENSODEG00000003465	PUM1	100	99.242	Octodon_degus
ENSG00000134644	PUM1	99	91.106	ENSONIG00000002290	pum1	94	90.843	Oreochromis_niloticus
ENSG00000134644	PUM1	95	76.069	ENSOANG00000004902	-	100	77.869	Ornithorhynchus_anatinus
ENSG00000134644	PUM1	100	100.000	ENSOCUG00000008641	PUM1	99	98.989	Oryctolagus_cuniculus
ENSG00000134644	PUM1	100	81.931	ENSORLG00000011482	pum1	94	90.602	Oryzias_latipes
ENSG00000134644	PUM1	98	93.012	ENSORLG00020019461	pum1	94	90.602	Oryzias_latipes_hni
ENSG00000134644	PUM1	100	82.054	ENSORLG00015011375	pum1	94	90.602	Oryzias_latipes_hsok
ENSG00000134644	PUM1	90	93.220	ENSOMEG00000009312	pum1	100	76.846	Oryzias_melastigma
ENSG00000134644	PUM1	100	99.306	ENSOGAG00000011063	PUM1	100	96.977	Otolemur_garnettii
ENSG00000134644	PUM1	100	100.000	ENSOARG00000001899	PUM1	100	99.757	Ovis_aries
ENSG00000134644	PUM1	100	100.000	ENSPPAG00000044003	PUM1	100	100.000	Pan_paniscus
ENSG00000134644	PUM1	100	100.000	ENSPPRG00000001370	PUM1	100	100.000	Panthera_pardus
ENSG00000134644	PUM1	100	100.000	ENSPTIG00000010798	PUM1	100	100.000	Panthera_tigris_altaica
ENSG00000134644	PUM1	100	100.000	ENSPTRG00000000453	PUM1	100	100.000	Pan_troglodytes
ENSG00000134644	PUM1	100	100.000	ENSPANG00000016338	PUM1	100	100.000	Papio_anubis
ENSG00000134644	PUM1	94	93.932	ENSPKIG00000010578	pum1	100	78.383	Paramormyrops_kingsleyae
ENSG00000134644	PUM1	100	98.130	ENSPSIG00000014118	PUM1	100	97.980	Pelodiscus_sinensis
ENSG00000134644	PUM1	100	78.439	ENSPMGG00000005836	pum1	100	82.108	Periophthalmus_magnuspinnatus
ENSG00000134644	PUM1	100	100.000	ENSPEMG00000010009	Pum1	100	99.306	Peromyscus_maniculatus_bairdii
ENSG00000134644	PUM1	100	99.119	ENSPCIG00000014151	PUM1	100	98.134	Phascolarctos_cinereus
ENSG00000134644	PUM1	93	90.843	ENSPFOG00000007289	pum1	93	90.361	Poecilia_formosa
ENSG00000134644	PUM1	98	90.843	ENSPLAG00000007256	pum1	94	90.361	Poecilia_latipinna
ENSG00000134644	PUM1	88	90.843	ENSPMEG00000019543	pum1	92	90.361	Poecilia_mexicana
ENSG00000134644	PUM1	100	80.941	ENSPREG00000005195	pum1	100	81.166	Poecilia_reticulata
ENSG00000134644	PUM1	100	100.000	ENSPPYG00000001621	PUM1	100	98.020	Pongo_abelii
ENSG00000134644	PUM1	100	98.958	ENSPCAG00000001979	PUM1	76	99.383	Procavia_capensis
ENSG00000134644	PUM1	100	99.664	ENSPCOG00000004398	PUM1	100	99.757	Propithecus_coquereli
ENSG00000134644	PUM1	100	100.000	ENSPVAG00000005207	PUM1	99	96.396	Pteropus_vampyrus
ENSG00000134644	PUM1	100	81.064	ENSPNYG00000009518	pum1	100	81.840	Pundamilia_nyererei
ENSG00000134644	PUM1	98	92.995	ENSPNAG00000026728	pum1	95	92.995	Pygocentrus_nattereri
ENSG00000134644	PUM1	100	100.000	ENSRNOG00000011709	Pum1	100	98.988	Rattus_norvegicus
ENSG00000134644	PUM1	100	100.000	ENSRBIG00000042521	PUM1	100	100.000	Rhinopithecus_bieti
ENSG00000134644	PUM1	100	100.000	ENSRROG00000020156	PUM1	100	100.000	Rhinopithecus_roxellana
ENSG00000134644	PUM1	100	100.000	ENSSBOG00000032037	PUM1	100	100.000	Saimiri_boliviensis_boliviensis
ENSG00000134644	PUM1	100	97.815	ENSSHAG00000010918	PUM1	100	97.815	Sarcophilus_harrisii
ENSG00000134644	PUM1	98	91.566	ENSSMAG00000010918	pum1	100	91.525	Scophthalmus_maximus
ENSG00000134644	PUM1	98	91.566	ENSSDUG00000009021	pum1	94	91.084	Seriola_dumerili
ENSG00000134644	PUM1	94	91.566	ENSSLDG00000009667	pum1	93	91.084	Seriola_lalandi_dorsalis
ENSG00000134644	PUM1	100	100.000	ENSSARG00000003055	PUM1	94	98.206	Sorex_araneus
ENSG00000134644	PUM1	100	98.007	ENSSPUG00000006267	PUM1	100	97.306	Sphenodon_punctatus
ENSG00000134644	PUM1	99	91.566	ENSSPAG00000016636	pum1	94	91.084	Stegastes_partitus
ENSG00000134644	PUM1	100	100.000	ENSSSCG00000003591	PUM1	100	100.000	Sus_scrofa
ENSG00000134644	PUM1	98	91.566	ENSTRUG00000013121	pum1	94	91.084	Takifugu_rubripes
ENSG00000134644	PUM1	99	91.346	ENSTNIG00000016983	pum1	93	90.865	Tetraodon_nigroviridis
ENSG00000134644	PUM1	100	100.000	ENSTBEG00000013810	PUM1	89	96.341	Tupaia_belangeri
ENSG00000134644	PUM1	99	98.776	ENSTTRG00000007436	PUM1	90	99.453	Tursiops_truncatus
ENSG00000134644	PUM1	100	100.000	ENSUAMG00000018262	-	100	99.261	Ursus_americanus
ENSG00000134644	PUM1	100	100.000	ENSUMAG00000009211	PUM1	100	99.758	Ursus_maritimus
ENSG00000134644	PUM1	100	100.000	ENSVPAG00000005902	PUM1	92	99.664	Vicugna_pacos
ENSG00000134644	PUM1	100	100.000	ENSVVUG00000014631	PUM1	100	99.758	Vulpes_vulpes
ENSG00000134644	PUM1	100	88.944	ENSXETG00000012904	pum1	99	87.657	Xenopus_tropicalis
ENSG00000134644	PUM1	98	90.843	ENSXMAG00000002945	pum1	94	90.361	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	20818387.	IDA	Component
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0003723	RNA binding	26724866.	IDA	Function
GO:0003730	mRNA 3'-UTR binding	18776931.20818387.21572425.25768905.	IDA	Function
GO:0005515	protein binding	23125361.25340845.	IPI	Function
GO:0005634	nucleus	-	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0007283	spermatogenesis	-	ISS	Process
GO:0008344	adult locomotory behavior	-	ISS	Process
GO:0010494	cytoplasmic stress granule	25340845.	IDA	Component
GO:0010608	posttranscriptional regulation of gene expression	25100735.	IDA	Process
GO:0010608	posttranscriptional regulation of gene expression	28431233.	IMP	Process
GO:0016441	posttranscriptional gene silencing	-	ISS	Process
GO:0016607	nuclear speck	-	IDA	Component
GO:0035196	production of miRNAs involved in gene silencing by miRNA	28431233.	IMP	Process
GO:0035198	miRNA binding	28431233.	IDA	Function
GO:0043488	regulation of mRNA stability	26724866.	IDA	Process
GO:0048863	stem cell differentiation	-	ISS	Process
GO:0051726	regulation of cell cycle	20818387.	IDA	Process
GO:0051983	regulation of chromosome segregation	26724866.	IDA	Process
GO:0060964	regulation of gene silencing by miRNA	18776931.	TAS	Process
GO:0061157	mRNA destabilization	-	ISS	Process
GO:1900246	positive regulation of RIG-I signaling pathway	25340845.	IDA	Process
GO:2000637	positive regulation of gene silencing by miRNA	20818387.22345517.	IDA	Process