EuRBPDB

Description

RBDs

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Paralogs

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000134698 (Gene tree)
Gene ID: 192670
Gene Symbol: AGO4
Alias: hAGO4|KIAA1567|FLJ20033|EIF2C4
Full Name: argonaute RISC component 4
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 50,261 bases
Position: chr1:35,807,630-35,857,890
Accession: 18424
RBP type: canonical RBP
Summary: This gene encodes a member of the Argonaute family of proteins which contain PAZ and PIWI domains and play an integral role in RNA interference and short-interfering-RNA-mediated gene silencing. This gene is located on chromosome 1 in a cluster of related family members. [provided by RefSeq, Mar 2017]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000362306	PAZ	PF02170.22	2.7e-27	1	1
ENSP00000362306	Piwi	PF02171.17	1.2e-104	1	1

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
19410546	An effector of RNA-directed DNA methylation in arabidopsis is an ARGONAUTE 4- and RNA-binding protein.	Cell	2009 May 1	He XJ	doi: 10.1016/j.cell.2009.04.028.
21878547	Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.	RNA	2011 Oct	Broderick JA	doi: 10.1261/rna.2778911
18266474	Dynamic regulation of ARGONAUTE4 within multiple nuclear bodies in Arabidopsis thaliana.	PLoS Genet	2008 Feb	Li CF	doi: 10.1371/journal.pgen.0040027.
24862207	RNA-directed DNA methylation requires stepwise binding of silencing factors to long non-coding RNA.	Plant J	2014 Jul	Bohmdorfer G	doi: 10.1111/tpj.12563
23013441	RNA polymerase V targets transcriptional silencing components to promoters of protein-coding genes.	Plant J	2013 Jan	Zheng Q	doi: 10.1111/tpj.12034
16839879	An ARGONAUTE4-containing nuclear processing center colocalized with Cajal bodies in Arabidopsis thaliana.	Cell	2006 Jul 14	Li CF	-
24493449	Characterizing RNA-protein interaction using cross-linking and metabolite supplemented nuclear RNA-immunoprecipitation.	Mol Biol Rep	2014 May	Au PC	doi: 10.1007/s11033-014-3154-1
27543392	Alfalfa dwarf cytorhabdovirus P protein is a local and systemic RNA silencing supressor which inhibits programmed RISC activity and prevents transitive amplification of RNA silencing.	Virus Res	2016 Sep 15	Bejerman N	doi: 10.1016/j.virusres.2016.08.008
29379150	RNA-directed DNA methylation involves co-transcriptional small-RNA-guided slicing of polymerase V transcripts in Arabidopsis.	Nat Plants	2018 Mar	Liu W	doi: 10.1038/s41477-017-0100-y

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000488778	AGO4-202	522	-	-	- (aa)	-	-
ENST00000373210	AGO4-201	7116	XM_005270578	ENSP00000362306	861 (aa)	XP_005270635	Q9HCK5
ENST00000496257	AGO4-203	297	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000134698's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134698	Schizophrenia	3E-6	26198764

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134698	rs11264213	1	35818353	A	Schizophrenia	26198764	[NR]	1.09	EFO_0000692

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000134698's network

* RBP PPI network refers to all genes directly bind to RBP

Paralogs

Ensembl ID	Gene Symbol	Coverage	Identiy	Paralog	Gene Symbol	Coverage	Identiy
ENSG00000134698	AGO4	99	80.876	ENSG00000126070	AGO3	100	85.737
ENSG00000134698	AGO4	99	79.034	ENSG00000123908	AGO2	99	78.372
ENSG00000134698	AGO4	99	83.489	ENSG00000092847	AGO1	100	84.131

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134698	AGO4	96	96.301	ENSAPOG00000023867	ago4	99	96.301	Acanthochromis_polyacanthus
ENSG00000134698	AGO4	99	99.534	ENSAMEG00000000573	AGO4	100	99.534	Ailuropoda_melanoleuca
ENSG00000134698	AGO4	92	97.733	ENSACIG00000014548	ago4	100	97.733	Amphilophus_citrinellus
ENSG00000134698	AGO4	92	93.073	ENSAPEG00000022426	ago4	100	93.073	Amphiprion_percula
ENSG00000134698	AGO4	100	96.339	ENSATEG00000006717	ago4	100	96.398	Anabas_testudineus
ENSG00000134698	AGO4	98	99.528	ENSAPLG00000010882	AGO4	100	99.528	Anas_platyrhynchos
ENSG00000134698	AGO4	99	98.480	ENSACAG00000017275	AGO4	99	98.480	Anolis_carolinensis
ENSG00000134698	AGO4	100	99.884	ENSANAG00000031428	AGO4	100	99.884	Aotus_nancymaae
ENSG00000134698	AGO4	100	96.224	ENSACLG00000005181	ago4	100	96.224	Astatotilapia_calliptera
ENSG00000134698	AGO4	100	96.453	ENSAMXG00000010318	ago4	100	96.474	Astyanax_mexicanus
ENSG00000134698	AGO4	99	98.834	ENSBTAG00000015220	AGO4	99	98.834	Bos_taurus
ENSG00000134698	AGO4	100	100.000	ENSCJAG00000001610	AGO4	100	100.000	Callithrix_jacchus
ENSG00000134698	AGO4	92	100.000	ENSCAFG00000024306	AGO4	100	100.000	Canis_familiaris
ENSG00000134698	AGO4	100	99.884	ENSCHIG00000026564	AGO4	100	99.884	Capra_hircus
ENSG00000134698	AGO4	99	99.883	ENSTSYG00000014007	AGO4	100	99.883	Carlito_syrichta
ENSG00000134698	AGO4	94	96.197	ENSCAPG00000009369	AGO4	100	96.197	Cavia_aperea
ENSG00000134698	AGO4	99	97.561	ENSCPOG00000011557	AGO4	99	97.561	Cavia_porcellus
ENSG00000134698	AGO4	100	100.000	ENSCCAG00000001397	AGO4	100	100.000	Cebus_capucinus
ENSG00000134698	AGO4	100	100.000	ENSCATG00000043421	AGO4	100	100.000	Cercocebus_atys
ENSG00000134698	AGO4	99	99.649	ENSCLAG00000012097	AGO4	100	99.649	Chinchilla_lanigera
ENSG00000134698	AGO4	100	100.000	ENSCSAG00000001090	AGO4	100	100.000	Chlorocebus_sabaeus
ENSG00000134698	AGO4	80	100.000	ENSCHOG00000006867	AGO4	81	100.000	Choloepus_hoffmanni
ENSG00000134698	AGO4	99	99.532	ENSCPBG00000018602	AGO4	98	99.532	Chrysemys_picta_bellii
ENSG00000134698	AGO4	99	100.000	ENSCANG00000016914	AGO4	100	100.000	Colobus_angolensis_palliatus
ENSG00000134698	AGO4	100	99.419	ENSCGRG00001002701	Ago4	100	99.419	Cricetulus_griseus_chok1gshd
ENSG00000134698	AGO4	99	99.415	ENSCGRG00000013335	Ago4	100	99.415	Cricetulus_griseus_crigri
ENSG00000134698	AGO4	92	91.709	ENSCSEG00000010696	ago4	100	91.709	Cynoglossus_semilaevis
ENSG00000134698	AGO4	100	97.683	ENSDARG00000100854	ago4	100	97.683	Danio_rerio
ENSG00000134698	AGO4	100	99.768	ENSDNOG00000015674	AGO4	100	99.768	Dasypus_novemcinctus
ENSG00000134698	AGO4	100	99.884	ENSDORG00000008933	Ago4	100	99.884	Dipodomys_ordii
ENSG00000134698	AGO4	60	100.000	ENSETEG00000018390	AGO4	83	100.000	Echinops_telfairi
ENSG00000134698	AGO4	100	100.000	ENSEASG00005012079	AGO4	100	100.000	Equus_asinus_asinus
ENSG00000134698	AGO4	100	100.000	ENSECAG00000024686	AGO4	100	100.000	Equus_caballus
ENSG00000134698	AGO4	79	97.173	ENSEEUG00000000745	AGO4	79	97.173	Erinaceus_europaeus
ENSG00000134698	AGO4	100	95.786	ENSELUG00000023873	ago4	100	95.786	Esox_lucius
ENSG00000134698	AGO4	100	99.884	ENSFCAG00000006218	AGO4	100	99.884	Felis_catus
ENSG00000134698	AGO4	99	99.883	ENSFDAG00000021483	AGO4	100	99.883	Fukomys_damarensis
ENSG00000134698	AGO4	97	88.756	ENSFHEG00000019658	ago4	100	88.756	Fundulus_heteroclitus
ENSG00000134698	AGO4	99	97.206	ENSGMOG00000009544	ago4	99	97.206	Gadus_morhua
ENSG00000134698	AGO4	100	99.535	ENSGALG00000039713	AGO4	100	99.535	Gallus_gallus
ENSG00000134698	AGO4	100	96.224	ENSGAFG00000017239	ago4	100	96.224	Gambusia_affinis
ENSG00000134698	AGO4	99	97.558	ENSGACG00000002683	ago4	99	97.558	Gasterosteus_aculeatus
ENSG00000134698	AGO4	92	99.496	ENSGAGG00000012897	AGO4	100	99.496	Gopherus_agassizii
ENSG00000134698	AGO4	99	96.592	ENSGGOG00000036532	AGO4	100	96.592	Gorilla_gorilla
ENSG00000134698	AGO4	100	96.224	ENSHBUG00000001525	ago4	100	96.224	Haplochromis_burtoni
ENSG00000134698	AGO4	100	99.884	ENSHGLG00000010241	AGO4	100	99.884	Heterocephalus_glaber_female
ENSG00000134698	AGO4	99	100.000	ENSHGLG00100005233	AGO4	99	100.000	Heterocephalus_glaber_male
ENSG00000134698	AGO4	100	96.110	ENSHCOG00000003725	ago4	100	96.110	Hippocampus_comes
ENSG00000134698	AGO4	100	96.339	ENSIPUG00000015600	ago4	100	96.339	Ictalurus_punctatus
ENSG00000134698	AGO4	99	99.884	ENSSTOG00000004725	AGO4	100	99.884	Ictidomys_tridecemlineatus
ENSG00000134698	AGO4	100	96.339	ENSKMAG00000018602	ago4	100	96.339	Kryptolebias_marmoratus
ENSG00000134698	AGO4	100	95.682	ENSLBEG00000010670	ago4	100	95.682	Labrus_bergylta
ENSG00000134698	AGO4	100	98.490	ENSLACG00000016888	AGO4	100	98.490	Latimeria_chalumnae
ENSG00000134698	AGO4	100	96.334	ENSLOCG00000000584	ago4	100	96.334	Lepisosteus_oculatus
ENSG00000134698	AGO4	93	99.251	ENSLAFG00000010394	AGO4	100	99.251	Loxodonta_africana
ENSG00000134698	AGO4	100	100.000	ENSMFAG00000035543	AGO4	100	100.000	Macaca_fascicularis
ENSG00000134698	AGO4	99	99.767	ENSMMUG00000003343	AGO4	100	100.000	Macaca_mulatta
ENSG00000134698	AGO4	100	100.000	ENSMNEG00000037723	AGO4	100	100.000	Macaca_nemestrina
ENSG00000134698	AGO4	99	100.000	ENSMLEG00000039490	AGO4	100	100.000	Mandrillus_leucophaeus
ENSG00000134698	AGO4	100	96.224	ENSMAMG00000003874	ago4	100	96.224	Mastacembelus_armatus
ENSG00000134698	AGO4	100	96.224	ENSMZEG00005026346	ago4	100	96.224	Maylandia_zebra
ENSG00000134698	AGO4	99	99.181	ENSMGAG00000003851	AGO4	99	99.181	Meleagris_gallopavo
ENSG00000134698	AGO4	82	100.000	ENSMAUG00000021743	Ago4	97	98.723	Mesocricetus_auratus
ENSG00000134698	AGO4	99	99.766	ENSMICG00000033507	AGO4	100	99.766	Microcebus_murinus
ENSG00000134698	AGO4	100	99.535	ENSMOCG00000005772	Ago4	100	99.535	Microtus_ochrogaster
ENSG00000134698	AGO4	92	96.725	ENSMMOG00000013473	ago4	100	96.725	Mola_mola
ENSG00000134698	AGO4	100	99.652	ENSMODG00000017888	AGO4	100	99.652	Monodelphis_domestica
ENSG00000134698	AGO4	99	95.571	ENSMALG00000011797	ago4	100	95.571	Monopterus_albus
ENSG00000134698	AGO4	100	99.071	MGP_CAROLIEiJ_G0026479	Ago4	100	99.071	Mus_caroli
ENSG00000134698	AGO4	100	98.839	ENSMUSG00000042500	Ago4	100	98.839	Mus_musculus
ENSG00000134698	AGO4	100	98.490	MGP_PahariEiJ_G0028810	Ago4	100	98.490	Mus_pahari
ENSG00000134698	AGO4	100	98.606	MGP_SPRETEiJ_G0027458	Ago4	100	98.606	Mus_spretus
ENSG00000134698	AGO4	92	100.000	ENSMPUG00000014876	AGO4	100	100.000	Mustela_putorius_furo
ENSG00000134698	AGO4	99	98.598	ENSMLUG00000017102	AGO4	98	98.598	Myotis_lucifugus
ENSG00000134698	AGO4	99	99.883	ENSNGAG00000020544	Ago4	100	99.883	Nannospalax_galili
ENSG00000134698	AGO4	100	96.224	ENSNBRG00000013492	ago4	100	96.224	Neolamprologus_brichardi
ENSG00000134698	AGO4	99	100.000	ENSNLEG00000011125	AGO4	100	100.000	Nomascus_leucogenys
ENSG00000134698	AGO4	90	98.462	ENSMEUG00000001023	AGO4	90	98.462	Notamacropus_eugenii
ENSG00000134698	AGO4	99	92.389	ENSOPRG00000012309	AGO4	100	92.389	Ochotona_princeps
ENSG00000134698	AGO4	93	99.875	ENSODEG00000006355	AGO4	97	99.875	Octodon_degus
ENSG00000134698	AGO4	100	96.224	ENSONIG00000013603	ago4	100	96.224	Oreochromis_niloticus
ENSG00000134698	AGO4	92	99.622	ENSOANG00000002082	AGO4	100	99.622	Ornithorhynchus_anatinus
ENSG00000134698	AGO4	100	99.768	ENSOCUG00000004076	AGO4	100	99.768	Oryctolagus_cuniculus
ENSG00000134698	AGO4	100	96.339	ENSORLG00000009865	ago4	92	96.339	Oryzias_latipes
ENSG00000134698	AGO4	100	96.339	ENSORLG00020016978	ago4	92	96.339	Oryzias_latipes_hni
ENSG00000134698	AGO4	100	96.339	ENSORLG00015008800	ago4	92	96.339	Oryzias_latipes_hsok
ENSG00000134698	AGO4	100	96.339	ENSOMEG00000006399	ago4	100	96.339	Oryzias_melastigma
ENSG00000134698	AGO4	93	98.498	ENSOGAG00000004233	-	100	98.498	Otolemur_garnettii
ENSG00000134698	AGO4	100	90.825	ENSOGAG00000027107	-	100	90.825	Otolemur_garnettii
ENSG00000134698	AGO4	99	99.069	ENSOARG00000019568	AGO4	98	99.069	Ovis_aries
ENSG00000134698	AGO4	99	100.000	ENSPPAG00000031752	AGO4	100	100.000	Pan_paniscus
ENSG00000134698	AGO4	100	99.884	ENSPPRG00000006520	AGO4	100	99.884	Panthera_pardus
ENSG00000134698	AGO4	99	99.883	ENSPTIG00000020262	AGO4	100	99.883	Panthera_tigris_altaica
ENSG00000134698	AGO4	100	100.000	ENSPTRG00000000527	AGO4	100	100.000	Pan_troglodytes
ENSG00000134698	AGO4	92	100.000	ENSPANG00000007232	AGO4	100	100.000	Papio_anubis
ENSG00000134698	AGO4	100	96.224	ENSPKIG00000022598	ago4	100	96.224	Paramormyrops_kingsleyae
ENSG00000134698	AGO4	99	99.532	ENSPSIG00000013832	AGO4	99	99.532	Pelodiscus_sinensis
ENSG00000134698	AGO4	92	97.607	ENSPMGG00000023325	ago4	100	97.607	Periophthalmus_magnuspinnatus
ENSG00000134698	AGO4	100	88.760	ENSPEMG00000022651	-	97	100.000	Peromyscus_maniculatus_bairdii
ENSG00000134698	AGO4	100	99.652	ENSPCIG00000000092	AGO4	100	99.652	Phascolarctos_cinereus
ENSG00000134698	AGO4	100	96.339	ENSPFOG00000001935	ago4	100	96.339	Poecilia_formosa
ENSG00000134698	AGO4	100	97.567	ENSPLAG00000011534	ago4	100	97.567	Poecilia_latipinna
ENSG00000134698	AGO4	100	96.339	ENSPMEG00000005049	ago4	100	96.339	Poecilia_mexicana
ENSG00000134698	AGO4	100	96.339	ENSPREG00000010315	ago4	100	96.339	Poecilia_reticulata
ENSG00000134698	AGO4	99	100.000	ENSPPYG00000001552	AGO4	100	100.000	Pongo_abelii
ENSG00000134698	AGO4	99	99.649	ENSPCOG00000015935	AGO4	100	99.649	Propithecus_coquereli
ENSG00000134698	AGO4	87	100.000	ENSPVAG00000005079	AGO4	88	100.000	Pteropus_vampyrus
ENSG00000134698	AGO4	100	96.224	ENSPNYG00000002089	ago4	100	96.224	Pundamilia_nyererei
ENSG00000134698	AGO4	100	97.103	ENSPNAG00000005191	ago4	100	97.103	Pygocentrus_nattereri
ENSG00000134698	AGO4	69	98.325	ENSRNOG00000025596	Ago4	100	98.325	Rattus_norvegicus
ENSG00000134698	AGO4	99	98.825	ENSRBIG00000040185	AGO4	100	100.000	Rhinopithecus_bieti
ENSG00000134698	AGO4	92	100.000	ENSRROG00000035783	AGO4	100	100.000	Rhinopithecus_roxellana
ENSG00000134698	AGO4	99	96.042	ENSSBOG00000026529	AGO4	100	99.868	Saimiri_boliviensis_boliviensis
ENSG00000134698	AGO4	99	98.839	ENSSHAG00000017320	AGO4	100	98.839	Sarcophilus_harrisii
ENSG00000134698	AGO4	100	96.339	ENSSFOG00015022028	ago4	100	96.398	Scleropages_formosus
ENSG00000134698	AGO4	100	93.855	ENSSMAG00000000808	ago4	93	95.611	Scophthalmus_maximus
ENSG00000134698	AGO4	100	95.357	ENSSDUG00000020781	ago4	100	97.103	Seriola_dumerili
ENSG00000134698	AGO4	92	97.733	ENSSLDG00000021841	ago4	100	97.733	Seriola_lalandi_dorsalis
ENSG00000134698	AGO4	79	99.638	ENSSARG00000011504	AGO4	79	99.638	Sorex_araneus
ENSG00000134698	AGO4	100	99.187	ENSSPUG00000000889	AGO4	100	99.187	Sphenodon_punctatus
ENSG00000134698	AGO4	99	93.647	ENSTGUG00000001631	AGO4	99	92.907	Taeniopygia_guttata
ENSG00000134698	AGO4	100	95.995	ENSTRUG00000008052	ago4	100	95.995	Takifugu_rubripes
ENSG00000134698	AGO4	99	97.200	ENSTNIG00000006331	ago4	99	97.200	Tetraodon_nigroviridis
ENSG00000134698	AGO4	77	100.000	ENSTBEG00000016478	AGO4	77	100.000	Tupaia_belangeri
ENSG00000134698	AGO4	99	96.136	ENSTTRG00000015086	AGO4	100	96.136	Tursiops_truncatus
ENSG00000134698	AGO4	92	100.000	ENSUAMG00000027156	-	100	100.000	Ursus_americanus
ENSG00000134698	AGO4	99	97.788	ENSUMAG00000006297	AGO4	99	96.616	Ursus_maritimus
ENSG00000134698	AGO4	88	99.341	ENSVPAG00000006662	AGO4	100	99.341	Vicugna_pacos
ENSG00000134698	AGO4	92	100.000	ENSVVUG00000000465	-	100	100.000	Vulpes_vulpes
ENSG00000134698	AGO4	100	85.615	ENSXETG00000009664	ago4	100	85.615	Xenopus_tropicalis
ENSG00000134698	AGO4	100	96.339	ENSXMAG00000016657	ago4	100	96.339	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000932	P-body	-	IEA	Component
GO:0003725	double-stranded RNA binding	19966796.	IDA	Function
GO:0003727	single-stranded RNA binding	19966796.	IDA	Function
GO:0005515	protein binding	15766526.19167051.19324964.19383768.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	15260970.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006402	mRNA catabolic process	18771919.	IDA	Process
GO:0007130	synaptonemal complex assembly	-	IEA	Process
GO:0007140	male meiotic nuclear division	-	IEA	Process
GO:0007223	Wnt signaling pathway, calcium modulating pathway	-	TAS	Process
GO:0008584	male gonad development	-	IEA	Process
GO:0010501	RNA secondary structure unwinding	19966796.	IDA	Process
GO:0010501	RNA secondary structure unwinding	22795694.	IMP	Process
GO:0010586	miRNA metabolic process	-	IEA	Process
GO:0010628	positive regulation of gene expression	-	TAS	Process
GO:0010629	negative regulation of gene expression	-	TAS	Process
GO:0016020	membrane	19946888.	HDA	Component
GO:0016442	RISC complex	15260970.19966796.	IDA	Component
GO:0016604	nuclear body	-	IDA	Component
GO:0022604	regulation of cell morphogenesis	-	IEA	Process
GO:0031054	pre-miRNA processing	19966796.	IDA	Process
GO:0035068	micro-ribonucleoprotein complex	-	IEA	Component
GO:0035194	posttranscriptional gene silencing by RNA	-	TAS	Process
GO:0035196	production of miRNAs involved in gene silencing by miRNA	22795694.	IMP	Process
GO:0035198	miRNA binding	15260970.	IDA	Function
GO:0035278	miRNA mediated inhibition of translation	18771919.	IDA	Process
GO:0035279	mRNA cleavage involved in gene silencing by miRNA	15260970.	IDA	Process
GO:0035280	miRNA loading onto RISC involved in gene silencing by miRNA	19966796.	IDA	Process
GO:0043066	negative regulation of apoptotic process	-	IEA	Process
GO:0045652	regulation of megakaryocyte differentiation	-	TAS	Process
GO:0070578	RISC-loading complex	19966796.	IDA	Component
GO:0090625	mRNA cleavage involved in gene silencing by siRNA	15260970.	IDA	Process