EuRBPDB

Description

Ensembl ID: ENSG00000134900 (Gene tree)
Gene ID: 7174
Gene Symbol: TPP2
Alias: TPPII
Full Name: tripeptidyl peptidase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 83,023 bases
Position: chr13:102,596,936-102,679,958
Accession: 12016
RBP type: non-canonical RBP
Summary: This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & HEK293	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000493770	TPP2-207	575	-	-	- (aa)	-	-
ENST00000376052	TPP2-201	5447	XM_005254070	ENSP00000365220	1262 (aa)	XP_005254127	Q5VZU9
ENST00000490420	TPP2-206	502	-	-	- (aa)	-	-
ENST00000490010	TPP2-205	691	-	-	- (aa)	-	-
ENST00000466153	TPP2-203	911	-	-	- (aa)	-	-
ENST00000482393	TPP2-204	720	-	-	- (aa)	-	-
ENST00000376065	TPP2-202	3931	XM_005254071	ENSP00000365233	1249 (aa)	XP_005254128	P29144
ENST00000496126	TPP2-208	332	-	-	- (aa)	-	-

Gene Model

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134900	Blood Pressure	5.81981414238264E-5	17903302
ENSG00000134900	Fibrinogen	9.6750000E-005	-
ENSG00000134900	Fibrinogen	5.6780000E-005	-
ENSG00000134900	Fibrinogen	5.8650000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134900	rs4772494	13	102603946	?	Red cell distribution width	30595370			EFO_0005192

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000134900	TPP2	99	35.325	WBGene00017686	tpp-2	95	35.325	Caenorhabditis_elegans

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000209	protein polyubiquitination	-	TAS	Process
GO:0004175	endopeptidase activity	9974389.	TAS	Function
GO:0004177	aminopeptidase activity	-	IEA	Function
GO:0004252	serine-type endopeptidase activity	-	IEA	Function
GO:0005515	protein binding	25416956.25910212.	IPI	Function
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005737	cytoplasm	9974389.	TAS	Component
GO:0005829	cytosol	21873635.	IBA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006508	proteolysis	-	IEA	Process
GO:0008240	tripeptidyl-peptidase activity	21873635.	IBA	Function
GO:0016604	nuclear body	-	IDA	Component
GO:0042802	identical protein binding	22483107.	IPI	Function