EuRBPDB

Description

Ensembl ID: ENSG00000134910 (Gene tree)
Gene ID: 3703
Gene Symbol: STT3A
Alias: TMC|MGC9042|STT3-A|ITM1
Full Name: STT3 oligosaccharyltransferase complex catalytic subunit A
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 33,504 bases
Position: chr11:125,591,712-125,625,215
Accession: 6172
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000534472	STT3A-216	1561	-	-	- (aa)	-	-
ENST00000527606	STT3A-210	569	-	ENSP00000436558	119 (aa)	-	E9PI32
ENST00000529196	STT3A-211	2402	-	ENSP00000436962	705 (aa)	-	P46977
ENST00000525946	STT3A-205	1383	-	-	- (aa)	-	-
ENST00000529886	STT3A-212	542	-	ENSP00000432912	117 (aa)	-	E9PN73
ENST00000649491	STT3A-217	4173	-	ENSP00000497336	705 (aa)	-	UPI0000071627
ENST00000531491	STT3A-214	2160	-	ENSP00000432820	613 (aa)	-	P46977
ENST00000531599	STT3A-215	973	-	-	- (aa)	-	-
ENST00000526213	STT3A-206	555	-	-	- (aa)	-	-
ENST00000526364	STT3A-207	617	-	-	- (aa)	-	-
ENST00000527456	STT3A-209	481	-	-	- (aa)	-	-
ENST00000525652	STT3A-204	607	-	ENSP00000435810	102 (aa)	-	A0A0C4DH80
ENST00000526726	STT3A-208	582	-	ENSP00000436523	194 (aa)	-	H0YET6
ENST00000524639	STT3A-202	582	-	-	- (aa)	-	-
ENST00000392708	STT3A-201	4558	XM_011542807	ENSP00000376472	705 (aa)	XP_011541109	P46977
ENST00000525431	STT3A-203	552	-	-	- (aa)	-	-
ENST00000531001	STT3A-213	325	-	-	- (aa)	-	-

Gene Model

Pathways

Pathway ID	Pathway Name	Source
hsa00510	N-Glycan biosynthesis	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04141	Protein processing in endoplasmic reticulum	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000134910	Attention Deficit Disorder with Hyperactivity	9E-7	23453885
ENSG00000134910	Bipolar Disorder	9E-7	23453885
ENSG00000134910	Child Development Disorders, Pervasive	9E-7	23453885
ENSG00000134910	Depressive Disorder	9E-7	23453885
ENSG00000134910	Schizophrenia	9E-7	23453885
ENSG00000134910	Schizophrenia	1E-6	21926974

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000134910	rs548181	11	125591814	G	Schizophrenia	21926974	[1.06-1.14]	1.1	EFO_0000692

Protein-Protein Interaction (PPI)

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	19167329.	IMP	Function
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity	-	ISS	Function
GO:0005515	protein binding	21903422.	IPI	Function
GO:0005789	endoplasmic reticulum membrane	-	TAS	Component
GO:0008250	oligosaccharyltransferase complex	19167329.	TAS	Component
GO:0016020	membrane	19946888.	HDA	Component
GO:0016021	integral component of membrane	-	IEA	Component
GO:0018279	protein N-linked glycosylation via asparagine	19167329.	IMP	Process
GO:0018279	protein N-linked glycosylation via asparagine	-	ISS	Process
GO:0018279	protein N-linked glycosylation via asparagine	-	TAS	Process
GO:0035000	oligosaccharyltransferase III complex	-	ISS	Component
GO:0043686	co-translational protein modification	19167329.	IMP	Process
GO:0046872	metal ion binding	-	IEA	Function