EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000135090 (Gene tree)
Gene ID: 51347
Gene Symbol: TAOK3
Alias: JIK|DPK|MAP3K18
Full Name: TAO kinase 3
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 223,145 bases
Position: chr12:118,149,801-118,372,945
Accession: 18133
RBP type: non-canonical RBP
Summary: The protein encoded by this gene is a serine/threonine protein kinase that activates the p38/MAPK14 stress-activated MAPK cascade but inhibits the basal activity of the MAPK8/JNK cascade. The encoded protein is a member of the GCK subfamily of STE20-like kinases. [provided by RefSeq, Oct 2016]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & Hela	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
28984199	Roles of alternative splicing in modulating transcriptional regulation.	BMC Syst Biol	2017 Oct 3	Li J	doi: 10.1186/s12918-017-0465-6.

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000535570	TAOK3-203	597	-	ENSP00000443465	136 (aa)	-	F5H5E0
ENST00000537822	TAOK3-208	597	-	ENSP00000439620	14 (aa)	-	F5H1I2
ENST00000541186	TAOK3-213	881	-	ENSP00000438820	93 (aa)	-	F5H3L7
ENST00000541878	TAOK3-215	578	-	ENSP00000444057	61 (aa)	-	F5H005
ENST00000540561	TAOK3-212	580	-	ENSP00000443487	38 (aa)	-	F5H5C7
ENST00000539872	TAOK3-211	594	-	ENSP00000438766	18 (aa)	-	F5H0M3
ENST00000536584	TAOK3-204	3229	-	-	- (aa)	-	-
ENST00000537952	TAOK3-209	2147	-	ENSP00000443834	438 (aa)	-	G3V1Q8
ENST00000538601	TAOK3-210	555	-	ENSP00000437389	185 (aa)	-	H0YF68
ENST00000542902	TAOK3-218	613	-	ENSP00000440315	57 (aa)	-	F5GY38
ENST00000541786	TAOK3-214	590	-	ENSP00000442541	21 (aa)	-	F5H7G4
ENST00000542532	TAOK3-216	641	-	ENSP00000441071	36 (aa)	-	F5GX96
ENST00000536979	TAOK3-205	777	-	ENSP00000441932	93 (aa)	-	F5GWV8
ENST00000419821	TAOK3-202	4301	XM_006719445	ENSP00000416374	898 (aa)	XP_006719508	Q9H2K8
ENST00000537569	TAOK3-207	675	-	-	- (aa)	-	-
ENST00000543709	TAOK3-219	597	-	-	- (aa)	-	-
ENST00000537305	TAOK3-206	3932	-	-	- (aa)	-	-
ENST00000542692	TAOK3-217	588	-	-	- (aa)	-	-
ENST00000392533	TAOK3-201	4384	XM_005253898	ENSP00000376317	898 (aa)	XP_005253955	Q9H2K8

Gene Model

Click here to download ENSG00000135090's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04010	MAPK signaling pathway	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135090	Glucose	5E-6	25524916
ENSG00000135090	Insulin Resistance	5E-6	25524916
ENSG00000135090	Glucose	2E-6	25524916
ENSG00000135090	Insulin Resistance	2E-6	25524916
ENSG00000135090	Bronchodilator Agents	5E-6	26634245
ENSG00000135090	Forced Expiratory Volume	5E-6	26634245
ENSG00000135090	Pulmonary Disease, Chronic Obstructive	5E-6	26634245
ENSG00000135090	Bronchodilator Agents	2E-6	26634245
ENSG00000135090	Forced Expiratory Volume	2E-6	26634245
ENSG00000135090	Pulmonary Disease, Chronic Obstructive	2E-6	26634245
ENSG00000135090	Morphine	3E-7	24909733

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000135090	rs650466	12	118208856	T	Post bronchodilator FEV1 in COPD	26634245	NR unit decrease	0.166	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000135090	rs61943529	12	118164051	A	Post bronchodilator FEV1 in COPD	26634245	NR unit decrease	0.164	EFO_0004314\|GO_0097366\|EFO_0000341
ENSG00000135090	rs673078	12	118353636	?	Glucose homeostasis traits	25524916	[-0.0964-0.2564] unit decrease	0.08	EFO_0004471\|EFO_0006896
ENSG00000135090	rs673078	12	118353636	?	Glucose homeostasis traits	25524916	[17.42-43.1] unit decrease	30.26	EFO_0004471\|EFO_0006896
ENSG00000135090	rs795484	12	118152057	A	Morphine dose requirement in tonsillectomy and adenoidectomy surgery	24909733	[10.0-21.1] unit increase	16.1	GO_0043278
ENSG00000135090	rs428073	12	118244946	T	Red cell distribution width	27863252	[0.02-0.035] unit decrease	0.02778707	EFO_0005192
ENSG00000135090	rs2280711	12	118212149	T	Neurociticism	29500382	z score increase	6.29	EFO_0007660
ENSG00000135090	rs6490177	12	118358280	A	Neurociticism	29500382	z score increase	6.54	EFO_0007660
ENSG00000135090	rs6490177	12	118358280	A	Neuroticism	29942085	z score increase	6.046	EFO_0007660
ENSG00000135090	rs353884	12	118225962	?	Red cell distribution width	30595370			EFO_0005192
ENSG00000135090	rs7314987	12	118274072	T	Neuroticism	30643256	[0.0093-0.0181] unit increase	0.013703822	EFO_0007660
ENSG00000135090	rs7314987	12	118274072	T	Depressive symptoms	30643256	[0.0058-0.0114] unit increase	0.008617761	EFO_0007006
ENSG00000135090	rs6490177	12	118358280	?	Neuroticism	30595370			EFO_0007660
ENSG00000135090	rs11068917	12	118353315	A	Well-being spectrum (multivariate analysis)	30643256	[0.0052-0.0099] unit increase	0.007531199	EFO_0007869

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135090's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000165	MAPK cascade	10924369.	IMP	Process
GO:0000186	activation of MAPKK activity	21873635.	IBA	Process
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	10559204.	IDA	Function
GO:0004709	MAP kinase kinase kinase activity	21873635.	IBA	Function
GO:0004860	protein kinase inhibitor activity	10559204.	TAS	Function
GO:0005515	protein binding	11278723.	IPI	Function
GO:0005524	ATP binding	-	IEA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005886	plasma membrane	-	IEA	Component
GO:0006281	DNA repair	-	IEA	Process
GO:0006468	protein phosphorylation	10559204.	IDA	Process
GO:0006468	protein phosphorylation	11278723.	IMP	Process
GO:0006469	negative regulation of protein kinase activity	-	IEA	Process
GO:0006974	cellular response to DNA damage stimulus	17396146.	IDA	Process
GO:0007095	mitotic G2 DNA damage checkpoint	17396146.	IMP	Process
GO:0016740	transferase activity	10559204.	IDA	Function
GO:0023014	signal transduction by protein phosphorylation	21873635.	IBA	Process
GO:0031098	stress-activated protein kinase signaling cascade	21873635.	IBA	Process
GO:0032147	activation of protein kinase activity	21873635.	IBA	Process
GO:0032874	positive regulation of stress-activated MAPK cascade	17396146.	IMP	Process
GO:0043507	positive regulation of JUN kinase activity	11278723.	IMP	Process
GO:0046329	negative regulation of JNK cascade	10559204.	IDA	Process
GO:0046330	positive regulation of JNK cascade	10924369.	IMP	Process
GO:0046777	protein autophosphorylation	10559204.	IDA	Process