EuRBPDB

Description

RBPome

Literatures

Expression

Transcripts

Gene Model

Phenotypes

GWAS

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000135250 (Gene tree)
Gene ID: 6733
Gene Symbol: SRPK2
Alias: SFRSK2
Full Name: SRSF protein kinase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Minus strand
Length: 288,663 bases
Position: chr7:105,110,704-105,399,366
Accession: 11306
RBP type: non-canonical RBP
Summary: (SRSF Protein Kinase 2) is a Protein Coding gene. Diseases associated with SRPK2 include Brain Stem Infarction and Internuclear Ophthalmoplegia. Among its related pathways are mRNA Splicing - Major Pathway. Gene Ontology (GO) annotations related to this gene include protein kinase activity. An important paralog of this gene is SRPK1.

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & HEK293	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
22658674	Insights into RNA biology from an atlas of mammalian mRNA-binding proteins	RIC & Hela	2012 May 31	Castello A	DOI: 10.1016/j.cell.2012.04.031
30528433	The Human RNA-Binding Proteome and Its Dynamics during Translational Arrest	XRNAX & MCF7	2018 Dec 6	Trendel J	DOI: 10.1016/j.cell.2018.11.004
30352994	Discovery of RNA-binding proteins and characterization of their dynamic responses by enhanced RNA interactome capture	RIC & Jurkat	2018 Oct 23	Perez-Perri JI	DOI:10.1038/s41467-018-06557-8

Literatures on RNA binding capacity

PID	Title	Article	Time	Author	Doi
26058814	Alternative splicing of the cell fate determinant Numb in hepatocellular carcinoma.	Hepatology	2015 Oct	Lu Y	doi: 10.1002/hep.27923
29153836	Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.	Cell	2017 Dec 14	Lee G	doi: 10.1016/j.cell.2017.10.037

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000462282	SRPK2-204	505	-	-	- (aa)	-	-
ENST00000466917	SRPK2-207	2565	-	-	- (aa)	-	-
ENST00000476117	SRPK2-209	703	-	-	- (aa)	-	-
ENST00000465072	SRPK2-205	954	-	ENSP00000417946	147 (aa)	-	F8WBW4
ENST00000357311	SRPK2-201	3700	XM_011516536	ENSP00000349863	688 (aa)	XP_011514838	P78362
ENST00000482897	SRPK2-212	715	-	ENSP00000419240	231 (aa)	-	C9JWF7
ENST00000477925	SRPK2-210	1336	-	ENSP00000420208	295 (aa)	-	H7C5L6
ENST00000493638	SRPK2-215	715	-	-	- (aa)	-	-
ENST00000485455	SRPK2-213	436	-	-	- (aa)	-	-
ENST00000474770	SRPK2-208	872	-	ENSP00000418786	204 (aa)	-	H7C521
ENST00000482862	SRPK2-211	329	-	-	- (aa)	-	-
ENST00000489828	SRPK2-214	2560	XM_006716098	ENSP00000419791	688 (aa)	XP_006716161	P78362
ENST00000393651	SRPK2-202	3650	XM_024446894	ENSP00000377262	699 (aa)	XP_024302662	P78362
ENST00000460391	SRPK2-203	666	-	ENSP00000417357	160 (aa)	-	C9J2M4
ENST00000465112	SRPK2-206	568	-	ENSP00000417446	68 (aa)	-	F8WAV6

Gene Model

Click here to download ENSG00000135250's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135250	Anthropometry	2.1820000E-005	-
ENSG00000135250	Anthropometry	2.0820000E-005	-
ENSG00000135250	Anthropometry	3.6540000E-006	-
ENSG00000135250	Anthropometry	6.4370000E-005	-
ENSG00000135250	Anthropometry	6.4370000E-005	-
ENSG00000135250	Waist Circumference	7.9640000E-005	-
ENSG00000135250	Waist Circumference	2.6980000E-005	-
ENSG00000135250	Insulin Resistance	8.1800000E-005	-
ENSG00000135250	monocyte chemoattractant protein 1 (66-77)	4.4270000E-005	-
ENSG00000135250	monocyte chemoattractant protein 1 (66-77)	9.6000000E-005	-
ENSG00000135250	monocyte chemoattractant protein 1 (66-77)	3.1840000E-005	-
ENSG00000135250	Schizophrenia	1E-9	26198764
ENSG00000135250	Emotions	9E-6	27089181
ENSG00000135250	Macular Degeneration	1E-9	26691988
ENSG00000135250	Wet Macular Degeneration	1E-9	26691988
ENSG00000135250	Body Mass Index	3E-8	25673412
ENSG00000135250	Waist Circumference	3E-8	25673412
ENSG00000135250	Schizophrenia	1E-9	25056061
ENSG00000135250	Myopia, Degenerative	2E-7	23049088

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000135250	rs4580973	7	105263212	A	Autism spectrum disorder or schizophrenia	28540026	[1.04-1.09]	1.06	EFO_0000692\|EFO_0003756
ENSG00000135250	rs41563	7	105212207	A	Autism spectrum disorder or schizophrenia	28540026	[1.05-1.09]	1.07	EFO_0000692\|EFO_0003756
ENSG00000135250	rs73186011	7	105186563	A	Subjective well-being	27089181	[0.025-0.065] unit increase	0.044919994	EFO_0007869
ENSG00000135250	rs6466055	7	105288617	A	Schizophrenia	25056061	[1.046-1.091]	1.068	EFO_0000692
ENSG00000135250	rs1142	7	105115879	?	Advanced age-related macular degeneration	26691988		1.11	EFO_1001492\|EFO_0001365\|EFO_0004683
ENSG00000135250	rs6466055	7	105288617	A	Schizophrenia	26198764	[NR]	1.07	EFO_0000692
ENSG00000135250	rs6968355	7	105117803	?	Myopia (pathological)	23049088	[NR]		EFO_0004207
ENSG00000135250	rs2057884	7	105289803	T	Schizophrenia	28991256	[1.05-1.09]	1.069	EFO_0000692
ENSG00000135250	rs1144	7	105115908	C	Waist circumference adjusted for body mass index	25673412	unit increase	0.019	EFO_0007789
ENSG00000135250	rs1144	7	105115908	T	Waist circumference adjusted for BMI (adjusted for smoking behaviour)	28443625	[0.0094-0.0236] unit decrease	0.0165	EFO_0004318\|EFO_0007789
ENSG00000135250	rs1144	7	105115908	T	General cognitive ability	29844566	z-score increase	5.962	EFO_0004337
ENSG00000135250	rs55658584	7	105354274	A	General cognitive ability	29844566	z-score increase	5.783	EFO_0004337
ENSG00000135250	rs7789569	7	105287139	?	Schizophrenia	29483656	[1.05-1.09]	1.067	EFO_0000692
ENSG00000135250	rs4730073	7	105215424	?	Waist-hip ratio	30595370			EFO_0004343
ENSG00000135250	rs7787448	7	105156888	?	White blood cell count	30595370			EFO_0004308
ENSG00000135250	rs7794036	7	105230001	?	Sunburns	30595370			EFO_0003958
ENSG00000135250	rs1006365	7	105128172	T	Smoking cessation (MTAG)	30643251	[0.0057-0.0118] unit decrease	0.00876314	EFO_0004319
ENSG00000135250	rs2057884	7	105289803	T	Schizophrenia	30285260	[1.05-1.09]	1.0709	EFO_0000692
ENSG00000135250	rs2057884	7	105289803	T	Schizophrenia	30285260	[1.05-1.09]	1.07	EFO_0000692
ENSG00000135250	rs6466055	7	105288617	A	Autism and schizophrenia (MTAG)	30804558	unit increase	0.046	EFO_0000692\|EFO_0003756

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135250's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs identified by RBPome

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135250	SRPK2	100	98.125	ENSMUSG00000062604	Srpk2	100	100.000	Mus_musculus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000245	spliceosomal complex assembly	21873635.	IBA	Process
GO:0000245	spliceosomal complex assembly	9472028.	IDA	Process
GO:0000287	magnesium ion binding	9472028.	IDA	Function
GO:0001525	angiogenesis	-	ISS	Process
GO:0003723	RNA binding	22658674.22681889.	HDA	Function
GO:0004674	protein serine/threonine kinase activity	21873635.	IBA	Function
GO:0004674	protein serine/threonine kinase activity	9472028.	IDA	Function
GO:0005515	protein binding	16189514.19592491.22365833.23602568.25416956.	IPI	Function
GO:0005524	ATP binding	9472028.	IDA	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005634	nucleus	9472028.	IDA	Component
GO:0005654	nucleoplasm	-	IDA	Component
GO:0005730	nucleolus	-	IDA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005737	cytoplasm	9472028.	IDA	Component
GO:0005829	cytosol	-	IDA	Component
GO:0006468	protein phosphorylation	9472028.	IDA	Process
GO:0008284	positive regulation of cell proliferation	18559500.	IDA	Process
GO:0008380	RNA splicing	9472028.	IDA	Process
GO:0010468	regulation of gene expression	21873635.	IBA	Process
GO:0010628	positive regulation of gene expression	-	ISS	Process
GO:0030154	cell differentiation	-	IEA	Process
GO:0035063	nuclear speck organization	-	ISS	Process
GO:0035556	intracellular signal transduction	21873635.	IBA	Process
GO:0035556	intracellular signal transduction	9472028.	IDA	Process
GO:0043525	positive regulation of neuron apoptotic process	-	ISS	Process
GO:0045070	positive regulation of viral genome replication	20498328.	IDA	Process
GO:0045071	negative regulation of viral genome replication	12417631.	IDA	Process
GO:0045087	innate immune response	12417631.	IC	Process
GO:0045787	positive regulation of cell cycle	-	ISS	Process
GO:0048024	regulation of mRNA splicing, via spliceosome	21205200.	TAS	Process
GO:0050684	regulation of mRNA processing	21873635.	IBA	Process
GO:0071889	14-3-3 protein binding	-	ISS	Function