EuRBPDB

Description

RBDs

RBPome

Expression

Transcripts

Gene Model

Phenotypes

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000135297 (Gene tree)
Gene ID: 25821
Gene Symbol: MTO1
Alias: N
Full Name: mitochondrial tRNA translation optimization 1
Gene Type: protein_coding
Species: Homo_sapiens
Status: confidence
Strand: Plus strand
Length: 47,659 bases
Position: chr6:73,461,578-73,509,236
Accession: 19261
RBP type: canonical RBP
Summary: This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000359328	GIDA_assoc	PF13932.6	9.7e-64	1	1
ENSP00000419561	GIDA_assoc	PF13932.6	1.1e-63	1	1
ENSP00000359323	GIDA_assoc	PF13932.6	1.2e-63	1	1
ENSP00000402038	GIDA_assoc	PF13932.6	1.2e-63	1	1
ENSP00000428863	GIDA_assoc	PF13932.6	6.6e-37	1	1

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
22681889	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts	4SURIC & HEK293	2012 May	Baltz AG	DOI: 10.1016/j.molcel.2012.05.021

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000415228	MTO1-204	2240	-	ENSP00000416397	192 (aa)	-	E7EWI1
ENST00000523763	MTO1-218	696	-	ENSP00000429595	115 (aa)	-	H0YBI9
ENST00000415954	MTO1-205	2837	-	ENSP00000402038	732 (aa)	-	Q9Y2Z2
ENST00000524046	MTO1-219	467	-	ENSP00000430660	86 (aa)	-	H0YC00
ENST00000521156	MTO1-216	886	-	ENSP00000428863	144 (aa)	-	H0YB81
ENST00000445187	MTO1-207	665	-	ENSP00000407580	98 (aa)	-	H7C2S9
ENST00000521032	MTO1-215	574	-	ENSP00000428302	110 (aa)	-	E7EWX0
ENST00000462039	MTO1-208	2416	-	-	- (aa)	-	-
ENST00000466977	MTO1-209	451	-	-	- (aa)	-	-
ENST00000520366	MTO1-214	202	-	-	- (aa)	-	-
ENST00000498286	MTO1-212	10857	-	ENSP00000419561	692 (aa)	-	Q9Y2Z2
ENST00000370305	MTO1-202	2174	-	ENSP00000359328	643 (aa)	-	Q9Y2Z2
ENST00000518210	MTO1-213	545	-	-	- (aa)	-	-
ENST00000442897	MTO1-206	521	-	ENSP00000396529	118 (aa)	-	E9PHR8
ENST00000370300	MTO1-201	2961	-	ENSP00000359323	717 (aa)	-	Q9Y2Z2
ENST00000522205	MTO1-217	882	-	ENSP00000428903	95 (aa)	-	E5RFF7
ENST00000485082	MTO1-210	600	-	-	- (aa)	-	-
ENST00000487960	MTO1-211	361	-	-	- (aa)	-	-
ENST00000370308	MTO1-203	2621	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000135297's gene model file

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135297	Personality Inventory	2.345e-005	-
ENSG00000135297	Personality Inventory	2.345e-005	-
ENSG00000135297	Personality Inventory	4.395e-005	-
ENSG00000135297	Blood Pressure	8.7950000E-005	-
ENSG00000135297	Blood Pressure	5.8700000E-005	-
ENSG00000135297	Blood Pressure	8.7950000E-005	-

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135297's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135297	MTO1	95	60.952	ENSAPOG00000021443	mto1	96	53.577	Acanthochromis_polyacanthus
ENSG00000135297	MTO1	95	95.238	ENSAMEG00000007806	MTO1	100	90.173	Ailuropoda_melanoleuca
ENSG00000135297	MTO1	95	60.952	ENSACIG00000014654	mto1	93	53.858	Amphilophus_citrinellus
ENSG00000135297	MTO1	95	60.952	ENSAOCG00000023507	mto1	94	54.560	Amphiprion_ocellaris
ENSG00000135297	MTO1	95	60.952	ENSAPEG00000011078	mto1	94	54.560	Amphiprion_percula
ENSG00000135297	MTO1	95	60.952	ENSATEG00000019401	mto1	96	53.787	Anabas_testudineus
ENSG00000135297	MTO1	90	82.955	ENSAPLG00000009903	MTO1	94	72.376	Anas_platyrhynchos
ENSG00000135297	MTO1	95	80.769	ENSACAG00000004481	MTO1	99	59.172	Anolis_carolinensis
ENSG00000135297	MTO1	97	97.143	ENSANAG00000019857	MTO1	100	93.182	Aotus_nancymaae
ENSG00000135297	MTO1	95	60.000	ENSACLG00000009986	mto1	95	53.364	Astatotilapia_calliptera
ENSG00000135297	MTO1	93	63.725	ENSAMXG00000020336	mto1	97	54.103	Astyanax_mexicanus
ENSG00000135297	MTO1	95	97.143	ENSBTAG00000016839	MTO1	100	88.873	Bos_taurus
ENSG00000135297	MTO1	90	57.955	WBGene00009944	mtcu-2	96	50.874	Caenorhabditis_elegans
ENSG00000135297	MTO1	100	95.087	ENSCJAG00000010003	MTO1	98	95.087	Callithrix_jacchus
ENSG00000135297	MTO1	95	98.095	ENSCAFG00000002655	MTO1	100	90.327	Canis_familiaris
ENSG00000135297	MTO1	95	98.095	ENSCAFG00020010043	MTO1	100	90.327	Canis_lupus_dingo
ENSG00000135297	MTO1	95	97.143	ENSCHIG00000014134	MTO1	99	90.269	Capra_hircus
ENSG00000135297	MTO1	95	95.192	ENSTSYG00000009988	MTO1	100	87.699	Carlito_syrichta
ENSG00000135297	MTO1	90	94.318	ENSCAPG00000017991	MTO1	99	80.287	Cavia_aperea
ENSG00000135297	MTO1	95	98.077	ENSCPOG00000013100	MTO1	100	86.275	Cavia_porcellus
ENSG00000135297	MTO1	95	98.077	ENSCCAG00000020119	MTO1	99	95.156	Cebus_capucinus
ENSG00000135297	MTO1	100	97.110	ENSCATG00000030762	MTO1	100	97.110	Cercocebus_atys
ENSG00000135297	MTO1	90	90.909	ENSCLAG00000013351	-	99	80.176	Chinchilla_lanigera
ENSG00000135297	MTO1	100	96.965	ENSCSAG00000014033	MTO1	100	96.965	Chlorocebus_sabaeus
ENSG00000135297	MTO1	95	97.115	ENSCHOG00000010356	MTO1	100	88.474	Choloepus_hoffmanni
ENSG00000135297	MTO1	95	88.571	ENSCPBG00000005210	MTO1	95	75.151	Chrysemys_picta_bellii
ENSG00000135297	MTO1	95	67.273	ENSCING00000021576	-	99	54.375	Ciona_intestinalis
ENSG00000135297	MTO1	99	61.607	ENSCSAVG00000009018	-	99	52.358	Ciona_savignyi
ENSG00000135297	MTO1	95	100.000	ENSCANG00000003200	MTO1	100	92.341	Colobus_angolensis_palliatus
ENSG00000135297	MTO1	95	92.381	ENSCGRG00001022063	Mto1	99	88.262	Cricetulus_griseus_chok1gshd
ENSG00000135297	MTO1	95	92.381	ENSCGRG00000018316	Mto1	100	84.880	Cricetulus_griseus_crigri
ENSG00000135297	MTO1	99	56.701	ENSCSEG00000008587	mto1	97	50.314	Cynoglossus_semilaevis
ENSG00000135297	MTO1	98	58.333	ENSCVAG00000015836	mto1	94	54.250	Cyprinodon_variegatus
ENSG00000135297	MTO1	99	57.732	ENSDARG00000055679	mto1	98	52.615	Danio_rerio
ENSG00000135297	MTO1	95	96.154	ENSDNOG00000015838	MTO1	100	88.348	Dasypus_novemcinctus
ENSG00000135297	MTO1	95	97.115	ENSDORG00000015529	Mto1	99	87.407	Dipodomys_ordii
ENSG00000135297	MTO1	95	62.857	FBgn0034735	CG4610	95	56.850	Drosophila_melanogaster
ENSG00000135297	MTO1	97	87.857	ENSETEG00000009559	MTO1	76	84.000	Echinops_telfairi
ENSG00000135297	MTO1	95	61.538	ENSEBUG00000014365	mto1	99	53.125	Eptatretus_burgeri
ENSG00000135297	MTO1	95	98.077	ENSEASG00005004331	MTO1	100	89.436	Equus_asinus_asinus
ENSG00000135297	MTO1	95	98.077	ENSECAG00000019823	MTO1	100	89.146	Equus_caballus
ENSG00000135297	MTO1	95	94.231	ENSEEUG00000008343	-	85	89.326	Erinaceus_europaeus
ENSG00000135297	MTO1	95	59.615	ENSELUG00000022936	mto1	94	56.044	Esox_lucius
ENSG00000135297	MTO1	94	99.029	ENSFCAG00000029600	MTO1	100	91.248	Felis_catus
ENSG00000135297	MTO1	95	85.714	ENSFALG00000007061	MTO1	98	73.355	Ficedula_albicollis
ENSG00000135297	MTO1	95	95.192	ENSFDAG00000006201	MTO1	98	86.637	Fukomys_damarensis
ENSG00000135297	MTO1	99	56.701	ENSFHEG00000009950	mto1	93	53.870	Fundulus_heteroclitus
ENSG00000135297	MTO1	98	48.585	ENSGMOG00000005985	mto1	98	51.227	Gadus_morhua
ENSG00000135297	MTO1	95	80.952	ENSGALG00000015923	MTO1	93	72.924	Gallus_gallus
ENSG00000135297	MTO1	98	57.407	ENSGAFG00000019362	mto1	95	48.750	Gambusia_affinis
ENSG00000135297	MTO1	95	58.095	ENSGACG00000007438	mto1	99	51.324	Gasterosteus_aculeatus
ENSG00000135297	MTO1	95	88.571	ENSGAGG00000010854	MTO1	96	76.167	Gopherus_agassizii
ENSG00000135297	MTO1	97	100.000	ENSGGOG00000041490	-	100	99.095	Gorilla_gorilla
ENSG00000135297	MTO1	95	95.192	ENSHGLG00000001518	MTO1	99	87.988	Heterocephalus_glaber_female
ENSG00000135297	MTO1	95	95.192	ENSHGLG00100013332	MTO1	99	86.502	Heterocephalus_glaber_male
ENSG00000135297	MTO1	99	57.798	ENSHCOG00000017556	mto1	99	52.888	Hippocampus_comes
ENSG00000135297	MTO1	99	57.732	ENSIPUG00000020394	MTO1	95	53.689	Ictalurus_punctatus
ENSG00000135297	MTO1	95	96.154	ENSSTOG00000007666	MTO1	100	90.318	Ictidomys_tridecemlineatus
ENSG00000135297	MTO1	95	97.115	ENSJJAG00000006640	Mto1	99	88.606	Jaculus_jaculus
ENSG00000135297	MTO1	95	60.000	ENSKMAG00000021430	mto1	95	52.816	Kryptolebias_marmoratus
ENSG00000135297	MTO1	99	56.701	ENSLBEG00000022690	mto1	98	54.247	Labrus_bergylta
ENSG00000135297	MTO1	79	51.648	ENSLOCG00000000453	-	73	56.897	Lepisosteus_oculatus
ENSG00000135297	MTO1	95	97.115	ENSLAFG00000007793	MTO1	100	90.000	Loxodonta_africana
ENSG00000135297	MTO1	95	100.000	ENSMFAG00000042481	MTO1	94	94.558	Macaca_fascicularis
ENSG00000135297	MTO1	100	97.222	ENSMMUG00000019270	MTO1	100	97.222	Macaca_mulatta
ENSG00000135297	MTO1	100	96.676	ENSMNEG00000038616	MTO1	100	96.676	Macaca_nemestrina
ENSG00000135297	MTO1	100	97.110	ENSMLEG00000044170	MTO1	100	97.110	Mandrillus_leucophaeus
ENSG00000135297	MTO1	95	60.952	ENSMAMG00000013076	mto1	95	53.201	Mastacembelus_armatus
ENSG00000135297	MTO1	95	60.952	ENSMZEG00005013882	mto1	95	53.517	Maylandia_zebra
ENSG00000135297	MTO1	90	80.682	ENSMGAG00000013830	MTO1	99	71.664	Meleagris_gallopavo
ENSG00000135297	MTO1	95	91.429	ENSMAUG00000021565	Mto1	99	86.838	Mesocricetus_auratus
ENSG00000135297	MTO1	95	96.190	ENSMICG00000032161	MTO1	100	91.185	Microcebus_murinus
ENSG00000135297	MTO1	95	92.381	ENSMOCG00000018371	Mto1	99	88.640	Microtus_ochrogaster
ENSG00000135297	MTO1	95	60.952	ENSMMOG00000001414	mto1	95	54.921	Mola_mola
ENSG00000135297	MTO1	95	85.577	ENSMODG00000018543	MTO1	100	79.856	Monodelphis_domestica
ENSG00000135297	MTO1	95	60.000	ENSMALG00000008389	mto1	93	55.189	Monopterus_albus
ENSG00000135297	MTO1	95	89.524	MGP_CAROLIEiJ_G0032470	Mto1	99	87.688	Mus_caroli
ENSG00000135297	MTO1	95	89.524	ENSMUSG00000032342	Mto1	99	87.444	Mus_musculus
ENSG00000135297	MTO1	96	88.138	MGP_PahariEiJ_G0015336	Mto1	99	88.288	Mus_pahari
ENSG00000135297	MTO1	95	90.476	MGP_SPRETEiJ_G0033610	Mto1	99	88.138	Mus_spretus
ENSG00000135297	MTO1	95	99.048	ENSMPUG00000004323	MTO1	100	90.029	Mustela_putorius_furo
ENSG00000135297	MTO1	95	99.038	ENSMLUG00000013527	MTO1	100	85.714	Myotis_lucifugus
ENSG00000135297	MTO1	95	93.333	ENSNGAG00000015680	Mto1	99	88.438	Nannospalax_galili
ENSG00000135297	MTO1	97	98.571	ENSNLEG00000001308	MTO1	100	94.282	Nomascus_leucogenys
ENSG00000135297	MTO1	73	91.250	ENSMEUG00000014515	-	57	97.674	Notamacropus_eugenii
ENSG00000135297	MTO1	97	85.000	ENSOPRG00000016673	-	70	87.105	Ochotona_princeps
ENSG00000135297	MTO1	95	95.192	ENSODEG00000015147	MTO1	100	85.872	Octodon_degus
ENSG00000135297	MTO1	95	61.538	ENSONIG00000011484	mto1	95	53.670	Oreochromis_niloticus
ENSG00000135297	MTO1	91	86.517	ENSOANG00000003443	MTO1	100	76.117	Ornithorhynchus_anatinus
ENSG00000135297	MTO1	95	98.077	ENSOCUG00000008468	MTO1	100	91.060	Oryctolagus_cuniculus
ENSG00000135297	MTO1	99	56.701	ENSORLG00000006039	mto1	95	53.155	Oryzias_latipes
ENSG00000135297	MTO1	99	56.701	ENSORLG00020016192	mto1	95	52.997	Oryzias_latipes_hni
ENSG00000135297	MTO1	99	55.670	ENSORLG00015014191	mto1	94	52.366	Oryzias_latipes_hsok
ENSG00000135297	MTO1	98	61.111	ENSOMEG00000021176	mto1	97	53.499	Oryzias_melastigma
ENSG00000135297	MTO1	95	94.286	ENSOGAG00000006692	MTO1	100	89.711	Otolemur_garnettii
ENSG00000135297	MTO1	95	97.143	ENSOARG00000006136	MTO1	100	88.584	Ovis_aries
ENSG00000135297	MTO1	100	99.533	ENSPPAG00000028710	MTO1	100	99.515	Pan_paniscus
ENSG00000135297	MTO1	95	97.143	ENSPPRG00000013725	MTO1	100	89.740	Panthera_pardus
ENSG00000135297	MTO1	95	98.095	ENSPTIG00000001836	MTO1	100	89.740	Panthera_tigris_altaica
ENSG00000135297	MTO1	100	99.533	ENSPTRG00000048593	MTO1	100	99.515	Pan_troglodytes
ENSG00000135297	MTO1	100	96.579	ENSPANG00000024449	MTO1	100	96.513	Papio_anubis
ENSG00000135297	MTO1	99	59.794	ENSPKIG00000008001	mto1	95	53.931	Paramormyrops_kingsleyae
ENSG00000135297	MTO1	95	87.619	ENSPSIG00000004469	MTO1	95	76.351	Pelodiscus_sinensis
ENSG00000135297	MTO1	99	56.701	ENSPMGG00000014811	mto1	96	55.079	Periophthalmus_magnuspinnatus
ENSG00000135297	MTO1	95	92.381	ENSPEMG00000024015	Mto1	99	87.519	Peromyscus_maniculatus_bairdii
ENSG00000135297	MTO1	95	80.000	ENSPMAG00000001707	MTO1	100	65.361	Petromyzon_marinus
ENSG00000135297	MTO1	99	56.701	ENSPFOG00000006388	mto1	92	54.874	Poecilia_formosa
ENSG00000135297	MTO1	99	56.701	ENSPLAG00000017042	mto1	96	54.602	Poecilia_latipinna
ENSG00000135297	MTO1	99	56.701	ENSPMEG00000017213	mto1	94	54.334	Poecilia_mexicana
ENSG00000135297	MTO1	99	56.701	ENSPREG00000014249	mto1	96	52.917	Poecilia_reticulata
ENSG00000135297	MTO1	97	99.286	ENSPPYG00000016776	MTO1	100	95.087	Pongo_abelii
ENSG00000135297	MTO1	95	96.154	ENSPCAG00000003531	MTO1	100	86.127	Procavia_capensis
ENSG00000135297	MTO1	98	93.636	ENSPCOG00000019343	MTO1	100	80.286	Propithecus_coquereli
ENSG00000135297	MTO1	95	96.190	ENSPVAG00000012721	MTO1	100	87.249	Pteropus_vampyrus
ENSG00000135297	MTO1	95	60.952	ENSPNYG00000017093	mto1	94	54.560	Pundamilia_nyererei
ENSG00000135297	MTO1	95	60.000	ENSPNAG00000023641	mto1	93	54.642	Pygocentrus_nattereri
ENSG00000135297	MTO1	95	89.524	ENSRNOG00000037659	Mto1	100	82.432	Rattus_norvegicus
ENSG00000135297	MTO1	95	100.000	ENSRBIG00000021154	MTO1	100	97.092	Rhinopithecus_bieti
ENSG00000135297	MTO1	100	97.110	ENSRROG00000030150	MTO1	100	97.110	Rhinopithecus_roxellana
ENSG00000135297	MTO1	90	60.227	YGL236C	MTO1	97	47.655	Saccharomyces_cerevisiae
ENSG00000135297	MTO1	97	97.143	ENSSBOG00000009456	MTO1	100	95.724	Saimiri_boliviensis_boliviensis
ENSG00000135297	MTO1	95	88.462	ENSSHAG00000003944	MTO1	99	80.000	Sarcophilus_harrisii
ENSG00000135297	MTO1	99	59.794	ENSSFOG00015013236	mto1	98	53.800	Scleropages_formosus
ENSG00000135297	MTO1	95	60.952	ENSSMAG00000016946	mto1	92	54.088	Scophthalmus_maximus
ENSG00000135297	MTO1	95	62.500	ENSSDUG00000022995	mto1	92	54.088	Seriola_dumerili
ENSG00000135297	MTO1	95	61.905	ENSSLDG00000017745	mto1	92	54.245	Seriola_lalandi_dorsalis
ENSG00000135297	MTO1	95	91.346	ENSSARG00000000522	MTO1	98	87.160	Sorex_araneus
ENSG00000135297	MTO1	95	84.762	ENSSPUG00000018137	MTO1	95	73.806	Sphenodon_punctatus
ENSG00000135297	MTO1	95	59.615	ENSSPAG00000008215	mto1	95	52.519	Stegastes_partitus
ENSG00000135297	MTO1	95	96.154	ENSSSCG00000004487	MTO1	100	89.595	Sus_scrofa
ENSG00000135297	MTO1	95	84.762	ENSTGUG00000012680	MTO1	95	71.884	Taeniopygia_guttata
ENSG00000135297	MTO1	95	60.000	ENSTRUG00000007003	mto1	94	53.787	Takifugu_rubripes
ENSG00000135297	MTO1	99	55.670	ENSTNIG00000018941	mto1	99	52.671	Tetraodon_nigroviridis
ENSG00000135297	MTO1	95	98.077	ENSTBEG00000003257	MTO1	85	92.949	Tupaia_belangeri
ENSG00000135297	MTO1	95	99.038	ENSTTRG00000005814	MTO1	85	89.818	Tursiops_truncatus
ENSG00000135297	MTO1	95	97.143	ENSUAMG00000006081	MTO1	100	90.751	Ursus_americanus
ENSG00000135297	MTO1	95	97.143	ENSUMAG00000012307	MTO1	100	90.751	Ursus_maritimus
ENSG00000135297	MTO1	95	88.462	ENSVPAG00000004971	MTO1	100	77.986	Vicugna_pacos
ENSG00000135297	MTO1	95	98.095	ENSVVUG00000013926	MTO1	100	90.327	Vulpes_vulpes
ENSG00000135297	MTO1	99	56.701	ENSXMAG00000024800	mto1	92	54.617	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0002098	tRNA wobble uridine modification	21873635.	IBA	Process
GO:0003723	RNA binding	22681889.	HDA	Function
GO:0005739	mitochondrion	21873635.	IBA	Component
GO:0030488	tRNA methylation	21873635.	IBA	Process
GO:0050660	flavin adenine dinucleotide binding	21873635.	IBA	Function
GO:0070899	mitochondrial tRNA wobble uridine modification	21873635.	IBA	Process