EuRBPDB

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  • Description
  • RBPome
  • Literatures
  • Expression
  • Transcripts
  • Gene Model
  • Pathways
  • PPI
  • Gene Ontology
Description
Ensembl ID
ENSG00000135446 (Gene tree)
Gene ID
1019
Gene Symbol
CDK4
Alias
PSK-J3
Full Name
cyclin dependent kinase 4
Gene Type
protein_coding
Species
Homo_sapiens
Status
confidence
Strand
Minus strand
Length
8,287 bases
Position
chr12:57,747,727-57,756,013
Accession
1773
RBP type
non-canonical RBP
Summary
The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
RNA binding proteome (RBPome)
PIDTitleMethod TimeAuthorDoi
30607034Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)OOPS & HEK2932019 Jan 3Queiroz RMLDOI: 10.1038/s41587-018-0001-2
30528433The Human RNA-Binding Proteome and Its Dynamics during Translational ArrestXRNAX & HEK2932018 Dec 6Trendel JDOI: 10.1016/j.cell.2018.11.004
29431736Capturing the interactome of newly transcribed RNAPolyT-RICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595
29431736Capturing the interactome of newly transcribed RNARICK & Hela2018 Feb 12Bao XDOI: 10.1038/nmeth.4595

Literatures on RNA binding capacity
PIDTitleArticle TimeAuthorDoi
12955883Aberrant p16INK4A RNA transcripts expressed in hepatocellular carcinoma cell lines regulate pRb phosphorylation by binding with CDK4, resulting in delayed cell cycle progression.Liver Int2003 JunCho JW-
22418736Transcriptional control of cell cycle-dependent kinase 4 by Smad proteins--implications for Alzheimer's disease.Neurobiol Aging2012 DecUeberham Udoi: 10.1016/j.neurobiolaging.2012.01.013
218203004-O-methylhonokiol inhibits colon tumor growth via p21-mediated suppression of NF-kB activity.J Nutr Biochem2012 JulOh JHdoi: 10.1016/j.jnutbio.2011.03.013
23919806Upregulation of Ying Yang 1 (YY1) suppresses esophageal squamous cell carcinoma development through heme oxygenase-1.Cancer Sci2013 NovLuo Jdoi: 10.1111/cas.12248
29322514The Yin and Yang of YY1 in tumor growth and suppression.Int J Cancer2018 Aug 1Khachigian LMdoi: 10.1002/ijc.31255
30206211CDK4 inhibition diminishes p53 activation by MDM2 antagonists.Cell Death Dis2018 Sep 11Sriraman Adoi: 10.1038/s41419-018-0968-0.
Expression
Transcripts
Transcript IDNameLengthRefSeq ID Protein IDLengthRefSeq IDUniportKB ID
ENST00000547853CDK4-205228-ENSP000004497252 (aa)-UPI000005E811
ENST00000547281CDK4-204825-ENSP00000447274186 (aa)-F8VZZ0
ENST00000552388CDK4-212694-ENSP00000448963170 (aa)-F8VYH9
ENST00000551800CDK4-209773-ENSP00000449391132 (aa)-F8VXD2
ENST00000551888CDK4-210636--- (aa)--
ENST00000553237CDK4-215952-ENSP0000044888574 (aa)-F8VYY1
ENST00000546489CDK4-203776-ENSP00000447779208 (aa)-F8VZ51
ENST00000552254CDK4-211769-ENSP00000449179203 (aa)-F8VWX7
ENST00000312990CDK4-2021650-ENSP00000316889111 (aa)-Q96BE9
ENST00000552713CDK4-213685--- (aa)--
ENST00000550419CDK4-207919-ENSP00000448098201 (aa)-F8VTV8
ENST00000552862CDK4-214447-ENSP00000446763115 (aa)-F8W1L8
ENST00000551706CDK4-208984--- (aa)--
ENST00000549606CDK4-206558-ENSP0000044700540 (aa)-F8VZ13
ENST00000257904CDK4-2012076-ENSP00000257904303 (aa)-P11802
Gene Model
Click here to download ENSG00000135446's gene model file
Pathways
Pathway IDPathway NameSource
hsa01522Endocrine resistanceKEGG
hsa04110Cell cycleKEGG
hsa04115p53 signaling pathwayKEGG
hsa04151PI3K-Akt signaling pathwayKEGG
hsa04218Cellular senescenceKEGG
hsa04530Tight junctionKEGG
hsa04660T cell receptor signaling pathwayKEGG
hsa04933AGE-RAGE signaling pathway in diabetic complicationsKEGG
hsa04934Cushing syndromeKEGG
hsa05160Hepatitis CKEGG
hsa05162MeaslesKEGG
hsa05163Human cytomegalovirus infectionKEGG
hsa05164Influenza AKEGG
hsa05165Human papillomavirus infectionKEGG
hsa05166Human T-cell leukemia virus 1 infectionKEGG
hsa05167Kaposi sarcoma-associated herpesvirus infectionKEGG
hsa05169Epstein-Barr virus infectionKEGG
hsa05200Pathways in cancerKEGG
hsa05203Viral carcinogenesisKEGG
hsa05212Pancreatic cancerKEGG
hsa05214GliomaKEGG
hsa05218MelanomaKEGG
hsa05219Bladder cancerKEGG
hsa05220Chronic myeloid leukemiaKEGG
hsa05222Small cell lung cancerKEGG
hsa05223Non-small cell lung cancerKEGG
hsa05224Breast cancerKEGG
hsa05225Hepatocellular carcinomaKEGG
Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135446's network

* RBP PPI network refers to all genes directly bind to RBP
Gene Ontology
Go IDGo_termPubmedIDEvidenceCategory
GO:0000079regulation of cyclin-dependent protein serine/threonine kinase activity-IEAProcess
GO:0000082G1/S transition of mitotic cell cycle7603984.IMPProcess
GO:0000307cyclin-dependent protein kinase holoenzyme complex17420273.18827403.IDAComponent
GO:0000785chromatin18827403.IDAComponent
GO:0002088lens development in camera-type eye-IEAProcess
GO:0004693cyclin-dependent protein serine/threonine kinase activity21873635.IBAFunction
GO:0004693cyclin-dependent protein serine/threonine kinase activity8114739.IDAFunction
GO:0004693cyclin-dependent protein serine/threonine kinase activity-TASFunction
GO:0005515protein binding7568034.8078588.8259215.8741839.8756624.9106657.9150368.9529249.11896535.11900540.14641107.15107404.15232106.15558030.16169070.16189514.16326706.16327805.16962592.17053782.17517622.17909018.17955473.19237555.19237565.19447967.19470470.21242975.21516116.21871133.21900206.21988832.22094256.22939624.23455922.23602568.24189400.24218572.24855949.25036637.25241761.25416956.25910212.26496610.27107012.27339980.27353360.IPIFunction
GO:0005524ATP binding-IEAFunction
GO:0005634nucleus21873635.IBAComponent
GO:0005634nucleus16109376.18827403.IDAComponent
GO:0005654nucleoplasm-TASComponent
GO:0005667transcription factor complex-IEAComponent
GO:0005730nucleolus18827403.IDAComponent
GO:0005829cytosol18827403.IDAComponent
GO:0005829cytosol-TASComponent
GO:0005923bicellular tight junction-IEAComponent
GO:0006367transcription initiation from RNA polymerase II promoter-TASProcess
GO:0006468protein phosphorylation21873635.IBAProcess
GO:0006468protein phosphorylation8114739.IDAProcess
GO:0007165signal transduction-IEAProcess
GO:0007623circadian rhythm-IEAProcess
GO:0008284positive regulation of cell proliferation7603984.IMPProcess
GO:0009636response to toxic substance-IEAProcess
GO:0010288response to lead ion-IEAProcess
GO:0010468regulation of gene expression17420273.IMPProcess
GO:0010971positive regulation of G2/M transition of mitotic cell cycle19124461.IDAProcess
GO:0016538cyclin-dependent protein serine/threonine kinase regulator activity-TASFunction
GO:0030332cyclin binding19124461.IPIFunction
GO:0031100animal organ regeneration-IEAProcess
GO:0031965nuclear membrane18827403.IDAComponent
GO:0032869cellular response to insulin stimulus-IEAProcess
GO:0033574response to testosterone-IEAProcess
GO:0040014regulation of multicellular organism growth-IEAProcess
GO:0042493response to drug18291362.IEPProcess
GO:0043065positive regulation of apoptotic process-IEAProcess
GO:0044877protein-containing complex binding-IEAFunction
GO:0045727positive regulation of translation-IEAProcess
GO:0045787positive regulation of cell cycle-TASProcess
GO:0045793positive regulation of cell size-IEAProcess
GO:0046626regulation of insulin receptor signaling pathway-IEAProcess
GO:0046890regulation of lipid biosynthetic process-IEAProcess
GO:0048146positive regulation of fibroblast proliferation17420273.IMPProcess
GO:0048471perinuclear region of cytoplasm-IEAComponent
GO:0050994regulation of lipid catabolic process-IEAProcess
GO:0051301cell division-IEAProcess
GO:0055093response to hyperoxia-IEAProcess
GO:0060612adipose tissue development-IEAProcess
GO:0071157negative regulation of cell cycle arrest19124461.IDAProcess
GO:0071222cellular response to lipopolysaccharide-IEAProcess
GO:0071353cellular response to interleukin-4-IEAProcess
GO:0097129cyclin D2-CDK4 complex-IEAComponent
GO:1904628cellular response to phorbol 13-acetate 12-myristate-IEAProcess
GO:1904637cellular response to ionomycin-IEAProcess
GO:2000134negative regulation of G1/S transition of mitotic cell cycle-TASProcess

Cancer associated literatures
PIDTitleArticle TimeAuthorDoi
19327170CDK4 IVS4-nt40 AA genotype and obesity-associated tumors/cancer in Italians - a case-control study.J Exp Clin Cancer Res2009 Mar 28Meenakshisundaram Rdoi: 10.1186/1756-9966-28-42.
29935356Lower miR-340 expression predicts poor prognosis of non-small cell lung cancer and promotes cell proliferation by targeting CDK4.Gene2018 Oct 30Qin Ydoi: 10.1016/j.gene.2018.06.062
24289491MicroRNA-206 induces G1 arrest in melanoma by inhibition of CDK4 and Cyclin D.Pigment Cell Melanoma Res2014 MarGeorgantas RW 3rddoi: 10.1111/pcmr.12200
21325289Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor.Clin Cancer Res2011 Apr 1Yu Jdoi: 10.1158/1078-0432.CCR-10-1551
24771220Cyclin-dependent kinase 4 overexpression is mostly independent of gene amplification and constitutes an independent prognosticator for nasopharyngeal carcinoma.Tumour Biol2014 JulChen TJdoi: 10.1007/s13277-014-1884-2
24751144Knocking down CDK4 mediates the elevation of let-7c suppressing cell growth in nasopharyngeal carcinoma.BMC Cancer2014 Apr 21Liu Zdoi: 10.1186/1471-2407-14-274.
18413728Cyclin D1 and CDK4 activity contribute to the undifferentiated phenotype in neuroblastoma.Cancer Res2008 Apr 15Molenaar JJdoi: 10.1158/0008-5472.CAN-07-5032.
24496383Synthetic lethal therapy for KRAS mutant non-small-cell lung carcinoma with nanoparticle-mediated CDK4 siRNA delivery.Mol Ther2014 MayMao CQdoi: 10.1038/mt.2014.18
25002028CDK 4/6 inhibitors sensitize PIK3CA mutant breast cancer to PI3K inhibitors.Cancer Cell2014 Jul 14Vora SRdoi: 10.1016/j.ccr.2014.05.020
26336885Prognostic value of HMGA2, CDK4, and JUN amplification in well-differentiated and dedifferentiated liposarcomas.Mod Pathol2015 NovSaada-Bouzid Edoi: 10.1038/modpathol.2015.96
14647432Enhanced malignant tumorigenesis in Cdk4 transgenic mice.Oncogene2004 Mar 11Miliani de Marval PL-
17139501Association of CDK4 and CCND1 mRNA overexpression in laryngeal squamous cell carcinomas occurs without CDK4 amplification.Virchows Arch2007 FebNadal A-
24614102CDK4 deficiency promotes genomic instability and enhances Myc-driven lymphomagenesis.J Clin Invest2014 AprLu Ydoi: 10.1172/JCI63139
27508976MDM2 and CDK4 Immunohistochemistry: Should It Be Used in Problematic Differentiated Lipomatous Tumors?: A New Perspective.Am J Surg Pathol2016 DecClay MR-
27597521Differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma: utility of p16 in combination with MDM2 and CDK4 immunohistochemistry.Hum Pathol2017 JanKammerer-Jacquet SFdoi: 10.1016/j.humpath.2016.08.009
26923330Targeting the RB-E2F pathway in breast cancer.Oncogene2016 Sep 15Johnson Jdoi: 10.1038/onc.2016.32
27542767A Phase I Study of the Cyclin-Dependent Kinase 4/6 Inhibitor Ribociclib (LEE011) in Patients with Advanced Solid Tumors and Lymphomas.Clin Cancer Res2016 Dec 1Infante JR-
28039467Targeting cancer stem cell propagation with palbociclib, a CDK4/6 inhibitor: Telomerase drives tumor cell heterogeneity.Oncotarget2017 Feb 7Bonuccelli Gdoi: 10.18632/oncotarget.14196.
28351928Ribociclib (LEE011): Mechanism of Action and Clinical Impact of This Selective Cyclin-Dependent Kinase 4/6 Inhibitor in Various Solid Tumors.Clin Cancer Res2017 Jul 1Tripathy Ddoi: 10.1158/1078-0432.CCR-16-3157
29562955MicroRNA-338-3p Inhibits Proliferation and Promotes Apoptosis of Multiple Myeloma Cells Through Targeting Cyclin-Dependent Kinase 4.Oncol Res2018 Dec 27Cao Ydoi: 10.3727/096504018X15213031799835
25348738MiR-124 retards bladder cancer growth by directly targeting CDK4.Acta Biochim Biophys Sin (Shanghai)2014 DecZhang Tdoi: 10.1093/abbs/gmu105
24982332Coordinated expression of cyclin-dependent kinase-4 and its regulators in human oral tumors.Anticancer Res2014 JulPoi MJ-
15208653Evidence for a cancer-specific switch at the CDK4 promoter with loss of control by both USF and c-Myc.Oncogene2004 Aug 12Pawar SA-
23839043Cell cycle regulators cyclin D1 and CDK4/6 have estrogen receptor-dependent divergent functions in breast cancer migration and stem cell-like activity.Cell Cycle2013 Aug 1Lamb Rdoi: 10.4161/cc.25403
23336272The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer.Breast Cancer Res2013 Jan 21Peurala Edoi: 10.1186/bcr3376.
27323123miR-124 radiosensitizes human esophageal cancer cell TE-1 by targeting CDK4.Genet Mol Res2016 Jun 3Zhang YHdoi: 10.4238/gmr.15027893.
16413469Requirement for CDK4 kinase function in breast cancer.Cancer Cell2006 JanYu Q-
14672406Early overexpression of Cdk4 and possible role of KRF and c-myc in chewing tobacco mediated oral cancer development.Mol Biol Rep2003 DecMishra R-
26416047Genetic polymorphisms in cell cycle regulatory genes CCND1 and CDK4 are associated with susceptibility to breast cancer.J BUON2015 Jul-AugUllah Shah A-
20179208Cyclin D1/cyclin-dependent kinase 4 interacts with filamin A and affects the migration and invasion potential of breast cancer cells.Cancer Res2010 Mar 1Zhong Zdoi: 10.1158/0008-5472.CAN-08-1108
18202766Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells.Int J Oncol2008 FebShin JS-
24444383Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells.BMC Cancer2014 Jan 20Kang Jdoi: 10.1186/1471-2407-14-32.
23776583Cdk4 and nek2 signal binucleation and centrosome amplification in a her2+ breast cancer model.PLoS One2013 Jun 11Harrison Pitner MKdoi: 10.1371/journal.pone.0065971
23684928Molecular interplay between cdk4 and p21 dictates G0/G1 cell cycle arrest in prostate cancer cells.Cancer Lett2013 Sep 1Gulappa Tdoi: 10.1016/j.canlet.2013.05.014
21278246Expression of p16 and retinoblastoma determines response to CDK4/6 inhibition in ovarian cancer.Clin Cancer Res2011 Mar 15Konecny GEdoi: 10.1158/1078-0432.CCR-10-2307
26735582RASSF1A inhibits gastric cancer cell proliferation by miR-711- mediated downregulation of CDK4 expression.Oncotarget2016 Feb 2Liao Adoi: 10.18632/oncotarget.6813.
23174577[Cytoplasmic expression of CDK4 protein and its correlation with the clinicopathologic features and prognosis of lung cancer].Nan Fang Yi Ke Da Xue Xue Bao2012 NovZhang Y-
24848372Modulated expression of genes encoding estrogen metabolizing enzymes by G1-phase cyclin-dependent kinases 6 and 4 in human breast cancer cells.PLoS One2014 May 21Jia Ydoi: 10.1371/journal.pone.0097448
22289176Cyclin-dependent kinase 4 is a novel target in micoRNA-195-mediated cell cycle arrest in bladder cancer cells.FEBS Lett2012 Feb 17Lin Ydoi: 10.1016/j.febslet.2012.01.027
21477379Elevated expression of CDK4 in lung cancer.J Transl Med2011 Apr 11Wu Adoi: 10.1186/1479-5876-9-38.
21777578The risk factor of gallbladder cancer: hyperplasia of mucous epithelium caused by gallstones associates with p16/CyclinD1/CDK4 pathway.Exp Mol Pathol2011 OctFeng Zdoi: 10.1016/j.yexmp.2011.06.004
26744345MiR-613 induces cell cycle arrest by targeting CDK4 in non-small cell lung cancer.Cell Oncol (Dordr)2016 AprLi Ddoi: 10.1007/s13402-015-0262-4
25486477The cyclin D1-CDK4 oncogenic interactome enables identification of potential novel oncogenes and clinical prognosis.Cell Cycle2014Jirawatnotai Sdoi: 10.4161/15384101.2014.946850.
25876993The Role of CDK4/6 Inhibition in Breast Cancer.Oncologist2015 MayMurphy CGdoi: 10.1634/theoncologist.2014-0443
19917880Aryl hydrocarbon receptor regulates cell cycle progression in human breast cancer cells via a functional interaction with cyclin-dependent kinase 4.Mol Pharmacol2010 FebBarhoover MAdoi: 10.1124/mol.109.059675
27815686CDK4 in lung, and head and neck cancers in old age: evaluation as a biomarker.Clin Transl Oncol2017 MayBanerjee Jdoi: 10.1007/s12094-016-1565-2
27206849A CDK4/6-Dependent Epigenetic Mechanism Protects Cancer Cells from PML-induced Senescence.Cancer Res2016 Jun 1Acevedo Mdoi: 10.1158/0008-5472.CAN-15-2347
28364361A novel method to generate single-cell-derived cancer-associated fibroblast clones.J Cancer Res Clin Oncol2017 AugHashimoto Hdoi: 10.1007/s00432-017-2409-3
28888575Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4.Gene2017 Nov 30Chen Sdoi: 10.1016/j.gene.2017.09.009
27049724Direct repression of the oncogene CDK4 by the tumor suppressor miR-486-5p in non-small cell lung cancer.Oncotarget2016 Jun 7Shao Ydoi: 10.18632/oncotarget.8514.
28508842A3 adenosine receptor agonist induce G1 cell cycle arrest via Cyclin D and cyclin-dependent kinase 4 pathways in OVCAR-3 and Caov-4 cell lines.J Cancer Res Ther2017 Jan-MarJoshaghani HRdoi: 10.4103/0973-1482.199381.
27564114Defining the transcriptional and biological response to CDK4/6 inhibition in relation to ER+/HER2- breast cancer.Oncotarget2016 Oct 25Knudsen ESdoi: 10.18632/oncotarget.11588.
27759034CDK4 regulates cancer stemness and is a novel therapeutic target for triple-negative breast cancer.Sci Rep2016 Oct 19Dai Mdoi: 10.1038/srep35383.
29115564miR-486 functions as a tumor suppressor in esophageal cancer by targeting CDK4/BCAS2.Oncol Rep2018 JanLang Bdoi: 10.3892/or.2017.6064
29335521Non-canonical roles of PFKFB3 in regulation of cell cycle through binding to CDK4.Oncogene2018 MarJia Wdoi: 10.1038/s41388-017-0072-4

Differential Expression

Expression in 33 cancers

Mutations
CancerChrPosition Mutation TypedbSNPProtein-change Allele FreqRBD
BLCAchr1257749498SilentNAL213L0.26
BLCAchr1257751664SilentNAG18G0.25
BLCAchr1257750957Missense_MutationnovelR163K0.33
BLCAchr1257751281Missense_MutationnovelE94K0.13
BRCAchr1257750982Missense_MutationNAK155Q0.28
CESCchr1257751317Missense_MutationnovelR82G0.42
CESCchr1257749198Missense_MutationnovelG268A0.14
CESCchr12577523245'UTRnovel0.28
CESCchr1257751538SilentNAL60L0.23
COADchr1257751036Missense_Mutationrs150281463V137I0.13
COADchr1257749302SilentnovelP233P0.14
GBMchr1257749260SilentnovelG247G0.16
HNSCchr1257749500Missense_MutationnovelL213F0.29
HNSCchr1257751510Frame_Shift_InsnovelN70Qfs*150.3
HNSCchr1257749490Missense_MutationnovelG216E0.18
HNSCchr1257749195Missense_Mutationrs779161525A269V0.18
KIRPchr1257751567Missense_MutationnovelI51V0.37
LAMLchr1257748609SilentnovelL276L0.04
LGGchr1257751316Missense_Mutationrs3211612R82Q0.45
LUADchr1257751647Missense_MutationNAR24L0.09
LUADchr1257750754SilentnovelL178L0.08
LUADchr1257751647Missense_MutationNAR24L0.29
LUADchr1257751651Missense_MutationNAA23S0.36
LUSCchr1257751046SilentnovelA133A0.14
LUSCchr1257751249SilentnovelL104L0.17
LUSCchr1257751539Missense_MutationnovelL60Q0.35
OVchr1257749258Missense_MutationnovelA248D0.19
OVchr1257750758Missense_MutationnovelT177I0.05
OVchr1257751033Missense_MutationnovelH138Y0.04
PAADchr1257751081Missense_Mutationrs587778185R122C0.23
PAADchr1257751290Missense_MutationnovelL91M0.18
READchr1257749196Missense_Mutationrs786202902A269T0.11
READchr1257751259Missense_MutationNAR101M0.35
SARCchr1257751675Missense_MutationnovelG15R0.36
SKCMchr1257751647Missense_Mutationrs104894340R24H0.26
SKCMchr1257751654Missense_MutationnovelK22Q0.55
SKCMchr1257751653Missense_MutationNAK22M0.48
SKCMchr1257751648Missense_MutationNAR24S0.87
SKCMchr1257751648Missense_Mutationrs11547328R24C0.17
SKCMchr1257749251SilentnovelP250P0.31
SKCMchr1257749252Missense_MutationnovelP250H0.32
SKCMchr1257751653Missense_MutationNAK22M0.26
SKCMchr1257751653Missense_MutationNAK22M0.25
SKCMchr1257751653Missense_MutationNAK22M0.17
SKCMchr1257751647Missense_MutationNAR24L0.74
STADchr1257750672Missense_MutationnovelE206K0.06
STADchr1257750707Missense_MutationnovelP194L0.07
UCECchr1257751614Missense_MutationNAK35R0.32
UCECchr1257751555Missense_MutationnovelR55C0.31
UCECchr1257751293Missense_MutationnovelT90A0.18
UCECchr1257751265Missense_MutationnovelD99G0.34
UCECchr1257750670Missense_MutationnovelE206D0.31
UCECchr1257748588SilentnovelR283R0.41
UCECchr1257750679SilentnovelI203I0.18
UCECchr1257749490Missense_MutationnovelG216V0.26
UCECchr1257751526Missense_MutationnovelE64D0.05
UCECchr1257751523Silentrs770618992A65A0.38
UCECchr1257751676Silentrs786203182V14V0.32
UCECchr1257748585SilentnovelI284I0.33
UCECchr1257751566Missense_MutationnovelI51S0.35
UCECchr1257750924Missense_MutationNAV174G0.48
UCECchr1257751291SilentnovelT90T0.09
UCECchr1257750749Missense_MutationnovelY180C0.47
UCECchr1257750730SilentNAL186L0.11
UCECchr1257751664SilentNAG18G0.41
UCECchr1257751323Missense_MutationnovelT80A0.36
UCECchr1257751566Missense_MutationnovelI51S0.34
UCECchr1257749477Silentrs773490152A220A0.27

Copy Number Variations (CNVs)
CancerTypeFreq Q-value
ACCAMP0.75560.022038
ACCDEL0.02220.20414
DLBCAMP0.20830.085003
GBMAMP0.21847.0361e-151
LGGAMP0.06437.8643e-40
LUADAMP0.24031.5136e-15
PCPGAMP0.09260.028953
READDEL0.07270.064633
SKCMAMP0.11995.5617e-09

Survival Analysis
CancerP-value Q-value
SARC0.0018

Kaplan-Meier Survival Analysis

MESO0.00015

Kaplan-Meier Survival Analysis

UCS0.0035

Kaplan-Meier Survival Analysis

SKCM0.00041

Kaplan-Meier Survival Analysis

LUSC0.027

Kaplan-Meier Survival Analysis

KIRP0.0086

Kaplan-Meier Survival Analysis

PCPG0.041

Kaplan-Meier Survival Analysis

BLCA0.028

Kaplan-Meier Survival Analysis

KICH0.039

Kaplan-Meier Survival Analysis

LIHC0.0001

Kaplan-Meier Survival Analysis

LGG0.0038

Kaplan-Meier Survival Analysis

UVM0.0015

Kaplan-Meier Survival Analysis

OV0.016

Kaplan-Meier Survival Analysis

Drugs

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Input Drug :


Input Cell Line :


Eesembl ID



Cell lines and drugs in GSE70138 or GSE92742


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