EuRBPDB

Basic Information
Cancer Related Information

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Description

Ensembl ID: ENSG00000135476 (Gene tree)
Gene ID: 9700
Gene Symbol: ESPL1
Alias: KIAA0165|ESP1|SEPA
Full Name: extra spindle pole bodies like 1, separase
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 25,378 bases
Position: chr12:53,268,266-53,293,643
Accession: 16856
RBP type: non-canonical RBP
Summary: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]

RNA binding proteome (RBPome)

PID	Title	Method	Time	Author	Doi
29431736	Capturing the interactome of newly transcribed RNA	RIC & Hela	2018 Feb 12	Bao X	DOI: 10.1038/nmeth.4595
30607034	Comprehensive identification of RNA protein interactions in any organism using orthogonal organic phase separation (OOPS)	OOPS & U2OS	2019 Jan 3	Queiroz RML	DOI: 10.1038/s41587-018-0001-2

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000553219	ESPL1-209	714	-	ENSP00000456450	207 (aa)	-	H3BRX7
ENST00000535123	ESPL1-202	1203	-	-	- (aa)	-	-
ENST00000552671	ESPL1-207	6665	-	ENSP00000447054	49 (aa)	-	H3BM31
ENST00000553016	ESPL1-208	1320	-	-	- (aa)	-	-
ENST00000257934	ESPL1-201	6623	XM_006719705	ENSP00000257934	2120 (aa)	XP_006719768	Q14674
ENST00000552462	ESPL1-205	6447	-	ENSP00000449831	2120 (aa)	-	Q14674
ENST00000549154	ESPL1-203	4078	-	-	- (aa)	-	-
ENST00000552600	ESPL1-206	894	-	-	- (aa)	-	-
ENST00000550026	ESPL1-204	522	-	-	- (aa)	-	-

Gene Model

Click here to download ENSG00000135476's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa04110	Cell cycle	KEGG
hsa04114	Oocyte meiosis	KEGG
hsa05166	Human T-cell leukemia virus 1 infection	KEGG

Phenotypes

ensgID	Trait	pValue	Pubmed ID
ENSG00000135476	Child Development Disorders, Pervasive	7.2000000E-005	-

GWAS

ensgID	SNP	Chromosome	Position	SNP-risk	Trait	PubmedID	95% CI	Or or BEAT	EFO ID
ENSG00000135476	rs2272313	12	53277765	A	Femoral neck bone mineral density	29499414	[0.02-0.048] unit increase	0.0337	EFO_0007785
ENSG00000135476	rs2272313	12	53277765	A	Lumbar spine bone mineral density	29499414	[0.043-0.074] unit increase	0.0583	EFO_0007701
ENSG00000135476	rs1056692	12	53293603	?	Colonoscopy-negative controls vs population controls	29228715	[NR]	1.37	EFO_0008460

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135476's network

* RBP PPI network refers to all genes directly bind to RBP

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0000070	mitotic sister chromatid segregation	12672959.	IMP	Process
GO:0000212	meiotic spindle organization	-	IEA	Process
GO:0000281	mitotic cytokinesis	11509732.	NAS	Process
GO:0003824	catalytic activity	12672959.	NAS	Function
GO:0004197	cysteine-type endopeptidase activity	21873635.	IBA	Function
GO:0005515	protein binding	12194817.12672959.	IPI	Function
GO:0005634	nucleus	21873635.	IBA	Component
GO:0005737	cytoplasm	21873635.	IBA	Component
GO:0005813	centrosome	21873635.	IBA	Component
GO:0005813	centrosome	12672959.	IDA	Component
GO:0005829	cytosol	-	TAS	Component
GO:0006508	proteolysis	-	IEA	Process
GO:0006915	apoptotic process	11875078.	TAS	Process
GO:0008234	cysteine-type peptidase activity	12672959.	NAS	Function
GO:0008234	cysteine-type peptidase activity	-	TAS	Function
GO:0040001	establishment of mitotic spindle localization	12672959.	NAS	Process
GO:0045143	homologous chromosome segregation	-	IEA	Process
GO:0045842	positive regulation of mitotic metaphase/anaphase transition	12672959.	NAS	Process
GO:0045875	negative regulation of sister chromatid cohesion	12194817.	NAS	Process
GO:0051307	meiotic chromosome separation	21873635.	IBA	Process
GO:0072686	mitotic spindle	21873635.	IBA	Component

Cancer associated literatures

PID	Title	Article	Time	Author	Doi
24792645	Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme.	J Neurooncol	2014 Aug	Mukherjee M	doi: 10.1007/s11060-014-1458-6
19351757	Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers.	Clin Cancer Res	2009 Apr 15	Meyer R	doi: 10.1158/1078-0432.CCR-08-2454
18616699	Effect of separase depletion on ionizing radiation-induced cell cycle checkpoints and survival in human lung cancer cell lines.	Cell Prolif	2008 Aug	Sak A	doi: 10.1111/j.1365-2184.2008.00540.x
28859055	Separase is a marker for prognosis and mitotic activity in breast cancer.	Br J Cancer	2017 Oct 24	Gurvits N	doi: 10.1038/bjc.2017.301
27966791	Separase: Function Beyond Cohesion Cleavage and an Emerging Oncogene.	J Cell Biochem	2017 Jun	Kumar R	doi: 10.1002/jcb.25835

Differential Expression

Expression in 33 cancers

Mutations

Cancer	Chr	Position	Mutation Type	dbSNP	Protein-change	Allele Freq
ACC	chr12	53279742	Missense_Mutation	novel	A792V	0.4
ACC	chr12	53269353	Silent	novel	P137P	0.48
BLCA	chr12	53277200	Silent	novel	I686I	0.34
BLCA	chr12	53286077	Missense_Mutation	NA	K1114M	0.22
BLCA	chr12	53292859	Missense_Mutation	rs779582000	R2017Q	0.06
BLCA	chr12	53282378	Missense_Mutation	NA	L912V	0.26
BLCA	chr12	53288682	Nonsense_Mutation	novel	S1564*	0.17
BLCA	chr12	53274961	Missense_Mutation	NA	R551W	0.29
BLCA	chr12	53292288	Missense_Mutation	rs763549148	S1936L	0.16
BLCA	chr12	53293466	Silent	novel	L2119L	0.11
BLCA	chr12	53269104	Silent	NA	L54L	0.07
BLCA	chr12	53291845	Silent	novel	V1892V	0.31
BLCA	chr12	53288644	Missense_Mutation	novel	E1551D	0.16
BLCA	chr12	53276758	Silent	rs772945895	L613L	0.22
BLCA	chr12	53283411	Missense_Mutation	novel	L984I	0.55
BLCA	chr12	53279746	Silent	NA	L793L	0.32
BLCA	chr12	53284155	Missense_Mutation	NA	E1059Q	0.38
BLCA	chr12	53284164	Missense_Mutation	novel	T1062A	0.37
BLCA	chr12	53269987	Nonsense_Mutation	novel	R349*	0.32
BLCA	chr12	53282282	Missense_Mutation	novel	L880V	0.3
BLCA	chr12	53284113	Missense_Mutation	NA	D1045N	0.25
BLCA	chr12	53269236	Missense_Mutation	novel	E98D	0.2
BLCA	chr12	53274903	Silent	novel	L531L	0.13
BLCA	chr12	53269954	Missense_Mutation	novel	E338K	0.39
BLCA	chr12	53284092	Missense_Mutation	NA	E1038K	0.33
BLCA	chr12	53282401	Silent	NA	L919L	0.07
BLCA	chr12	53269339	Missense_Mutation	novel	R133C	0.18
BLCA	chr12	53286452	Nonsense_Mutation	novel	S1239*	0.2
BRCA	chr12	53286194	Missense_Mutation	NA	S1153N	0.17
BRCA	chr12	53288126	Missense_Mutation	novel	S1444N	0.15
BRCA	chr12	53292383	Missense_Mutation	novel	N1968H	0.08
BRCA	chr12	53269638	Silent	rs745521721	L232L	0.46
BRCA	chr12	53272752	Missense_Mutation	NA	F467L	0.12
BRCA	chr12	53286650	Nonsense_Mutation	NA	S1305*	0.59
BRCA	chr12	53293565	3'UTR	novel		0.27
BRCA	chr12	53286568	Missense_Mutation	novel	G1278R	0.08
BRCA	chr12	53270375	Splice_Region	novel		0.14
BRCA	chr12	53286271	Missense_Mutation	rs371853647	Q1179E	0.12
BRCA	chr12	53288701	Splice_Site	novel	X1570_splice	0.07
BRCA	chr12	53286175	Missense_Mutation	novel	D1147N	0.07
BRCA	chr12	53288035	Missense_Mutation	NA	E1414K	0.2
BRCA	chr12	53269168	Missense_Mutation	NA	E76Q	0.23
BRCA	chr12	53289454	Missense_Mutation	NA	G1658V	0.18
BRCA	chr12	53283146	Missense_Mutation	rs746647343	I937V	0.76
BRCA	chr12	53268766	5'UTR	novel		0.32
BRCA	chr12	53269878	Silent	NA	A312A	0.14
CESC	chr12	53290991	Missense_Mutation	rs375540909	L1839M	0.25
CESC	chr12	53286739	Nonsense_Mutation	novel	Q1335*	0.12
CESC	chr12	53285958	Silent	novel	V1074V	0.47
CESC	chr12	53277120	Missense_Mutation	NA	L660V	0.27
CESC	chr12	53286330	Silent	NA	L1198L	0.38
CESC	chr12	53270675	Splice_Region	novel		0.19
CESC	chr12	53290102	Frame_Shift_Ins	novel	*L1711Cfs52**	0.08
CESC	chr12	53270389	Silent	novel	G385G	0.22
CESC	chr12	53281546	Missense_Mutation	novel	D847N	0.53
CESC	chr12	53286829	Frame_Shift_Del	novel	*F1365Lfs29**	0.22
CESC	chr12	53290377	Missense_Mutation	novel	D1758H	0.19
CESC	chr12	53293319	Missense_Mutation	NA	D2070H	0.14
CESC	chr12	53279785	Silent	rs567728499	L806L	0.39
CESC	chr12	53269898	Missense_Mutation	rs566763422	S319L	0.45
CESC	chr12	53286576	Silent	rs780440223	L1280L	0.38
COAD	chr12	53289573	Missense_Mutation	NA	R1698C	0.33
COAD	chr12	53292004	Missense_Mutation	novel	W1904C	0.34
COAD	chr12	53283235	Silent	NA	V966V	0.25
COAD	chr12	53288001	Silent	novel	E1402E	0.29
COAD	chr12	53293378	Silent	novel	L2089L	0.25
COAD	chr12	53276653	Silent	rs144474323	P578P	0.38
COAD	chr12	53289214	Silent	rs779415897	R1611R	0.45
COAD	chr12	53269629	Silent	novel	I229I	0.28
COAD	chr12	53270734	Silent	novel	V435V	0.13
COAD	chr12	53282303	Missense_Mutation	novel	D887N	0.25
COAD	chr12	53289421	Missense_Mutation	rs749239351	R1647Q	0.17
COAD	chr12	53269624	Missense_Mutation	rs375659071	V228M	0.22
COAD	chr12	53269987	Nonsense_Mutation	novel	R349*	0.39
COAD	chr12	53274980	Missense_Mutation	novel	A557V	0.34
COAD	chr12	53283511	Missense_Mutation	novel	L1017R	0.29
COAD	chr12	53281598	Missense_Mutation	rs752710244	R864Q	0.37
COAD	chr12	53286319	Missense_Mutation	rs200640004	A1195T	0.29
COAD	chr12	53269298	Missense_Mutation	novel	R119H	0.35
COAD	chr12	53293510	3'UTR	novel		0.33
COAD	chr12	53286668	Frame_Shift_Del	NA	*Q1311Rfs21**	0.46
COAD	chr12	53272771	Missense_Mutation	NA	A474T	0.31
COAD	chr12	53269471	Missense_Mutation	novel	L177F	0.37
COAD	chr12	53269842	Silent	novel	L300L	0.4
COAD	chr12	53290916	Missense_Mutation	novel	G1814C	0.49
COAD	chr12	53286318	Silent	rs61740151	A1194A	0.33
COAD	chr12	53290983	Missense_Mutation	NA	R1836H	0.39
COAD	chr12	53276705	Missense_Mutation	rs747148602	R596W	0.36
COAD	chr12	53276726	Missense_Mutation	novel	R603C	0.16
COAD	chr12	53274979	Missense_Mutation	novel	A557T	0.16
COAD	chr12	53283421	Missense_Mutation	novel	V987A	0.29
COAD	chr12	53291812	Missense_Mutation	novel	Q1881H	0.31
COAD	chr12	53288667	Missense_Mutation	rs766352133	R1559Q	0.19
COAD	chr12	53272842	Missense_Mutation	novel	E497D	0.36
COAD	chr12	53284126	Missense_Mutation	rs575347377	S1049L	0.18
DLBC	chr12	53289544	Missense_Mutation	novel	P1688L	0.41
DLBC	chr12	53286880	Missense_Mutation	novel	R1382W	0.1
ESCA	chr12	53274997	Nonsense_Mutation	novel	E563*	0.23
ESCA	chr12	53277150	Missense_Mutation	novel	R670G	0.4
ESCA	chr12	53292013	Missense_Mutation	novel	M1907I	0.1
ESCA	chr12	53284102	Missense_Mutation	novel	R1041H	0.24
ESCA	chr12	53269721	Missense_Mutation	rs761300540	R260H	0.18
ESCA	chr12	53269346	Missense_Mutation	novel	A135D	0.4
GBM	chr12	53269488	Frame_Shift_Del	novel	*S182Rfs18**	0.1
GBM	chr12	53269158	Silent	NA	G72G	0.36
GBM	chr12	53277545	Missense_Mutation	novel	D721N	0.19
GBM	chr12	53288607	Missense_Mutation	novel	S1539T	0.33
GBM	chr12	53289170	Missense_Mutation	novel	Y1597H	0.38
GBM	chr12	53292381	Missense_Mutation	novel	A1967G	0.11
GBM	chr12	53288612	Missense_Mutation	novel	K1541Q	0.08
GBM	chr12	53269092	Silent	novel	C50C	0.41
GBM	chr12	53269238	Missense_Mutation	novel	R99Q	0.42
GBM	chr12	53290428	Nonsense_Mutation	novel	E1775*	0.46
GBM	chr12	53270026	Missense_Mutation	novel	S362C	0.06
GBM	chr12	53277105	Nonsense_Mutation	novel	E655*	0.14
GBM	chr12	53290392	Missense_Mutation	rs755703187	A1763T	0.35
GBM	chr12	53288204	Missense_Mutation	rs749013341	R1470H	0.38
GBM	chr12	53291771	Nonsense_Mutation	novel	R1868*	0.47
GBM	chr12	53270688	Missense_Mutation	novel	L420W	0.21
GBM	chr12	53286865	Missense_Mutation	novel	V1377L	0.19
GBM	chr12	53288620	Silent	novel	L1543L	0.5
GBM	chr12	53281606	Missense_Mutation	novel	L867I	0.05
GBM	chr12	53269532	Missense_Mutation	NA	R197L	0.15
GBM	chr12	53277514	Silent	novel	E710E	0.13
GBM	chr12	53270035	Missense_Mutation	novel	A365S	0.12
GBM	chr12	53293411	Silent	NA	P2100P	0.19
GBM	chr12	53281614	Missense_Mutation	novel	W869C	0.25
GBM	chr12	53289178	Frame_Shift_Del	novel	*L1600Sfs53**	0.07
GBM	chr12	53290938	Missense_Mutation	novel	R1821H	0.4
GBM	chr12	53276832	Missense_Mutation	novel	Y638S	0.5
GBM	chr12	53269905	Silent	rs200510757	V321V	0.28
GBM	chr12	53269563	Silent	rs762879377	A207A	0.07
GBM	chr12	53282300	Missense_Mutation	rs757464917	R886W	0.07
GBM	chr12	53284069	Missense_Mutation	novel	F1030Y	0.11
HNSC	chr12	53289535	Missense_Mutation	novel	G1685V	0.77
HNSC	chr12	53282352	Missense_Mutation	novel	Q903L	0.33
HNSC	chr12	53288034	Silent	novel	E1413E	0.41
HNSC	chr12	53269956	Silent	novel	E338E	0.25
HNSC	chr12	53286654	Silent	novel	E1306E	0.11
HNSC	chr12	53270776	Silent	novel	L449L	0.25
HNSC	chr12	53270788	Missense_Mutation	novel	M453I	0.06
HNSC	chr12	53270789	Missense_Mutation	novel	G454R	0.06
HNSC	chr12	53269113	Nonsense_Mutation	novel	C57*	0.55
HNSC	chr12	53277521	Missense_Mutation	novel	E713K	0.28
HNSC	chr12	53290873	Silent	novel	L1799L	0.36
HNSC	chr12	53286350	Missense_Mutation	novel	S1205F	0.21
HNSC	chr12	53286710	Missense_Mutation	novel	S1325F	0.25
HNSC	chr12	53281597	Nonsense_Mutation	novel	R864*	0.37
HNSC	chr12	53270064	Silent	novel	L374L	0.63
HNSC	chr12	53293420	Missense_Mutation	novel	K2103N	0.17
KICH	chr12	53276715	Missense_Mutation	novel	T599S	0.15
KICH	chr12	53269423	Missense_Mutation	rs145536592	R161W	0.2
KICH	chr12	53291746	Silent	rs527909578	Y1859Y	0.19
KIRC	chr12	53279781	Missense_Mutation	rs750838036	R805I	0.24
KIRC	chr12	53291785	Silent	NA	L1872L	0.4
KIRC	chr12	53293472	Nonstop_Mutation	NA	2121Qext13	0.06
KIRC	chr12	53289168	Missense_Mutation	NA	L1596P	0.32
KIRC	chr12	53269118	Missense_Mutation	rs770277802	Q59R	0.22
KIRC	chr12	53292277	Splice_Site	NA	X1933_splice	0.34
KIRC	chr12	53290383	Missense_Mutation	NA	I1760F	0.21
KIRC	chr12	53291761	Silent	NA	T1864T	0.21
KIRP	chr12	53293448	Missense_Mutation	NA	Y2113H	0.47
KIRP	chr12	53269938	Silent	NA	P332P	0.25
KIRP	chr12	53291821	Silent	rs760990800	T1884T	0.9
KIRP	chr12	53286643	Missense_Mutation	NA	P1303T	0.51
KIRP	chr12	53289496	Missense_Mutation	rs200673617	R1672H	0.3
LAML	chr12	53290923	Missense_Mutation	novel	A1816V	0.09
LAML	chr12	53269661	Frame_Shift_Ins	novel	*G241Mfs43**	0.67
LGG	chr12	53286567	Silent	NA	L1277L	0.5
LGG	chr12	53288672	Missense_Mutation	rs754484022	R1561W	0.28
LGG	chr12	53290449	Missense_Mutation	NA	A1782T	0.21
LGG	chr12	53292064	Silent	novel	L1924L	0.15
LGG	chr12	53292593	Missense_Mutation	novel	V1978L	0.23
LIHC	chr12	53290426	Missense_Mutation	rs542853803	R1774Q	0.22
LIHC	chr12	53281540	Missense_Mutation	novel	H845Y	0.56
LIHC	chr12	53293592	3'UTR	novel		0.44
LIHC	chr12	53276802	Missense_Mutation	NA	H628L	0.33
LIHC	chr12	53290367	Silent	novel	L1754L	0.44
LUAD	chr12	53286613	Missense_Mutation	NA	G1293C	0.27
LUAD	chr12	53269507	Missense_Mutation	novel	H189Y	0.06
LUAD	chr12	53269906	Silent	NA	L322L	0.37
LUAD	chr12	53290425	Nonsense_Mutation	novel	R1774*	0.11
LUAD	chr12	53293412	Nonsense_Mutation	novel	R2101*	0.15
LUAD	chr12	53289421	Missense_Mutation	rs749239351	R1647Q	0.1
LUAD	chr12	53283183	Missense_Mutation	novel	I949S	0.14
LUAD	chr12	53292310	Silent	novel	V1943V	0.38
LUAD	chr12	53277110	Silent	novel	A656A	0.22
LUAD	chr12	53279821	Silent	novel	H818H	0.35
LUAD	chr12	53291859	Missense_Mutation	novel	K1897M	0.12
LUAD	chr12	53269369	Missense_Mutation	rs199588886	V143M	0.37
LUSC	chr12	53285985	Missense_Mutation	novel	K1083N	0.24
LUSC	chr12	53293311	Missense_Mutation	novel	R2067P	0.23
LUSC	chr12	53286782	Missense_Mutation	novel	P1349H	0.11
LUSC	chr12	53269125	Silent	novel	L61L	0.46
LUSC	chr12	53269498	Missense_Mutation	novel	E186Q	0.14
LUSC	chr12	53269816	Nonsense_Mutation	novel	Q292*	0.26
LUSC	chr12	53269536	Silent	NA	A198A	0.35
LUSC	chr12	53293373	Missense_Mutation	novel	P2088S	0.62
LUSC	chr12	53286695	Missense_Mutation	novel	R1320H	0.07
LUSC	chr12	53269720	Missense_Mutation	rs142300200	R260C	0.37
LUSC	chr12	53288323	Frame_Shift_Del	novel	*E1511Kfs24**	0.22
LUSC	chr12	53283443	Silent	NA	L994L	0.42
LUSC	chr12	53289190	Silent	rs145634647	F1603F	0.42
LUSC	chr12	53293525	3'UTR	novel		0.24
LUSC	chr12	53283165	Missense_Mutation	novel	H943R	0.54
LUSC	chr12	53293366	Frame_Shift_Ins	novel	*A2087Gfs66**	0.16
LUSC	chr12	53277512	Nonsense_Mutation	NA	E710*	0.14
LUSC	chr12	53277553	Silent	novel	L723L	0.31
LUSC	chr12	53293427	Frame_Shift_Ins	novel	*G2107Wfs46**	0.41
LUSC	chr12	53288630	Missense_Mutation	novel	C1547S	0.07
LUSC	chr12	53269167	Silent	novel	L75L	0.29
LUSC	chr12	53269682	Missense_Mutation	novel	R247K	0.34
LUSC	chr12	53290128	Silent	novel	G1719G	0.21
OV	chr12	53292599	Missense_Mutation	novel	G1980R	0.05
OV	chr12	53288608	Silent	novel	S1539S	0.21
OV	chr12	53286846	Silent	novel	P1370P	0.09
OV	chr12	53288548	Silent	novel	T1519T	0.34
OV	chr12	53272801	Missense_Mutation	novel	C484S	0.08
OV	chr12	53277547	Missense_Mutation	NA	D721E	0.31
OV	chr12	53272829	Missense_Mutation	novel	G493V	0.31
OV	chr12	53284067	Silent	novel	L1029L	0.08
OV	chr12	53288584	Missense_Mutation	novel	W1531C	0.13
OV	chr12	53282269	Silent	novel	T875T	0.06
OV	chr12	53288639	Missense_Mutation	novel	K1550Q	0.08
OV	chr12	53286838	Missense_Mutation	novel	V1368I	0.11
OV	chr12	53289251	Missense_Mutation	novel	V1624F	0.05
OV	chr12	53288660	Missense_Mutation	novel	G1557R	0.24
OV	chr12	53283456	Frame_Shift_Ins	novel	*G999Afs12**	0.05
OV	chr12	53289212	Missense_Mutation	novel	R1611G	0.05
OV	chr12	53286825	Silent	novel	T1363T	0.1
OV	chr12	53269181	Missense_Mutation	novel	L80P	0.08
OV	chr12	53291820	Missense_Mutation	novel	T1884I	0.03
OV	chr12	53282359	Silent	NA	L905L	0.16
OV	chr12	53288003	Missense_Mutation	NA	D1403G	0.16
OV	chr12	53291763	Missense_Mutation	novel	Q1865R	0.04
OV	chr12	53293401	Missense_Mutation	NA	R2097H	0.26
OV	chr12	53282288	Silent	NA	L882L	0.09
OV	chr12	53281540	In_Frame_Ins	novel	H845delinsRD	0.41
PAAD	chr12	53281546	Missense_Mutation	novel	D847N	0.18
PAAD	chr12	53286478	Nonsense_Mutation	novel	Q1248*	0.18
PAAD	chr12	53288002	Missense_Mutation	novel	D1403N	0.2
PAAD	chr12	53292300	Missense_Mutation	rs774946140	S1940N	0.06
PRAD	chr12	53272791	Silent	NA	S480S	0.09
PRAD	chr12	53270002	Missense_Mutation	NA	R354C	0.16
PRAD	chr12	53283182	Missense_Mutation	novel	I949V	0.11
PRAD	chr12	53286456	Silent	novel	N1240N	0.38
PRAD	chr12	53289589	Missense_Mutation	novel	P1703L	0.35
READ	chr12	53276653	Silent	rs144474323	P578P	0.47
READ	chr12	53290132	Missense_Mutation	rs149892921	V1721M	0.13
READ	chr12	53270758	Silent	novel	G443G	0.39
SARC	chr12	53289543	Missense_Mutation	novel	P1688S	0.23
SARC	chr12	53286816	Silent	novel	V1360V	0.1
SARC	chr12	53286817	Missense_Mutation	novel	P1361S	0.11
SARC	chr12	53286143	Missense_Mutation	rs777519085	I1136T	0.42
SARC	chr12	53292582	Missense_Mutation	novel	G1974V	0.25
SKCM	chr12	53289101	Silent	NA	L1574L	0.28
SKCM	chr12	53286186	Silent	rs148885660	L1150L	0.3
SKCM	chr12	53269371	Silent	NA	V143V	0.33
SKCM	chr12	53276701	Silent	rs147987096	A594A	0.28
SKCM	chr12	53268778	Silent	NA	F4F	0.16
SKCM	chr12	53269373	Missense_Mutation	NA	A144V	0.41
SKCM	chr12	53270748	Missense_Mutation	NA	A440V	0.3
SKCM	chr12	53272724	Missense_Mutation	NA	S458F	0.24
SKCM	chr12	53277563	Missense_Mutation	rs539894607	R727C	0.2
SKCM	chr12	53289284	Missense_Mutation	NA	H1635Y	0.06
SKCM	chr12	53292052	Silent	NA	S1920S	0.17
SKCM	chr12	53283521	Silent	NA	K1020K	0.69
SKCM	chr12	53276853	Missense_Mutation	NA	T645I	0.96
SKCM	chr12	53284127	Silent	rs148775541	S1049S	0.31
SKCM	chr12	53293382	Missense_Mutation	novel	Y2091H	0.28
SKCM	chr12	53291694	Missense_Mutation	NA	M1842R	0.37
SKCM	chr12	53293543	3'UTR	novel		0.32
SKCM	chr12	53292377	Nonsense_Mutation	NA	R1966*	0.19
SKCM	chr12	53269297	Missense_Mutation	novel	R119G	0.16
SKCM	chr12	53289567	Nonsense_Mutation	NA	Q1696*	0.42
SKCM	chr12	53289514	Missense_Mutation	NA	S1678F	0.62
SKCM	chr12	53292836	Silent	novel	F2009F	0.15
SKCM	chr12	53289462	Missense_Mutation	novel	L1661F	0.72
SKCM	chr12	53277563	Missense_Mutation	rs539894607	R727C	0.08
SKCM	chr12	53289299	Missense_Mutation	NA	L1640F	0.26
SKCM	chr12	53288061	Silent	novel	S1422S	0.51
SKCM	chr12	53269444	Missense_Mutation	NA	R168W	0.07
SKCM	chr12	53279841	Missense_Mutation	NA	T825I	0.12
SKCM	chr12	53293309	Silent	NA	D2066D	0.39
SKCM	chr12	53276735	Missense_Mutation	rs775293865	I606V	0.11
SKCM	chr12	53277563	Missense_Mutation	rs539894607	R727C	0.58
SKCM	chr12	53292870	Missense_Mutation	NA	R2021W	0.4
SKCM	chr12	53286685	Missense_Mutation	novel	G1317R	0.3
SKCM	chr12	53270799	Splice_Site	NA	X457_splice	0.24
SKCM	chr12	53283433	Missense_Mutation	novel	S991L	0.59
SKCM	chr12	53270402	Nonsense_Mutation	NA	Q390*	0.21
STAD	chr12	53286448	Missense_Mutation	NA	P1238T	0.15
STAD	chr12	53288048	Missense_Mutation	rs531311020	R1418Q	0.27
STAD	chr12	53269962	Nonsense_Mutation	novel	C340*	0.08
STAD	chr12	53277102	Missense_Mutation	novel	R654W	0.21
STAD	chr12	53292320	Missense_Mutation	NA	S1947R	0.26
STAD	chr12	53286432	Silent	NA	L1232L	0.1
STAD	chr12	53283496	Missense_Mutation	NA	L1012S	0.06
STAD	chr12	53292808	Missense_Mutation	novel	Y2000C	0.32
STAD	chr12	53272739	Nonsense_Mutation	novel	L463*	0.2
STAD	chr12	53274945	Silent	NA	P545P	0.15
STAD	chr12	53269641	Silent	NA	V233V	0.16
STAD	chr12	53288565	Missense_Mutation	NA	E1525V	0.24
STAD	chr12	53286165	Silent	NA	S1143S	0.16
STAD	chr12	53286294	Silent	rs765718188	V1186V	0.3
STAD	chr12	53292291	Missense_Mutation	NA	P1937L	0.41
STAD	chr12	53290850	Missense_Mutation	NA	A1792T	0.42
STAD	chr12	53292598	Frame_Shift_Ins	novel	*E1981Gfs6**	0.45
STAD	chr12	53285996	Missense_Mutation	NA	Q1087R	0.05
STAD	chr12	53292858	Missense_Mutation	NA	R2017W	0.39
STAD	chr12	53289120	Frame_Shift_Del	NA	L1581*	0.13
STAD	chr12	53276652	Missense_Mutation	rs149272357	P578L	0.25
STAD	chr12	53279841	Missense_Mutation	NA	T825I	0.2
STAD	chr12	53277895	Missense_Mutation	NA	R767W	0.12
STAD	chr12	53286586	Missense_Mutation	NA	T1284A	0.06
STAD	chr12	53290150	Silent	NA	L1727L	0.13
STAD	chr12	53284085	Silent	rs200962229	G1035G	0.29
STAD	chr12	53269046	Missense_Mutation	novel	A35V	0.18
STAD	chr12	53286610	Missense_Mutation	novel	W1292R	0.24
STAD	chr12	53277826	Missense_Mutation	NA	S744P	0.18
STAD	chr12	53283449	Silent	NA	C996C	0.18
STAD	chr12	53291803	Silent	NA	G1878G	0.3
THCA	chr12	53286593	Missense_Mutation	NA	Q1286L	0.06
UCEC	chr12	53270797	Splice_Region	rs756038295	T456T	0.48
UCEC	chr12	53268904	Intron	novel		0.3
UCEC	chr12	53292377	Nonsense_Mutation	NA	R1966*	0.32
UCEC	chr12	53289218	Missense_Mutation	novel	P1613S	0.33
UCEC	chr12	53269623	Silent	novel	H227H	0.54
UCEC	chr12	53270405	In_Frame_Del	novel	S392_Q399del	0.1
UCEC	chr12	53276654	Missense_Mutation	novel	E579K	0.41
UCEC	chr12	53269500	Missense_Mutation	NA	E186D	0.11
UCEC	chr12	53272765	Missense_Mutation	NA	L472I	0.31
UCEC	chr12	53281530	Silent	rs143458983	S841S	0.26
UCEC	chr12	53269531	Nonsense_Mutation	novel	R197*	0.45
UCEC	chr12	53269293	Silent	NA	T117T	0.29
UCEC	chr12	53269761	Silent	rs758940498	S273S	0.23
UCEC	chr12	53269972	Missense_Mutation	novel	L344I	0.05
UCEC	chr12	53283458	Silent	NA	G999G	0.31
UCEC	chr12	53286824	Missense_Mutation	rs747176870	T1363M	0.29
UCEC	chr12	53290937	Missense_Mutation	NA	R1821C	0.23
UCEC	chr12	53269982	Missense_Mutation	novel	L347P	0.05
UCEC	chr12	53277491	Missense_Mutation	novel	A703S	0.18
UCEC	chr12	53281598	Missense_Mutation	rs752710244	R864Q	0.24
UCEC	chr12	53291750	Silent	novel	L1861L	0.22
UCEC	chr12	53279796	Missense_Mutation	rs780763709	S810L	0.32
UCEC	chr12	53288077	Missense_Mutation	NA	A1428T	0.63
UCEC	chr12	53290850	Missense_Mutation	NA	A1792T	0.23
UCEC	chr12	53292957	Missense_Mutation	NA	I2050V	0.41
UCEC	chr12	53284162	Missense_Mutation	novel	C1061Y	0.15
UCEC	chr12	53289138	Frame_Shift_Del	novel	*G1587Afs66**	0.32
UCEC	chr12	53269426	Nonsense_Mutation	novel	R162*	0.39
UCEC	chr12	53290896	Missense_Mutation	novel	L1807P	0.35
UCEC	chr12	53288048	Missense_Mutation	novel	R1418L	0.3
UCEC	chr12	53292063	Missense_Mutation	novel	L1924P	0.09
UCEC	chr12	53292001	Silent	rs539162861	P1903P	0.35
UCEC	chr12	53284085	Silent	rs200962229	G1035G	0.54
UCEC	chr12	53289495	Missense_Mutation	rs765613239	R1672C	0.59
UCEC	chr12	53292918	Missense_Mutation	novel	R2037C	0.44
UCEC	chr12	53284118	Silent	novel	L1046L	0.25
UCEC	chr12	53269237	Nonsense_Mutation	novel	R99*	0.13
UCEC	chr12	53269978	Missense_Mutation	novel	G346C	0.18
UCEC	chr12	53277913	Missense_Mutation	novel	A773S	0.37
UCEC	chr12	53269942	Missense_Mutation	novel	R334W	0.49
UCEC	chr12	53290125	Silent	rs769120082	P1718P	0.35
UCEC	chr12	53286415	Missense_Mutation	novel	Y1227H	0.44
UCEC	chr12	53284106	Silent	NA	N1042N	0.41
UCEC	chr12	53281565	Missense_Mutation	NA	Y853C	0.11
UCEC	chr12	53276634	Missense_Mutation	novel	S572N	0.25
UCEC	chr12	53292650	Silent	novel	L1997L	0.44
UCEC	chr12	53286633	Frame_Shift_Del	novel	*S1301Vfs23**	0.38
UCEC	chr12	53288694	Missense_Mutation	novel	A1568V	0.33
UCEC	chr12	53277476	Missense_Mutation	novel	E698K	0.2
UCEC	chr12	53279734	Splice_Region	novel	P789P	0.21
UCEC	chr12	53281597	Nonsense_Mutation	novel	R864*	0.15
UCEC	chr12	53291771	Nonsense_Mutation	novel	R1868*	0.4
UCEC	chr12	53269064	Missense_Mutation	novel	R41Q	0.39
UCEC	chr12	53269762	Missense_Mutation	rs533105519	A274T	0.17
UCEC	chr12	53272797	Silent	rs752304217	P482P	0.3
UCEC	chr12	53286402	Silent	novel	I1222I	0.28
UCEC	chr12	53288654	Missense_Mutation	novel	D1555Y	0.31
UCEC	chr12	53293312	Silent	rs369327696	R2067R	0.15
UCEC	chr12	53290943	Nonsense_Mutation	novel	Q1823*	0.1
UCEC	chr12	53276711	Missense_Mutation	rs147544896	D598N	0.49
UCEC	chr12	53283164	Missense_Mutation	novel	H943N	0.22
UCEC	chr12	53292004	Missense_Mutation	novel	W1904C	0.1
UCEC	chr12	53268926	Intron	novel		0.39
UCEC	chr12	53286708	Silent	NA	A1324A	0.51
UCEC	chr12	53269738	Missense_Mutation	rs372670255	R266C	0.38
UCEC	chr12	53274978	Silent	novel	A556A	0.08
UCEC	chr12	53283396	Frame_Shift_Ins	novel	*W981Mfs23**	0.37
UCEC	chr12	53286529	Nonsense_Mutation	novel	R1265*	0.13
UCEC	chr12	53286824	Missense_Mutation	rs747176870	T1363M	0.36
UCEC	chr12	53274996	Missense_Mutation	novel	K562N	0.38
UCEC	chr12	53282382	Missense_Mutation	novel	S913N	0.36
UCEC	chr12	53286553	Missense_Mutation	novel	A1273T	0.21
UCEC	chr12	53279809	Silent	NA	G814G	0.34
UCEC	chr12	53292654	Missense_Mutation	novel	Y1998C	0.33
UCEC	chr12	53268909	Intron	novel		0.25
UCEC	chr12	53293370	Missense_Mutation	novel	A2087P	0.22
UCEC	chr12	53283396	Frame_Shift_Ins	novel	*W981Mfs23**	0.36
UCEC	chr12	53290206	Silent	NA	Q1745Q	0.28
UCEC	chr12	53272854	Missense_Mutation	novel	E501D	0.1
UCEC	chr12	53274901	Silent	novel	L531L	0.35
UCEC	chr12	53282329	Missense_Mutation	novel	K895N	0.55
UCEC	chr12	53284086	Missense_Mutation	novel	E1036K	0.1
UCEC	chr12	53288604	Missense_Mutation	novel	S1538F	0.46
UCEC	chr12	53281508	Missense_Mutation	novel	L834S	0.33
UCEC	chr12	53286466	Nonsense_Mutation	novel	Q1244*	0.54
UCEC	chr12	53288159	Missense_Mutation	novel	S1455N	0.4
UCEC	chr12	53269959	Silent	NA	S339S	0.24
UCEC	chr12	53284089	Silent	NA	L1037L	0.24
UCEC	chr12	53284119	Missense_Mutation	novel	C1047R	0.35
UCEC	chr12	53291731	Silent	novel	I1854I	0.08
UCEC	chr12	53286217	Missense_Mutation	novel	L1161M	0.3

Copy Number Variations (CNVs)

Cancer	Type	Freq	Q-value
DLBC	AMP	0.1875	0.085003
READ	DEL	0.0667	0.064633
STAD	DEL	0.0975	0.22179

Survival Analysis

Cancer	P-value	Q-value
THYM	0.0029	Kaplan-Meier Survival Analysis
KIRC	0.00087	Kaplan-Meier Survival Analysis
STAD	0.0028	Kaplan-Meier Survival Analysis
SARC	0.0019	Kaplan-Meier Survival Analysis
MESO	0.0001	Kaplan-Meier Survival Analysis
ACC	0.00011	Kaplan-Meier Survival Analysis
SKCM	0.00075	Kaplan-Meier Survival Analysis
KIRP	0.00012	Kaplan-Meier Survival Analysis
PAAD	0.0034	Kaplan-Meier Survival Analysis
PCPG	0.034	Kaplan-Meier Survival Analysis
KICH	0.00056	Kaplan-Meier Survival Analysis
UCEC	0.00011	Kaplan-Meier Survival Analysis
LIHC	0.00021	Kaplan-Meier Survival Analysis
CHOL	0.028	Kaplan-Meier Survival Analysis
LUAD	0.00023	Kaplan-Meier Survival Analysis

Drugs

EuRBPDB

Description

RBPome

Expression

Transcripts

Gene Model

Pathways

Phenotypes

GWAS

PPI

Gene Ontology

Select Dataset :

Input Drug :

Input Cell Line :

Eesembl ID

Cell lines and drugs in GSE70138 or GSE92742