EuRBPDB

Description

RBDs

Expression

Transcripts

Gene Model

Pathways

PPI

Orthologs

Gene Ontology

Description

Ensembl ID: ENSG00000135587 (Gene tree)
Gene ID: 6610
Gene Symbol: SMPD2
Alias: nSMase|ISC1
Full Name: sphingomyelin phosphodiesterase 2
Gene Type: protein_coding
Species: Homo_sapiens
Status: putative
Strand: Plus strand
Length: 3,277 bases
Position: chr6:109,440,646-109,443,922
Accession: 11121
RBP type: canonical RBP
Summary: This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]

RNA binding domains(RBDs)

Protein ID	Domain	Pfam ID	E-value	Domain number	Total number
ENSP00000258052	Exo_endo_phos	PF03372.23	1.5e-12	1	1

Expression

Transcripts

Transcript ID	Name	Length	RefSeq ID	Protein ID	Length	RefSeq ID	UniportKB ID
ENST00000458487	SMPD2-203	613	XM_005267109	ENSP00000399731	204 (aa)	XP_005267166	H0Y5N2
ENST00000439615	SMPD2-202	482	-	-	- (aa)	-	-
ENST00000258052	SMPD2-201	1645	XM_011536079	ENSP00000258052	423 (aa)	XP_011534381	O60906

Gene Model

Click here to download ENSG00000135587's gene model file

Pathways

Pathway ID	Pathway Name	Source
hsa00600	Sphingolipid metabolism	KEGG
hsa01100	Metabolic pathways	KEGG
hsa04071	Sphingolipid signaling pathway	KEGG

Protein-Protein Interaction (PPI)

Clik here to download ENSG00000135587's network

* RBP PPI network refers to all genes directly bind to RBP

Orthologs

Ensembl ID	Gene Symbol	Coverage	Identiy	Ortholog	Gene Symbol	Coverage	Identiy	Species
ENSG00000135587	SMPD2	100	86.761	ENSAMEG00000016431	SMPD2	100	86.761	Ailuropoda_melanoleuca
ENSG00000135587	SMPD2	93	45.161	ENSACIG00000010069	smpd2b	75	51.097	Amphilophus_citrinellus
ENSG00000135587	SMPD2	95	44.737	ENSAOCG00000014544	smpd2b	72	51.572	Amphiprion_ocellaris
ENSG00000135587	SMPD2	95	44.498	ENSAPEG00000023764	smpd2b	72	51.250	Amphiprion_percula
ENSG00000135587	SMPD2	98	42.404	ENSATEG00000025113	smpd2b	100	41.136	Anabas_testudineus
ENSG00000135587	SMPD2	94	42.708	ENSACAG00000009270	SMPD2	75	54.276	Anolis_carolinensis
ENSG00000135587	SMPD2	100	92.199	ENSANAG00000028732	SMPD2	100	92.199	Aotus_nancymaae
ENSG00000135587	SMPD2	93	45.610	ENSACLG00000022892	smpd2b	72	51.875	Astatotilapia_calliptera
ENSG00000135587	SMPD2	91	36.559	ENSAMXG00000013614	smpd2b	73	50.160	Astyanax_mexicanus
ENSG00000135587	SMPD2	100	84.870	ENSBTAG00000008145	SMPD2	69	84.870	Bos_taurus
ENSG00000135587	SMPD2	91	35.961	WBGene00012105	T27F6.6	70	39.739	Caenorhabditis_elegans
ENSG00000135587	SMPD2	100	92.435	ENSCJAG00000005756	SMPD2	100	92.435	Callithrix_jacchus
ENSG00000135587	SMPD2	100	85.343	ENSCAFG00000003816	SMPD2	100	85.343	Canis_familiaris
ENSG00000135587	SMPD2	100	84.634	ENSCHIG00000022563	SMPD2	100	84.634	Capra_hircus
ENSG00000135587	SMPD2	100	83.215	ENSTSYG00000008525	SMPD2	100	83.215	Carlito_syrichta
ENSG00000135587	SMPD2	81	74.709	ENSCAPG00000008057	SMPD2	97	74.709	Cavia_aperea
ENSG00000135587	SMPD2	100	77.541	ENSCPOG00000003102	SMPD2	98	77.541	Cavia_porcellus
ENSG00000135587	SMPD2	100	92.671	ENSCCAG00000036357	SMPD2	100	92.671	Cebus_capucinus
ENSG00000135587	SMPD2	100	95.981	ENSCATG00000015266	SMPD2	100	95.981	Cercocebus_atys
ENSG00000135587	SMPD2	99	73.392	ENSCLAG00000009948	SMPD2	98	73.836	Chinchilla_lanigera
ENSG00000135587	SMPD2	100	95.981	ENSCSAG00000015322	SMPD2	100	95.981	Chlorocebus_sabaeus
ENSG00000135587	SMPD2	95	44.845	ENSCPBG00000017837	SMPD2	78	56.563	Chrysemys_picta_bellii
ENSG00000135587	SMPD2	100	95.508	ENSCANG00000029491	SMPD2	100	95.508	Colobus_angolensis_palliatus
ENSG00000135587	SMPD2	97	80.340	ENSCGRG00001019999	Smpd2	99	79.616	Cricetulus_griseus_chok1gshd
ENSG00000135587	SMPD2	97	80.340	ENSCGRG00000008928	Smpd2	99	79.616	Cricetulus_griseus_crigri
ENSG00000135587	SMPD2	96	42.553	ENSCSEG00000016030	smpd2b	95	41.844	Cynoglossus_semilaevis
ENSG00000135587	SMPD2	95	45.894	ENSCVAG00000020815	smpd2b	95	44.286	Cyprinodon_variegatus
ENSG00000135587	SMPD2	75	49.375	ENSDARG00000052701	smpd2b	73	49.375	Danio_rerio
ENSG00000135587	SMPD2	76	50.000	ENSDARG00000040523	smpd2a	75	49.533	Danio_rerio
ENSG00000135587	SMPD2	100	80.378	ENSDNOG00000003948	SMPD2	99	80.378	Dasypus_novemcinctus
ENSG00000135587	SMPD2	99	82.701	ENSDORG00000006485	Smpd2	100	82.701	Dipodomys_ordii
ENSG00000135587	SMPD2	66	34.982	FBgn0035421	CG12034	64	35.395	Drosophila_melanogaster
ENSG00000135587	SMPD2	79	49.254	ENSEBUG00000002962	smpd2b	74	50.789	Eptatretus_burgeri
ENSG00000135587	SMPD2	100	84.870	ENSEASG00005006484	SMPD2	100	84.870	Equus_asinus_asinus
ENSG00000135587	SMPD2	100	84.161	ENSECAG00000016972	SMPD2	100	84.161	Equus_caballus
ENSG00000135587	SMPD2	96	44.076	ENSELUG00000021534	smpd2b	95	43.128	Esox_lucius
ENSG00000135587	SMPD2	100	86.288	ENSFCAG00000006358	SMPD2	100	86.288	Felis_catus
ENSG00000135587	SMPD2	95	44.845	ENSFALG00000003639	SMPD2	78	57.632	Ficedula_albicollis
ENSG00000135587	SMPD2	95	46.602	ENSFHEG00000017395	smpd2b	94	45.146	Fundulus_heteroclitus
ENSG00000135587	SMPD2	93	40.050	ENSGMOG00000015239	smpd2b	94	40.547	Gadus_morhua
ENSG00000135587	SMPD2	87	46.067	ENSGALG00000033245	SMPD2	78	56.386	Gallus_gallus
ENSG00000135587	SMPD2	95	46.135	ENSGAFG00000016345	smpd2b	94	45.169	Gambusia_affinis
ENSG00000135587	SMPD2	96	44.630	ENSGACG00000005132	smpd2b	97	43.675	Gasterosteus_aculeatus
ENSG00000135587	SMPD2	94	45.550	ENSGAGG00000023942	SMPD2	77	57.188	Gopherus_agassizii
ENSG00000135587	SMPD2	100	98.818	ENSGGOG00000003394	SMPD2	100	98.818	Gorilla_gorilla
ENSG00000135587	SMPD2	99	80.095	ENSHGLG00000000226	SMPD2	100	80.095	Heterocephalus_glaber_female
ENSG00000135587	SMPD2	99	80.095	ENSHGLG00100016698	SMPD2	100	80.095	Heterocephalus_glaber_male
ENSG00000135587	SMPD2	75	50.938	ENSHCOG00000001358	smpd2b	74	50.938	Hippocampus_comes
ENSG00000135587	SMPD2	93	43.035	ENSIPUG00000024794	smpd2b	94	43.284	Ictalurus_punctatus
ENSG00000135587	SMPD2	92	43.223	ENSIPUG00000017284	smpd2a	70	51.389	Ictalurus_punctatus
ENSG00000135587	SMPD2	99	81.775	ENSSTOG00000028661	SMPD2	99	81.775	Ictidomys_tridecemlineatus
ENSG00000135587	SMPD2	99	82.734	ENSJJAG00000019368	Smpd2	99	82.734	Jaculus_jaculus
ENSG00000135587	SMPD2	98	45.540	ENSKMAG00000015753	smpd2b	71	53.185	Kryptolebias_marmoratus
ENSG00000135587	SMPD2	95	43.301	ENSLBEG00000024878	smpd2b	96	42.823	Labrus_bergylta
ENSG00000135587	SMPD2	90	44.757	ENSLACG00000016351	smpd2b	77	50.938	Latimeria_chalumnae
ENSG00000135587	SMPD2	88	39.665	ENSLOCG00000009741	smpd2b	73	50.949	Lepisosteus_oculatus
ENSG00000135587	SMPD2	99	78.571	ENSLAFG00000003298	SMPD2	100	78.385	Loxodonta_africana
ENSG00000135587	SMPD2	100	95.981	ENSMFAG00000033236	SMPD2	100	95.981	Macaca_fascicularis
ENSG00000135587	SMPD2	100	95.981	ENSMNEG00000042401	SMPD2	100	95.981	Macaca_nemestrina
ENSG00000135587	SMPD2	88	95.722	ENSMLEG00000039457	SMPD2	100	95.722	Mandrillus_leucophaeus
ENSG00000135587	SMPD2	96	44.681	ENSMAMG00000004710	smpd2b	95	43.499	Mastacembelus_armatus
ENSG00000135587	SMPD2	93	45.610	ENSMZEG00005002958	smpd2b	72	51.875	Maylandia_zebra
ENSG00000135587	SMPD2	87	44.944	ENSMGAG00000006821	SMPD2	78	55.280	Meleagris_gallopavo
ENSG00000135587	SMPD2	97	81.311	ENSMAUG00000008721	Smpd2	99	80.576	Mesocricetus_auratus
ENSG00000135587	SMPD2	100	88.180	ENSMICG00000014442	SMPD2	100	88.180	Microcebus_murinus
ENSG00000135587	SMPD2	98	77.966	ENSMOCG00000019666	Smpd2	99	77.966	Microtus_ochrogaster
ENSG00000135587	SMPD2	92	45.614	ENSMMOG00000012679	smpd2b	92	44.612	Mola_mola
ENSG00000135587	SMPD2	93	56.618	ENSMODG00000017971	SMPD2	93	57.598	Monodelphis_domestica
ENSG00000135587	SMPD2	95	45.107	ENSMALG00000000267	smpd2b	94	43.914	Monopterus_albus
ENSG00000135587	SMPD2	99	77.381	MGP_CAROLIEiJ_G0015268	Smpd2	100	77.381	Mus_caroli
ENSG00000135587	SMPD2	99	76.905	ENSMUSG00000019822	Smpd2	100	76.905	Mus_musculus
ENSG00000135587	SMPD2	99	76.905	MGP_PahariEiJ_G0030686	Smpd2	100	76.905	Mus_pahari
ENSG00000135587	SMPD2	99	76.667	MGP_SPRETEiJ_G0016077	Smpd2	100	76.667	Mus_spretus
ENSG00000135587	SMPD2	100	85.579	ENSMPUG00000010005	SMPD2	100	85.579	Mustela_putorius_furo
ENSG00000135587	SMPD2	100	82.979	ENSMLUG00000003793	SMPD2	100	82.979	Myotis_lucifugus
ENSG00000135587	SMPD2	58	89.344	ENSNGAG00000013670	Smpd2	93	89.344	Nannospalax_galili
ENSG00000135587	SMPD2	91	44.500	ENSNBRG00000008403	smpd2b	71	50.645	Neolamprologus_brichardi
ENSG00000135587	SMPD2	100	96.690	ENSNLEG00000012570	SMPD2	100	96.690	Nomascus_leucogenys
ENSG00000135587	SMPD2	95	54.094	ENSMEUG00000004602	SMPD2	94	55.112	Notamacropus_eugenii
ENSG00000135587	SMPD2	100	78.723	ENSOPRG00000012612	SMPD2	100	78.723	Ochotona_princeps
ENSG00000135587	SMPD2	93	44.853	ENSONIG00000014702	smpd2b	92	43.627	Oreochromis_niloticus
ENSG00000135587	SMPD2	100	83.688	ENSOCUG00000008607	SMPD2	100	83.688	Oryctolagus_cuniculus
ENSG00000135587	SMPD2	95	46.043	ENSORLG00000006334	smpd2b	71	53.628	Oryzias_latipes
ENSG00000135587	SMPD2	95	45.803	ENSORLG00020015231	smpd2b	71	53.312	Oryzias_latipes_hni
ENSG00000135587	SMPD2	92	46.192	ENSORLG00015010424	smpd2b	71	53.312	Oryzias_latipes_hsok
ENSG00000135587	SMPD2	95	45.084	ENSOMEG00000016121	smpd2b	94	44.125	Oryzias_melastigma
ENSG00000135587	SMPD2	100	82.270	ENSOGAG00000015505	SMPD2	100	81.797	Otolemur_garnettii
ENSG00000135587	SMPD2	100	77.986	ENSOARG00000010409	SMPD2	100	77.986	Ovis_aries
ENSG00000135587	SMPD2	100	99.054	ENSPPAG00000031363	SMPD2	100	99.054	Pan_paniscus
ENSG00000135587	SMPD2	100	86.288	ENSPPRG00000000099	SMPD2	100	86.288	Panthera_pardus
ENSG00000135587	SMPD2	100	86.288	ENSPTIG00000008954	SMPD2	100	86.288	Panthera_tigris_altaica
ENSG00000135587	SMPD2	100	99.054	ENSPTRG00000018484	SMPD2	100	99.054	Pan_troglodytes
ENSG00000135587	SMPD2	100	96.454	ENSPANG00000024480	SMPD2	100	96.454	Papio_anubis
ENSG00000135587	SMPD2	87	39.548	ENSPKIG00000011322	smpd2a	70	48.287	Paramormyrops_kingsleyae
ENSG00000135587	SMPD2	99	37.313	ENSPMGG00000000230	smpd2b	74	48.693	Periophthalmus_magnuspinnatus
ENSG00000135587	SMPD2	97	79.951	ENSPEMG00000018109	Smpd2	99	79.951	Peromyscus_maniculatus_bairdii
ENSG00000135587	SMPD2	99	40.686	ENSPMAG00000002460	smpd2b	92	50.926	Petromyzon_marinus
ENSG00000135587	SMPD2	93	58.911	ENSPCIG00000005984	SMPD2	93	59.500	Phascolarctos_cinereus
ENSG00000135587	SMPD2	95	46.618	ENSPFOG00000014164	smpd2b	94	45.652	Poecilia_formosa
ENSG00000135587	SMPD2	95	46.618	ENSPLAG00000014950	smpd2b	94	45.652	Poecilia_latipinna
ENSG00000135587	SMPD2	95	46.618	ENSPMEG00000002286	smpd2b	94	45.652	Poecilia_mexicana
ENSG00000135587	SMPD2	95	46.377	ENSPREG00000012181	smpd2b	94	45.411	Poecilia_reticulata
ENSG00000135587	SMPD2	100	96.454	ENSPPYG00000016908	-	73	96.454	Pongo_abelii
ENSG00000135587	SMPD2	100	79.196	ENSPCAG00000011808	SMPD2	100	79.196	Procavia_capensis
ENSG00000135587	SMPD2	100	88.889	ENSPCOG00000001714	SMPD2	100	88.889	Propithecus_coquereli
ENSG00000135587	SMPD2	100	84.161	ENSPVAG00000006556	SMPD2	100	84.161	Pteropus_vampyrus
ENSG00000135587	SMPD2	93	45.522	ENSPNYG00000005567	smpd2b	71	51.923	Pundamilia_nyererei
ENSG00000135587	SMPD2	94	45.610	ENSPNAG00000007986	smpd2b	93	44.634	Pygocentrus_nattereri
ENSG00000135587	SMPD2	100	78.960	ENSRNOG00000000306	Smpd2	100	78.960	Rattus_norvegicus
ENSG00000135587	SMPD2	100	95.981	ENSRBIG00000033388	SMPD2	100	95.981	Rhinopithecus_bieti
ENSG00000135587	SMPD2	100	96.217	ENSRROG00000037705	SMPD2	100	96.217	Rhinopithecus_roxellana
ENSG00000135587	SMPD2	100	92.671	ENSSBOG00000033929	SMPD2	100	92.671	Saimiri_boliviensis_boliviensis
ENSG00000135587	SMPD2	92	39.894	ENSSFOG00015022890	smpd2	96	42.389	Scleropages_formosus
ENSG00000135587	SMPD2	93	44.988	ENSSMAG00000008963	smpd2b	72	51.258	Scophthalmus_maximus
ENSG00000135587	SMPD2	95	44.337	ENSSDUG00000000098	smpd2b	94	43.614	Seriola_dumerili
ENSG00000135587	SMPD2	95	45.610	ENSSLDG00000009497	smpd2b	94	44.878	Seriola_lalandi_dorsalis
ENSG00000135587	SMPD2	100	80.378	ENSSARG00000006192	SMPD2	100	80.378	Sorex_araneus
ENSG00000135587	SMPD2	95	44.330	ENSSPUG00000013852	SMPD2	78	55.763	Sphenodon_punctatus
ENSG00000135587	SMPD2	95	44.737	ENSSPAG00000001844	smpd2b	94	43.541	Stegastes_partitus
ENSG00000135587	SMPD2	100	83.924	ENSSSCG00000004408	SMPD2	100	83.924	Sus_scrofa
ENSG00000135587	SMPD2	94	44.041	ENSTGUG00000001713	SMPD2	99	47.549	Taeniopygia_guttata
ENSG00000135587	SMPD2	93	46.420	ENSTRUG00000025701	smpd2b	94	45.432	Takifugu_rubripes
ENSG00000135587	SMPD2	93	45.658	ENSTNIG00000018297	smpd2b	99	44.913	Tetraodon_nigroviridis
ENSG00000135587	SMPD2	100	82.506	ENSTBEG00000009336	SMPD2	100	82.506	Tupaia_belangeri
ENSG00000135587	SMPD2	100	80.142	ENSTTRG00000004183	SMPD2	100	80.142	Tursiops_truncatus
ENSG00000135587	SMPD2	100	87.234	ENSUAMG00000018011	SMPD2	100	87.234	Ursus_americanus
ENSG00000135587	SMPD2	89	86.400	ENSUMAG00000025505	SMPD2	93	86.400	Ursus_maritimus
ENSG00000135587	SMPD2	97	39.196	ENSXETG00000000421	smpd2	83	48.795	Xenopus_tropicalis
ENSG00000135587	SMPD2	90	44.872	ENSXCOG00000015987	smpd2b	91	44.103	Xiphophorus_couchianus
ENSG00000135587	SMPD2	93	45.792	ENSXMAG00000018088	smpd2b	92	45.297	Xiphophorus_maculatus

Gene Ontology

Go ID	Go_term	PubmedID	Evidence	Category
GO:0004767	sphingomyelin phosphodiesterase activity	21873635.	IBA	Function
GO:0005886	plasma membrane	-	TAS	Component
GO:0005887	integral component of plasma membrane	9520418.	TAS	Component
GO:0005901	caveola	21873635.	IBA	Component
GO:0006684	sphingomyelin metabolic process	21873635.	IBA	Process
GO:0006685	sphingomyelin catabolic process	-	IEA	Process
GO:0006687	glycosphingolipid metabolic process	-	TAS	Process
GO:0009612	response to mechanical stimulus	-	IEA	Process
GO:0035556	intracellular signal transduction	-	IEA	Process
GO:0046513	ceramide biosynthetic process	-	IEA	Process
GO:0046872	metal ion binding	-	IEA	Function
GO:2000304	positive regulation of ceramide biosynthetic process	-	TAS	Process